Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P40749

- SYT4_MOUSE

UniProt

P40749 - SYT4_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Synaptotagmin-4

Gene

Syt4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

May be involved in Ca2+-dependent exocytosis of secretory vesicles through Ca2+ and phospholipid binding to the C2 domain or may serve as Ca2+ sensors in the process of vesicular trafficking and exocytosis.

Cofactori

Binds 3 calcium ions per subunit. The ions are bound to the C2 domains (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi184 – 1841Calcium 1By similarity
Metal bindingi184 – 1841Calcium 2By similarity
Metal bindingi191 – 1911Calcium 1By similarity
Metal bindingi245 – 2451Calcium 1; via carbonyl oxygenBy similarity
Metal bindingi246 – 2461Calcium 1By similarity
Metal bindingi246 – 2461Calcium 2By similarity
Metal bindingi246 – 2461Calcium 3By similarity
Metal bindingi249 – 2491Calcium 3By similarity
Metal bindingi252 – 2521Calcium 2By similarity
Metal bindingi252 – 2521Calcium 3By similarity

GO - Molecular functioni

  1. calcium ion binding Source: MGI
  2. phosphatidylserine binding Source: Ensembl
  3. transporter activity Source: InterPro

GO - Biological processi

  1. exocytosis Source: InterPro
  2. negative regulation of calcium ion-dependent exocytosis Source: Ensembl
  3. negative regulation of vesicle fusion Source: Ensembl
  4. neurotransmitter secretion Source: MGI
  5. regulation of calcium ion-dependent exocytosis Source: UniProtKB
  6. synaptic vesicle transport Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptotagmin-4
Alternative name(s):
Synaptotagmin IV
Short name:
SytIV
Gene namesi
Name:Syt4
Synonyms:Syt3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 18

Organism-specific databases

MGIiMGI:101759. Syt4.

Subcellular locationi

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. dense core granule Source: Ensembl
  3. integral component of membrane Source: UniProtKB
  4. neuron projection Source: MGI
  5. perinuclear region of cytoplasm Source: MGI
  6. synaptic vesicle Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 425425Synaptotagmin-4PRO_0000183949Add
BLAST

Proteomic databases

MaxQBiP40749.
PRIDEiP40749.

PTM databases

PhosphoSiteiP40749.

Expressioni

Tissue specificityi

Expressed in many regions of the nervous system but is undetectable in extra neural tissues.

Gene expression databases

BgeeiP40749.
CleanExiMM_SYT3.
MM_SYT4.
ExpressionAtlasiP40749. baseline and differential.
GenevestigatoriP40749.

Structurei

3D structure databases

ProteinModelPortaliP40749.
SMRiP40749. Positions 152-425.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1616VesicularSequence AnalysisAdd
BLAST
Topological domaini38 – 425388CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei17 – 3721HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini155 – 258104C2 1PROSITE-ProRule annotationAdd
BLAST
Domaini289 – 392104C2 2PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni147 – 297151Phospholipid bindingCuratedAdd
BLAST

Sequence similaritiesi

Belongs to the synaptotagmin family.Curated
Contains 2 C2 domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG292488.
GeneTreeiENSGT00760000118973.
HOVERGENiHBG005010.
InParanoidiP40749.
OMAiQIAKWHM.
OrthoDBiEOG75J0N2.
PhylomeDBiP40749.
TreeFamiTF315600.

Family and domain databases

Gene3Di2.60.40.150. 2 hits.
InterProiIPR000008. C2_dom.
IPR001565. Synaptotagmin.
IPR028683. SYT4.
[Graphical view]
PANTHERiPTHR10024:SF114. PTHR10024:SF114. 1 hit.
PfamiPF00168. C2. 2 hits.
[Graphical view]
PRINTSiPR00399. SYNAPTOTAGMN.
SMARTiSM00239. C2. 2 hits.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 2 hits.
PROSITEiPS50004. C2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P40749-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAPITTSRVE FDEIPTVVGI FSAFGLVFTV SLFAWICCQR RSAKSNKTPP
60 70 80 90 100
YKFVHVLKGV DIYPENLSSK KKFGGDDKSE VKGKAALPNL SLHLDLEKRD
110 120 130 140 150
LNGNFPKANP KAGSSSDLEN VTPKLFTETE KEANSPESLK SSTSLTSEEK
160 170 180 190 200
QEKLGTLFLS LEYNFEKKAF VVNIKEAQGL PAMDEQSMTS DPYIKMTILP
210 220 230 240 250
EKKHRVKTRV LRKTLDPVFD ETFTFYGIPY PHIQELSLHF TVLSFDRFSR
260 270 280 290 300
DDVIGEVLIP LSGIELSDGK MLMTREIIKR NAKKSSGRGE LLVSLCYQST
310 320 330 340 350
TNTLTVVVLK ARHLPKSDVS GLSDPYVKVN LYHAKKRISK KKTHVKKCTP
360 370 380 390 400
NAVFNELFVF DIPCESLEEI SVEFLVLDSE RGSRNEVIGR LVLGATAEGS
410 420
GGGHWKEICD FPRRQIAKWH MLCDG
Length:425
Mass (Da):47,659
Last modified:July 11, 2003 - v2
Checksum:i9A01144898CDFCEB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti70 – 701K → Q in AAA20971. (PubMed:8058779)Curated
Sequence conflicti85 – 851A → T in AAA20971. (PubMed:8058779)Curated
Sequence conflicti220 – 2201D → G in AAA20971. (PubMed:8058779)Curated
Sequence conflicti246 – 2461D → N in BAC31726. (PubMed:16141072)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U10355 mRNA. Translation: AAA20971.1.
AK032106 mRNA. Translation: BAC27705.1.
AK043985 mRNA. Translation: BAC31726.1.
AK050515 mRNA. Translation: BAC34301.1.
AK083960 mRNA. Translation: BAC39080.1.
AK148681 mRNA. Translation: BAE28640.1.
BC058208 mRNA. Translation: AAH58208.1.
CCDSiCCDS29109.1.
RefSeqiNP_033334.2. NM_009308.3.
UniGeneiMm.233846.

Genome annotation databases

EnsembliENSMUST00000025110; ENSMUSP00000025110; ENSMUSG00000024261.
GeneIDi20983.
KEGGimmu:20983.
UCSCiuc008ehy.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U10355 mRNA. Translation: AAA20971.1 .
AK032106 mRNA. Translation: BAC27705.1 .
AK043985 mRNA. Translation: BAC31726.1 .
AK050515 mRNA. Translation: BAC34301.1 .
AK083960 mRNA. Translation: BAC39080.1 .
AK148681 mRNA. Translation: BAE28640.1 .
BC058208 mRNA. Translation: AAH58208.1 .
CCDSi CCDS29109.1.
RefSeqi NP_033334.2. NM_009308.3.
UniGenei Mm.233846.

3D structure databases

ProteinModelPortali P40749.
SMRi P40749. Positions 152-425.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei P40749.

Proteomic databases

MaxQBi P40749.
PRIDEi P40749.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000025110 ; ENSMUSP00000025110 ; ENSMUSG00000024261 .
GeneIDi 20983.
KEGGi mmu:20983.
UCSCi uc008ehy.1. mouse.

Organism-specific databases

CTDi 6860.
MGIi MGI:101759. Syt4.

Phylogenomic databases

eggNOGi NOG292488.
GeneTreei ENSGT00760000118973.
HOVERGENi HBG005010.
InParanoidi P40749.
OMAi QIAKWHM.
OrthoDBi EOG75J0N2.
PhylomeDBi P40749.
TreeFami TF315600.

Miscellaneous databases

NextBioi 299976.
PROi P40749.
SOURCEi Search...

Gene expression databases

Bgeei P40749.
CleanExi MM_SYT3.
MM_SYT4.
ExpressionAtlasi P40749. baseline and differential.
Genevestigatori P40749.

Family and domain databases

Gene3Di 2.60.40.150. 2 hits.
InterProi IPR000008. C2_dom.
IPR001565. Synaptotagmin.
IPR028683. SYT4.
[Graphical view ]
PANTHERi PTHR10024:SF114. PTHR10024:SF114. 1 hit.
Pfami PF00168. C2. 2 hits.
[Graphical view ]
PRINTSi PR00399. SYNAPTOTAGMN.
SMARTi SM00239. C2. 2 hits.
[Graphical view ]
SUPFAMi SSF49562. SSF49562. 2 hits.
PROSITEi PS50004. C2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Brain.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain cortex, Medulla oblongata, Pancreas, Spinal ganglion and Sympathetic ganglion.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Eye.

Entry informationi

Entry nameiSYT4_MOUSE
AccessioniPrimary (citable) accession number: P40749
Secondary accession number(s): Q3UFC1, Q8BGH3, Q8BRL6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: July 11, 2003
Last modified: October 29, 2014
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3