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P40829 (GABT_MYCLE) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
4-aminobutyrate aminotransferase

EC=2.6.1.19
Alternative name(s):
(S)-3-amino-2-methylpropionate transaminase
EC=2.6.1.22
GABA aminotransferase
Short name=GABA-AT
Gamma-amino-N-butyrate transaminase
Short name=GABA transaminase
Glutamate:succinic semialdehyde transaminase
L-AIBAT
Gene names
Name:gabT
Ordered Locus Names:ML0485
ORF Names:B1177_F2_67, MLCB1259.03c
OrganismMycobacterium leprae (strain TN) [Complete proteome] [HAMAP]
Taxonomic identifier272631 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium

Protein attributes

Sequence length446 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate.

(S)-3-amino-2-methylpropanoate + 2-oxoglutarate = 2-methyl-3-oxopropanoate + L-glutamate.

Cofactor

Pyridoxal phosphate.

Pathway

Amino-acid degradation; 4-aminobutanoate degradation.

Sequence similarities

Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 4464464-aminobutyrate aminotransferase
PRO_0000120385

Amino acid modifications

Modified residue2911N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
P40829 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: 576A6872DF6BDDC2

FASTA44647,215
        10         20         30         40         50         60 
MTSVEQSRQL VTEIPGPVSL ELAKRLNAAV PRGVGVTLPV FVTRAAGGVI EDVDGNRLID 

        70         80         90        100        110        120 
LGSGIAVTTI GNSSPRVVDA VRAQVADFTH TCFIITPYEE YVAVTEQLNR ITPGSGEKRS 

       130        140        150        160        170        180 
VLFNSGAEAV ENSIKVARSY TRKPAVVAFD HAYHGRTNLT MALTAKSMPY KSGFGPFAPE 

       190        200        210        220        230        240 
IYRAPLSYPY RDGLLNKDLA TDGKLAGARA INVIEKQVGA DDLAAVIIEP IQGEGGFIVP 

       250        260        270        280        290        300 
AEGFLATLLD WCRKNNVMFI ADEVQTGFAR TGAMFACEHD GIVPDLICTA KGIADGLPLA 

       310        320        330        340        350        360 
AVTGRAEIMN APHVSGLGGT FGGNPVACAA ALATITTIEN DGLIQRAQQI ERLITDRLLR 

       370        380        390        400        410        420 
LQDADDRIGD VRGRGAMIAV ELVKSGTAEP DPELTEKVAT AAHATGVIIL TCGMFGNIIR 

       430        440 
LLPPLTISDE LLAEGLDILS RILGDF 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U00011 Genomic DNA. Translation: AAA17107.1.
AL023591 Genomic DNA. Translation: CAA19078.1.
AL583918 Genomic DNA. Translation: CAC29993.1.
PIRS72743.
RefSeqNP_301425.1. NC_002677.1.

3D structure databases

ProteinModelPortalP40829.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272631.ML0485.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAC29993; CAC29993; CAC29993.
GeneID909237.
KEGGmle:ML0485.
PATRIC18051804. VBIMycLep78757_0849.

Organism-specific databases

LepromaML0485.
CMRSearch...

Phylogenomic databases

eggNOGCOG0160.
HOGENOMHOG000020206.
KOK07250.
OMANLCAEAN.
OrthoDBEOG6QVRHN.
ProtClustDBPRK06058.

Enzyme and pathway databases

UniPathwayUPA00733.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProIPR004632. 4NH2But_aminotransferase_bac.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERPTHR11986. PTHR11986. 1 hit.
PfamPF00202. Aminotran_3. 1 hit.
[Graphical view]
PIRSFPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMSSF53383. SSF53383. 1 hit.
TIGRFAMsTIGR00700. GABAtrnsam. 1 hit.
PROSITEPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGABT_MYCLE
AccessionPrimary (citable) accession number: P40829
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 13, 2013
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways