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P40831

- GLMS_MYCLE

UniProt

P40831 - GLMS_MYCLE

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Protein
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]
Gene
glmS, ML0371, B229_C3_238
Organism
Mycobacterium leprae (strain TN)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source By similarity.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2 – 21Nucleophile; for GATase activity By similarity
Active sitei620 – 6201For Fru-6P isomerization activity By similarity

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. carbohydrate biosynthetic process Source: InterPro
  2. glutamine metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Protein family/group databases

MEROPSiC44.971.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] (EC:2.6.1.16)
Alternative name(s):
D-fructose-6-phosphate amidotransferase
GFAT
Glucosamine-6-phosphate synthase
Hexosephosphate aminotransferase
L-glutamine--D-fructose-6-phosphate amidotransferase
Gene namesi
Name:glmS
Ordered Locus Names:ML0371
ORF Names:B229_C3_238
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000000806: Chromosome

Organism-specific databases

LepromaiML0371.

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 625624Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation
PRO_0000135354Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi272631.ML0371.

Structurei

3D structure databases

ProteinModelPortaliP40831.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 229228Glutamine amidotransferase type-2
Add
BLAST
Domaini298 – 437140SIS 1
Add
BLAST
Domaini470 – 615146SIS 2
Add
BLAST

Sequence similaritiesi

Contains 2 SIS domains.

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiCOG0449.
HOGENOMiHOG000258896.
KOiK00820.
OMAiSVFETQT.
OrthoDBiEOG6KT2Q1.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS.
InterProiIPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P40831-1 [UniParc]FASTAAdd to Basket

« Hide

MCGLVGYVGQ RPACGVVMDA LRRMEYRGYD SSGIALINGS AKSGNLTVRR    50
RAGRLSNLES VLAEMVPASL AGNVGLGHIR WATHGRPTDR NAHPHRDATG 100
KIAVVHNGII ENFPSLRHEL EIAGVEFVSD TDTEVAVHLV AQAYCAGETA 150
GDFVGSVLAV LRRLQGHFTL VFANADEPGT IVAARRSTPL VLGIGDGEMF 200
VGSDVAAFIE HTRQAVELGQ DQAVVITADG YRISDFDGND DAVNARTFHI 250
DWDLAAAEKG GYEYFMLKEI AEQPDAVVDT LLGHFTGGRI VLDEQRLSDQ 300
ELREIDKVFV VACGTAYHSG LLAKYTIEHW TRLPVEVELA SEFRYRDPVL 350
DRSTLVVAIS QSGETADTLE AVRHAKEQKA KVLAICNTNG SQIPRECDAV 400
LYTRAGPEIG VASTKTFLAQ VAANYLLGLA LAQARGTKYP DEVQREYREL 450
EAMPDLVARV IAGMGPVADL AYRFAQSTTV LFLGRHVGYP VALEGALKLK 500
ELAYMHAEGF AAGELKHGPI ALIEENLPVI VVMPSPKGSA MLHAKLLSNI 550
REIQTRGAVT IVIAEEGDDT VRLYADHLIE LPAVSTLLQP LLSTIPLQVF 600
AASVAQARGY DVDKPRNLAK SVTVE 625
Length:625
Mass (Da):67,560
Last modified:January 23, 2007 - v3
Checksum:iCDEE0B62CBA4AE93
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti555 – 5562TR → IS in AAA17307. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00020 Genomic DNA. Translation: AAA17307.1.
AL583918 Genomic DNA. Translation: CAC29879.1.
PIRiC86955.
S72993.
RefSeqiNP_301365.1. NC_002677.1.
WP_010907689.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC29879; CAC29879; CAC29879.
GeneIDi909050.
KEGGimle:ML0371.
PATRICi18051358. VBIMycLep78757_0628.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00020 Genomic DNA. Translation: AAA17307.1 .
AL583918 Genomic DNA. Translation: CAC29879.1 .
PIRi C86955.
S72993.
RefSeqi NP_301365.1. NC_002677.1.
WP_010907689.1. NC_002677.1.

3D structure databases

ProteinModelPortali P40831.
ModBasei Search...

Protein-protein interaction databases

STRINGi 272631.ML0371.

Protein family/group databases

MEROPSi C44.971.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC29879 ; CAC29879 ; CAC29879 .
GeneIDi 909050.
KEGGi mle:ML0371.
PATRICi 18051358. VBIMycLep78757_0628.

Organism-specific databases

Lepromai ML0371.

Phylogenomic databases

eggNOGi COG0449.
HOGENOMi HOG000258896.
KOi K00820.
OMAi SVFETQT.
OrthoDBi EOG6KT2Q1.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
HAMAPi MF_00164. GlmS.
InterProi IPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view ]
PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
Pfami PF01380. SIS. 2 hits.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
TIGRFAMsi TIGR01135. glmS. 1 hit.
PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Smith D.R., Robison K.
    Submitted (MAR-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TN.

Entry informationi

Entry nameiGLMS_MYCLE
AccessioniPrimary (citable) accession number: P40831
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 101 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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