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Protein

HTH-type transcriptional activator RhaR

Gene

rhaR

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Activates expression of the rhaSR operon in response to L-rhamnose.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi195 – 214H-T-H motifUniRule annotationAdd BLAST20
DNA bindingi244 – 267H-T-H motifUniRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processRhamnose metabolism, Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciSENT99287:G1FZD-4089-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional activator RhaRUniRule annotation
Alternative name(s):
L-rhamnose operon transcriptional activator RhaRUniRule annotation
Gene namesi
Name:rhaRUniRule annotation
Synonyms:rhaC1
Ordered Locus Names:STM4049
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001945591 – 282HTH-type transcriptional activator RhaRAdd BLAST282

Proteomic databases

PaxDbiP40865
PRIDEiP40865

Interactioni

Subunit structurei

Binds DNA as a dimer.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei246Interaction with sigma-70UniRule annotation1

Protein-protein interaction databases

STRINGi99287.STM4049

Structurei

3D structure databases

ProteinModelPortaliP40865
SMRiP40865
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4108BRW Bacteria
ENOG410XYX0 LUCA
HOGENOMiHOG000290513
KOiK02854
OMAiNREVGMT
PhylomeDBiP40865

Family and domain databases

Gene3Di2.60.120.10, 1 hit
HAMAPiMF_01533 HTH_type_RhaR, 1 hit
InterProiView protein in InterPro
IPR003313 AraC-bd
IPR009057 Homeobox-like_sf
IPR018060 HTH_AraC
IPR018062 HTH_AraC-typ_CS
IPR014710 RmlC-like_jellyroll
IPR011051 RmlC_Cupin_sf
IPR023699 Tscrpt_act_RhaR
IPR020449 Tscrpt_reg_HTH_AraC-type
PfamiView protein in Pfam
PF02311 AraC_binding, 1 hit
PF12833 HTH_18, 1 hit
PRINTSiPR00032 HTHARAC
SMARTiView protein in SMART
SM00342 HTH_ARAC, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
SSF51182 SSF51182, 1 hit
PROSITEiView protein in PROSITE
PS00041 HTH_ARAC_FAMILY_1, 1 hit
PS01124 HTH_ARAC_FAMILY_2, 1 hit

Sequencei

Sequence statusi: Complete.

P40865-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANQLILLKK DFFTDEQQAV TVADRYPQDV FAEHTHEFCE LVMVWRGNGL
60 70 80 90 100
HVLNERPYRI TRGDLFYIRA EDKHSYTSVN DLVLQNIIYC PERLKLNVNW
110 120 130 140 150
QAMIPGFQGA QWHPHWRLGS MGMNQARQVI NQLEHESNGR DPLANEMAEL
160 170 180 190 200
LFGQLVMTLK RHRYATDDLP ATSRETLLDK LITALANSLE CPFALDAFCQ
210 220 230 240 250
QEQCSERVLR QQFRAQTGMT INQYLRQVRI CHAQYLLQHS PLMISEISMQ
260 270 280
CGFEDSNYFS VVFTRETGMT PSQWRHLSNQ SD
Length:282
Mass (Da):32,858
Last modified:December 13, 2001 - v2
Checksum:i657BF8FE7DE1CF20
GO

Sequence cautioni

The sequence M85157 differs from that shown. Reason: Frameshift at position 211.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006468 Genomic DNA Translation: AAL22889.1
M85157 Genomic DNA No translation available.
RefSeqiNP_462930.1, NC_003197.2
WP_000013290.1, NC_003197.2

Genome annotation databases

EnsemblBacteriaiAAL22889; AAL22889; STM4049
GeneIDi1255576
KEGGistm:STM4049
PATRICifig|99287.12.peg.4266

Similar proteinsi

Entry informationi

Entry nameiRHAR_SALTY
AccessioniPrimary (citable) accession number: P40865
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: December 13, 2001
Last modified: March 28, 2018
This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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