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P40757

- ALN_LITCT

UniProt

P40757 - ALN_LITCT

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Protein

Allantoinase, mitochondrial

Gene
ALN
Organism
Lithobates catesbeiana (American bullfrog) (Rana catesbeiana)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

(S)-allantoin + H2O = allantoate.

Cofactori

Binds 2 zinc ions per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi76 – 761Zinc 1 By similarity
Metal bindingi78 – 781Zinc 1 By similarity
Metal bindingi163 – 1631Zinc 1; via carbamate group By similarity
Metal bindingi163 – 1631Zinc 2; via carbamate group By similarity
Metal bindingi199 – 1991Zinc 2 By similarity
Metal bindingi251 – 2511Zinc 2 By similarity
Metal bindingi324 – 3241Zinc 1 By similarity

GO - Molecular functioni

  1. allantoinase activity Source: UniProtKB-EC
  2. cobalt ion binding Source: InterPro
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. allantoin catabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00395; UER00653.

Names & Taxonomyi

Protein namesi
Recommended name:
Allantoinase, mitochondrial (EC:3.5.2.5)
Gene namesi
Name:ALN
OrganismiLithobates catesbeiana (American bullfrog) (Rana catesbeiana)
Taxonomic identifieri8400 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraNeobatrachiaRanoideaRanidaeRanaAquarana

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 484Allantoinase, mitochondrialPRO_0000007371
Transit peptidei1 – ?Mitochondrion Reviewed prediction

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei163 – 1631N6-carboxylysine By similarity

Post-translational modificationi

Carbamylation allows a single lysine to coordinate two zinc ions By similarity.

Expressioni

Tissue specificityi

Liver and kidney.

Interactioni

Subunit structurei

Homotetramer By similarity.

Structurei

3D structure databases

ProteinModelPortaliP40757.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOVERGENiHBG004211.

Family and domain databases

Gene3Di2.30.40.10. 1 hit.
InterProiIPR017593. Allantoinase.
IPR002195. Dihydroorotase_CS.
IPR011059. Metal-dep_hydrolase_composite.
[Graphical view]
SUPFAMiSSF51338. SSF51338. 1 hit.
TIGRFAMsiTIGR03178. allantoinase. 1 hit.
PROSITEiPS00482. DIHYDROOROTASE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P40757-1 [UniParc]FASTAAdd to Basket

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MALKSKPGIM NITPGSKISV IRSKRVIQAN TISSCDIIIS DGKISSVLAW    50
GKHVTSGAKL LDVGDLVVMA GIIDPHVHVN EPGRTDWEGY RTATLAAAAG 100
GITAIVDMPL NSLPPTTSVT NFHTKLQAAK RQCYVDVAFW GGVIPDNQVE 150
LIPMLQAGVA GFKCFLINSG VPEFPHVSVT DLHTAMSELQ GTNSVLLFHA 200
ELEIAKPAPE IGDSTLYQTF LDSRPDDMEI AAVQLVADLC QQYKVRCHIV 250
HLSSAQSLTI IRKAKEAGAP LTVETTHHYL SLSSEHIPPG ATYFKCCPPV 300
RGHRNKEALW NALLQGHIDM VVSDHSPCTP DLKLLKEGDY MKAWGGISSL 350
QFGLPLFWTS ARTRGFSLTD VSQLLSSNTA KLCGLGIVKE PLKWVMMLIW 400
SSGILTKSFR CKKMIFITRI SSPHIWDSFF KEKSWLLLFE GLLFISKGSM 450
LPNQLENLFL YTLWSLVKPV HPVHPIIRKN LPHI 484
Length:484
Mass (Da):53,257
Last modified:February 1, 1995 - v1
Checksum:iA2DC377B850DC402
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U03471 mRNA. Translation: AAA19116.1.
PIRiA53595.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U03471 mRNA. Translation: AAA19116.1 .
PIRi A53595.

3D structure databases

ProteinModelPortali P40757.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG004211.

Enzyme and pathway databases

UniPathwayi UPA00395 ; UER00653 .

Family and domain databases

Gene3Di 2.30.40.10. 1 hit.
InterProi IPR017593. Allantoinase.
IPR002195. Dihydroorotase_CS.
IPR011059. Metal-dep_hydrolase_composite.
[Graphical view ]
SUPFAMi SSF51338. SSF51338. 1 hit.
TIGRFAMsi TIGR03178. allantoinase. 1 hit.
PROSITEi PS00482. DIHYDROOROTASE_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Amphibian allantoinase. Molecular cloning, tissue distribution, and functional expression."
    Hayashi S., Jain S., Chu R., Alvares K., Xu B., Erfurth F., Usuda N., Rao M.S., Reddy S.K., Noguchi T., Reddy J.K., Yeldandi A.Y.
    J. Biol. Chem. 269:12269-12276(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 365-381.
    Tissue: Liver.

Entry informationi

Entry nameiALN_LITCT
AccessioniPrimary (citable) accession number: P40757
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: April 16, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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