Reviewed,
UniProtKB/Swiss-Prot P40829 (GABT_MYCLE)
Last modified
February 9, 2010.
Version 72.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: 4-aminobutyrate aminotransferase EC=2.6.1.19 Alternative name(s): Gamma-amino-N-butyrate transaminase Short name=GABA transaminase GABA aminotransferase Short name=GABA-AT L-AIBAT (S)-3-amino-2-methylpropionate transaminase EC=2.6.1.22 Glutamate:succinic semialdehyde transaminase | ||||||
| Gene names |
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| Organism | Mycobacterium leprae [Complete proteome] [HAMAP] | ||||||
| Taxonomic identifier | 1769 [NCBI] | ||||||
| Taxonomic lineage | Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium |
Protein attributes
| Sequence length | 446 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | 4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate. (S)-3-amino-2-methylpropanoate + 2-oxoglutarate = 2-methyl-3-oxopropanoate + L-glutamate. |
| Cofactor | Pyridoxal phosphate. |
| Pathway | |
| Sequence similarities | Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. |
Ontologies
| Keywords | |
|---|---|
| Ligand | Pyridoxal phosphate |
| Molecular function | Aminotransferase Transferase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | gamma-aminobutyric acid metabolic process Inferred from electronic annotation. Source: InterPro |
| Molecular function | (S)-3-amino-2-methylpropionate transaminase activity Inferred from electronic annotation. Source: EC 4-aminobutyrate transaminase activityInferred from electronic annotation. Source: EC pyridoxal phosphate bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| « Hide 'large scale' references | |
| [1] | Smith D.R., Robison K. Submitted (MAR-1994) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [2] | "Massive gene decay in the leprosy bacillus." Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R., Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E., Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K., Duthoy S. Barrell B.G.Nature 409:1007-1011(2001) [PubMed: 11234002] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TN. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | U00011 Genomic DNA. Translation: AAA17107.1. AL023591 Genomic DNA. Translation: CAA19078.1. AL583918 Genomic DNA. Translation: CAC29993.1. |
| PIR | S72743. |
| RefSeq | NP_301425.1. |
3D structure databases | |
| SMR | P40829. Positions 19-445. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 909237. |
| KEGG | mle:ML0485. |
| NMPDR | fig|272631.1.peg.297. |
Organism-specific databases | |
| Leproma | ML0485. |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | HBG725944. |
| OMA | TTIGNSA. |
Enzyme and pathway databases | |
| BioCyc | MLEP272631:ML0485-MONOMER. |
| BRENDA | 2.6.1.19. 808. 2.6.1.22. 808. |
Family and domain databases | |
| InterPro | IPR004632. 4NH2But_aminotransferase_bac. IPR005814. Aminotrans_3. IPR015424. PyrdxlP-dep_Trfase_major_dom. IPR015421. PyrdxlP-dep_Trfase_major_sub1. [Graphical view] |
| Gene3D | G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit. |
| PANTHER | PTHR11986. Aminotrans_3. 1 hit. |
| Pfam | PF00202. Aminotran_3. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR00700. GABAtrnsam. 1 hit. |
| PROSITE | PS00600. AA_TRANSFER_CLASS_3. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | GABT_MYCLE | ||||||||
| Accession | Primary (citable) accession number: P40829 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


