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Protein

Homeobox protein DLX-2

Gene

Dlx2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi155 – 21460HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • chromatin binding Source: MGI
  • DNA binding Source: MGI
  • RNA polymerase II regulatory region sequence-specific DNA binding Source: NTNU_SB
  • single-stranded RNA binding Source: MGI
  • transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding Source: NTNU_SB

GO - Biological processi

  • branching morphogenesis of a nerve Source: MGI
  • cartilage development Source: MGI
  • cell differentiation Source: MGI
  • cerebral cortex GABAergic interneuron differentiation Source: MGI
  • cerebral cortex GABAergic interneuron fate commitment Source: MGI
  • embryonic cranial skeleton morphogenesis Source: MGI
  • embryonic skeletal system development Source: MGI
  • forebrain neuron differentiation Source: MGI
  • hippocampus development Source: MGI
  • negative regulation of Notch signaling pathway Source: MGI
  • negative regulation of oligodendrocyte differentiation Source: MGI
  • negative regulation of transcription from RNA polymerase II promoter Source: MGI
  • odontogenesis of dentin-containing tooth Source: MGI
  • olfactory bulb development Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
  • proximal/distal pattern formation Source: MGI
  • regulation of transcription from RNA polymerase II promoter Source: MGI
  • regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment Source: MGI
  • subpallium development Source: MGI
  • transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein DLX-2
Alternative name(s):
Homeobox protein TES-1
Gene namesi
Name:Dlx2
Synonyms:Tes-1, Tes1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:94902. Dlx2.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 332332Homeobox protein DLX-2PRO_0000049024Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei235 – 2351PhosphoserineBy similarity

Post-translational modificationi

Phosphorylated by serine/threonine kinases.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP40764.
PRIDEiP40764.

PTM databases

iPTMnetiP40764.
PhosphoSiteiP40764.

Expressioni

Tissue specificityi

Expressed only in neural and other ectodermal structures of the head: the brain, the vomeronasal organ, and the preameloblasts of the teeth. Primarily expressed in the germinal cells of the ventral forebrain in the midgestational embryo, and in both dorsal and ventral ventricular zones in late embryogenesis and early postnatal life.1 Publication

Developmental stagei

Developmentally regulated.

Gene expression databases

BgeeiP40764.
CleanExiMM_DLX2.
ExpressionAtlasiP40764. baseline and differential.
GenevisibleiP40764. MM.

Interactioni

Protein-protein interaction databases

BioGridi199235. 4 interactions.
STRINGi10090.ENSMUSP00000024159.

Structurei

3D structure databases

ProteinModelPortaliP40764.
SMRiP40764. Positions 156-212.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi41 – 499Poly-Ser
Compositional biasi78 – 836Poly-Gly
Compositional biasi254 – 26512Poly-GlyAdd
BLAST
Compositional biasi311 – 3199Poly-His

Sequence similaritiesi

Belongs to the distal-less homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0850. Eukaryota.
ENOG410ZHZR. LUCA.
HOGENOMiHOG000231940.
HOVERGENiHBG005493.
InParanoidiP40764.
KOiK18488.
OMAiMHSNQIT.
OrthoDBiEOG70W3F8.
PhylomeDBiP40764.
TreeFamiTF350606.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR022135. Distal-less_N.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view]
PfamiPF12413. DLL_N. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P40764-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGVFDSLVA DMHSTQITAS STYHQHQQPP SGAGAGPGGN SNSSSSNSSL
60 70 80 90 100
HKPQESPTLP VSTATDSSYY TNQQHPAGGG GGGASPYAHM GSYQYHASGL
110 120 130 140 150
NNVSYSAKSS YDLGYTAAYT SYAPYGTSSS PVNNEPDKED LEPEIRIVNG
160 170 180 190 200
KPKKVRKPRT IYSSFQLAAL QRRFQKTQYL ALPERAELAA SLGLTQTQVK
210 220 230 240 250
IWFQNRRSKF KKMWKSGEIP TEQHPGASAS PPCASPPVSA PASWDFGAPQ
260 270 280 290 300
RMAGGGPGSG GGGAGSSGSS PSSAASAFLG NYPWYHQASG SASHLQATAP
310 320 330
LLHPSQTPQA HHHHHHHHHA GGGAPVSAGT IF
Length:332
Mass (Da):34,746
Last modified:February 1, 1995 - v1
Checksum:iFEC8483D1CAA71EA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M80540 mRNA. Translation: AAA40412.1.
M83184 mRNA. Translation: AAA18487.1.
U51002 Genomic DNA. Translation: AAB40901.1.
CCDSiCCDS16117.1.
PIRiA45581.
JH0465.
RefSeqiNP_034184.1. NM_010054.2.
UniGeneiMm.3896.

Genome annotation databases

EnsembliENSMUST00000024159; ENSMUSP00000024159; ENSMUSG00000023391.
GeneIDi13392.
KEGGimmu:13392.
UCSCiuc008kax.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M80540 mRNA. Translation: AAA40412.1.
M83184 mRNA. Translation: AAA18487.1.
U51002 Genomic DNA. Translation: AAB40901.1.
CCDSiCCDS16117.1.
PIRiA45581.
JH0465.
RefSeqiNP_034184.1. NM_010054.2.
UniGeneiMm.3896.

3D structure databases

ProteinModelPortaliP40764.
SMRiP40764. Positions 156-212.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199235. 4 interactions.
STRINGi10090.ENSMUSP00000024159.

PTM databases

iPTMnetiP40764.
PhosphoSiteiP40764.

Proteomic databases

PaxDbiP40764.
PRIDEiP40764.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000024159; ENSMUSP00000024159; ENSMUSG00000023391.
GeneIDi13392.
KEGGimmu:13392.
UCSCiuc008kax.2. mouse.

Organism-specific databases

CTDi1746.
MGIiMGI:94902. Dlx2.

Phylogenomic databases

eggNOGiKOG0850. Eukaryota.
ENOG410ZHZR. LUCA.
HOGENOMiHOG000231940.
HOVERGENiHBG005493.
InParanoidiP40764.
KOiK18488.
OMAiMHSNQIT.
OrthoDBiEOG70W3F8.
PhylomeDBiP40764.
TreeFamiTF350606.

Miscellaneous databases

PROiP40764.
SOURCEiSearch...

Gene expression databases

BgeeiP40764.
CleanExiMM_DLX2.
ExpressionAtlasiP40764. baseline and differential.
GenevisibleiP40764. MM.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR022135. Distal-less_N.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view]
PfamiPF12413. DLL_N. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Isolation and characterization of a novel cDNA clone encoding a homeodomain that is developmentally regulated in the ventral forebrain."
    Porteus M.H., Bulfone A., Ciaranello R.D., Rubenstein J.L.R.
    Neuron 7:221-229(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/cJ.
  2. Cited for: SEQUENCE REVISION.
  3. "Sequence, organization, and transcription of the Dlx-1 and Dlx-2 locus."
    McGuinness T., Porteus M.H., Smiga S., Bulfone A., Kingsley C., Qiu M., Liu J.K., Long J.E., Xu D., Rubenstein J.L.R.
    Genomics 35:473-485(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129.
  4. "Spatially restricted expression of a member of a new family of murine Distal-less homeobox genes in the developing forebrain."
    Robinson G.W., Wray S., Mahon K.A.
    New Biol. 3:1183-1194(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 26-332.
  5. "The mouse Dlx-2 (Tes-1) gene is expressed in spatially restricted domains of the forebrain, face and limbs in midgestation mouse embryos."
    Bulfone A., Kim H.J., Puelles L., Porteus M.H., Grippo J.F., Rubenstein J.L.
    Mech. Dev. 40:129-140(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  6. Erratum
    Bulfone A., Kim H.J., Puelles L., Porteus M.H., Grippo J.F., Rubenstein J.L.
    Mech. Dev. 42:187-187(1993)
    Cited for: SEQUENCE REVISION.

Entry informationi

Entry nameiDLX2_MOUSE
AccessioniPrimary (citable) accession number: P40764
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: June 8, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.