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P40753

- ANFB_MOUSE

UniProt

P40753 - ANFB_MOUSE

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Protein
Natriuretic peptides B
Gene
Nppb
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.

GO - Biological processi

  1. cGMP biosynthetic process Source: UniProtKB
  2. cellular response to mechanical stimulus Source: Ensembl
  3. heart development Source: Ensembl
  4. inflammatory response Source: Ensembl
  5. negative regulation of cell growth Source: Ensembl
  6. negative regulation of smooth muscle cell proliferation Source: Ensembl
  7. negative regulation of systemic arterial blood pressure Source: Ensembl
  8. positive regulation of renal sodium excretion Source: Ensembl
  9. positive regulation of urine volume Source: Ensembl
  10. receptor guanylyl cyclase signaling pathway Source: UniProtKB
  11. regulation of blood vessel size Source: UniProtKB-KW
  12. response to calcium ion Source: Ensembl
  13. response to drug Source: Ensembl
  14. response to hypoxia Source: Ensembl
  15. response to lipopolysaccharide Source: Ensembl
  16. response to organic cyclic compound Source: Ensembl
  17. response to peptide hormone Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hormone, Vasoactive

Names & Taxonomyi

Protein namesi
Recommended name:
Natriuretic peptides B
Alternative name(s):
Gamma-brain natriuretic peptide
Cleaved into the following chain:
Gene namesi
Name:Nppb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:97368. Nppb.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: Ensembl
  2. nucleus Source: Ensembl
  3. perinuclear region of cytoplasm Source: Ensembl
  4. protein complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Disruption phenotypei

Mice are viable and fertile and do not display gross skeletal abnormalities. Fluid-electrolyte balance and blood pressure remain normal although an increased rate of focal fibrotic lesions is observed within the cardiac ventricles.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626 By similarity
Add
BLAST
Peptidei27 – 12195Natriuretic peptides B
PRO_0000001533Add
BLAST
Peptidei77 – 12145Brain natriuretic peptide
PRO_0000001534Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi99 ↔ 115 By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiP40753.

PTM databases

PhosphoSiteiP40753.

Expressioni

Tissue specificityi

Expressed abundantly in the ventricle, and in a lesser extent in the atrium.

Gene expression databases

BgeeiP40753.
CleanExiMM_NPPB.
GenevestigatoriP40753.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099521.

Structurei

3D structure databases

ProteinModelPortaliP40753.
SMRiP40753. Positions 90-118.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG67899.
HOGENOMiHOG000033937.
HOVERGENiHBG004227.
InParanoidiP40753.
KOiK12335.
OMAiVTHISSC.
OrthoDBiEOG7P2XV4.
PhylomeDBiP40753.
TreeFamiTF106304.

Family and domain databases

InterProiIPR000663. Natr_peptide.
IPR002408. Natriuretic_peptide_brain.
[Graphical view]
PfamiPF00212. ANP. 1 hit.
[Graphical view]
PRINTSiPR00712. BNATPEPTIDE.
SMARTiSM00183. NAT_PEP. 1 hit.
[Graphical view]
PROSITEiPS00263. NATRIURETIC_PEPTIDE. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform Long (identifier: P40753-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MDLLKVLSQM ILFLLFLYLS PLGGHSYPLG SPSQSPEQFK MQKLLELIRE    50
KSEEMAQRQL LKDQGLTKEH PKRVLRSQGS TLRVQQRPQN SKVTHISSCF 100
GHKIDRIGSV SRLGCNALKL L 121
Length:121
Mass (Da):13,756
Last modified:November 1, 1995 - v2
Checksum:i4F62AC9445E293B9
GO
Isoform Short (identifier: P40753-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     43-43: Missing.

Show »
Length:120
Mass (Da):13,628
Checksum:iC1F52E3DCAC8BC46
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei43 – 431Missing in isoform Short.
VSP_000263

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti27 – 271Y → H in AAB26344. 1 Publication
Sequence conflicti71 – 711P → L in AAB26344. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D16497 Genomic DNA. Translation: BAA03948.1.
S58667 Genomic DNA. Translation: AAB26344.2.
BC061165 mRNA. Translation: AAH61165.1.
CCDSiCCDS18926.1. [P40753-1]
PIRiA49144.
I49548.
RefSeqiNP_001274277.1. NM_001287348.1. [P40753-2]
NP_032752.1. NM_008726.5. [P40753-1]
UniGeneiMm.2740.

Genome annotation databases

EnsembliENSMUST00000103231; ENSMUSP00000099521; ENSMUSG00000029019. [P40753-1]
GeneIDi18158.
KEGGimmu:18158.
UCSCiuc008vto.2. mouse. [P40753-1]
uc008vtp.2. mouse. [P40753-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D16497 Genomic DNA. Translation: BAA03948.1 .
S58667 Genomic DNA. Translation: AAB26344.2 .
BC061165 mRNA. Translation: AAH61165.1 .
CCDSi CCDS18926.1. [P40753-1 ]
PIRi A49144.
I49548.
RefSeqi NP_001274277.1. NM_001287348.1. [P40753-2 ]
NP_032752.1. NM_008726.5. [P40753-1 ]
UniGenei Mm.2740.

3D structure databases

ProteinModelPortali P40753.
SMRi P40753. Positions 90-118.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000099521.

PTM databases

PhosphoSitei P40753.

Proteomic databases

PRIDEi P40753.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000103231 ; ENSMUSP00000099521 ; ENSMUSG00000029019 . [P40753-1 ]
GeneIDi 18158.
KEGGi mmu:18158.
UCSCi uc008vto.2. mouse. [P40753-1 ]
uc008vtp.2. mouse. [P40753-2 ]

Organism-specific databases

CTDi 4879.
MGIi MGI:97368. Nppb.

Phylogenomic databases

eggNOGi NOG67899.
HOGENOMi HOG000033937.
HOVERGENi HBG004227.
InParanoidi P40753.
KOi K12335.
OMAi VTHISSC.
OrthoDBi EOG7P2XV4.
PhylomeDBi P40753.
TreeFami TF106304.

Miscellaneous databases

NextBioi 293424.
PROi P40753.
SOURCEi Search...

Gene expression databases

Bgeei P40753.
CleanExi MM_NPPB.
Genevestigatori P40753.

Family and domain databases

InterProi IPR000663. Natr_peptide.
IPR002408. Natriuretic_peptide_brain.
[Graphical view ]
Pfami PF00212. ANP. 1 hit.
[Graphical view ]
PRINTSi PR00712. BNATPEPTIDE.
SMARTi SM00183. NAT_PEP. 1 hit.
[Graphical view ]
PROSITEi PS00263. NATRIURETIC_PEPTIDE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of the complementary DNA and gene that encode mouse brain natriuretic peptide and generation of transgenic mice that overexpress the brain natriuretic peptide gene."
    Ogawa Y., Itoh H., Tamura N., Suga S., Yoshimasa T., Uehira M., Matsuda S., Shiono S., Nishimoto H., Nakao K.
    J. Clin. Invest. 93:1911-1921(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: BALB/c.
    Tissue: Heart.
  2. "Structure, expression, and genomic mapping of the mouse natriuretic peptide type-B gene."
    Steinhelper M.E.
    Circ. Res. 72:984-992(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: BALB/c.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG).
    Tissue: Testis.
  4. Cited for: DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiANFB_MOUSE
AccessioniPrimary (citable) accession number: P40753
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: November 1, 1995
Last modified: July 9, 2014
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi