Reviewed, UniProtKB/Swiss-Prot P40840 (BR2ED_RANES)

Names and origin

Protein names	Recommended name:     Brevinin-2Ed
Organism	Rana esculenta (Edible frog)
Taxonomic identifier	8401 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Neobatrachia › Ranoidea › Ranidae › Rana › Pelophylax

Protein attributes

Sequence length	29 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Shows antibacterial activity against representative Gram-negative and Gram-positive bacterial species, and hemolytic activity.
Subcellular location	Secreted.
Tissue specificity	Expressed by the skin glands.
Sequence similarities	Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily.

Ontologies

Keywords
Biological process	Cytolysis Hemolysis
Cellular component	Secreted
Molecular function	Amphibian defense peptide Antibiotic Antimicrobial
Technical term	Direct protein sequencing
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Peptide	1 – 29	29	Brevinin-2Ed
Amino acid modifications
	Disulfide bond	23 ↔ 29

Sequences

	Sequence		Length	Mass (Da)
	P40840-1 [UniParc]. Last modified February 1, 1995. Version 1. Checksum: 33299AFDA6CE8612	FASTA	29	3,002
	10 20 GILDSLKNLA KNAGQILLNK ASCKLSGQC

References

[1]

"Antimicrobial peptides from skin secretions of Rana esculenta. Molecular cloning of cDNAs encoding esculentin and brevinins and isolation of new active peptides." Simmaco M., Mignogna G., Barra D., Bossa F. J. Biol. Chem. 269:11956-11961(1994) [PubMed: 8163497] [Abstract] Cited for: PROTEIN SEQUENCE, DISULFIDE BOND. Tissue: Skin secretion.

Cross-references

Sequence databases
PIR	D55998.
3D structure databases
ModBase	Search...
Phylogenomic databases
HOVERGEN	P40840.
Family and domain databases
InterPro	IPR012521. Antimicrobial_2. [Graphical view]
Pfam	PF08023. Antimicrobial_2. 1 hit. [Graphical view]
ProDom	P40840. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

BR2ED_RANES

Accession

Primary (citable) accession number: P40840

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	July 22, 2008
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)