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P40757

- ALN_LITCT

UniProt

P40757 - ALN_LITCT

Protein

Allantoinase, mitochondrial

Gene

ALN

Organism
Lithobates catesbeiana (American bullfrog) (Rana catesbeiana)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    (S)-allantoin + H2O = allantoate.

    Cofactori

    Binds 2 zinc ions per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi76 – 761Zinc 1By similarity
    Metal bindingi78 – 781Zinc 1By similarity
    Metal bindingi163 – 1631Zinc 1; via carbamate groupBy similarity
    Metal bindingi163 – 1631Zinc 2; via carbamate groupBy similarity
    Metal bindingi199 – 1991Zinc 2By similarity
    Metal bindingi251 – 2511Zinc 2By similarity
    Metal bindingi324 – 3241Zinc 1By similarity

    GO - Molecular functioni

    1. allantoinase activity Source: UniProtKB-EC
    2. cobalt ion binding Source: InterPro
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. allantoin catabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    UniPathwayiUPA00395; UER00653.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Allantoinase, mitochondrial (EC:3.5.2.5)
    Gene namesi
    Name:ALN
    OrganismiLithobates catesbeiana (American bullfrog) (Rana catesbeiana)
    Taxonomic identifieri8400 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraNeobatrachiaRanoideaRanidaeRanaAquarana

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrion Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 484Allantoinase, mitochondrialPRO_0000007371
    Transit peptidei1 – ?MitochondrionSequence Analysis

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei163 – 1631N6-carboxylysineBy similarity

    Post-translational modificationi

    Carbamylation allows a single lysine to coordinate two zinc ions.By similarity

    Expressioni

    Tissue specificityi

    Liver and kidney.

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP40757.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the DHOase family. Allantoinase subfamily.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    HOVERGENiHBG004211.

    Family and domain databases

    Gene3Di2.30.40.10. 1 hit.
    InterProiIPR017593. Allantoinase.
    IPR002195. Dihydroorotase_CS.
    IPR011059. Metal-dep_hydrolase_composite.
    [Graphical view]
    SUPFAMiSSF51338. SSF51338. 1 hit.
    TIGRFAMsiTIGR03178. allantoinase. 1 hit.
    PROSITEiPS00482. DIHYDROOROTASE_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P40757-1 [UniParc]FASTAAdd to Basket

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    MALKSKPGIM NITPGSKISV IRSKRVIQAN TISSCDIIIS DGKISSVLAW    50
    GKHVTSGAKL LDVGDLVVMA GIIDPHVHVN EPGRTDWEGY RTATLAAAAG 100
    GITAIVDMPL NSLPPTTSVT NFHTKLQAAK RQCYVDVAFW GGVIPDNQVE 150
    LIPMLQAGVA GFKCFLINSG VPEFPHVSVT DLHTAMSELQ GTNSVLLFHA 200
    ELEIAKPAPE IGDSTLYQTF LDSRPDDMEI AAVQLVADLC QQYKVRCHIV 250
    HLSSAQSLTI IRKAKEAGAP LTVETTHHYL SLSSEHIPPG ATYFKCCPPV 300
    RGHRNKEALW NALLQGHIDM VVSDHSPCTP DLKLLKEGDY MKAWGGISSL 350
    QFGLPLFWTS ARTRGFSLTD VSQLLSSNTA KLCGLGIVKE PLKWVMMLIW 400
    SSGILTKSFR CKKMIFITRI SSPHIWDSFF KEKSWLLLFE GLLFISKGSM 450
    LPNQLENLFL YTLWSLVKPV HPVHPIIRKN LPHI 484
    Length:484
    Mass (Da):53,257
    Last modified:February 1, 1995 - v1
    Checksum:iA2DC377B850DC402
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U03471 mRNA. Translation: AAA19116.1.
    PIRiA53595.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U03471 mRNA. Translation: AAA19116.1 .
    PIRi A53595.

    3D structure databases

    ProteinModelPortali P40757.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG004211.

    Enzyme and pathway databases

    UniPathwayi UPA00395 ; UER00653 .

    Family and domain databases

    Gene3Di 2.30.40.10. 1 hit.
    InterProi IPR017593. Allantoinase.
    IPR002195. Dihydroorotase_CS.
    IPR011059. Metal-dep_hydrolase_composite.
    [Graphical view ]
    SUPFAMi SSF51338. SSF51338. 1 hit.
    TIGRFAMsi TIGR03178. allantoinase. 1 hit.
    PROSITEi PS00482. DIHYDROOROTASE_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Amphibian allantoinase. Molecular cloning, tissue distribution, and functional expression."
      Hayashi S., Jain S., Chu R., Alvares K., Xu B., Erfurth F., Usuda N., Rao M.S., Reddy S.K., Noguchi T., Reddy J.K., Yeldandi A.Y.
      J. Biol. Chem. 269:12269-12276(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 365-381.
      Tissue: Liver.

    Entry informationi

    Entry nameiALN_LITCT
    AccessioniPrimary (citable) accession number: P40757
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3