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Protein

Hexose transporter HXT8

Gene

HXT8

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probable glucose transporter.

GO - Molecular functioni

  • fructose transmembrane transporter activity Source: SGD
  • glucose transmembrane transporter activity Source: SGD
  • mannose transmembrane transporter activity Source: SGD

GO - Biological processi

  • fructose transport Source: GOC
  • glucose transmembrane transport Source: GOC
  • hexose transport Source: SGD
  • mannose transport Source: GOC
Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-31641-MONOMER.
ReactomeiR-SCE-428790. Facilitative Na+-independent glucose transporters.

Names & Taxonomyi

Protein namesi
Recommended name:
Hexose transporter HXT8
Gene namesi
Name:HXT8
Ordered Locus Names:YJL214W
ORF Names:HRA569, J0232
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome X

Organism-specific databases

EuPathDBiFungiDB:YJL214W.
SGDiS000003750. HXT8.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6161CytoplasmicSequence analysisAdd
BLAST
Transmembranei62 – 8221Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini83 – 11836ExtracellularSequence analysisAdd
BLAST
Transmembranei119 – 13921Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini140 – 1456CytoplasmicSequence analysis
Transmembranei146 – 16621Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini167 – 17610ExtracellularSequence analysis
Transmembranei177 – 19721Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini198 – 2036CytoplasmicSequence analysis
Transmembranei204 – 22421Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini225 – 23814ExtracellularSequence analysisAdd
BLAST
Transmembranei239 – 25921Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini260 – 34283CytoplasmicSequence analysisAdd
BLAST
Transmembranei343 – 35917Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini360 – 3656ExtracellularSequence analysis
Transmembranei366 – 38318Helical; Name=8Sequence analysisAdd
BLAST
Topological domaini384 – 3907CytoplasmicSequence analysis
Transmembranei391 – 41121Helical; Name=9Sequence analysisAdd
BLAST
Topological domaini412 – 43322ExtracellularSequence analysisAdd
BLAST
Transmembranei434 – 45421Helical; Name=10Sequence analysisAdd
BLAST
Topological domaini455 – 47117CytoplasmicSequence analysisAdd
BLAST
Transmembranei472 – 49221Helical; Name=11Sequence analysisAdd
BLAST
Topological domaini493 – 4931ExtracellularSequence analysis
Transmembranei494 – 51421Helical; Name=12Sequence analysisAdd
BLAST
Topological domaini515 – 56955CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 569569Hexose transporter HXT8PRO_0000050398Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi92 – 921N-linked (GlcNAc...)Sequence analysis
Glycosylationi102 – 1021N-linked (GlcNAc...)Sequence analysis
Glycosylationi429 – 4291N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PeptideAtlasiP40886.

Interactioni

Protein-protein interaction databases

BioGridi33545. 41 interactions.
DIPiDIP-8121N.
IntActiP40886. 1 interaction.
MINTiMINT-1359800.

Structurei

3D structure databases

ProteinModelPortaliP40886.
SMRiP40886. Positions 69-530.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00720000108754.
HOGENOMiHOG000202870.
InParanoidiP40886.
KOiK08139.
OrthoDBiEOG73JM4H.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport_like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P40886-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDRKTNLPE EPIFEEAEDD GCPSIENSSH LSVPTVEENK DFSEYNGEEA
60 70 80 90 100
EEVVVPEKPA SAYATVSIMC LCMAFGGFMS GWDTGTISGF VNQTDFLRRF
110 120 130 140 150
GNYSHSKNTY YLSNVRTGLI VSIFNVGSAI GCLFLSKLGD IYGRCMGLII
160 170 180 190 200
VIVVYMVGIV IQIASIDKWY QYFIGRIIAG IGAGSISVLA PMLISETAPK
210 220 230 240 250
HIRGTLLACW QLMVTFAIFL GYCTNYGTKT YSNSVQWRVP LGLCFAWAII
260 270 280 290 300
MIGGMTFVPE SPRFLVQVGK IEQAKASFAK SNKLSVDDPA VVAEIDLLVA
310 320 330 340 350
GVEAEEAMGT ASWKELFSRK TKVFQRLTMT VMINSLQQLT GDNYFFYYGT
360 370 380 390 400
TIFKSVGMND SFETSIVLGI VNFASCFFSL YSVDKLGRRR CLLLGAATMT
410 420 430 440 450
ACMVIYASVG VTRLYPNGKS EPSSKGAGNC TIVFTCFYIF CFSCTWGPVC
460 470 480 490 500
YVIISETFPL RVRSKCMSVA TAANLLWGFL IGFFTPFITS AINFYYGYVF
510 520 530 540 550
MGCLAFSYFY VFFFVPETKG LTLEEVDEMW MDGVLPWKSE SWVPASRRDG
560
DYDNEKLQHD EKPFYKRMF
Length:569
Mass (Da):63,493
Last modified:February 1, 1995 - v1
Checksum:i391C2DE8E9DB0FF2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z34098 Genomic DNA. Translation: CAA83997.1.
Z49489 Genomic DNA. Translation: CAA89511.1.
BK006943 Genomic DNA. Translation: DAA08597.1.
PIRiS50771.
RefSeqiNP_012321.1. NM_001181647.1.

Genome annotation databases

EnsemblFungiiYJL214W; YJL214W; YJL214W.
GeneIDi853216.
KEGGisce:YJL214W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z34098 Genomic DNA. Translation: CAA83997.1.
Z49489 Genomic DNA. Translation: CAA89511.1.
BK006943 Genomic DNA. Translation: DAA08597.1.
PIRiS50771.
RefSeqiNP_012321.1. NM_001181647.1.

3D structure databases

ProteinModelPortaliP40886.
SMRiP40886. Positions 69-530.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33545. 41 interactions.
DIPiDIP-8121N.
IntActiP40886. 1 interaction.
MINTiMINT-1359800.

Proteomic databases

PeptideAtlasiP40886.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYJL214W; YJL214W; YJL214W.
GeneIDi853216.
KEGGisce:YJL214W.

Organism-specific databases

EuPathDBiFungiDB:YJL214W.
SGDiS000003750. HXT8.

Phylogenomic databases

GeneTreeiENSGT00720000108754.
HOGENOMiHOG000202870.
InParanoidiP40886.
KOiK08139.
OrthoDBiEOG73JM4H.

Enzyme and pathway databases

BioCyciYEAST:G3O-31641-MONOMER.
ReactomeiR-SCE-428790. Facilitative Na+-independent glucose transporters.

Miscellaneous databases

PROiP40886.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport_like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence analysis of a 40.2 kb DNA fragment located near the left telomere of yeast chromosome X."
    Vandenbol M., Durand P., Bolle P.-A., Dion C., Portetelle D., Hilger F.
    Yeast 10:1657-1662(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
    Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K.
    , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
    EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  5. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.

Entry informationi

Entry nameiHXT8_YEAST
AccessioniPrimary (citable) accession number: P40886
Secondary accession number(s): D6VVY1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: June 8, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 623 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.