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Protein

Protein MKT1

Gene

MKT1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for propagation of M2 dsRNA satellite at temperature above 30 degrees Celsius if an L-A RNA virus carrying NEX (N) is present in the cells.

Miscellaneous

Present with 3430 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • endodeoxyribonuclease activity Source: SGD

GO - Biological processi

  • cellular response to DNA damage stimulus Source: SGD
  • DNA repair Source: InterPro
  • interspecies interaction between organisms Source: SGD

Enzyme and pathway databases

BioCyciYEAST:G3O-33114-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Protein MKT1
Gene namesi
Name:MKT1
Ordered Locus Names:YNL085W
ORF Names:N2302
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNL085W
SGDiS000005029 MKT1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000964951 – 830Protein MKT1Add BLAST830

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki4Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources
Modified residuei358PhosphoserineCombined sources1
Modified residuei362PhosphoserineCombined sources1
Modified residuei371PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP40850
PaxDbiP40850
PRIDEiP40850

PTM databases

iPTMnetiP40850

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi35738, 314 interactors
DIPiDIP-6530N
IntActiP40850, 37 interactors
MINTiP40850
STRINGi4932.YNL085W

Structurei

3D structure databases

ProteinModelPortaliP40850
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000113598
InParanoidiP40850
OMAiHEYLGLQ
OrthoDBiEOG092C0WW7

Family and domain databases

CDDicd09902 H3TH_MKT1, 1 hit
InterProiView protein in InterPro
IPR022039 MKT1_C
IPR037314 MKT1_H3TH
IPR022040 MKT1_N
IPR029060 PIN-like_dom_sf
IPR006086 XPG-I_dom
IPR006084 XPG/Rad2
IPR006085 XPG_DNA_repair_N
PANTHERiPTHR11081 PTHR11081, 1 hit
PfamiView protein in Pfam
PF12246 MKT1_C, 1 hit
PF12247 MKT1_N, 1 hit
PF00752 XPG_N, 1 hit
SMARTiView protein in SMART
SM00484 XPGI, 1 hit
SM00485 XPGN, 1 hit
SUPFAMiSSF88723 SSF88723, 2 hits

Sequencei

Sequence statusi: Complete.

P40850-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIKSLESFL FERGLVGSYA IEALNNCTLD IDVNHYVSRL LTNKREQYLD
60 70 80 90 100
AIGGFPTSLK MYLESDLKIF KDFNITPIFV FNGGLTYNQL EASGHFTAAS
110 120 130 140 150
ASASISSTTT SSSGTNATTR SNTESVLLQR SRGWTQWNNL ISSNQNSYID
160 170 180 190 200
QPIQPQEPFR HNTTIDSKAY QNDLIAYFIE HGYMYQVAPY SSWFQLAYLL
210 220 230 240 250
NSAYIDAIYG PTDCLMLDCV DRFILGMEFP NKEFRFIDRS RVMKDLGCTH
260 270 280 290 300
EEFIDIAMAV GNDLQPTTLP PLQIYPVPQL FDIALEMVLN TGTNFYAYQL
310 320 330 340 350
STTLQNDSKE NIQNYQRGIS ALRYMPVLKD TGKVELFVQE IVVSEEDSEK
360 370 380 390 400
NNKDGKKSNL SSPSSASSSA SPATTVTKNA SEKLTYEKSS TKEVRKPRDI
410 420 430 440 450
PNDVHDFIGQ MLPHEYYFYR SIGLVTGKLF DAIVTGVYPE EPPLGGGSST
460 470 480 490 500
SYKKLVSKSV EIFKNKEINL LTQPINRYYQ IKQIKQVKWY AANEPTTLTN
510 520 530 540 550
RMSPSMFETI NHLIVKTETS DEKEFSISEF ITTINGSSNM AKDFISEKVI
560 570 580 590 600
FPNSVPIESK LNSPFNLLST NFLRLLVLLE FFTFDFKEKL LEPTRWGEVF
610 620 630 640 650
LKLNELNIDS KYHESVIIFL VFLKCDVLKL DEEVQPPAPS ALSQATLRSY
660 670 680 690 700
PEESLYVLLI TRVLTLFQVD QKPSNYHGPI DKKTLIFRDH LSFIKENLNE
710 720 730 740 750
LFEAVLISSL TSGEFNRLSL DNFGWARKIV RYLPFKLDSP NTIMAMMWEF
760 770 780 790 800
FLQKYLHNGN AKNDALSLVA TEFNTYKSTP NLDEQFVESH RFLLEISKVM
810 820 830
QELNAAKLID ENVFKLFTKA VEFTTTALSS
Length:830
Mass (Da):94,495
Last modified:February 1, 1996 - v2
Checksum:iBD976D8387E4F708
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti809 – 830IDENV…TALSS → TMKTCLNYH in AAC49470 (PubMed:7532890).CuratedAdd BLAST22

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti30D → G in strain: 2574, ATCC 24657 / D273-10B, ATCC 200060 / W303, Sigma 1278B, YJM 1129, YJM 270, YJM 627 and YJM 789. 1
Natural varianti453K → R in strain: ATCC 24657 / D273-10B, ATCC 200060 / W303, Sigma 1278B, YJM 1129, YJM 270, YJM 627 and YJM 789. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09129 Genomic DNA Translation: AAC49470.1
AF458969 Genomic DNA Translation: AAM00519.1
AF458975 Genomic DNA Translation: AAM00555.1
AF458977 Genomic DNA Translation: AAM00567.1
AF458978 Genomic DNA Translation: AAM00573.1
AF458980 Genomic DNA Translation: AAM00585.1
AF458981 Genomic DNA Translation: AAM00591.1
DQ116825 Genomic DNA Translation: AAZ23277.1
DQ116826 Genomic DNA Translation: AAZ23278.1
DQ116827 Genomic DNA Translation: AAZ23279.1
DQ116828 Genomic DNA Translation: AAZ23280.1
X89016 Genomic DNA Translation: CAA61425.1
Z71361 Genomic DNA Translation: CAA95961.1
Z71360 Genomic DNA Translation: CAA95960.1
BK006947 Genomic DNA Translation: DAA10460.1
PIRiS57537
RefSeqiNP_014314.3, NM_001182923.3

Genome annotation databases

EnsemblFungiiYNL085W; YNL085W; YNL085W
GeneIDi855639
KEGGisce:YNL085W

Similar proteinsi

Entry informationi

Entry nameiMKT1_YEAST
AccessioniPrimary (citable) accession number: P40850
Secondary accession number(s): D6W194, Q45T81, Q8TF89
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1996
Last modified: March 28, 2018
This is version 153 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health