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P40797 (PNUT_DROME) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein peanut
Gene names
Name:pnut
ORF Names:CG8705
OrganismDrosophila melanogaster (Fruit fly)
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length539 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in cytokinesis and possibly cellularization. Also acts as an enhancer of the sina gene, thus having a role in photoreceptor development. Ref.1

Subunit structure

May well assemble into a multicomponent structure.

Subcellular location

Apical cell membrane; Peripheral membrane protein. Cleavage furrow. Note: Localized to the cleavage furrow of dividing cells during cytokinesis and to the intercellular bridge connecting postmitotic daughter cells. Equally found on the cell surfaces of the embryonic central nervous system and on the apical membranes of developing photoreceptor cells in the eye imaginal disk. Ref.1

Developmental stage

Maternal gene products found in the early embryo prior to zygotic transcription. Ref.1

Sequence similarities

Belongs to the septin family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 539539Protein peanut
PRO_0000173510

Regions

Nucleotide binding149 – 1568GTP By similarity
Nucleotide binding288 – 2969GTP By similarity
Coiled coil420 – 51697 Potential

Sites

Binding site1831GTP By similarity
Binding site2091GTP; via amide nitrogen By similarity
Binding site3451GTP; via amide nitrogen and carbonyl oxygen By similarity
Binding site3601GTP By similarity

Amino acid modifications

Modified residue61Phosphoserine Ref.5
Modified residue131Phosphoserine Ref.5
Modified residue5171Phosphoserine Ref.6

Experimental info

Sequence conflict791G → S in AAA19603. Ref.1
Sequence conflict2491S → N in AAA19603. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P40797 [UniParc].

Last modified November 8, 2005. Version 2.
Checksum: A8009F7E6F331A32

FASTA53960,143
        10         20         30         40         50         60 
MNSPRSNAVN GGSGGAISAL PSTLAQLALR DKQQAASASA SSATNGSSGS ESLVGVGGRP 

        70         80         90        100        110        120 
PNQPPSVPVA ASGKLDTSGG GASNGDSNKL THDLQEKEHQ QAQKPQKPPL PVRQKPMEIA 

       130        140        150        160        170        180 
GYVGFANLPN QVYRKAVKRG FEFTLMVVGA SGLGKSTLIN SMFLSDIYNA EQYPGPSLRK 

       190        200        210        220        230        240 
KKTVAVEATK VMLKENGVNL TLTVVDTPGF GDAVDNSNCW VPILEYVDSK YEEYLTAESR 

       250        260        270        280        290        300 
VYRKTISDSR VHCCLYFIAP SGHGLLPLDI ACMQSLSDKV NLVPVIAKAD TMTPDEVHLF 

       310        320        330        340        350        360 
KKQILNEIAQ HKIKIYDFPA TLEDAAEEAK TTQNLRSRVP FAVVGANTII EQDGKKVRGR 

       370        380        390        400        410        420 
RYPWGLVEVE NLTHCDFIAL RNMVIRTHLQ DLKDVTNNVH YENYRCRKLS ELGLVDGKAR 

       430        440        450        460        470        480 
LSNKNPLTQM EEEKREHEQK MKKMEAEMEQ VFDMKVKEKM QKLRDSELEL ARRHEERKKA 

       490        500        510        520        530 
LELQIRELEE KRREFEREKK EWEDVNHVTL EELKRRSLGA NSSTDNVDGK KEKKKKGLF

« Hide

References

« Hide 'large scale' references
[1]"The Drosophila peanut gene is required for cytokinesis and encodes a protein similar to yeast putative bud neck filament proteins."
Neufeld T.P., Rubin G.M.
Cell 77:371-379(1994) [PubMed: 8181057] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE.
[2]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[3]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: Berkeley.
[4]"A Drosophila full-length cDNA resource."
Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E.
Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed: 12537569] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Berkeley.
Tissue: Embryo.
[5]"An integrated chemical, mass spectrometric and computational strategy for (quantitative) phosphoproteomics: application to Drosophila melanogaster Kc167 cells."
Bodenmiller B., Mueller L.N., Pedrioli P.G.A., Pflieger D., Juenger M.A., Eng J.K., Aebersold R., Tao W.A.
Mol. Biosyst. 3:275-286(2007) [PubMed: 17372656] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-6 AND SER-13, MASS SPECTROMETRY.
[6]"Phosphoproteome analysis of Drosophila melanogaster embryos."
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.
J. Proteome Res. 7:1675-1682(2008) [PubMed: 18327897] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-517, MASS SPECTROMETRY.
Tissue: Embryo.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U08103 mRNA. Translation: AAA19603.1.
AE013599 Genomic DNA. Translation: AAM68857.1.
AY058663 mRNA. Translation: AAL13892.1.
PIRA54294.
RefSeqNP_477064.1. NM_057716.3.
NP_724659.1. NM_165597.1.
UniGeneDm.4132.

3D structure databases

ProteinModelPortalP40797.
SMRP40797. Positions 110-410.
ModBaseSearch...

Protein-protein interaction databases

IntActP40797. 1 interaction.
MINTMINT-291495.
STRINGP40797.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0088792; FBpp0087869; FBgn0013726.
FBtr0088793; FBpp0087870; FBgn0013726.
GeneID35801.
KEGGdme:Dmel_CG8705.

Organism-specific databases

CTD35801.
FlyBaseFBgn0013726. pnut.

Phylogenomic databases

eggNOGinNOG08653.
GeneTreeEMGT00050000002763.
InParanoidP40797.
OMAFKKQILN.
OrthoDBEOG4WM38Z.
PhylomeDBP40797.

Gene expression databases

BgeeP40797.
GermOnlineCG8705. Drosophila melanogaster.

Family and domain databases

InterProIPR000038. Cell_div_GTP-bd.
[Graphical view]
PANTHERPTHR18884. Cell_Div_GTP_bd. 1 hit.
PfamPF00735. Septin. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio795276.

Entry information

Entry namePNUT_DROME
AccessionPrimary (citable) accession number: P40797
Secondary accession number(s): Q0E9F5, Q9V385
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: November 8, 2005
Last modified: January 25, 2012
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents