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P40829

- GABT_MYCLE

UniProt

P40829 - GABT_MYCLE

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Protein

4-aminobutyrate aminotransferase

Gene
gabT, ML0485, B1177_F2_67, MLCB1259.03c
Organism
Mycobacterium leprae (strain TN)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate.
(S)-3-amino-2-methylpropanoate + 2-oxoglutarate = 2-methyl-3-oxopropanoate + L-glutamate.

Cofactori

Pyridoxal phosphate.

Pathwayi

GO - Molecular functioni

  1. (S)-3-amino-2-methylpropionate transaminase activity Source: UniProtKB-EC
  2. 4-aminobutyrate transaminase activity Source: UniProtKB-EC
  3. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. gamma-aminobutyric acid catabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00733.

Names & Taxonomyi

Protein namesi
Recommended name:
4-aminobutyrate aminotransferase (EC:2.6.1.19)
Alternative name(s):
(S)-3-amino-2-methylpropionate transaminase (EC:2.6.1.22)
GABA aminotransferase
Short name:
GABA-AT
Gamma-amino-N-butyrate transaminase
Short name:
GABA transaminase
Glutamate:succinic semialdehyde transaminase
L-AIBAT
Gene namesi
Name:gabT
Ordered Locus Names:ML0485
ORF Names:B1177_F2_67, MLCB1259.03c
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000000806: Chromosome

Organism-specific databases

LepromaiML0485.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 4464464-aminobutyrate aminotransferasePRO_0000120385Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei291 – 2911N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Protein-protein interaction databases

STRINGi272631.ML0485.

Structurei

3D structure databases

ProteinModelPortaliP40829.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0160.
HOGENOMiHOG000020206.
KOiK07250.
OMAiNSFTHTA.
OrthoDBiEOG6QVRHN.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR004632. 4NH2But_aminotransferase_bac.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR00700. GABAtrnsam. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P40829-1 [UniParc]FASTAAdd to Basket

« Hide

MTSVEQSRQL VTEIPGPVSL ELAKRLNAAV PRGVGVTLPV FVTRAAGGVI    50
EDVDGNRLID LGSGIAVTTI GNSSPRVVDA VRAQVADFTH TCFIITPYEE 100
YVAVTEQLNR ITPGSGEKRS VLFNSGAEAV ENSIKVARSY TRKPAVVAFD 150
HAYHGRTNLT MALTAKSMPY KSGFGPFAPE IYRAPLSYPY RDGLLNKDLA 200
TDGKLAGARA INVIEKQVGA DDLAAVIIEP IQGEGGFIVP AEGFLATLLD 250
WCRKNNVMFI ADEVQTGFAR TGAMFACEHD GIVPDLICTA KGIADGLPLA 300
AVTGRAEIMN APHVSGLGGT FGGNPVACAA ALATITTIEN DGLIQRAQQI 350
ERLITDRLLR LQDADDRIGD VRGRGAMIAV ELVKSGTAEP DPELTEKVAT 400
AAHATGVIIL TCGMFGNIIR LLPPLTISDE LLAEGLDILS RILGDF 446
Length:446
Mass (Da):47,215
Last modified:February 1, 1995 - v1
Checksum:i576A6872DF6BDDC2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00011 Genomic DNA. Translation: AAA17107.1.
AL023591 Genomic DNA. Translation: CAA19078.1.
AL583918 Genomic DNA. Translation: CAC29993.1.
PIRiS72743.
RefSeqiNP_301425.1. NC_002677.1.
WP_010907749.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC29993; CAC29993; CAC29993.
GeneIDi909237.
KEGGimle:ML0485.
PATRICi18051804. VBIMycLep78757_0849.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00011 Genomic DNA. Translation: AAA17107.1 .
AL023591 Genomic DNA. Translation: CAA19078.1 .
AL583918 Genomic DNA. Translation: CAC29993.1 .
PIRi S72743.
RefSeqi NP_301425.1. NC_002677.1.
WP_010907749.1. NC_002677.1.

3D structure databases

ProteinModelPortali P40829.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272631.ML0485.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC29993 ; CAC29993 ; CAC29993 .
GeneIDi 909237.
KEGGi mle:ML0485.
PATRICi 18051804. VBIMycLep78757_0849.

Organism-specific databases

Lepromai ML0485.

Phylogenomic databases

eggNOGi COG0160.
HOGENOMi HOG000020206.
KOi K07250.
OMAi NSFTHTA.
OrthoDBi EOG6QVRHN.

Enzyme and pathway databases

UniPathwayi UPA00733 .

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProi IPR004632. 4NH2But_aminotransferase_bac.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR11986. PTHR11986. 1 hit.
Pfami PF00202. Aminotran_3. 1 hit.
[Graphical view ]
PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR00700. GABAtrnsam. 1 hit.
PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Smith D.R., Robison K.
    Submitted (MAR-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TN.

Entry informationi

Entry nameiGABT_MYCLE
AccessioniPrimary (citable) accession number: P40829
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: September 3, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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