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Protein

Hexose transporter HXT8

Gene

HXT8

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probable glucose transporter.

Miscellaneous

Present with 623 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • fructose transmembrane transporter activity Source: SGD
  • glucose transmembrane transporter activity Source: SGD
  • mannose transmembrane transporter activity Source: SGD
  • sugar:proton symporter activity Source: GO_Central

GO - Biological processi

  • glucose import Source: GO_Central
  • hexose transport Source: SGD

Keywordsi

Biological processSugar transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-31641-MONOMER.
ReactomeiR-SCE-189200. Cellular hexose transport.
R-SCE-8856825. Cargo recognition for clathrin-mediated endocytosis.

Names & Taxonomyi

Protein namesi
Recommended name:
Hexose transporter HXT8
Gene namesi
Name:HXT8
Ordered Locus Names:YJL214W
ORF Names:HRA569, J0232
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome X

Organism-specific databases

EuPathDBiFungiDB:YJL214W.
SGDiS000003750. HXT8.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 61CytoplasmicSequence analysisAdd BLAST61
Transmembranei62 – 82Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini83 – 118ExtracellularSequence analysisAdd BLAST36
Transmembranei119 – 139Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini140 – 145CytoplasmicSequence analysis6
Transmembranei146 – 166Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini167 – 176ExtracellularSequence analysis10
Transmembranei177 – 197Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini198 – 203CytoplasmicSequence analysis6
Transmembranei204 – 224Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini225 – 238ExtracellularSequence analysisAdd BLAST14
Transmembranei239 – 259Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini260 – 342CytoplasmicSequence analysisAdd BLAST83
Transmembranei343 – 359Helical; Name=7Sequence analysisAdd BLAST17
Topological domaini360 – 365ExtracellularSequence analysis6
Transmembranei366 – 383Helical; Name=8Sequence analysisAdd BLAST18
Topological domaini384 – 390CytoplasmicSequence analysis7
Transmembranei391 – 411Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini412 – 433ExtracellularSequence analysisAdd BLAST22
Transmembranei434 – 454Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini455 – 471CytoplasmicSequence analysisAdd BLAST17
Transmembranei472 – 492Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini493ExtracellularSequence analysis1
Transmembranei494 – 514Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini515 – 569CytoplasmicSequence analysisAdd BLAST55

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000503981 – 569Hexose transporter HXT8Add BLAST569

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi92N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi102N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi429N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiP40886.

Interactioni

Protein-protein interaction databases

BioGridi33545. 57 interactors.
DIPiDIP-8121N.
IntActiP40886. 1 interactor.
MINTiMINT-1359800.
STRINGi4932.YJL214W.

Structurei

3D structure databases

ProteinModelPortaliP40886.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00890000139648.
HOGENOMiHOG000202870.
InParanoidiP40886.
KOiK08139.
OrthoDBiEOG092C1Q5W.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiView protein in InterPro
IPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
PfamiView protein in Pfam
PF00083. Sugar_tr. 1 hit.
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiView protein in PROSITE
PS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P40886-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDRKTNLPE EPIFEEAEDD GCPSIENSSH LSVPTVEENK DFSEYNGEEA
60 70 80 90 100
EEVVVPEKPA SAYATVSIMC LCMAFGGFMS GWDTGTISGF VNQTDFLRRF
110 120 130 140 150
GNYSHSKNTY YLSNVRTGLI VSIFNVGSAI GCLFLSKLGD IYGRCMGLII
160 170 180 190 200
VIVVYMVGIV IQIASIDKWY QYFIGRIIAG IGAGSISVLA PMLISETAPK
210 220 230 240 250
HIRGTLLACW QLMVTFAIFL GYCTNYGTKT YSNSVQWRVP LGLCFAWAII
260 270 280 290 300
MIGGMTFVPE SPRFLVQVGK IEQAKASFAK SNKLSVDDPA VVAEIDLLVA
310 320 330 340 350
GVEAEEAMGT ASWKELFSRK TKVFQRLTMT VMINSLQQLT GDNYFFYYGT
360 370 380 390 400
TIFKSVGMND SFETSIVLGI VNFASCFFSL YSVDKLGRRR CLLLGAATMT
410 420 430 440 450
ACMVIYASVG VTRLYPNGKS EPSSKGAGNC TIVFTCFYIF CFSCTWGPVC
460 470 480 490 500
YVIISETFPL RVRSKCMSVA TAANLLWGFL IGFFTPFITS AINFYYGYVF
510 520 530 540 550
MGCLAFSYFY VFFFVPETKG LTLEEVDEMW MDGVLPWKSE SWVPASRRDG
560
DYDNEKLQHD EKPFYKRMF
Length:569
Mass (Da):63,493
Last modified:February 1, 1995 - v1
Checksum:i391C2DE8E9DB0FF2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z34098 Genomic DNA. Translation: CAA83997.1.
Z49489 Genomic DNA. Translation: CAA89511.1.
BK006943 Genomic DNA. Translation: DAA08597.1.
PIRiS50771.
RefSeqiNP_012321.1. NM_001181647.1.

Genome annotation databases

EnsemblFungiiYJL214W; YJL214W; YJL214W.
GeneIDi853216.
KEGGisce:YJL214W.

Similar proteinsi

Entry informationi

Entry nameiHXT8_YEAST
AccessioniPrimary (citable) accession number: P40886
Secondary accession number(s): D6VVY1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: September 27, 2017
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names