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P40886 (HXT8_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hexose transporter HXT8
Gene names
Name:HXT8
Ordered Locus Names:YJL214W
ORF Names:J0232, HRA569
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length569 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Probable glucose transporter.

Subcellular location

Membrane; Multi-pass membrane protein.

Miscellaneous

Present with 623 molecules/cell in log phase SD medium. Ref.4

Sequence similarities

Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 569569Hexose transporter HXT8
PRO_0000050398

Regions

Topological domain1 – 6161Cytoplasmic Potential
Transmembrane62 – 8221Helical; Name=1; Potential
Topological domain83 – 11836Extracellular Potential
Transmembrane119 – 13921Helical; Name=2; Potential
Topological domain140 – 1456Cytoplasmic Potential
Transmembrane146 – 16621Helical; Name=3; Potential
Topological domain167 – 17610Extracellular Potential
Transmembrane177 – 19721Helical; Name=4; Potential
Topological domain198 – 2036Cytoplasmic Potential
Transmembrane204 – 22421Helical; Name=5; Potential
Topological domain225 – 23814Extracellular Potential
Transmembrane239 – 25921Helical; Name=6; Potential
Topological domain260 – 34283Cytoplasmic Potential
Transmembrane343 – 35917Helical; Name=7; Potential
Topological domain360 – 3656Extracellular Potential
Transmembrane366 – 38318Helical; Name=8; Potential
Topological domain384 – 3907Cytoplasmic Potential
Transmembrane391 – 41121Helical; Name=9; Potential
Topological domain412 – 43322Extracellular Potential
Transmembrane434 – 45421Helical; Name=10; Potential
Topological domain455 – 47117Cytoplasmic Potential
Transmembrane472 – 49221Helical; Name=11; Potential
Topological domain4931Extracellular Potential
Transmembrane494 – 51421Helical; Name=12; Potential
Topological domain515 – 56955Cytoplasmic Potential

Amino acid modifications

Glycosylation921N-linked (GlcNAc...) Potential
Glycosylation1021N-linked (GlcNAc...) Potential
Glycosylation4291N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
P40886 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: 391C2DE8E9DB0FF2

FASTA56963,493
        10         20         30         40         50         60 
MTDRKTNLPE EPIFEEAEDD GCPSIENSSH LSVPTVEENK DFSEYNGEEA EEVVVPEKPA 

        70         80         90        100        110        120 
SAYATVSIMC LCMAFGGFMS GWDTGTISGF VNQTDFLRRF GNYSHSKNTY YLSNVRTGLI 

       130        140        150        160        170        180 
VSIFNVGSAI GCLFLSKLGD IYGRCMGLII VIVVYMVGIV IQIASIDKWY QYFIGRIIAG 

       190        200        210        220        230        240 
IGAGSISVLA PMLISETAPK HIRGTLLACW QLMVTFAIFL GYCTNYGTKT YSNSVQWRVP 

       250        260        270        280        290        300 
LGLCFAWAII MIGGMTFVPE SPRFLVQVGK IEQAKASFAK SNKLSVDDPA VVAEIDLLVA 

       310        320        330        340        350        360 
GVEAEEAMGT ASWKELFSRK TKVFQRLTMT VMINSLQQLT GDNYFFYYGT TIFKSVGMND 

       370        380        390        400        410        420 
SFETSIVLGI VNFASCFFSL YSVDKLGRRR CLLLGAATMT ACMVIYASVG VTRLYPNGKS 

       430        440        450        460        470        480 
EPSSKGAGNC TIVFTCFYIF CFSCTWGPVC YVIISETFPL RVRSKCMSVA TAANLLWGFL 

       490        500        510        520        530        540 
IGFFTPFITS AINFYYGYVF MGCLAFSYFY VFFFVPETKG LTLEEVDEMW MDGVLPWKSE 

       550        560 
SWVPASRRDG DYDNEKLQHD EKPFYKRMF

« Hide

References

« Hide 'large scale' references
[1]"Sequence analysis of a 40.2 kb DNA fragment located near the left telomere of yeast chromosome X."
Vandenbol M., Durand P., Bolle P.-A., Dion C., Portetelle D., Hilger F.
Yeast 10:1657-1662(1994) [PubMed: 7725802] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K. expand/collapse author list , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
EMBO J. 15:2031-2049(1996) [PubMed: 8641269] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed: 14562106] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[5]"A global topology map of the Saccharomyces cerevisiae membrane proteome."
Kim H., Melen K., Oesterberg M., von Heijne G.
Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed: 16847258] [Abstract]
Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
Strain: ATCC 208353 / W303-1A.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		Z34098 Genomic DNA. Translation: CAA83997.1.
Z49489 Genomic DNA. Translation: CAA89511.1.
BK006943 Genomic DNA. Translation: DAA08597.1.
PIRS50771.
RefSeqNP_012321.1. NM_001181647.1.

3D structure databases

ProteinModelPortalP40886.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-8121N.
MINTMINT-1359800.
STRINGP40886.

Proteomic databases

PeptideAtlasP40886.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYJL214W; YJL214W; YJL214W.
GeneID853216.
KEGGsce:YJL214W.
NMPDRfig|4932.3.peg.3284.

Organism-specific databases

CYGDYJL214w.
SGDS000003750. HXT8.

Phylogenomic databases

eggNOGfuNOG06406.
GeneTreeEFGT00070000008710.
HOGENOMHBG744444.
OrthoDBEOG43246F.

Gene expression databases

ArrayExpressP40886.
GenevestigatorP40886.
GermOnlineYJL214W. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005828. Sub_transporter.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
KOK08139.
PfamPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSPR00171. SUGRTRNSPORT.
SUPFAMSSF103473. MFS_gen_substrate_transporter. 1 hit.
TIGRFAMsTIGR00879. SP. 1 hit.
PROSITEPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio973407.

Entry information

Entry nameHXT8_YEAST
AccessionPrimary (citable) accession number: P40886
Secondary accession number(s): D6VVY1
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: December 14, 2011
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome X

Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents