Skip Header

 
Contribute Send feedback
Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot P40884 (MALX1_YEAST)

Last modified October 13, 2009. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Probable alpha-glucosidase YJL216C
    EC=3.2.1.20
Alternative name(s):
    Maltase
Gene names
Ordered Locus Names: YJL216C
ORF Names: J0228, HRF581
OrganismSaccharomyces cerevisiae (Baker's yeast) [Complete proteome]
Taxonomic identifier4932 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length581 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

Probable alpha-glucosidase involved in maltose metabolism.

Catalytic activity

Hydrolysis of terminal, non-reducing (1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose.

Induction

Transcriptionally regulated by PDR8. Ref.3

Sequence similarities

Belongs to the glycosyl hydrolase 13 family.

Ontologies

Keywords
   Biological processMaltose metabolism
   Molecular functionGlycosidase
Hydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processmaltose metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionalpha-glucosidase activity

Inferred from electronic annotation. Source: EC

cation binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 581581Probable alpha-glucosidase YJL216C
PRO_0000054331

Sites

Active site2101Nucleophile By similarity
Active site2721Proton donor By similarity
Active site3471 By similarity

Sequences

Sequence LengthMass (Da)Tools
P40884-1 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: 7B65BB7BA583ADF9

FASTA58167,557
        10         20         30         40         50         60 
MTIIHNPKWW KEATVYQIYP ASFKDSNNDG WGDLAGITSK LDYVKELGVD AIWVCPFYDS 

        70         80         90        100        110        120 
PQEDMGYDIA NYEKVWPRYG TNEDCFQMIE EAHKRGIKVI VDLVINHCSE EHEWFKESRS 

       130        140        150        160        170        180 
SKANPKRDWF FWRPPKGYDE KGNPIPPNNW RSFFGGSAWR YDEKTGEFFL HVFALGQPDF 

       190        200        210        220        230        240 
NWENEECRKA IYDSSVGYWL RHNVDGFRID VGSMYSKVEG LPDAPITDPT VPYQKGTEFF 

       250        260        270        280        290        300 
INGPRIHEYH KEMHNYMLSQ VPEGKEIMTV GEVGIGNEDD FRVYTSAKEG ELNMMFNFKH 

       310        320        330        340        350        360 
TSVGENPKCK YELIPFTLKD FKLALAESFL FIENTDCWST IYLENHDQPR SVSRFGSDSP 

       370        380        390        400        410        420 
KWREISSKML ATLIISLTGT VFIYQGQELG MPNFKNRKIE QIKCVEGTGT YAAIKRDYGE 

       430        440        450        460        470        480 
DSEKMKKFFE ALALISRDHG RTPFPWSADE PSAGFSKDAK PWIDMNESFR DGINAEAELK 

       490        500        510        520        530        540 
DKNSVFFFWK KALQVRKEHK DILVYGHNFQ FIDLDNDKLF MFTKDTDNKK MFAVFNFSSD 

       550        560        570        580 
NTDFSVPDNE ASYTMFFGNY ANSNGDSRTL QPWEGRLYLL K 

« Hide

References

« Hide 'large scale' references
[1]"Sequence analysis of a 40.2 kb DNA fragment located near the left telomere of yeast chromosome X."
Vandenbol M., Durand P., Bolle P.-A., Dion C., Portetelle D., Hilger F.
Yeast 10:1657-1662(1994) [PubMed: 7725802] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K. expand/collapse author list , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
EMBO J. 15:2031-2049(1996) [PubMed: 8641269] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]"A general strategy to uncover transcription factor properties identifies a new regulator of drug resistance in yeast."
Hikkel I., Lucau-Danila A., Delaveau T., Marc P., Devaux F., Jacq C.
J. Biol. Chem. 278:11427-11432(2003) [PubMed: 12529331] [Abstract]
Cited for: INDUCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

Z34098 Genomic DNA. Translation: CAA83995.1.
Z49491 Genomic DNA. Translation: CAA89513.1.
PIRS50769.
RefSeqNP_012319.1.

3D structure databases

HSSPHSSP built from PDB template 1UOK based on UniProtKB P21332.
ModBaseSearch...

Protein-protein interaction databases

STRINGP40884.

Protein family/group databases

CAZyGH13. Glycoside Hydrolase Family 13.

Genome annotation databases

EnsemblYJL216C; YJL216C; YJL216C; Saccharomyces cerevisiae. [Genome view]
GeneID853214.
GenomeReviewsGene locus YJL216C in contig Y13136_GR.
KEGGsce:YJL216C.
NMPDRfig|4932.3.peg.3282.

Organism-specific databases

CYGDYJL216c.
SGDS000003752. YJL216C.

Phylogenomic databases

HOGENOMP40884.

Enzyme and pathway databases

BRENDA3.2.1.20. 250.

Gene expression databases

ArrayExpressP40884.
GenevestigatorP40884.
GermOnlineYJL216C. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR013780. Glyco_hydro_13_b.
IPR006047. Glyco_hydro_13_cat.
IPR006589. Glyco_hydro_13_sub_cat.
IPR013781. Glyco_hydro_sg_catalytic.
[Graphical view]
Gene3DG3DSA:2.60.40.1180. Glyco_hydro_13_b. 1 hit.
G3DSA:3.20.20.80. Glyco_hydro_cat. 1 hit.
PfamPF00128. Alpha-amylase. 1 hit.
[Graphical view]
SMARTSM00642. Aamy. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio973404.

Entry information

Entry nameMALX1_YEAST
AccessionPrimary (citable) accession number: P40884
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: October 13, 2009
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

Relevant documents

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries

SIMILARITY comments

Index of protein domains and families

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome X

Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents