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Protein

Chloride anion exchanger

Gene

SLC26A3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Chloride/bicarbonate exchanger. Mediates the efficient absorption of chloride ions in the colon, participating in fluid homeostasis. Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAntiport, Transport
LigandChloride

Enzyme and pathway databases

ReactomeiR-HSA-427601. Multifunctional anion exchangers.

Protein family/group databases

TCDBi2.A.53.2.18. the sulfate permease (sulp) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Chloride anion exchanger
Alternative name(s):
Down-regulated in adenoma
Short name:
Protein DRA
Solute carrier family 26 member 3
Gene namesi
Name:SLC26A3
Synonyms:DRA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:3018. SLC26A3.

Subcellular locationi

  • Apical cell membrane 1 Publication; Multi-pass membrane protein 1 Publication
  • Membrane By similarity; Multi-pass membrane protein By similarity

  • Note: Localized in sperm membranes. Midpiece of sperm tail. Colocalizes with CFTR at the midpiece of sperm tail (By similarity).By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 76CytoplasmicCuratedAdd BLAST76
Transmembranei77 – 97HelicalSequence analysisAdd BLAST21
Topological domaini98 – 99ExtracellularCurated2
Transmembranei100 – 120HelicalSequence analysisAdd BLAST21
Topological domaini121 – 124CytoplasmicCurated4
Transmembranei125 – 145HelicalSequence analysisAdd BLAST21
Topological domaini146 – 175ExtracellularCuratedAdd BLAST30
Transmembranei176 – 196HelicalSequence analysisAdd BLAST21
Topological domaini197CytoplasmicCurated1
Transmembranei198 – 218HelicalSequence analysisAdd BLAST21
Topological domaini219 – 257ExtracellularCuratedAdd BLAST39
Transmembranei258 – 278HelicalSequence analysisAdd BLAST21
Topological domaini279 – 342CytoplasmicCuratedAdd BLAST64
Transmembranei343 – 363HelicalSequence analysisAdd BLAST21
Topological domaini364 – 374ExtracellularCuratedAdd BLAST11
Transmembranei375 – 395HelicalSequence analysisAdd BLAST21
Topological domaini396 – 411CytoplasmicCuratedAdd BLAST16
Transmembranei412 – 432HelicalSequence analysisAdd BLAST21
Topological domaini433 – 469ExtracellularCuratedAdd BLAST37
Transmembranei470 – 490HelicalSequence analysisAdd BLAST21
Topological domaini491 – 701CytoplasmicCuratedAdd BLAST211

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Diarrhea 1, secretory chloride, congenital (DIAR1)10 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disease characterized by voluminous watery stools containing an excess of chloride. The children with this disease are often premature.
See also OMIM:214700
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_007428120G → S in DIAR1. 3 PublicationsCorresponds to variant dbSNP:rs386833479Ensembl.1
Natural variantiVAR_007429124H → L in DIAR1. 2 PublicationsCorresponds to variant dbSNP:rs121913030Ensembl.1
Natural variantiVAR_066062129P → L in DIAR1. 2 PublicationsCorresponds to variant dbSNP:rs386833480Ensembl.1
Natural variantiVAR_066063131P → L in DIAR1. 2 PublicationsCorresponds to variant dbSNP:rs386833481Ensembl.1
Natural variantiVAR_007430131P → R in DIAR1. 3 PublicationsCorresponds to variant dbSNP:rs386833481Ensembl.1
Natural variantiVAR_077354134S → N in DIAR1. 1 Publication1
Natural variantiVAR_066064136M → I in DIAR1. 1 PublicationCorresponds to variant dbSNP:rs386833483Ensembl.1
Natural variantiVAR_077355175R → S in DIAR1. 1 PublicationCorresponds to variant dbSNP:rs386833484Ensembl.1
Natural variantiVAR_066065204Y → D in DIAR1. 1 PublicationCorresponds to variant dbSNP:rs386833487Ensembl.1
Natural variantiVAR_012777206S → P in DIAR1. 1 PublicationCorresponds to variant dbSNP:rs386833488Ensembl.1
Natural variantiVAR_066066220H → P in DIAR1. 2 PublicationsCorresponds to variant dbSNP:rs386833489Ensembl.1
Natural variantiVAR_007432318Missing in DIAR1. 3 PublicationsCorresponds to variant dbSNP:rs386833491Ensembl.1
Natural variantiVAR_066067343C → Y in DIAR1. 1 PublicationCorresponds to variant dbSNP:rs386833444Ensembl.1
Natural variantiVAR_066068344 – 349FGIAMV → DA in DIAR1. 1 Publication6
Natural variantiVAR_066069379G → A in DIAR1. 1 PublicationCorresponds to variant dbSNP:rs386833446Ensembl.1
Natural variantiVAR_077356394S → I in DIAR1. 1 Publication1
Natural variantiVAR_066070398S → F in DIAR1. 1 PublicationCorresponds to variant dbSNP:rs143839547Ensembl.1
Natural variantiVAR_077357438S → P in DIAR1. 1 PublicationCorresponds to variant dbSNP:rs763669046Ensembl.1
Natural variantiVAR_012778468D → V in DIAR1. 1 PublicationCorresponds to variant dbSNP:rs386833454Ensembl.1
Natural variantiVAR_077358495Q → P in DIAR1. 1 Publication1
Natural variantiVAR_066071496L → R in DIAR1. 1 PublicationCorresponds to variant dbSNP:rs386833457Ensembl.1
Natural variantiVAR_077359508C → R in DIAR1. 1 Publication1
Natural variantiVAR_066072520Y → C in DIAR1. 1 PublicationCorresponds to variant dbSNP:rs386833462Ensembl.1
Natural variantiVAR_066073521K → N in DIAR1. 1 PublicationCorresponds to variant dbSNP:rs386833463Ensembl.1
Natural variantiVAR_007433527Missing in DIAR1. 1 Publication1
Natural variantiVAR_066074544I → N in DIAR1. 1 PublicationCorresponds to variant dbSNP:rs386833467Ensembl.1
Natural variantiVAR_077360547A → E in DIAR1. 1 Publication1
Natural variantiVAR_066075652D → N in DIAR1. 1 PublicationCorresponds to variant dbSNP:rs140426439Ensembl.1
Natural variantiVAR_077361654S → P in DIAR1. 1 Publication1
Natural variantiVAR_077362675I → II in DIAR1. 1 PublicationCorresponds to variant dbSNP:rs121913031Ensembl.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi1811.
MalaCardsiSLC26A3.
MIMi214700. phenotype.
OpenTargetsiENSG00000091138.
Orphaneti53689. Congenital chloride diarrhea.
PharmGKBiPA35044.

Polymorphism and mutation databases

BioMutaiSLC26A3.
DMDMi729367.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000801611 – 764Chloride anion exchangerAdd BLAST764

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi153N-linked (GlcNAc...)1 Publication1
Glycosylationi161N-linked (GlcNAc...)1 Publication1
Glycosylationi165N-linked (GlcNAc...)1 Publication1

Post-translational modificationi

N-glycosylation is required for efficient cell surface expression, and protection from proteolytic degradation.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP40879.
PeptideAtlasiP40879.
PRIDEiP40879.

PTM databases

iPTMnetiP40879.
PhosphoSitePlusiP40879.

Expressioni

Developmental stagei

Expression is significantly decreased in adenomas (polyps) and adenocarcinomas of the colon.

Gene expression databases

BgeeiENSG00000091138.
CleanExiHS_SLC26A3.
ExpressionAtlasiP40879. baseline and differential.
GenevisibleiP40879. HS.

Organism-specific databases

HPAiHPA036055.

Interactioni

Subunit structurei

Interacts with CFTR, SLC26A6 and SLC9A3R1 (By similarity). Interacts with PDZK1.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
SLC9A3R2Q155995EBI-8542350,EBI-1149760

Protein-protein interaction databases

BioGridi108145. 1 interactor.
IntActiP40879. 2 interactors.
MINTiMINT-1787198.
STRINGi9606.ENSP00000345873.

Structurei

3D structure databases

ProteinModelPortaliP40879.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini525 – 720STASPROSITE-ProRule annotationAdd BLAST196

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0236. Eukaryota.
COG0659. LUCA.
GeneTreeiENSGT00760000119026.
HOGENOMiHOG000006546.
HOVERGENiHBG000639.
InParanoidiP40879.
KOiK14078.
OMAiQETIGDC.
OrthoDBiEOG090B02P3.
PhylomeDBiP40879.
TreeFamiTF313784.

Family and domain databases

Gene3Di3.30.750.24. 2 hits.
InterProiView protein in InterPro
IPR018045. S04_transporter_CS.
IPR011547. SLC26A/SulP_dom.
IPR001902. SLC26A/SulP_fam.
IPR030321. SLC26A3.
IPR002645. STAS_dom.
PANTHERiPTHR11814. PTHR11814. 1 hit.
PTHR11814:SF150. PTHR11814:SF150. 1 hit.
PfamiView protein in Pfam
PF01740. STAS. 1 hit.
PF00916. Sulfate_transp. 1 hit.
SUPFAMiSSF52091. SSF52091. 2 hits.
TIGRFAMsiTIGR00815. sulP. 1 hit.
PROSITEiView protein in PROSITE
PS01130. SLC26A. 1 hit.
PS50801. STAS. 1 hit.

Sequencei

Sequence statusi: Complete.

P40879-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIEPFGNQYI VARPVYSTNA FEENHKKTGR HHKTFLDHLK VCCSCSPQKA
60 70 80 90 100
KRIVLSLFPI ASWLPAYRLK EWLLSDIVSG ISTGIVAVLQ GLAFALLVDI
110 120 130 140 150
PPVYGLYASF FPAIIYLFFG TSRHISVGPF PILSMMVGLA VSGAVSKAVP
160 170 180 190 200
DRNATTLGLP NNSNNSSLLD DERVRVAAAA SVTVLSGIIQ LAFGILRIGF
210 220 230 240 250
VVIYLSESLI SGFTTAAAVH VLVSQLKFIF QLTVPSHTDP VSIFKVLYSV
260 270 280 290 300
FSQIEKTNIA DLVTALIVLL VVSIVKEINQ RFKDKLPVPI PIEFIMTVIA
310 320 330 340 350
AGVSYGCDFK NRFKVAVVGD MNPGFQPPIT PDVETFQNTV GDCFGIAMVA
360 370 380 390 400
FAVAFSVASV YSLKYDYPLD GNQELIALGL GNIVCGVFRG FAGSTALSRS
410 420 430 440 450
AVQESTGGKT QIAGLIGAII VLIVVLAIGF LLAPLQKSVL AALALGNLKG
460 470 480 490 500
MLMQFAEIGR LWRKDKYDCL IWIMTFIFTI VLGLGLGLAA SVAFQLLTIV
510 520 530 540 550
FRTQFPKCST LANIGRTNIY KNKKDYYDMY EPEGVKIFRC PSPIYFANIG
560 570 580 590 600
FFRRKLIDAV GFSPLRILRK RNKALRKIRK LQKQGLLQVT PKGFICTVDT
610 620 630 640 650
IKDSDEELDN NQIEVLDQPI NTTDLPFHID WNDDLPLNIE VPKISLHSLI
660 670 680 690 700
LDFSAVSFLD VSSVRGLKSI LQEFIRIKVD VYIVGTDDDF IEKLNRYEFF
710 720 730 740 750
DGEVKSSIFF LTIHDAVLHI LMKKDYSTSK FNPSQEKDGK IDFTINTNGG
760
LRNRVYEVPV ETKF
Length:764
Mass (Da):84,505
Last modified:February 1, 1995 - v1
Checksum:i694C5BC2D4121F6D
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05366068R → Q. Corresponds to variant dbSNP:rs10280704Ensembl.1
Natural variantiVAR_007428120G → S in DIAR1. 3 PublicationsCorresponds to variant dbSNP:rs386833479Ensembl.1
Natural variantiVAR_007429124H → L in DIAR1. 2 PublicationsCorresponds to variant dbSNP:rs121913030Ensembl.1
Natural variantiVAR_066062129P → L in DIAR1. 2 PublicationsCorresponds to variant dbSNP:rs386833480Ensembl.1
Natural variantiVAR_066063131P → L in DIAR1. 2 PublicationsCorresponds to variant dbSNP:rs386833481Ensembl.1
Natural variantiVAR_007430131P → R in DIAR1. 3 PublicationsCorresponds to variant dbSNP:rs386833481Ensembl.1
Natural variantiVAR_077354134S → N in DIAR1. 1 Publication1
Natural variantiVAR_066064136M → I in DIAR1. 1 PublicationCorresponds to variant dbSNP:rs386833483Ensembl.1
Natural variantiVAR_077355175R → S in DIAR1. 1 PublicationCorresponds to variant dbSNP:rs386833484Ensembl.1
Natural variantiVAR_066065204Y → D in DIAR1. 1 PublicationCorresponds to variant dbSNP:rs386833487Ensembl.1
Natural variantiVAR_012777206S → P in DIAR1. 1 PublicationCorresponds to variant dbSNP:rs386833488Ensembl.1
Natural variantiVAR_066066220H → P in DIAR1. 2 PublicationsCorresponds to variant dbSNP:rs386833489Ensembl.1
Natural variantiVAR_007431307C → W1 PublicationCorresponds to variant dbSNP:rs34407351Ensembl.1
Natural variantiVAR_007432318Missing in DIAR1. 3 PublicationsCorresponds to variant dbSNP:rs386833491Ensembl.1
Natural variantiVAR_066067343C → Y in DIAR1. 1 PublicationCorresponds to variant dbSNP:rs386833444Ensembl.1
Natural variantiVAR_066068344 – 349FGIAMV → DA in DIAR1. 1 Publication6
Natural variantiVAR_066069379G → A in DIAR1. 1 PublicationCorresponds to variant dbSNP:rs386833446Ensembl.1
Natural variantiVAR_077356394S → I in DIAR1. 1 Publication1
Natural variantiVAR_066070398S → F in DIAR1. 1 PublicationCorresponds to variant dbSNP:rs143839547Ensembl.1
Natural variantiVAR_077357438S → P in DIAR1. 1 PublicationCorresponds to variant dbSNP:rs763669046Ensembl.1
Natural variantiVAR_012778468D → V in DIAR1. 1 PublicationCorresponds to variant dbSNP:rs386833454Ensembl.1
Natural variantiVAR_077358495Q → P in DIAR1. 1 Publication1
Natural variantiVAR_066071496L → R in DIAR1. 1 PublicationCorresponds to variant dbSNP:rs386833457Ensembl.1
Natural variantiVAR_077359508C → R in DIAR1. 1 Publication1
Natural variantiVAR_066072520Y → C in DIAR1. 1 PublicationCorresponds to variant dbSNP:rs386833462Ensembl.1
Natural variantiVAR_066073521K → N in DIAR1. 1 PublicationCorresponds to variant dbSNP:rs386833463Ensembl.1
Natural variantiVAR_007433527Missing in DIAR1. 1 Publication1
Natural variantiVAR_066074544I → N in DIAR1. 1 PublicationCorresponds to variant dbSNP:rs386833467Ensembl.1
Natural variantiVAR_077360547A → E in DIAR1. 1 Publication1
Natural variantiVAR_053661554R → Q. Corresponds to variant dbSNP:rs2301635Ensembl.1
Natural variantiVAR_066075652D → N in DIAR1. 1 PublicationCorresponds to variant dbSNP:rs140426439Ensembl.1
Natural variantiVAR_077361654S → P in DIAR1. 1 Publication1
Natural variantiVAR_077362675I → II in DIAR1. 1 PublicationCorresponds to variant dbSNP:rs121913031Ensembl.1
Natural variantiVAR_053662753N → S. Corresponds to variant dbSNP:rs35342296Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L02785 mRNA. Translation: AAA58443.1.
BC025671 mRNA. Translation: AAH25671.1.
CCDSiCCDS5748.1.
PIRiA47456.
RefSeqiNP_000102.1. NM_000111.2.
XP_011514169.1. XM_011515867.2.
UniGeneiHs.1650.

Genome annotation databases

EnsembliENST00000340010; ENSP00000345873; ENSG00000091138.
GeneIDi1811.
KEGGihsa:1811.
UCSCiuc003ver.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L02785 mRNA. Translation: AAA58443.1.
BC025671 mRNA. Translation: AAH25671.1.
CCDSiCCDS5748.1.
PIRiA47456.
RefSeqiNP_000102.1. NM_000111.2.
XP_011514169.1. XM_011515867.2.
UniGeneiHs.1650.

3D structure databases

ProteinModelPortaliP40879.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108145. 1 interactor.
IntActiP40879. 2 interactors.
MINTiMINT-1787198.
STRINGi9606.ENSP00000345873.

Protein family/group databases

TCDBi2.A.53.2.18. the sulfate permease (sulp) family.

PTM databases

iPTMnetiP40879.
PhosphoSitePlusiP40879.

Polymorphism and mutation databases

BioMutaiSLC26A3.
DMDMi729367.

Proteomic databases

PaxDbiP40879.
PeptideAtlasiP40879.
PRIDEiP40879.

Protocols and materials databases

DNASUi1811.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000340010; ENSP00000345873; ENSG00000091138.
GeneIDi1811.
KEGGihsa:1811.
UCSCiuc003ver.3. human.

Organism-specific databases

CTDi1811.
DisGeNETi1811.
GeneCardsiSLC26A3.
HGNCiHGNC:3018. SLC26A3.
HPAiHPA036055.
MalaCardsiSLC26A3.
MIMi126650. gene.
214700. phenotype.
neXtProtiNX_P40879.
OpenTargetsiENSG00000091138.
Orphaneti53689. Congenital chloride diarrhea.
PharmGKBiPA35044.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0236. Eukaryota.
COG0659. LUCA.
GeneTreeiENSGT00760000119026.
HOGENOMiHOG000006546.
HOVERGENiHBG000639.
InParanoidiP40879.
KOiK14078.
OMAiQETIGDC.
OrthoDBiEOG090B02P3.
PhylomeDBiP40879.
TreeFamiTF313784.

Enzyme and pathway databases

ReactomeiR-HSA-427601. Multifunctional anion exchangers.

Miscellaneous databases

GeneWikiiSLC26A3.
GenomeRNAii1811.
PROiP40879.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000091138.
CleanExiHS_SLC26A3.
ExpressionAtlasiP40879. baseline and differential.
GenevisibleiP40879. HS.

Family and domain databases

Gene3Di3.30.750.24. 2 hits.
InterProiView protein in InterPro
IPR018045. S04_transporter_CS.
IPR011547. SLC26A/SulP_dom.
IPR001902. SLC26A/SulP_fam.
IPR030321. SLC26A3.
IPR002645. STAS_dom.
PANTHERiPTHR11814. PTHR11814. 1 hit.
PTHR11814:SF150. PTHR11814:SF150. 1 hit.
PfamiView protein in Pfam
PF01740. STAS. 1 hit.
PF00916. Sulfate_transp. 1 hit.
SUPFAMiSSF52091. SSF52091. 2 hits.
TIGRFAMsiTIGR00815. sulP. 1 hit.
PROSITEiView protein in PROSITE
PS01130. SLC26A. 1 hit.
PS50801. STAS. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiS26A3_HUMAN
AccessioniPrimary (citable) accession number: P40879
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: February 15, 2017
This is version 162 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.