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Protein

Esculentin-1A

Gene
N/A
Organism
Pelophylax esculentus (Edible frog) (Rana esculenta)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Shows antibacterial activity against representative Gram-negative and Gram-positive bacterial species, and hemolytic activity.

GO - Biological processi

Keywordsi

Molecular functionAmphibian defense peptide, Antibiotic, Antimicrobial
Biological processCytolysis, Hemolysis

Names & Taxonomyi

Protein namesi
Recommended name:
Esculentin-1A
OrganismiPelophylax esculentus (Edible frog) (Rana esculenta)
Taxonomic identifieri8401 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraNeobatrachiaRanoideaRanidaePelophylax

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001653671 – 46Esculentin-1AAdd BLAST46

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi40 ↔ 461 Publication

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the skin glands.

Structurei

Secondary structure

146
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi5 – 19Combined sources15

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2N6MNMR-A1-20[»]
5XDJNMR-A1-20[»]
SMRiP40843
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG005608

Family and domain databases

InterProiView protein in InterPro
IPR012521 Antimicrobial_frog_2
PfamiView protein in Pfam
PF08023 Antimicrobial_2, 1 hit

Sequencei

Sequence statusi: Complete.

P40843-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40 
GIFSKLAGKK IKNLLISGLK NVGKEVGMDV VRTGIDIAGC KIKGEC
Length:46
Mass (Da):4,803
Last modified:February 1, 1995 - v1
Checksum:iCDD607B576AF98EF
GO

Sequence databases

PIRiG53578

Similar proteinsi

Entry informationi

Entry nameiES1A_PELES
AccessioniPrimary (citable) accession number: P40843
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 22, 2017
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing
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Main funding by: National Institutes of Health