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Protein

Homeobox protein DLX-2

Gene

Dlx2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a transcriptional activator (PubMed:21875655). Plays a role in terminal differentiation of interneurons, such as amacrine and bipolar cells in the developing retina (PubMed:21875655). Likely to play a regulatory role in the development of the ventral forebrain (PubMed:1678612). May play a role in craniofacial patterning and morphogenesis (PubMed:1678612).2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi155 – 214HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

  • chromatin binding Source: MGI
  • DNA binding Source: MGI
  • RNA polymerase II regulatory region sequence-specific DNA binding Source: NTNU_SB
  • single-stranded RNA binding Source: MGI
  • transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: NTNU_SB

GO - Biological processi

  • branching morphogenesis of a nerve Source: MGI
  • cartilage development Source: MGI
  • cell differentiation Source: MGI
  • cerebral cortex GABAergic interneuron differentiation Source: MGI
  • cerebral cortex GABAergic interneuron fate commitment Source: MGI
  • embryonic cranial skeleton morphogenesis Source: MGI
  • embryonic skeletal system development Source: MGI
  • forebrain neuron differentiation Source: MGI
  • hippocampus development Source: MGI
  • negative regulation of Notch signaling pathway Source: MGI
  • negative regulation of oligodendrocyte differentiation Source: MGI
  • negative regulation of photoreceptor cell differentiation Source: UniProtKB
  • negative regulation of transcription by RNA polymerase II Source: MGI
  • odontogenesis of dentin-containing tooth Source: MGI
  • olfactory bulb development Source: MGI
  • positive regulation of amacrine cell differentiation Source: UniProtKB
  • positive regulation of cell differentiation Source: UniProtKB
  • positive regulation of transcription by RNA polymerase II Source: NTNU_SB
  • proximal/distal pattern formation Source: MGI
  • regulation of transcription by RNA polymerase II Source: MGI
  • regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment Source: MGI
  • subpallium development Source: MGI

Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding
Biological processDifferentiation, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein DLX-2
Alternative name(s):
Homeobox protein TES-1
Gene namesi
Name:Dlx2
Synonyms:Tes-1, Tes1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:94902 Dlx2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000490241 – 332Homeobox protein DLX-2Add BLAST332

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei235PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated by serine/threonine kinases.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP40764
PeptideAtlasiP40764
PRIDEiP40764

PTM databases

iPTMnetiP40764
PhosphoSitePlusiP40764

Expressioni

Tissue specificityi

Expressed only in neural and other ectodermal structures of the head: the brain, the vomeronasal organ, and the preameloblasts of the teeth (PubMed:8098616). Primarily expressed in the germinal cells of the ventral forebrain in the midgestational embryo, and in both dorsal and ventral ventricular zones in late embryogenesis and early postnatal life (PubMed:8098616). Expressed in the inner nuclear layer of the retina (PubMed:21875655).2 Publications

Developmental stagei

Expressed in developing retinal progenitor cells at 12 dpc (PubMed:21875655). Developmentally regulated (PubMed:1678612, PubMed:1687503).3 Publications

Gene expression databases

BgeeiENSMUSG00000023391
CleanExiMM_DLX2
ExpressionAtlasiP40764 baseline and differential
GenevisibleiP40764 MM

Interactioni

Subunit structurei

Interacts (via homeobox DNA-binding domain) with POU4F2; this interaction enhances retinal ganglion cell (RGC) differentiation (PubMed:21875655).1 Publication

Protein-protein interaction databases

BioGridi199235, 4 interactors
STRINGi10090.ENSMUSP00000024159

Structurei

3D structure databases

ProteinModelPortaliP40764
SMRiP40764
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi41 – 49Poly-Ser9
Compositional biasi78 – 83Poly-Gly6
Compositional biasi254 – 265Poly-GlyAdd BLAST12
Compositional biasi311 – 319Poly-His9

Sequence similaritiesi

Belongs to the distal-less homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0850 Eukaryota
ENOG410ZHZR LUCA
GeneTreeiENSGT00910000143987
HOGENOMiHOG000231940
HOVERGENiHBG005493
InParanoidiP40764
KOiK18488
OMAiFLGNYPW
OrthoDBiEOG091G0P17
PhylomeDBiP40764
TreeFamiTF350606

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR022135 Distal-less_N
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
IPR000047 HTH_motif
PfamiView protein in Pfam
PF12413 DLL_N, 1 hit
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
PR00031 HTHREPRESSR
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

P40764-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGVFDSLVA DMHSTQITAS STYHQHQQPP SGAGAGPGGN SNSSSSNSSL
60 70 80 90 100
HKPQESPTLP VSTATDSSYY TNQQHPAGGG GGGASPYAHM GSYQYHASGL
110 120 130 140 150
NNVSYSAKSS YDLGYTAAYT SYAPYGTSSS PVNNEPDKED LEPEIRIVNG
160 170 180 190 200
KPKKVRKPRT IYSSFQLAAL QRRFQKTQYL ALPERAELAA SLGLTQTQVK
210 220 230 240 250
IWFQNRRSKF KKMWKSGEIP TEQHPGASAS PPCASPPVSA PASWDFGAPQ
260 270 280 290 300
RMAGGGPGSG GGGAGSSGSS PSSAASAFLG NYPWYHQASG SASHLQATAP
310 320 330
LLHPSQTPQA HHHHHHHHHA GGGAPVSAGT IF
Length:332
Mass (Da):34,746
Last modified:February 1, 1995 - v1
Checksum:iFEC8483D1CAA71EA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M80540 mRNA Translation: AAA40412.1
M83184 mRNA Translation: AAA18487.1
U51002 Genomic DNA Translation: AAB40901.1
CCDSiCCDS16117.1
PIRiA45581
JH0465
RefSeqiNP_034184.1, NM_010054.2
UniGeneiMm.3896

Genome annotation databases

EnsembliENSMUST00000024159; ENSMUSP00000024159; ENSMUSG00000023391
GeneIDi13392
KEGGimmu:13392
UCSCiuc008kax.2 mouse

Similar proteinsi

Entry informationi

Entry nameiDLX2_MOUSE
AccessioniPrimary (citable) accession number: P40764
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: March 28, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health