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P40837

- BR2EA_RANES

UniProt

P40837 - BR2EA_RANES

Protein

Brevinin-2Ea

Gene
N/A
Organism
Rana esculenta (Edible frog) (Pelophylax esculentus)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Shows antibacterial activity against representative Gram-negative and Gram-positive bacterial species, and hemolytic activity.

    GO - Biological processi

    1. defense response to bacterium Source: UniProtKB-KW
    2. hemolysis in other organism Source: UniProtKB-KW

    Keywords - Molecular functioni

    Amphibian defense peptide, Antibiotic, Antimicrobial

    Keywords - Biological processi

    Cytolysis, Hemolysis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Brevinin-2Ea
    OrganismiRana esculenta (Edible frog) (Pelophylax esculentus)
    Taxonomic identifieri8401 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraNeobatrachiaRanoideaRanidaePelophylax

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Peptidei1 – 3333Brevinin-2EaPRO_0000044643Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi27 ↔ 331 Publication

    Keywords - PTMi

    Disulfide bond

    Expressioni

    Tissue specificityi

    Expressed by the skin glands.

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    HOVERGENiHBG107535.

    Family and domain databases

    InterProiIPR012521. Antimicrobial_frog_2.
    [Graphical view]
    PfamiPF08023. Antimicrobial_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P40837-1 [UniParc]FASTAAdd to Basket

    « Hide

    GILDTLKNLA ISAAKGAAQG LVNKASCKLS GQC                     33
    Length:33
    Mass (Da):3,245
    Last modified:February 1, 1995 - v1
    Checksum:i4C940BDE699FF616
    GO

    Sequence databases

    PIRiA55998.

    Cross-referencesi

    Sequence databases

    PIRi A55998.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG107535.

    Family and domain databases

    InterProi IPR012521. Antimicrobial_frog_2.
    [Graphical view ]
    Pfami PF08023. Antimicrobial_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Antimicrobial peptides from skin secretions of Rana esculenta. Molecular cloning of cDNAs encoding esculentin and brevinins and isolation of new active peptides."
      Simmaco M., Mignogna G., Barra D., Bossa F.
      J. Biol. Chem. 269:11956-11961(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE, DISULFIDE BOND.
      Tissue: Skin secretion.

    Entry informationi

    Entry nameiBR2EA_RANES
    AccessioniPrimary (citable) accession number: P40837
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3