Hexose transporter HXT8 - Saccharomyces cerevisiae (Baker's yeast)

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Reviewed, UniProtKB/Swiss-Prot P40886 (HXT8_YEAST)

Last modified October 13, 2009. Version 70. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
Hexose transporter HXT8

Gene names

Name:	HXT8
Ordered Locus Names:	YJL214W
ORF Names:	J0232, HRA569

Organism

Saccharomyces cerevisiae (Baker's yeast) [Complete proteome]

Taxonomic identifier

4932 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

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Protein attributes

Sequence length	569 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	Probable glucose transporter.
Subcellular location	Membrane; Multi-pass membrane protein.
Miscellaneous	Present with 623 molecules/cell in log phase SD medium. Ref.3
Sequence similarities	Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. [View classification]

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Ontologies

Keywords
Biological process	Sugar transport Transport
Cellular component	Membrane
Domain	Repeat Transmembrane
PTM	Glycoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	hexose transport Inferred from genetic interaction. Source: SGD transmembrane transport Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	fructose transmembrane transporter activity Inferred from genetic interaction. Source: SGD glucose transmembrane transporter activity Inferred from genetic interaction. Source: SGD mannose transmembrane transporter activity Inferred from genetic interaction. Source: SGD
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 569

569

Hexose transporter HXT8

PRO_0000050398

Regions

Topological domain

1 – 61

Cytoplasmic Potential

Transmembrane

62 – 82

1 Potential

Topological domain

83 – 118

Extracellular Potential

Transmembrane

119 – 139

2 Potential

Topological domain

140 – 145

Cytoplasmic Potential

Transmembrane

146 – 166

3 Potential

Topological domain

167 – 176

Extracellular Potential

Transmembrane

177 – 197

4 Potential

Topological domain

198 – 203

Cytoplasmic Potential

Transmembrane

204 – 224

5 Potential

Topological domain

225 – 238

Extracellular Potential

Transmembrane

239 – 259

6 Potential

Topological domain

260 – 342

Cytoplasmic Potential

Transmembrane

343 – 359

7 Potential

Topological domain

360 – 365

Extracellular Potential

Transmembrane

366 – 383

8 Potential

Topological domain

384 – 390

Cytoplasmic Potential

Transmembrane

391 – 411

9 Potential

Topological domain

412 – 433

Extracellular Potential

Transmembrane

434 – 454

10 Potential

Topological domain

455 – 471

Cytoplasmic Potential

Transmembrane

472 – 492

11 Potential

Topological domain

493

Extracellular Potential

Transmembrane

494 – 514

12 Potential

Topological domain

515 – 569

Cytoplasmic Potential

Amino acid modifications

Glycosylation

N-linked (GlcNAc...) Potential

Glycosylation

102

N-linked (GlcNAc...) Potential

Glycosylation

429

N-linked (GlcNAc...) Potential

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Sequences

Sequence

Length

Mass (Da)

Tools

P40886-1 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: 391C2DE8E9DB0FF2
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FASTA

569

63,493

        10         20         30         40         50         60 
MTDRKTNLPE EPIFEEAEDD GCPSIENSSH LSVPTVEENK DFSEYNGEEA EEVVVPEKPA 

        70         80         90        100        110        120 
SAYATVSIMC LCMAFGGFMS GWDTGTISGF VNQTDFLRRF GNYSHSKNTY YLSNVRTGLI 

       130        140        150        160        170        180 
VSIFNVGSAI GCLFLSKLGD IYGRCMGLII VIVVYMVGIV IQIASIDKWY QYFIGRIIAG 

       190        200        210        220        230        240 
IGAGSISVLA PMLISETAPK HIRGTLLACW QLMVTFAIFL GYCTNYGTKT YSNSVQWRVP 

       250        260        270        280        290        300 
LGLCFAWAII MIGGMTFVPE SPRFLVQVGK IEQAKASFAK SNKLSVDDPA VVAEIDLLVA 

       310        320        330        340        350        360 
GVEAEEAMGT ASWKELFSRK TKVFQRLTMT VMINSLQQLT GDNYFFYYGT TIFKSVGMND 

       370        380        390        400        410        420 
SFETSIVLGI VNFASCFFSL YSVDKLGRRR CLLLGAATMT ACMVIYASVG VTRLYPNGKS 

       430        440        450        460        470        480 
EPSSKGAGNC TIVFTCFYIF CFSCTWGPVC YVIISETFPL RVRSKCMSVA TAANLLWGFL 

       490        500        510        520        530        540 
IGFFTPFITS AINFYYGYVF MGCLAFSYFY VFFFVPETKG LTLEEVDEMW MDGVLPWKSE 

       550        560 
SWVPASRRDG DYDNEKLQHD EKPFYKRMF

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence analysis of a 40.2 kb DNA fragment located near the left telomere of yeast chromosome X." Vandenbol M., Durand P., Bolle P.-A., Dion C., Portetelle D., Hilger F. Yeast 10:1657-1662(1994) [PubMed: 7725802] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[2]	"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X." Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K. Karpfinger-Hartl L. EMBO J. 15:2031-2049(1996) [PubMed: 8641269] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[3]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed: 14562106] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[4]	"A global topology map of the Saccharomyces cerevisiae membrane proteome." Kim H., Melen K., Oesterberg M., von Heijne G. Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed: 16847258] [Abstract] Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

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Cross-references

Sequence databases
	Z34098 Genomic DNA. Translation: CAA83997.1. Z49489 Genomic DNA. Translation: CAA89511.1.
PIR	S50771.
RefSeq	NP_012321.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:8121N.
STRING	P40886.
Proteomic databases
PeptideAtlas	P40886.
Genome annotation databases
Ensembl	YJL214W; YJL214W; YJL214W; Saccharomyces cerevisiae. [Genome view]
GeneID	853216.
GenomeReviews	Gene locus YJL214W in contig Y13136_GR.
KEGG	sce:YJL214W.
NMPDR	fig\|4932.3.peg.3284.
Organism-specific databases
CYGD	YJL214w.
SGD	S000003750. HXT8.
Phylogenomic databases
HOGENOM	P40886.
Gene expression databases
ArrayExpress	P40886.
Genevestigator	P40886.
GermOnline	YJL214W. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR005828. Sub_transporter. IPR003663. Sugar/inositol_transpt. IPR005829. Sugar_transporter_CS. [Graphical view]
Pfam	PF00083. Sugar_tr. 1 hit. [Graphical view]
PRINTS	PR00171. SUGRTRNSPORT.
TIGRFAMs	TIGR00879. SP. 1 hit.
PROSITE	PS50850. MFS. 1 hit. PS00216. SUGAR_TRANSPORT_1. 1 hit. PS00217. SUGAR_TRANSPORT_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	973407.

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Entry information

Entry name

HXT8_YEAST

Accession

Primary (citable) accession number: P40886

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	October 13, 2009
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome X

Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents