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P40881

- CAH_METTE

UniProt

P40881 - CAH_METTE

Protein

Carbonic anhydrase

Gene
N/A
Organism
Methanosarcina thermophila
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Reversible hydration of carbon dioxide. Essential to photosynthetic carbon dioxide fixation.

    Catalytic activityi

    H2CO3 = CO2 + H2O.

    Cofactori

    Zinc.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei96 – 961Proton donor/acceptor
    Metal bindingi115 – 1151Zinc2 Publications
    Active sitei118 – 1181
    Metal bindingi151 – 1511Zinc2 Publications
    Metal bindingi156 – 1561Zinc2 Publications
    Binding sitei236 – 2361Substrate1 Publication

    GO - Molecular functioni

    1. carbonate dehydratase activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    Keywords - Molecular functioni

    Lyase

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BRENDAi4.2.1.1. 3281.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Carbonic anhydrase (EC:4.2.1.1)
    OrganismiMethanosarcina thermophila
    Taxonomic identifieri2210 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 34341 PublicationAdd
    BLAST
    Chaini35 – 247213Carbonic anhydrasePRO_0000004273Add
    BLAST

    Interactioni

    Subunit structurei

    Homotrimer.2 Publications

    Structurei

    Secondary structure

    1
    247
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi44 – 463
    Beta strandi54 – 563
    Beta strandi73 – 808
    Beta strandi91 – 977
    Beta strandi100 – 1023
    Beta strandi113 – 1164
    Beta strandi119 – 1213
    Turni122 – 1243
    Helixi128 – 1303
    Beta strandi132 – 1343
    Beta strandi137 – 1437
    Beta strandi154 – 1618
    Beta strandi172 – 1787
    Beta strandi189 – 1924
    Beta strandi199 – 2013
    Helixi210 – 2145
    Turni224 – 2274
    Helixi228 – 24417

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1QQ0X-ray1.76A1-247[»]
    1QREX-ray1.46A1-247[»]
    1QRFX-ray1.55A35-247[»]
    1QRGX-ray1.72A35-247[»]
    1QRLX-ray1.85A35-247[»]
    1QRMX-ray1.95A35-247[»]
    1THJX-ray2.80A/B/C35-247[»]
    3OTMX-ray1.50A36-247[»]
    3OTZX-ray1.60A35-247[»]
    3OU9X-ray1.80A35-247[»]
    3OUPX-ray1.65A35-247[»]
    3OW5X-ray1.80A35-247[»]
    DisProtiDP00110.
    ProteinModelPortaliP40881.
    SMRiP40881. Positions 35-247.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP40881.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni93 – 953Substrate binding
    Regioni109 – 1102Substrate binding

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Family and domain databases

    InterProiIPR001451. Hexapep_transf.
    IPR011004. Trimer_LpxA-like.
    [Graphical view]
    PfamiPF00132. Hexapep. 2 hits.
    [Graphical view]
    SUPFAMiSSF51161. SSF51161. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P40881-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMFNKQIFTI LILSLSLALA GSGCISEGAE DNVAQEITVD EFSNIRENPV    50
    TPWNPEPSAP VIDPTAYIDP QASVIGEVTI GANVMVSPMA SIRSDEGMPI 100
    FVGDRSNVQD GVVLHALETI NEEGEPIEDN IVEVDGKEYA VYIGNNVSLA 150
    HQSQVHGPAA VGDDTFIGMQ AFVFKSKVGN NCVLEPRSAA IGVTIPDGRY 200
    IPAGMVVTSQ AEADKLPEVT DDYAYSHTNE AVVYVNVHLA EGYKETS 247
    Length:247
    Mass (Da):26,414
    Last modified:February 1, 1995 - v1
    Checksum:i1256EB566DB9207C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U08885 Genomic DNA. Translation: AAA73428.1.
    PIRiA57712.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U08885 Genomic DNA. Translation: AAA73428.1 .
    PIRi A57712.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1QQ0 X-ray 1.76 A 1-247 [» ]
    1QRE X-ray 1.46 A 1-247 [» ]
    1QRF X-ray 1.55 A 35-247 [» ]
    1QRG X-ray 1.72 A 35-247 [» ]
    1QRL X-ray 1.85 A 35-247 [» ]
    1QRM X-ray 1.95 A 35-247 [» ]
    1THJ X-ray 2.80 A/B/C 35-247 [» ]
    3OTM X-ray 1.50 A 36-247 [» ]
    3OTZ X-ray 1.60 A 35-247 [» ]
    3OU9 X-ray 1.80 A 35-247 [» ]
    3OUP X-ray 1.65 A 35-247 [» ]
    3OW5 X-ray 1.80 A 35-247 [» ]
    DisProti DP00110.
    ProteinModelPortali P40881.
    SMRi P40881. Positions 35-247.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi P40881.
    ChEMBLi CHEMBL3932.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    BRENDAi 4.2.1.1. 3281.

    Miscellaneous databases

    EvolutionaryTracei P40881.

    Family and domain databases

    InterProi IPR001451. Hexapep_transf.
    IPR011004. Trimer_LpxA-like.
    [Graphical view ]
    Pfami PF00132. Hexapep. 2 hits.
    [Graphical view ]
    SUPFAMi SSF51161. SSF51161. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "A carbonic anhydrase from the archaeon Methanosarcina thermophila."
      Alber B.E., Ferry J.G.
      Proc. Natl. Acad. Sci. U.S.A. 91:6909-6913(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 35-60.
      Strain: DSM 1825 / TM-1.
    2. "A left-hand beta-helix revealed by the crystal structure of a carbonic anhydrase from the archaeon Methanosarcina thermophila."
      Kisker C., Schindelin H., Alber B.E., Ferry J.G., Rees D.C.
      EMBO J. 15:2323-2330(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 35-247 IN COMPLEX WITH ZINC.
    3. "A closer look at the active site of gamma-class carbonic anhydrases: high-resolution crystallographic studies of the carbonic anhydrase from Methanosarcina thermophila."
      Iverson T.M., Alber B.E., Kisker C., Ferry J.G., Rees D.C.
      Biochemistry 39:9222-9231(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.46 ANGSTROMS) IN COMPLEX WITH ZINC AND SUBSTRATE.

    Entry informationi

    Entry nameiCAH_METTE
    AccessioniPrimary (citable) accession number: P40881
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Direct protein sequencing

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3