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Protein

Ras-related protein Rac1

Gene

Rac1

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in axon outgrowth and myoblast fusion. Plays a role in regulating dorsal closure during embryogenesis. Involved in integrin alpha-PS3/beta-nu-mediated phagocytosis of Gram-positive S.aureus by hemocytes.3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 17GTPBy similarity8
Nucleotide bindingi57 – 61GTPBy similarity5
Nucleotide bindingi115 – 118GTPBy similarity4

GO - Molecular functioni

  • GTPase activating protein binding Source: FlyBase
  • GTPase activity Source: FlyBase
  • GTP binding Source: UniProtKB-KW
  • protein kinase binding Source: FlyBase

GO - Biological processi

  • actin cytoskeleton organization Source: FlyBase
  • actin cytoskeleton reorganization Source: FlyBase
  • actin filament bundle assembly Source: FlyBase
  • actin filament organization Source: FlyBase
  • activation of protein kinase activity Source: FlyBase
  • adherens junction maintenance Source: FlyBase
  • axonal fasciculation Source: FlyBase
  • axon extension Source: FlyBase
  • axon guidance Source: FlyBase
  • axon midline choice point recognition Source: FlyBase
  • border follicle cell migration Source: FlyBase
  • cell competition in a multicellular organism Source: FlyBase
  • cell morphogenesis Source: FlyBase
  • cell proliferation Source: FlyBase
  • cortical actin cytoskeleton organization Source: FlyBase
  • dendrite development Source: FlyBase
  • dendrite morphogenesis Source: FlyBase
  • determination of digestive tract left/right asymmetry Source: FlyBase
  • dorsal appendage formation Source: FlyBase
  • dorsal closure Source: UniProtKB
  • dorsal closure, amnioserosa morphology change Source: FlyBase
  • dorsal closure, elongation of leading edge cells Source: FlyBase
  • dorsal closure, spreading of leading edge cells Source: FlyBase
  • embryonic anterior midgut (ectodermal) morphogenesis Source: FlyBase
  • encapsulation of foreign target Source: FlyBase
  • germ-band shortening Source: FlyBase
  • glial cell migration Source: FlyBase
  • head involution Source: FlyBase
  • hemocyte development Source: FlyBase
  • hemocyte migration Source: FlyBase
  • imaginal disc-derived wing hair site selection Source: FlyBase
  • immune response-regulating cell surface receptor signaling pathway involved in phagocytosis Source: FlyBase
  • JNK cascade Source: FlyBase
  • lamellipodium assembly Source: FlyBase
  • melanotic encapsulation of foreign target Source: FlyBase
  • memory Source: FlyBase
  • mesodermal cell migration Source: FlyBase
  • motor neuron axon guidance Source: FlyBase
  • muscle attachment Source: FlyBase
  • muscle fiber development Source: FlyBase
  • myoblast fusion Source: FlyBase
  • myoblast proliferation Source: FlyBase
  • negative regulation of lamellipodium assembly Source: FlyBase
  • nephrocyte filtration Source: FlyBase
  • neuron projection development Source: FlyBase
  • neuron projection morphogenesis Source: FlyBase
  • open tracheal system development Source: FlyBase
  • ovarian follicle cell development Source: FlyBase
  • peripheral nervous system development Source: FlyBase
  • positive regulation of axon extension Source: FlyBase
  • positive regulation of axon guidance Source: FlyBase
  • positive regulation of cell-matrix adhesion Source: FlyBase
  • positive regulation of filopodium assembly Source: FlyBase
  • positive regulation of protein serine/threonine kinase activity Source: UniProtKB
  • positive regulation of wound healing Source: FlyBase
  • regulation of axonogenesis Source: FlyBase
  • regulation of dendrite morphogenesis Source: FlyBase
  • regulation of hemocyte differentiation Source: FlyBase
  • regulation of locomotor rhythm Source: FlyBase
  • regulation of synapse assembly Source: FlyBase
  • regulation of synapse organization Source: FlyBase
  • rhabdomere development Source: FlyBase
  • salivary gland morphogenesis Source: FlyBase
  • sensory perception of touch Source: FlyBase
  • small GTPase mediated signal transduction Source: InterPro
  • tracheal outgrowth, open tracheal system Source: FlyBase
  • ventral cord development Source: FlyBase

Keywordsi

Molecular functionDevelopmental protein
Biological processPhagocytosis
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DME-114604 GPVI-mediated activation cascade
R-DME-1433557 Signaling by SCF-KIT
R-DME-193648 NRAGE signals death through JNK
R-DME-194840 Rho GTPase cycle
R-DME-2029482 Regulation of actin dynamics for phagocytic cup formation
R-DME-350376 Activation of RAC1:GTP by FZ:DSH complex
R-DME-376172 DSCAM interactions
R-DME-389359 CD28 dependent Vav1 pathway
R-DME-3928662 EPHB-mediated forward signaling
R-DME-3928664 Ephrin signaling
R-DME-3928665 EPH-ephrin mediated repulsion of cells
R-DME-4086400 PCP/CE pathway
R-DME-416482 G alpha (12/13) signalling events
R-DME-418885 DCC mediated attractive signaling
R-DME-4420097 VEGFA-VEGFR2 Pathway
R-DME-445144 Signal transduction by L1
R-DME-5218920 VEGFR2 mediated vascular permeability
R-DME-5625740 RHO GTPases activate PKNs
R-DME-5625900 RHO GTPases activate CIT
R-DME-5627123 RHO GTPases activate PAKs
R-DME-5663213 RHO GTPases Activate WASPs and WAVEs
R-DME-5687128 MAPK6/MAPK4 signaling
R-DME-6798695 Neutrophil degranulation
R-DME-8849471 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
R-DME-983231 Factors involved in megakaryocyte development and platelet production
SignaLinkiP40792

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rac1
Gene namesi
Name:Rac1
Synonyms:RacA
ORF Names:CG2248
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0010333 Rac1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001988931 – 189Ras-related protein Rac1Add BLAST189
PropeptideiPRO_0000281244190 – 192Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei189Cysteine methyl esterBy similarity1
Lipidationi189S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiP40792
PRIDEiP40792

Expressioni

Gene expression databases

BgeeiFBgn0010333
ExpressionAtlasiP40792 baseline and differential
GenevisibleiP40792 DM

Interactioni

Subunit structurei

Interacts with Sra-1. Interacts (via REM 1 repeats) with Pkn (via N-terminus).3 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • GTPase activating protein binding Source: FlyBase
  • protein kinase binding Source: FlyBase

Protein-protein interaction databases

BioGridi63689, 122 interactors
IntActiP40792, 4 interactors
STRINGi7227.FBpp0304252

Structurei

3D structure databases

ProteinModelPortaliP40792
SMRiP40792
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi32 – 40Effector regionSequence analysis9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rho family.Curated

Phylogenomic databases

eggNOGiKOG0393 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00760000118978
InParanoidiP40792
KOiK04392
OMAiKECSAIT
OrthoDBiEOG091G0KCM
PhylomeDBiP40792

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR003578 Small_GTPase_Rho
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51420 RHO, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P40792-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQAIKCVVVG DGAVGKTCLL ISYTTNAFPG EYIPTVFDNY SANVMVDAKP
60 70 80 90 100
INLGLWDTAG QEDYDRLRPL SYPQTDVFLI CFSLVNPASF ENVRAKWYPE
110 120 130 140 150
VRHHCPSTPI ILVGTKLDLR DDKNTIEKLR DKKLAPITYP QGLAMAKEIG
160 170 180 190
AVKYLECSAL TQKGLKTVFD EAIRSVLCPV LQPKSKRKCA LL
Length:192
Mass (Da):21,354
Last modified:February 1, 1996 - v2
Checksum:iF910B54BDBD8AFA3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti135A → V in AAA62870 (PubMed:7958857).Curated1
Sequence conflicti143 – 146LAMA → SGHG in AAA67040 (PubMed:7835340).Curated4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U11823 mRNA Translation: AAA62870.1
L38309 mRNA Translation: AAA67040.1
Z35642 mRNA Translation: CAA84709.1
AE014296 Genomic DNA Translation: AAF47469.1
AY060408 mRNA Translation: AAL25447.1
PIRiI45715
S51718
S54295
RefSeqiNP_001261247.1, NM_001274318.1
NP_476950.1, NM_057602.4
UniGeneiDm.4299

Genome annotation databases

EnsemblMetazoaiFBtr0072730; FBpp0072614; FBgn0010333
FBtr0331868; FBpp0304252; FBgn0010333
GeneIDi38146
KEGGidme:Dmel_CG2248

Similar proteinsi

Entry informationi

Entry nameiRAC1_DROME
AccessioniPrimary (citable) accession number: P40792
Secondary accession number(s): Q9W0H7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1996
Last modified: May 23, 2018
This is version 181 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health