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Protein

Hexose transporter HXT9

Gene

HXT9

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probable glucose transporter.

GO - Molecular functioni

  • fructose transmembrane transporter activity Source: SGD
  • galactose transmembrane transporter activity Source: SGD
  • glucose transmembrane transporter activity Source: SGD
  • mannose transmembrane transporter activity Source: SGD

GO - Biological processi

  • fructose transport Source: GOC
  • galactose transport Source: GOC
  • glucose transport Source: GOC
  • hexose transport Source: SGD
  • mannose transport Source: GOC
Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-31643-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Hexose transporter HXT9
Gene namesi
Name:HXT9
Ordered Locus Names:YJL219W
ORF Names:HRC567, J0222
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome X

Organism-specific databases

CYGDiYJL219w.
EuPathDBiFungiDB:YJL219W.
SGDiS000003755. HXT9.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5656CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei57 – 7721Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini78 – 11235ExtracellularSequence AnalysisAdd
BLAST
Transmembranei113 – 13321Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini134 – 1396CytoplasmicSequence Analysis
Transmembranei140 – 16021Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini161 – 17010ExtracellularSequence Analysis
Transmembranei171 – 19121Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini192 – 1976CytoplasmicSequence Analysis
Transmembranei198 – 21821Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini219 – 23214ExtracellularSequence AnalysisAdd
BLAST
Transmembranei233 – 25321Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini254 – 33683CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei337 – 35317Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini354 – 3596ExtracellularSequence Analysis
Transmembranei360 – 37718Helical; Name=8Sequence AnalysisAdd
BLAST
Topological domaini378 – 3847CytoplasmicSequence Analysis
Transmembranei385 – 40521Helical; Name=9Sequence AnalysisAdd
BLAST
Topological domaini406 – 42924ExtracellularSequence AnalysisAdd
BLAST
Transmembranei430 – 45021Helical; Name=10Sequence AnalysisAdd
BLAST
Topological domaini451 – 46717CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei468 – 48821Helical; Name=11Sequence AnalysisAdd
BLAST
Topological domaini489 – 4891ExtracellularSequence Analysis
Transmembranei490 – 51021Helical; Name=12Sequence AnalysisAdd
BLAST
Topological domaini511 – 56757CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 567567Hexose transporter HXT9PRO_0000050399Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei17 – 171PhosphoserineBy similarity
Modified residuei21 – 211PhosphoserineBy similarity
Modified residuei27 – 271PhosphoserineBy similarity
Modified residuei35 – 351PhosphoserineBy similarity
Modified residuei38 – 381PhosphoserineBy similarity
Glycosylationi87 – 871N-linked (GlcNAc...)Sequence Analysis
Glycosylationi227 – 2271N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein, Phosphoprotein

Interactioni

Protein-protein interaction databases

BioGridi33562. 26 interactions.
DIPiDIP-4609N.
IntActiP40885. 1 interaction.
MINTiMINT-479522.
STRINGi4932.YJL219W.

Structurei

3D structure databases

ProteinModelPortaliP40885.
SMRiP40885. Positions 64-526.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00720000108754.
HOGENOMiHOG000202870.
InParanoidiP40885.
KOiK08139.
OrthoDBiEOG73JM4H.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR005828. Sub_transporter.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P40885-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGVNNTSAN DLSTTESNSN SVANAPSVKT EHNDSKNSLN LDATEPPIDL
60 70 80 90 100
PQKPLSAYTT VAILCLMIAF GGFIFGWDTG TISGFVNLSD FIRRFGQKND
110 120 130 140 150
KGTYYLSKVR MGLIVSIFNI GCAIGGIVLS KVGDIYGRRI GLITVTAIYV
160 170 180 190 200
VGILIQITSI NKWYQYFIGR IISGLGVGGI AVLSPMLISE VAPKQIRGTL
210 220 230 240 250
VQLYQLMCTM GIFLGYCTNY GTKNYHNATQ WRVGLGLCFA WTTFMVSGMM
260 270 280 290 300
FVPESPRYLI EVGKDEEAKR SLSKSNKVSV DDPALLAEYD TIKAGIELEK
310 320 330 340 350
LAGNASWSEL LSTKTKVFQR VLMGVMIQSL QQLTGDNYFF YYGTTIFKSV
360 370 380 390 400
GLKDSFQTSI IIGVVNFFSS FIAVYTIERF GRRTCLLWGA ASMLCCFAVF
410 420 430 440 450
ASVGVTKLWP QGSSHQDITS QGAGNCMIVF TMFFIFSFAT TWAGGCYVIV
460 470 480 490 500
SETFPLRVKS RGMAIATAAN WMWGFLISFF TPFITGAINF YYGYVFLGCL
510 520 530 540 550
VFAYFYVFFF VPETKGLTLE EVNTMWLEGV PAWKSASWVP PERRTADYDA
560
DAIDHDDRPI YKRFFSS
Length:567
Mass (Da):62,858
Last modified:February 1, 1995 - v1
Checksum:i2CF4C8617D9B2701
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z34098 Genomic DNA. Translation: CAA83991.1.
Z49494 Genomic DNA. Translation: CAA89516.1.
BK006943 Genomic DNA. Translation: DAA08593.1.
PIRiS50708.
RefSeqiNP_012316.1. NM_001181652.1.

Genome annotation databases

EnsemblFungiiYJL219W; YJL219W; YJL219W.
GeneIDi853236.
KEGGisce:YJL219W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z34098 Genomic DNA. Translation: CAA83991.1.
Z49494 Genomic DNA. Translation: CAA89516.1.
BK006943 Genomic DNA. Translation: DAA08593.1.
PIRiS50708.
RefSeqiNP_012316.1. NM_001181652.1.

3D structure databases

ProteinModelPortaliP40885.
SMRiP40885. Positions 64-526.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33562. 26 interactions.
DIPiDIP-4609N.
IntActiP40885. 1 interaction.
MINTiMINT-479522.
STRINGi4932.YJL219W.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYJL219W; YJL219W; YJL219W.
GeneIDi853236.
KEGGisce:YJL219W.

Organism-specific databases

CYGDiYJL219w.
EuPathDBiFungiDB:YJL219W.
SGDiS000003755. HXT9.

Phylogenomic databases

GeneTreeiENSGT00720000108754.
HOGENOMiHOG000202870.
InParanoidiP40885.
KOiK08139.
OrthoDBiEOG73JM4H.

Enzyme and pathway databases

BioCyciYEAST:G3O-31643-MONOMER.

Miscellaneous databases

NextBioi973458.
PROiP40885.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR005828. Sub_transporter.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence analysis of a 40.2 kb DNA fragment located near the left telomere of yeast chromosome X."
    Vandenbol M., Durand P., Bolle P.-A., Dion C., Portetelle D., Hilger F.
    Yeast 10:1657-1662(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
    Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K.
    , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
    EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.

Entry informationi

Entry nameiHXT9_YEAST
AccessioniPrimary (citable) accession number: P40885
Secondary accession number(s): D6VVX7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: June 24, 2015
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.