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Protein

Natriuretic peptides B

Gene

Nppb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHormone, Vasoactive

Names & Taxonomyi

Protein namesi
Recommended name:
Natriuretic peptides B
Alternative name(s):
Gamma-brain natriuretic peptide
Cleaved into the following chain:
Gene namesi
Name:Nppb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:97368 Nppb

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Disruption phenotypei

Mice are viable and fertile and do not display gross skeletal abnormalities. Fluid-electrolyte balance and blood pressure remain normal although an increased rate of focal fibrotic lesions is observed within the cardiac ventricles.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26By similarityAdd BLAST26
PeptideiPRO_000000153327 – 121Natriuretic peptides BAdd BLAST95
PeptideiPRO_000000153477 – 121Brain natriuretic peptideAdd BLAST45

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi99 ↔ 115By similarity

Post-translational modificationi

The brain natriuretic peptide 32 form is cleaved at Ser-91 by the prolyl endopeptidase FAP (seprase) activity (in vitro).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei91 – 92Cleavage; by FAPBy similarity2

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP40753
PeptideAtlasiP40753
PRIDEiP40753

PTM databases

PhosphoSitePlusiP40753

Expressioni

Tissue specificityi

Expressed abundantly in the ventricle, and in a lesser extent in the atrium.

Gene expression databases

BgeeiENSMUSG00000029019
CleanExiMM_NPPB
ExpressionAtlasiP40753 baseline and differential
GenevisibleiP40753 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099521

Structurei

3D structure databases

ProteinModelPortaliP40753
SMRiP40753
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the natriuretic peptide family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J2F8 Eukaryota
ENOG410ZE1B LUCA
GeneTreeiENSGT00510000049822
HOGENOMiHOG000033937
HOVERGENiHBG004227
InParanoidiP40753
KOiK12335
OMAiSGCFGRK
OrthoDBiEOG091G0T3N
PhylomeDBiP40753
TreeFamiTF106304

Family and domain databases

InterProiView protein in InterPro
IPR000663 Natr_peptide
IPR030480 Natr_peptide_CS
IPR002408 Natriuretic_peptide_brain
PfamiView protein in Pfam
PF00212 ANP, 1 hit
PRINTSiPR00712 BNATPEPTIDE
SMARTiView protein in SMART
SM00183 NAT_PEP, 1 hit
PROSITEiView protein in PROSITE
PS00263 NATRIURETIC_PEPTIDE, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Long (identifier: P40753-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDLLKVLSQM ILFLLFLYLS PLGGHSYPLG SPSQSPEQFK MQKLLELIRE
60 70 80 90 100
KSEEMAQRQL LKDQGLTKEH PKRVLRSQGS TLRVQQRPQN SKVTHISSCF
110 120
GHKIDRIGSV SRLGCNALKL L
Length:121
Mass (Da):13,756
Last modified:November 1, 1995 - v2
Checksum:i4F62AC9445E293B9
GO
Isoform Short (identifier: P40753-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     43-43: Missing.

Show »
Length:120
Mass (Da):13,628
Checksum:iC1F52E3DCAC8BC46
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti27Y → H in AAB26344 (PubMed:8097440).Curated1
Sequence conflicti71P → L in AAB26344 (PubMed:8097440).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00026343Missing in isoform Short. Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D16497 Genomic DNA Translation: BAA03948.1
S58667 Genomic DNA Translation: AAB26344.2
BC061165 mRNA Translation: AAH61165.1
CCDSiCCDS18926.1 [P40753-1]
PIRiA49144
I49548
RefSeqiNP_001274277.1, NM_001287348.1 [P40753-2]
NP_032752.1, NM_008726.5 [P40753-1]
UniGeneiMm.2740

Genome annotation databases

EnsembliENSMUST00000103231; ENSMUSP00000099521; ENSMUSG00000029019 [P40753-1]
GeneIDi18158
KEGGimmu:18158
UCSCiuc008vto.3 mouse [P40753-1]
uc008vtp.3 mouse [P40753-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiANFB_MOUSE
AccessioniPrimary (citable) accession number: P40753
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: November 1, 1995
Last modified: May 23, 2018
This is version 130 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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