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Protein

Ras-related protein Rac1

Gene

Rac1

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in axon outgrowth and myoblast fusion. Plays a role in regulating dorsal closure during embryogenesis. Involved in integrin alpha-PS3/beta-nu-mediated phagocytosis of Gram-positive S.aureus by hemocytes.3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 17GTPBy similarity8
Nucleotide bindingi57 – 61GTPBy similarity5
Nucleotide bindingi115 – 118GTPBy similarity4

GO - Molecular functioni

  • GTPase activating protein binding Source: FlyBase
  • GTPase activity Source: FlyBase
  • GTP binding Source: UniProtKB-KW
  • protein kinase binding Source: FlyBase

GO - Biological processi

  • actin cytoskeleton organization Source: FlyBase
  • actin cytoskeleton reorganization Source: FlyBase
  • actin filament bundle assembly Source: FlyBase
  • actin filament organization Source: FlyBase
  • activation of protein kinase activity Source: FlyBase
  • adherens junction maintenance Source: FlyBase
  • axonal fasciculation Source: FlyBase
  • axon extension Source: FlyBase
  • axon guidance Source: FlyBase
  • axon midline choice point recognition Source: FlyBase
  • border follicle cell migration Source: FlyBase
  • cell-cell junction organization Source: FlyBase
  • cell competition in a multicellular organism Source: FlyBase
  • cell morphogenesis Source: FlyBase
  • cell proliferation Source: FlyBase
  • cellular response to DNA damage stimulus Source: FlyBase
  • cortical actin cytoskeleton organization Source: FlyBase
  • dendrite development Source: FlyBase
  • dendrite morphogenesis Source: FlyBase
  • determination of digestive tract left/right asymmetry Source: FlyBase
  • dorsal appendage formation Source: FlyBase
  • dorsal closure Source: UniProtKB
  • dorsal closure, amnioserosa morphology change Source: FlyBase
  • dorsal closure, elongation of leading edge cells Source: FlyBase
  • dorsal closure, spreading of leading edge cells Source: FlyBase
  • embryonic anterior midgut (ectodermal) morphogenesis Source: FlyBase
  • encapsulation of foreign target Source: FlyBase
  • establishment of ommatidial planar polarity Source: FlyBase
  • establishment of tissue polarity Source: FlyBase
  • germ-band shortening Source: FlyBase
  • glial cell migration Source: FlyBase
  • head involution Source: FlyBase
  • hemocyte development Source: FlyBase
  • hemocyte migration Source: FlyBase
  • imaginal disc-derived wing hair site selection Source: FlyBase
  • immune response-regulating cell surface receptor signaling pathway involved in phagocytosis Source: FlyBase
  • JNK cascade Source: FlyBase
  • lamellipodium assembly Source: FlyBase
  • melanotic encapsulation of foreign target Source: FlyBase
  • memory Source: FlyBase
  • mesodermal cell migration Source: FlyBase
  • microtubule-based process Source: FlyBase
  • morphogenesis of larval imaginal disc epithelium Source: FlyBase
  • motor neuron axon guidance Source: FlyBase
  • muscle attachment Source: FlyBase
  • muscle fiber development Source: FlyBase
  • myoblast fusion Source: FlyBase
  • myoblast proliferation Source: FlyBase
  • negative regulation of lamellipodium assembly Source: FlyBase
  • nephrocyte filtration Source: FlyBase
  • neuron projection development Source: FlyBase
  • neuron projection morphogenesis Source: FlyBase
  • open tracheal system development Source: FlyBase
  • ovarian follicle cell development Source: FlyBase
  • peripheral nervous system development Source: FlyBase
  • phagocytosis Source: FlyBase
  • positive regulation of axon extension Source: FlyBase
  • positive regulation of axon guidance Source: FlyBase
  • positive regulation of cell-matrix adhesion Source: FlyBase
  • positive regulation of filopodium assembly Source: FlyBase
  • positive regulation of protein serine/threonine kinase activity Source: UniProtKB
  • positive regulation of wound healing Source: FlyBase
  • regulation of axonogenesis Source: FlyBase
  • regulation of cell cycle Source: FlyBase
  • regulation of dendrite morphogenesis Source: FlyBase
  • regulation of hemocyte differentiation Source: FlyBase
  • regulation of locomotor rhythm Source: FlyBase
  • regulation of synapse assembly Source: FlyBase
  • regulation of synapse organization Source: FlyBase
  • rhabdomere development Source: FlyBase
  • salivary gland morphogenesis Source: FlyBase
  • sensory perception of touch Source: FlyBase
  • small GTPase mediated signal transduction Source: InterPro
  • tracheal outgrowth, open tracheal system Source: FlyBase
  • ventral cord development Source: FlyBase

Keywordsi

Molecular functionDevelopmental protein
Biological processPhagocytosis
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DME-114604. GPVI-mediated activation cascade.
R-DME-1433557. Signaling by SCF-KIT.
R-DME-193648. NRAGE signals death through JNK.
R-DME-194840. Rho GTPase cycle.
R-DME-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-DME-350376. Activation of RAC1:GTP by FZ:DSH complex.
R-DME-376172. DSCAM interactions.
R-DME-389359. CD28 dependent Vav1 pathway.
R-DME-3928662. EPHB-mediated forward signaling.
R-DME-3928664. Ephrin signaling.
R-DME-3928665. EPH-ephrin mediated repulsion of cells.
R-DME-4086400. PCP/CE pathway.
R-DME-416482. G alpha (12/13) signalling events.
R-DME-418885. DCC mediated attractive signaling.
R-DME-4420097. VEGFA-VEGFR2 Pathway.
R-DME-445144. Signal transduction by L1.
R-DME-5218920. VEGFR2 mediated vascular permeability.
R-DME-5625900. RHO GTPases activate CIT.
R-DME-5627123. RHO GTPases activate PAKs.
R-DME-5663213. RHO GTPases Activate WASPs and WAVEs.
R-DME-5687128. MAPK6/MAPK4 signaling.
R-DME-6798695. Neutrophil degranulation.
R-DME-8849471. PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases.
R-DME-8875555. MET activates RAP1 and RAC1.
R-DME-983231. Factors involved in megakaryocyte development and platelet production.
SignaLinkiP40792.

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rac1
Gene namesi
Name:Rac1
Synonyms:RacA
ORF Names:CG2248
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0010333. Rac1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001988931 – 189Ras-related protein Rac1Add BLAST189
PropeptideiPRO_0000281244190 – 192Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei189Cysteine methyl esterBy similarity1
Lipidationi189S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiP40792.
PRIDEiP40792.

Expressioni

Gene expression databases

BgeeiFBgn0010333.
ExpressionAtlasiP40792. differential.
GenevisibleiP40792. DM.

Interactioni

Subunit structurei

Interacts with Sra-1. Interacts (via REM 1 repeats) with Pkn (via N-terminus).3 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • GTPase activating protein binding Source: FlyBase
  • protein kinase binding Source: FlyBase

Protein-protein interaction databases

BioGridi63689. 122 interactors.
IntActiP40792. 4 interactors.
STRINGi7227.FBpp0304252.

Structurei

3D structure databases

ProteinModelPortaliP40792.
SMRiP40792.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi32 – 40Effector regionSequence analysis9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rho family.Curated

Phylogenomic databases

eggNOGiKOG0393. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00760000118978.
InParanoidiP40792.
KOiK04392.
OMAiSSHKMCT.
OrthoDBiEOG091G0KCM.
PhylomeDBiP40792.

Family and domain databases

InterProiView protein in InterPro
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003578. Small_GTPase_Rho.
PfamiView protein in Pfam
PF00071. Ras. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiView protein in PROSITE
PS51420. RHO. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P40792-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQAIKCVVVG DGAVGKTCLL ISYTTNAFPG EYIPTVFDNY SANVMVDAKP
60 70 80 90 100
INLGLWDTAG QEDYDRLRPL SYPQTDVFLI CFSLVNPASF ENVRAKWYPE
110 120 130 140 150
VRHHCPSTPI ILVGTKLDLR DDKNTIEKLR DKKLAPITYP QGLAMAKEIG
160 170 180 190
AVKYLECSAL TQKGLKTVFD EAIRSVLCPV LQPKSKRKCA LL
Length:192
Mass (Da):21,354
Last modified:February 1, 1996 - v2
Checksum:iF910B54BDBD8AFA3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti135A → V in AAA62870 (PubMed:7958857).Curated1
Sequence conflicti143 – 146LAMA → SGHG in AAA67040 (PubMed:7835340).Curated4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U11823 mRNA. Translation: AAA62870.1.
L38309 mRNA. Translation: AAA67040.1.
Z35642 mRNA. Translation: CAA84709.1.
AE014296 Genomic DNA. Translation: AAF47469.1.
AY060408 mRNA. Translation: AAL25447.1.
PIRiI45715.
S51718.
S54295.
RefSeqiNP_001261247.1. NM_001274318.1.
NP_476950.1. NM_057602.4.
UniGeneiDm.4299.

Genome annotation databases

EnsemblMetazoaiFBtr0072730; FBpp0072614; FBgn0010333.
FBtr0331868; FBpp0304252; FBgn0010333.
GeneIDi38146.
KEGGidme:Dmel_CG2248.

Similar proteinsi

Entry informationi

Entry nameiRAC1_DROME
AccessioniPrimary (citable) accession number: P40792
Secondary accession number(s): Q9W0H7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1996
Last modified: November 22, 2017
This is version 178 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families