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P40753

- ANFB_MOUSE

UniProt

P40753 - ANFB_MOUSE

Protein

Natriuretic peptides B

Gene

Nppb

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.

    GO - Biological processi

    1. cellular response to mechanical stimulus Source: Ensembl
    2. cGMP biosynthetic process Source: UniProtKB
    3. heart development Source: Ensembl
    4. inflammatory response Source: Ensembl
    5. negative regulation of cell growth Source: Ensembl
    6. negative regulation of smooth muscle cell proliferation Source: Ensembl
    7. negative regulation of systemic arterial blood pressure Source: Ensembl
    8. positive regulation of renal sodium excretion Source: Ensembl
    9. positive regulation of urine volume Source: Ensembl
    10. receptor guanylyl cyclase signaling pathway Source: UniProtKB
    11. regulation of blood vessel size Source: UniProtKB-KW
    12. response to calcium ion Source: Ensembl
    13. response to drug Source: Ensembl
    14. response to hypoxia Source: Ensembl
    15. response to lipopolysaccharide Source: Ensembl
    16. response to organic cyclic compound Source: Ensembl
    17. response to peptide hormone Source: Ensembl

    Keywords - Molecular functioni

    Hormone, Vasoactive

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Natriuretic peptides B
    Alternative name(s):
    Gamma-brain natriuretic peptide
    Cleaved into the following chain:
    Gene namesi
    Name:Nppb
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:97368. Nppb.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: Ensembl
    2. nucleus Source: Ensembl
    3. perinuclear region of cytoplasm Source: Ensembl
    4. protein complex Source: MGI

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Disruption phenotypei

    Mice are viable and fertile and do not display gross skeletal abnormalities. Fluid-electrolyte balance and blood pressure remain normal although an increased rate of focal fibrotic lesions is observed within the cardiac ventricles.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626By similarityAdd
    BLAST
    Peptidei27 – 12195Natriuretic peptides BPRO_0000001533Add
    BLAST
    Peptidei77 – 12145Brain natriuretic peptidePRO_0000001534Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi99 ↔ 115By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PRIDEiP40753.

    PTM databases

    PhosphoSiteiP40753.

    Expressioni

    Tissue specificityi

    Expressed abundantly in the ventricle, and in a lesser extent in the atrium.

    Gene expression databases

    BgeeiP40753.
    CleanExiMM_NPPB.
    GenevestigatoriP40753.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000099521.

    Structurei

    3D structure databases

    ProteinModelPortaliP40753.
    SMRiP40753. Positions 90-118.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the natriuretic peptide family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG67899.
    HOGENOMiHOG000033937.
    HOVERGENiHBG004227.
    InParanoidiP40753.
    KOiK12335.
    OMAiVTHISSC.
    OrthoDBiEOG7P2XV4.
    PhylomeDBiP40753.
    TreeFamiTF106304.

    Family and domain databases

    InterProiIPR000663. Natr_peptide.
    IPR002408. Natriuretic_peptide_brain.
    [Graphical view]
    PfamiPF00212. ANP. 1 hit.
    [Graphical view]
    PRINTSiPR00712. BNATPEPTIDE.
    SMARTiSM00183. NAT_PEP. 1 hit.
    [Graphical view]
    PROSITEiPS00263. NATRIURETIC_PEPTIDE. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform Long (identifier: P40753-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDLLKVLSQM ILFLLFLYLS PLGGHSYPLG SPSQSPEQFK MQKLLELIRE    50
    KSEEMAQRQL LKDQGLTKEH PKRVLRSQGS TLRVQQRPQN SKVTHISSCF 100
    GHKIDRIGSV SRLGCNALKL L 121
    Length:121
    Mass (Da):13,756
    Last modified:November 1, 1995 - v2
    Checksum:i4F62AC9445E293B9
    GO
    Isoform Short (identifier: P40753-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         43-43: Missing.

    Show »
    Length:120
    Mass (Da):13,628
    Checksum:iC1F52E3DCAC8BC46
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti27 – 271Y → H in AAB26344. (PubMed:8097440)Curated
    Sequence conflicti71 – 711P → L in AAB26344. (PubMed:8097440)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei43 – 431Missing in isoform Short. CuratedVSP_000263

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D16497 Genomic DNA. Translation: BAA03948.1.
    S58667 Genomic DNA. Translation: AAB26344.2.
    BC061165 mRNA. Translation: AAH61165.1.
    CCDSiCCDS18926.1. [P40753-1]
    PIRiA49144.
    I49548.
    RefSeqiNP_001274277.1. NM_001287348.1. [P40753-2]
    NP_032752.1. NM_008726.5. [P40753-1]
    UniGeneiMm.2740.

    Genome annotation databases

    EnsembliENSMUST00000103231; ENSMUSP00000099521; ENSMUSG00000029019. [P40753-1]
    GeneIDi18158.
    KEGGimmu:18158.
    UCSCiuc008vto.2. mouse. [P40753-1]
    uc008vtp.2. mouse. [P40753-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D16497 Genomic DNA. Translation: BAA03948.1 .
    S58667 Genomic DNA. Translation: AAB26344.2 .
    BC061165 mRNA. Translation: AAH61165.1 .
    CCDSi CCDS18926.1. [P40753-1 ]
    PIRi A49144.
    I49548.
    RefSeqi NP_001274277.1. NM_001287348.1. [P40753-2 ]
    NP_032752.1. NM_008726.5. [P40753-1 ]
    UniGenei Mm.2740.

    3D structure databases

    ProteinModelPortali P40753.
    SMRi P40753. Positions 90-118.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000099521.

    PTM databases

    PhosphoSitei P40753.

    Proteomic databases

    PRIDEi P40753.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000103231 ; ENSMUSP00000099521 ; ENSMUSG00000029019 . [P40753-1 ]
    GeneIDi 18158.
    KEGGi mmu:18158.
    UCSCi uc008vto.2. mouse. [P40753-1 ]
    uc008vtp.2. mouse. [P40753-2 ]

    Organism-specific databases

    CTDi 4879.
    MGIi MGI:97368. Nppb.

    Phylogenomic databases

    eggNOGi NOG67899.
    HOGENOMi HOG000033937.
    HOVERGENi HBG004227.
    InParanoidi P40753.
    KOi K12335.
    OMAi VTHISSC.
    OrthoDBi EOG7P2XV4.
    PhylomeDBi P40753.
    TreeFami TF106304.

    Miscellaneous databases

    NextBioi 293424.
    PROi P40753.
    SOURCEi Search...

    Gene expression databases

    Bgeei P40753.
    CleanExi MM_NPPB.
    Genevestigatori P40753.

    Family and domain databases

    InterProi IPR000663. Natr_peptide.
    IPR002408. Natriuretic_peptide_brain.
    [Graphical view ]
    Pfami PF00212. ANP. 1 hit.
    [Graphical view ]
    PRINTSi PR00712. BNATPEPTIDE.
    SMARTi SM00183. NAT_PEP. 1 hit.
    [Graphical view ]
    PROSITEi PS00263. NATRIURETIC_PEPTIDE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of the complementary DNA and gene that encode mouse brain natriuretic peptide and generation of transgenic mice that overexpress the brain natriuretic peptide gene."
      Ogawa Y., Itoh H., Tamura N., Suga S., Yoshimasa T., Uehira M., Matsuda S., Shiono S., Nishimoto H., Nakao K.
      J. Clin. Invest. 93:1911-1921(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: BALB/c.
      Tissue: Heart.
    2. "Structure, expression, and genomic mapping of the mouse natriuretic peptide type-B gene."
      Steinhelper M.E.
      Circ. Res. 72:984-992(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: BALB/c.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG).
      Tissue: Testis.
    4. Cited for: DISRUPTION PHENOTYPE.

    Entry informationi

    Entry nameiANFB_MOUSE
    AccessioniPrimary (citable) accession number: P40753
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 108 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3