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P40814

- T3MO_SALTY

UniProt

P40814 - T3MO_SALTY

Protein

Type III restriction-modification system StyLTI enzyme mod

Gene

mod

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 2 (23 Jan 2002)
      Previous versions | rss
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    Functioni

    Binds the system-specific DNA recognition site 5'-CAGAG-3'. Necessary for restriction and for methylation of A-4.

    Catalytic activityi

    S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine.

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. N-methyltransferase activity Source: InterPro
    3. site-specific DNA-methyltransferase (adenine-specific) activity Source: UniProtKB-EC

    GO - Biological processi

    1. DNA restriction-modification system Source: UniProtKB-KW

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    Restriction system

    Keywords - Ligandi

    DNA-binding, S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciSENT99287:GCTI-358-MONOMER.

    Protein family/group databases

    REBASEi5598. M.StyLT2ORF357P.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Type III restriction-modification system StyLTI enzyme mod (EC:2.1.1.72)
    Short name:
    M.StyLTI
    Alternative name(s):
    StyLTI methyltransferase
    Gene namesi
    Name:mod
    Ordered Locus Names:STM0357
    OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
    Taxonomic identifieri99287 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
    ProteomesiUP000001014: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 652652Type III restriction-modification system StyLTI enzyme modPRO_0000088032Add
    BLAST

    Proteomic databases

    PaxDbiP40814.
    PRIDEiP40814.

    Interactioni

    Subunit structurei

    Contains two different subunits: res and mod. Mod is a homotetramer By similarity.By similarity

    Protein-protein interaction databases

    STRINGi99287.STM0357.

    Structurei

    3D structure databases

    ProteinModelPortaliP40814.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni135 – 1384Binding of S-adenosyl methionineSequence Analysis

    Sequence similaritiesi

    Belongs to the N(4)/N(6)-methyltransferase family.Curated

    Phylogenomic databases

    eggNOGiCOG2189.
    HOGENOMiHOG000253523.
    KOiK07316.
    OMAiYLANCHE.
    OrthoDBiEOG6W9X8K.

    Family and domain databases

    Gene3Di3.40.50.150. 3 hits.
    InterProiIPR002295. D21N6_MeTrfase.
    IPR002941. DNA_methylase_N4/N6.
    IPR002052. DNA_methylase_N6_adenine_CS.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PfamiPF01555. N6_N4_Mtase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF015855. TypeIII_Mtase_mKpnI. 1 hit.
    PRINTSiPR00506. D21N6MTFRASE.
    SUPFAMiSSF53335. SSF53335. 3 hits.
    PROSITEiPS00092. N6_MTASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P40814-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLKDNQKHNE SVAPNSAFLS ELQRALPEFF TADRYNEQGE LIAKGGFDLA    50
    RFERALKARN IDELTSGYQI DFIGKDYAKK QAGEKSVTVI VPDVEHNTLA 100
    ENKNSHNLFL TGDNLDVLRH LQNNYADTVD MIYIDPPYNT GSDGFVYPDH 150
    FEYSDRALQD MFGLNDTELA RLKSIQGKST HSAWLSFMYP RLFLARKLLK 200
    DTGFIFISID DNEYANLKLM MDEIFGEGGF VTNVMWKRKK EISNDSDNVS 250
    IQGEYILVYA KTGQGALRLE PLSKEYIQKS YKEPTEQFPE GKWRPVPLTV 300
    SKGLSGGGYT YKITTPNGTV HERLWAYPEA SYQKLVADNL VYFGKDNGGI 350
    PQRVMYAHHS KGQPTTNYWD NVASNKEGKK EILDLFGDNV FDTPKPTALL 400
    KKIIKLAIDK DGVVLDFFAG SGTTAHAVMA LNEEDGGQRT FILCTIDQAL 450
    SNNTIAKKAG YNTIDEISRE RITRVAAKIR ANNPATNSDL GFKHYRFATP 500
    TQQTLDDLDS FDIATGHFIN TSGQLAAFTE SGFTDMINPF SARGLGVPGG 550
    ASGEETLLTT WLVADGYKMD IDVQTVDFSG YCARYVDNTR LYLIDERWGT 600
    EQTRDLLNHI GTHQLPVQTI VIYGYSFDLE SIRELEIGLK QLDQKVNLVK 650
    RY 652
    Length:652
    Mass (Da):73,336
    Last modified:January 23, 2002 - v2
    Checksum:i385DE4851545C84E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti55 – 551Missing(PubMed:8387444)Curated
    Sequence conflicti126 – 1261A → S(PubMed:8387444)Curated
    Sequence conflicti587 – 5882DN → ND(PubMed:8387444)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M90544 Genomic DNA. No translation available.
    AE006468 Genomic DNA. Translation: AAL19311.1.
    PIRiJN0657.
    RefSeqiNP_459352.1. NC_003197.1.

    Genome annotation databases

    EnsemblBacteriaiAAL19311; AAL19311; STM0357.
    GeneIDi1251876.
    KEGGistm:STM0357.
    PATRICi32379033. VBISalEnt20916_0378.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M90544 Genomic DNA. No translation available.
    AE006468 Genomic DNA. Translation: AAL19311.1 .
    PIRi JN0657.
    RefSeqi NP_459352.1. NC_003197.1.

    3D structure databases

    ProteinModelPortali P40814.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 99287.STM0357.

    Protein family/group databases

    REBASEi 5598. M.StyLT2ORF357P.

    Proteomic databases

    PaxDbi P40814.
    PRIDEi P40814.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL19311 ; AAL19311 ; STM0357 .
    GeneIDi 1251876.
    KEGGi stm:STM0357.
    PATRICi 32379033. VBISalEnt20916_0378.

    Phylogenomic databases

    eggNOGi COG2189.
    HOGENOMi HOG000253523.
    KOi K07316.
    OMAi YLANCHE.
    OrthoDBi EOG6W9X8K.

    Enzyme and pathway databases

    BioCyci SENT99287:GCTI-358-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.150. 3 hits.
    InterProi IPR002295. D21N6_MeTrfase.
    IPR002941. DNA_methylase_N4/N6.
    IPR002052. DNA_methylase_N6_adenine_CS.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    Pfami PF01555. N6_N4_Mtase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF015855. TypeIII_Mtase_mKpnI. 1 hit.
    PRINTSi PR00506. D21N6MTFRASE.
    SUPFAMi SSF53335. SSF53335. 3 hits.
    PROSITEi PS00092. N6_MTASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence of the Salmonella typhimurium StyLT1 restriction-modification genes: homologies with EcoP1 and EcoP15 type-III R-M systems and presence of helicase domains."
      Dartois V., de Backer O., Colson C.
      Gene 127:105-110(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: LT7.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: LT2 / SGSC1412 / ATCC 700720.

    Entry informationi

    Entry nameiT3MO_SALTY
    AccessioniPrimary (citable) accession number: P40814
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: January 23, 2002
    Last modified: October 1, 2014
    This is version 97 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Restriction enzymes and methylases
      Classification of restriction enzymes and methylases and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3