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Protein

Brevinin-2Ea

Gene
N/A
Organism
Pelophylax esculentus (Edible frog) (Rana esculenta)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Shows antibacterial activity against representative Gram-negative and Gram-positive bacterial species, and hemolytic activity.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Amphibian defense peptide, Antibiotic, Antimicrobial

Keywords - Biological processi

Cytolysis, Hemolysis

Names & Taxonomyi

Protein namesi
Recommended name:
Brevinin-2Ea
OrganismiPelophylax esculentus (Edible frog) (Rana esculenta)
Taxonomic identifieri8401 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraNeobatrachiaRanoideaRanidaePelophylax

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Peptidei1 – 3333Brevinin-2EaPRO_0000044643Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi27 ↔ 331 Publication

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the skin glands.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG107535.

Family and domain databases

InterProiIPR012521. Antimicrobial_frog_2.
[Graphical view]
PfamiPF08023. Antimicrobial_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P40837-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30 
GILDTLKNLA ISAAKGAAQG LVNKASCKLS GQC
Length:33
Mass (Da):3,245
Last modified:February 1, 1995 - v1
Checksum:i4C940BDE699FF616
GO

Sequence databases

PIRiA55998.

Cross-referencesi

Sequence databases

PIRiA55998.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG107535.

Family and domain databases

InterProiIPR012521. Antimicrobial_frog_2.
[Graphical view]
PfamiPF08023. Antimicrobial_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBR2EA_PELES
AccessioniPrimary (citable) accession number: P40837
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: January 7, 2015
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.