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P40831

- GLMS_MYCLE

UniProt

P40831 - GLMS_MYCLE

Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

    Catalytic activityi

    L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei2 – 21Nucleophile; for GATase activityUniRule annotation
    Active sitei620 – 6201For Fru-6P isomerization activityUniRule annotation

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro
    2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. carbohydrate biosynthetic process Source: InterPro
    2. glutamine metabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminotransferase, Transferase

    Protein family/group databases

    MEROPSiC44.971.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
    Alternative name(s):
    D-fructose-6-phosphate amidotransferaseUniRule annotation
    GFATUniRule annotation
    Glucosamine-6-phosphate synthaseUniRule annotation
    Hexosephosphate aminotransferaseUniRule annotation
    L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
    Gene namesi
    Name:glmSUniRule annotation
    Ordered Locus Names:ML0371
    ORF Names:B229_C3_238
    OrganismiMycobacterium leprae (strain TN)
    Taxonomic identifieri272631 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
    ProteomesiUP000000806: Chromosome

    Organism-specific databases

    LepromaiML0371.

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedUniRule annotation
    Chaini2 – 625624Glutamine--fructose-6-phosphate aminotransferase [isomerizing]PRO_0000135354Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi272631.ML0371.

    Structurei

    3D structure databases

    ProteinModelPortaliP40831.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 229228Glutamine amidotransferase type-2UniRule annotationAdd
    BLAST
    Domaini298 – 437140SIS 1UniRule annotationAdd
    BLAST
    Domaini470 – 615146SIS 2UniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 glutamine amidotransferase type-2 domain.UniRule annotation
    Contains 2 SIS domains.UniRule annotation

    Keywords - Domaini

    Glutamine amidotransferase, Repeat

    Phylogenomic databases

    eggNOGiCOG0449.
    HOGENOMiHOG000258896.
    KOiK00820.
    OMAiSVFETQT.
    OrthoDBiEOG6KT2Q1.

    Family and domain databases

    Gene3Di3.60.20.10. 1 hit.
    HAMAPiMF_00164. GlmS.
    InterProiIPR017932. GATase_2_dom.
    IPR005855. GlmS_trans.
    IPR029055. Ntn_hydrolases_N.
    IPR001347. SIS.
    [Graphical view]
    PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
    PfamiPF01380. SIS. 2 hits.
    [Graphical view]
    SUPFAMiSSF56235. SSF56235. 1 hit.
    TIGRFAMsiTIGR01135. glmS. 1 hit.
    PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
    PS51464. SIS. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P40831-1 [UniParc]FASTAAdd to Basket

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    MCGLVGYVGQ RPACGVVMDA LRRMEYRGYD SSGIALINGS AKSGNLTVRR    50
    RAGRLSNLES VLAEMVPASL AGNVGLGHIR WATHGRPTDR NAHPHRDATG 100
    KIAVVHNGII ENFPSLRHEL EIAGVEFVSD TDTEVAVHLV AQAYCAGETA 150
    GDFVGSVLAV LRRLQGHFTL VFANADEPGT IVAARRSTPL VLGIGDGEMF 200
    VGSDVAAFIE HTRQAVELGQ DQAVVITADG YRISDFDGND DAVNARTFHI 250
    DWDLAAAEKG GYEYFMLKEI AEQPDAVVDT LLGHFTGGRI VLDEQRLSDQ 300
    ELREIDKVFV VACGTAYHSG LLAKYTIEHW TRLPVEVELA SEFRYRDPVL 350
    DRSTLVVAIS QSGETADTLE AVRHAKEQKA KVLAICNTNG SQIPRECDAV 400
    LYTRAGPEIG VASTKTFLAQ VAANYLLGLA LAQARGTKYP DEVQREYREL 450
    EAMPDLVARV IAGMGPVADL AYRFAQSTTV LFLGRHVGYP VALEGALKLK 500
    ELAYMHAEGF AAGELKHGPI ALIEENLPVI VVMPSPKGSA MLHAKLLSNI 550
    REIQTRGAVT IVIAEEGDDT VRLYADHLIE LPAVSTLLQP LLSTIPLQVF 600
    AASVAQARGY DVDKPRNLAK SVTVE 625
    Length:625
    Mass (Da):67,560
    Last modified:January 23, 2007 - v3
    Checksum:iCDEE0B62CBA4AE93
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti555 – 5562TR → IS in AAA17307. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00020 Genomic DNA. Translation: AAA17307.1.
    AL583918 Genomic DNA. Translation: CAC29879.1.
    PIRiC86955.
    S72993.
    RefSeqiNP_301365.1. NC_002677.1.
    WP_010907689.1. NC_002677.1.

    Genome annotation databases

    EnsemblBacteriaiCAC29879; CAC29879; CAC29879.
    GeneIDi909050.
    KEGGimle:ML0371.
    PATRICi18051358. VBIMycLep78757_0628.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00020 Genomic DNA. Translation: AAA17307.1 .
    AL583918 Genomic DNA. Translation: CAC29879.1 .
    PIRi C86955.
    S72993.
    RefSeqi NP_301365.1. NC_002677.1.
    WP_010907689.1. NC_002677.1.

    3D structure databases

    ProteinModelPortali P40831.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272631.ML0371.

    Protein family/group databases

    MEROPSi C44.971.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAC29879 ; CAC29879 ; CAC29879 .
    GeneIDi 909050.
    KEGGi mle:ML0371.
    PATRICi 18051358. VBIMycLep78757_0628.

    Organism-specific databases

    Lepromai ML0371.

    Phylogenomic databases

    eggNOGi COG0449.
    HOGENOMi HOG000258896.
    KOi K00820.
    OMAi SVFETQT.
    OrthoDBi EOG6KT2Q1.

    Family and domain databases

    Gene3Di 3.60.20.10. 1 hit.
    HAMAPi MF_00164. GlmS.
    InterProi IPR017932. GATase_2_dom.
    IPR005855. GlmS_trans.
    IPR029055. Ntn_hydrolases_N.
    IPR001347. SIS.
    [Graphical view ]
    PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
    Pfami PF01380. SIS. 2 hits.
    [Graphical view ]
    SUPFAMi SSF56235. SSF56235. 1 hit.
    TIGRFAMsi TIGR01135. glmS. 1 hit.
    PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
    PS51464. SIS. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Smith D.R., Robison K.
      Submitted (MAR-1994) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TN.

    Entry informationi

    Entry nameiGLMS_MYCLE
    AccessioniPrimary (citable) accession number: P40831
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 102 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3