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Protein

Protein shuttle craft

Gene

stc

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays an essential role during the late stages of embryonic neurogenesis. May either fine-tune the guidance or the spatial maintenance of the migrating SNB and in nerve roots, which are composed of axons originating from distinct groups of motor neurons and may be required to either guide or maintain the position of these nerves along a direct and straight path to their ultimate targets in particular muscle fields. May play a role in egg chamber development and/or may confer essential maternal contributions to the early embryo.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri386 – 433RING-type; atypicalPROSITE-ProRule annotationAdd BLAST48
Zinc fingeri474 – 492NF-X1-type 1Add BLAST19
Zinc fingeri527 – 546NF-X1-type 2Add BLAST20
Zinc fingeri585 – 604NF-X1-type 3Add BLAST20
Zinc fingeri644 – 667NF-X1-type 4Add BLAST24
Zinc fingeri706 – 725NF-X1-type 5Add BLAST20
Zinc fingeri733 – 752NF-X1-type 6Add BLAST20
Zinc fingeri844 – 867NF-X1-type 7Add BLAST24
Zinc fingeri876 – 896NF-X1-type 8Add BLAST21

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, RNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein shuttle craft
Gene namesi
Name:stc
ORF Names:CG3647
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0001978. stc.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: FlyBase

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000561901 – 1106Protein shuttle craftAdd BLAST1106

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei335Phosphothreonine1 Publication1
Modified residuei336Phosphoserine1 Publication1
Modified residuei339Phosphoserine1 Publication1
Modified residuei343Phosphoserine1 Publication1
Modified residuei354Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP40798.
PRIDEiP40798.

PTM databases

iPTMnetiP40798.

Expressioni

Tissue specificityi

Ovaries and embryonic central nervous system.

Developmental stagei

Major expression is seen in the ovaries while moderate levels of expression are observed during embryogenesis and throughout subsequent stages of fly development.

Gene expression databases

BgeeiFBgn0001978.
ExpressionAtlasiP40798. differential.
GenevisibleiP40798. DM.

Interactioni

Protein-protein interaction databases

BioGridi60906. 21 interactors.
IntActiP40798. 2 interactors.
MINTiMINT-279983.
STRINGi7227.FBpp0080265.

Structurei

3D structure databases

ProteinModelPortaliP40798.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1006 – 1071R3HPROSITE-ProRule annotationAdd BLAST66

Sequence similaritiesi

Belongs to the NFX1 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri386 – 433RING-type; atypicalPROSITE-ProRule annotationAdd BLAST48
Zinc fingeri474 – 492NF-X1-type 1Add BLAST19
Zinc fingeri527 – 546NF-X1-type 2Add BLAST20
Zinc fingeri585 – 604NF-X1-type 3Add BLAST20
Zinc fingeri644 – 667NF-X1-type 4Add BLAST24
Zinc fingeri706 – 725NF-X1-type 5Add BLAST20
Zinc fingeri733 – 752NF-X1-type 6Add BLAST20
Zinc fingeri844 – 867NF-X1-type 7Add BLAST24
Zinc fingeri876 – 896NF-X1-type 8Add BLAST21

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1952. Eukaryota.
ENOG410XR02. LUCA.
GeneTreeiENSGT00400000022083.
InParanoidiP40798.
KOiK12236.
OMAiHPCNILC.
OrthoDBiEOG091G057V.
PhylomeDBiP40798.

Family and domain databases

CDDicd02643. R3H_NF-X1. 1 hit.
Gene3Di3.30.1370.50. 1 hit.
InterProiView protein in InterPro
IPR034078. NFX1_fam.
IPR001374. R3H_dom.
IPR034076. R3H_NF-X1.
IPR019786. Zinc_finger_PHD-type_CS.
IPR000967. Znf_NFX1.
IPR001841. Znf_RING.
PANTHERiPTHR12360. PTHR12360. 1 hit.
PfamiView protein in Pfam
PF01424. R3H. 1 hit.
PF01422. zf-NF-X1. 7 hits.
SMARTiView protein in SMART
SM00393. R3H. 1 hit.
SM00438. ZnF_NFX. 9 hits.
SUPFAMiSSF82708. SSF82708. 1 hit.
PROSITEiView protein in PROSITE
PS51061. R3H. 1 hit.
PS50089. ZF_RING_2. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform A (identifier: P40798-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEYWQQLTN GAGEAGPGNE SSAMADCNGG HESAAVGGSC NRHSNNNYVN
60 70 80 90 100
FNQFIMQHNL GGGAPSNATS TMQHPVGSSY TNFSLGGGGG AFGLNPPVAS
110 120 130 140 150
ASTSHFANVS HQSPNFYSQA MIPTYQNGDG IARVTVTSSY GSVNPSNSNF
160 170 180 190 200
SSFYTPFGNN PFDFSASKLQ ASAPEFVPNF AKLSLEETPA AATTNGNSTA
210 220 230 240 250
SLETAINETR PRTLRAQEPA ERGANNQCSN HNYERERERE RDRDRDRERD
260 270 280 290 300
RDRDRDRDRD RDRDRDRDSR PGNTRQQRRS DYRDDREDRY ERSDRRRPQK
310 320 330 340 350
QQRYDNHRSN KRRDDWNRNR DRINGFPRAV DDLDTSNESA HPSPEKQSQL
360 370 380 390 400
QQISPRRGPP LPPADNEKLS QREKLVRDIE QRRLECLVCV EAIKSHQPTW
410 420 430 440 450
SCRNCYHMLH LKCTITWASS SKSEVGWRCP ACQNVLQDLP RDYLCFCGKL
460 470 480 490 500
KNPPVSRTEL AHSCGEVCCR IEGCSHACTL LCHPGPCPPC QANVVRSCGC
510 520 530 540 550
GRSTKTMQCA MKEEVLCGEI CDKLLNCGEH RCQAECHSGK CAACSEQVVQ
560 570 580 590 600
QCHCGKQERK VPCTRESQDK RTYSCKDSCG QPLPCGHHKC KDSCHAGSCR
610 620 630 640 650
PCKLSPEQIT SCPCGKMPVP AGQRSSCLDP IPTCEGICSR TLRCGKPAHP
660 670 680 690 700
HQCGSKCHLG QCPPCPKQTG VKCRCGHMDQ MIKCRQLCNR ADDARCKRRC
710 720 730 740 750
TKKRSCGKHK CNVECCIDID HDCPLPCNRT LSCGKHKCDQ PCHRGNCPPC
760 770 780 790 800
YRSSFEELYC ECGAEVIYPP VPCGTKKPIC KLPCSRIHPC DHPPQHNCHS
810 820 830 840 850
GPTCPPCMIF TTKLCHGNHE LRKTIPCSQP NFSCGMACGK PLPCGGHKCI
860 870 880 890 900
KPCHEGPCQS AGEICRQSCT KPRPTCGHKC AAACHEGACP ETPCKELVEV
910 920 930 940 950
QCECGNRKQN RSCQELAREH SRIATIQLAS SMAEMSRGNY MELSEILAPA
960 970 980 990 1000
KKSNKTLDCN DECRLLERNR RLAAALSSGN SDTKQKCLTK YSEFVRGFAK
1010 1020 1030 1040 1050
KNPALTKSVY ETLTDLVKLA KESKQRSRSH SFPTMNREKR QLVHELCEVF
1060 1070 1080 1090 1100
GIESVSYDKE PNRNVVATAH KDRCWFPATS IMEVLARESG QRRVPVPSNN

AWGLKK
Length:1,106
Mass (Da):123,183
Last modified:February 2, 2004 - v2
Checksum:i9502C6185994700D
GO
Isoform B (identifier: P40798-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     109-115: Missing.

Show »
Length:1,099
Mass (Da):122,433
Checksum:iFC62621A04AB44BB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti12A → P in AAB60255 (PubMed:8524296).Curated1
Sequence conflicti25A → V in AAB60255 (PubMed:8524296).Curated1
Sequence conflicti617M → I in AAB60255 (PubMed:8524296).Curated1
Sequence conflicti784C → S in AAB60255 (PubMed:8524296).Curated1
Sequence conflicti820 – 821EL → DW in AAB60255 (PubMed:8524296).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_005757109 – 115Missing in isoform B. 1 Publication7

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09306 mRNA. Translation: AAB60255.1.
AE014134 Genomic DNA. Translation: AAF53441.2.
AE014134 Genomic DNA. Translation: AAN10891.1.
AF145679 mRNA. Translation: AAD38654.1.
PIRiT13938.
T44598.
RefSeqiNP_476598.1. NM_057250.4. [P40798-2]
NP_476599.1. NM_057251.4. [P40798-1]
UniGeneiDm.7818.

Genome annotation databases

EnsemblMetazoaiFBtr0080705; FBpp0080265; FBgn0001978. [P40798-1]
FBtr0080706; FBpp0080266; FBgn0001978. [P40798-2]
GeneIDi34888.
KEGGidme:Dmel_CG3647.

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSTC_DROME
AccessioniPrimary (citable) accession number: P40798
Secondary accession number(s): Q8IP49, Q9VJQ1, Q9Y0Z5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 2, 2004
Last modified: August 30, 2017
This is version 153 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families