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Protein

Potassium channel toxin alpha-KTx 2.2

Gene
N/A
Organism
Centruroides margaritatus (Scorpion)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Potent inhibitor of voltage-gated potassium channels such as Kv1.1/KCNA1 (IC50=0.144 nM), Kv1.2/KCNA2 (IC50=0.675 nM), Kv1.3/KCNA3 (IC50=0.23 nM) and Shaker (Kd=160 nM).1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei28Basic residue of the functional dyadBy similarity1
Sitei37Aromatic residue of the functional dyadBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin

Protein family/group databases

TCDBi8.B.8.1.3. the Alpha-ktx15 scorpion toxin (Alpha-ktx15) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel toxin alpha-KTx 2.2
Alternative name(s):
Margatoxin1 Publication
Short name:
MgTX1 Publication
OrganismiCentruroides margaritatus (Scorpion)
Taxonomic identifieri29018 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeCentruroides

Subcellular locationi

  • Secreted 1 Publication

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00000449041 – 39Potassium channel toxin alpha-KTx 2.21 PublicationAdd BLAST39

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi7 ↔ 291 Publication
Disulfide bondi13 ↔ 341 Publication
Disulfide bondi17 ↔ 361 Publication

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.1 Publication

Structurei

Secondary structure

139
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi10 – 13Combined sources4
Helixi14 – 20Combined sources7
Beta strandi26 – 30Combined sources5
Beta strandi33 – 37Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MTXNMR-A1-39[»]
ProteinModelPortaliP40755.
SMRiP40755.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP40755.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni37 – 39Interaction with Kv1.3 channelsSequence analysis3

Domaini

Has the structural arrangement of an alpha-helix connected to a beta-sheet by disulfide bonds (CSalpha/beta).1 Publication

Sequence similaritiesi

Family and domain databases

Gene3Di3.30.30.10. 1 hit.
InterProiView protein in InterPro
IPR003614. Scorpion_toxin-like.
IPR001947. Scorpion_toxinS_K_inh.
PfamiView protein in Pfam
PF00451. Toxin_2. 1 hit.
PRINTSiPR00286. CHARYBDTOXIN.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD003586. Scorpion_toxinS. 1 hit.
SUPFAMiSSF57095. SSF57095. 1 hit.
PROSITEiView protein in PROSITE
PS01138. SCORP_SHORT_TOXIN. 1 hit.

Sequencei

Sequence statusi: Complete.

P40755-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30 
TIINVKCTSP KQCLPPCKAQ FGQSAGAKCM NGKCKCYPH
Length:39
Mass (Da):4,185
Last modified:February 1, 1995 - v1
Checksum:i0FB748318014BE0D
GO

Sequence databases

PIRiA48523.

Similar proteinsi

Entry informationi

Entry nameiKAX22_CENMA
AccessioniPrimary (citable) accession number: P40755
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: August 30, 2017
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Scorpion potassium channel toxins
    Nomenclature of scorpion potassium channel toxins and list of entries
  3. SIMILARITY comments
    Index of protein domains and families