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Protein

Ornithine decarboxylase 1

Gene

Odc1

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.By similarity

Catalytic activityi

L-ornithine = putrescine + CO2.By similarity

Cofactori

pyridoxal 5'-phosphateBy similarity

Enzyme regulationi

Inhibited by antizyme (AZ) in response to polyamine levels. AZ inhibits the assembly of the functional homodimer by binding to ODC monomers and targeting them for ubiquitin-independent proteolytic destruction by the 26S proteasome.By similarity

Pathwayi: putrescine biosynthesis via L-ornithine pathway

This protein is involved in step 1 of the subpathway that synthesizes putrescine from L-ornithine.
Proteins known to be involved in this subpathway in this organism are:
  1. Ornithine decarboxylase 2 (Odc2), Ornithine decarboxylase 1 (Odc1)
This subpathway is part of the pathway putrescine biosynthesis via L-ornithine pathway, which is itself part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes putrescine from L-ornithine, the pathway putrescine biosynthesis via L-ornithine pathway and in Amine and polyamine biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei191Stacks against the aromatic ring of pyridoxal phosphate and stabilizes reaction intermediatesBy similarity1
Binding sitei194Pyridoxal phosphateBy similarity1
Binding sitei231Pyridoxal phosphate; via amino nitrogenBy similarity1
Active sitei343Proton donor; shared with dimeric partnerBy similarity1
Binding sitei344Substrate; shared with dimeric partnerBy similarity1
Binding sitei372Pyridoxal phosphateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylase, Lyase
Biological processPolyamine biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

ReactomeiR-DME-351143 Agmatine biosynthesis
R-DME-351202 Metabolism of polyamines
UniPathwayiUPA00535; UER00288

Names & Taxonomyi

Protein namesi
Recommended name:
Ornithine decarboxylase 1 (EC:4.1.1.17)
Short name:
ODC
Gene namesi
Name:Odc1
ORF Names:CG8721
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0013307 Odc1

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001498991 – 394Ornithine decarboxylase 1Add BLAST394

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei62N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

PaxDbiP40807
PRIDEiP40807

Expressioni

Developmental stagei

Expressed in adults.1 Publication

Gene expression databases

BgeeiFBgn0013307
GenevisibleiP40807 DM

Interactioni

Subunit structurei

Homodimer. Only the dimer is catalytically active, as the active sites are constructed of residues from both monomers.By similarity

Protein-protein interaction databases

BioGridi61627, 1 interactor
IntActiP40807, 1 interactor
STRINGi7227.FBpp0087939

Structurei

3D structure databases

ProteinModelPortaliP40807
SMRiP40807
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni265 – 268Pyridoxal phosphate bindingBy similarity4
Regioni314 – 315Substrate bindingBy similarity2

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0622 Eukaryota
COG0019 LUCA
GeneTreeiENSGT00390000011560
InParanoidiP40807
KOiK01581
OMAiVVGYICE
OrthoDBiEOG091G0AJV
PhylomeDBiP40807

Family and domain databases

Gene3Di2.40.37.10, 2 hits
3.20.20.10, 1 hit
InterProiView protein in InterPro
IPR009006 Ala_racemase/Decarboxylase_C
IPR022643 De-COase2_C
IPR022657 De-COase2_CS
IPR022644 De-COase2_N
IPR022653 De-COase2_pyr-phos_BS
IPR000183 Orn/DAP/Arg_de-COase
IPR002433 Orn_de-COase
IPR029066 PLP-binding_barrel
PfamiView protein in Pfam
PF02784 Orn_Arg_deC_N, 1 hit
PF00278 Orn_DAP_Arg_deC, 1 hit
PRINTSiPR01179 ODADCRBXLASE
PR01182 ORNDCRBXLASE
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit
PROSITEiView protein in PROSITE
PS00878 ODR_DC_2_1, 1 hit
PS00879 ODR_DC_2_2, 1 hit

Sequencei

Sequence statusi: Complete.

P40807-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAATPEIQF YERELNIRRV IEECDLQRLD QALNICDLSS VERKLRLWQK
60 70 80 90 100
LLPRIKPFYA VKCNDDPMVV RLLAQLGAGF DCASKNEVKL VLGFDVSPER
110 120 130 140 150
IIFANPCRPV SHLEYAKEHQ VSNGTVDNEF EVYKLHTHYP NSNLIVRFKS
160 170 180 190 200
EAKEAQCPLG DKFGCDADVD AAALMLLAKS LELKVTGTSF HVGSGCSELQ
210 220 230 240 250
AYDRAIKKAK NLFKFGALLG YDMDFLDIGG GFPGSDDVKF EKIAESVNTS
260 270 280 290 300
VQRHFPDERV HIIAEPGRFF VAAACTLVCK IHAKREIRNE AGKLDTVMYY
310 320 330 340 350
LNDGVYGSFN CILYDHQVVI AEHYLDNAES LPHLKSLIWG PSCDALDKIS
360 370 380 390
EDLHLPNLNR GDLLGFRNMG AYTMPIASAF NGFEVPKTLY FQAI
Length:394
Mass (Da):44,195
Last modified:April 12, 2005 - v3
Checksum:i5D2F348D1467E39B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti44 – 45KL → NV in CAA47167 (PubMed:8329117).Curated2
Sequence conflicti44 – 45KL → NV in CAA47165 (PubMed:8329117).Curated2
Sequence conflicti242K → Q in CAA47165 (PubMed:8329117).Curated1
Sequence conflicti325L → Q in CAA47165 (PubMed:8329117).Curated1
Sequence conflicti348K → Q in CAA47165 (PubMed:8329117).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X66601 Genomic DNA Translation: CAA47167.1
X66599 mRNA Translation: CAA47165.1
AE013599 Genomic DNA Translation: AAF59150.1
AY094710 mRNA Translation: AAM11063.1
RefSeqiNP_477052.2, NM_057704.5
UniGeneiDm.3665

Genome annotation databases

EnsemblMetazoaiFBtr0088863; FBpp0087939; FBgn0013307
GeneIDi35766
KEGGidme:Dmel_CG8721

Similar proteinsi

Entry informationi

Entry nameiDCOR1_DROME
AccessioniPrimary (citable) accession number: P40807
Secondary accession number(s): Q9V352
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: April 12, 2005
Last modified: May 23, 2018
This is version 139 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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