P40808 (DCOR2_DROME) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 86.
History...
Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Ornithine decarboxylase 2 Short name=ODC EC=4.1.1.17 Alternative name(s): dODC2 | ||||
| Gene names |
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| Organism | Drosophila melanogaster (Fruit fly) | ||||
| Taxonomic identifier | 7227 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora |
Protein attributes
| Sequence length | 393 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Catalytic activity | L-ornithine = putrescine + CO2. |
| Cofactor | Pyridoxal phosphate. |
| Pathway | |
| Sequence similarities | Belongs to the Orn/Lys/Arg decarboxylase class-II family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Polyamine biosynthesis |
| Ligand | Pyridoxal phosphate |
| Molecular function | Decarboxylase Lyase |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | polyamine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | ornithine decarboxylase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| CG12116 | Q9W3F1 | 1 | EBI-178569,EBI-193758 | |
| nmd | Q9VL02 | 1 | EBI-178569,EBI-146380 |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 393 | 393 | Ornithine decarboxylase 2 | PRO_0000149900 | |||||
Sites | |||||||||
| Active site | 343 | 1 | Proton donor; shared with dimeric partner By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 62 | 1 | N6-(pyridoxal phosphate)lysine By similarity | ||||||
Experimental info | |||||||||
| Sequence conflict | 94 | 1 | L → F in CAA47166. Ref.1 | ||||||
| Sequence conflict | 143 | 1 | N → S in CAA47166. Ref.1 | ||||||
| Sequence conflict | 241 | 1 | E → K in CAA47166. Ref.1 | ||||||
| Sequence conflict | 346 | 1 | M → L in CAA47166. Ref.1 | ||||||
Sequences
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References
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | X66600 Genomic DNA. Translation: CAA47166.1. AE013599 Genomic DNA. Translation: AAF59149.2. |
| RefSeq | NP_477053.2. NM_057705.2. |
| UniGene | Dm.5265. |
3D structure databases | |
| ProteinModelPortal | P40808. |
| SMR | P40808. Positions 2-393. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | P40808. 2 interactions. |
| MINT | MINT-929037. |
| STRING | P40808. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblMetazoa | FBtr0088864; FBpp0087940; FBgn0013308. |
| GeneID | 35767. |
| KEGG | dme:Dmel_CG8719. |
| NMPDR | fig|7227.3.peg.3798. |
Organism-specific databases | |
| CTD | 35767. |
| FlyBase | FBgn0013308. Odc2. |
Phylogenomic databases | |
| eggNOG | inNOG06353. |
| InParanoid | P40808. |
| OMA | IKYACTH. |
| OrthoDB | EOG473N6V. |
| PhylomeDB | P40808. |
Gene expression databases | |
| Bgee | P40808. |
| GermOnline | CG8719. Drosophila melanogaster. |
Family and domain databases | |
| InterPro | IPR009006. Ala_racemase/Decarboxylase_C. IPR022643. De-COase2_C. IPR022644. De-COase2_N. IPR022653. De-COase2_pyr-phos_BS. IPR000183. Orn/DAP/Arg_de-COase. IPR002433. Orn_de-COase. [Graphical view] |
| Gene3D | G3DSA:2.40.37.10. Ala_racemase/Decarboxylase_C. 1 hit. |
| KO | K01581. |
| Pfam | PF02784. Orn_Arg_deC_N. 1 hit. PF00278. Orn_DAP_Arg_deC. 1 hit. [Graphical view] |
| PRINTS | PR01179. ODADCRBXLASE. PR01182. ORNDCRBXLASE. |
| SUPFAM | SSF50621. Racem_decarbox_C. 1 hit. |
| PROSITE | PS00878. ODR_DC_2_1. 1 hit. PS00879. ODR_DC_2_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 795123. |
Entry information
| Entry name | DCOR2_DROME | ||||||||
| Accession | Primary (citable) accession number: P40808 Secondary accession number(s): Q9V353 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Drosophila annotation project | ||||||||
Relevant documents
| Drosophila Drosophila: entries, gene names and cross-references to FlyBase |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with