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Protein

Flagellar biosynthesis protein FlhA

Gene

flhA

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Bacterial flagellum biogenesis, Bacterial flagellum protein export, Protein transport, Transport

Protein family/group databases

TCDBi3.A.6.2.1. the type iii (virulence-related) secretory pathway (iiisp) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Flagellar biosynthesis protein FlhA
Gene namesi
Name:flhA
Ordered Locus Names:STM1913
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000001014 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei24 – 44HelicalSequence analysisAdd BLAST21
Transmembranei46 – 66HelicalSequence analysisAdd BLAST21
Transmembranei71 – 91HelicalSequence analysisAdd BLAST21
Transmembranei95 – 115HelicalSequence analysisAdd BLAST21
Transmembranei121 – 141HelicalSequence analysisAdd BLAST21
Transmembranei209 – 229HelicalSequence analysisAdd BLAST21
Transmembranei247 – 267HelicalSequence analysisAdd BLAST21
Transmembranei296 – 316HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001900171 – 692Flagellar biosynthesis protein FlhAAdd BLAST692

Proteomic databases

PaxDbiP40729.
PRIDEiP40729.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
fliHP159342EBI-6410261,EBI-6410310

Protein-protein interaction databases

IntActiP40729. 4 interactors.
STRINGi99287.STM1913.

Structurei

Secondary structure

1692
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi354 – 356Combined sources3
Beta strandi362 – 367Combined sources6
Helixi369 – 371Combined sources3
Turni372 – 375Combined sources4
Beta strandi377 – 379Combined sources3
Helixi382 – 397Combined sources16
Beta strandi405 – 409Combined sources5
Beta strandi417 – 422Combined sources6
Beta strandi425 – 431Combined sources7
Beta strandi436 – 440Combined sources5
Beta strandi450 – 455Combined sources6
Beta strandi457 – 459Combined sources3
Beta strandi462 – 468Combined sources7
Helixi471 – 476Combined sources6
Beta strandi480 – 483Combined sources4
Helixi484 – 498Combined sources15
Turni499 – 503Combined sources5
Helixi506 – 517Combined sources12
Helixi521 – 525Combined sources5
Turni526 – 531Combined sources6
Helixi534 – 546Combined sources13
Helixi554 – 564Combined sources11
Helixi565 – 567Combined sources3
Helixi571 – 581Combined sources11
Helixi583 – 590Combined sources8
Helixi606 – 615Combined sources10
Beta strandi616 – 618Combined sources3
Helixi624 – 642Combined sources19
Beta strandi647 – 650Combined sources4
Turni652 – 654Combined sources3
Helixi655 – 662Combined sources8
Turni663 – 665Combined sources3
Beta strandi670 – 673Combined sources4
Turni674 – 676Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3A5IX-ray2.80A/B328-692[»]
SMRiP40729.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP40729.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105D7B. Bacteria.
COG1298. LUCA.
HOGENOMiHOG000254014.
KOiK02400.
OMAiETKELGW.
PhylomeDBiP40729.

Family and domain databases

InterProiIPR025505. FHIPEP_CS.
IPR006301. FlhA.
IPR001712. T3SS_FHIPEP.
[Graphical view]
PfamiPF00771. FHIPEP. 1 hit.
[Graphical view]
PIRSFiPIRSF005419. FlhA. 1 hit.
PRINTSiPR00949. TYPE3IMAPROT.
TIGRFAMsiTIGR01398. FlhA. 1 hit.
PROSITEiPS00994. FHIPEP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P40729-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANLVAMLRL PSNLKSTQWQ ILAGPILILL ILSMMVLPLP AFILDLLFTF
60 70 80 90 100
NIALSIMVLL VAMFTQRTLD FAAFPTILLF TTLLRLALNV ASTRIILMEG
110 120 130 140 150
HTGAAAAGKV VEAFGHFLVG GNFAIGIVVF IILVIINFMV ITKGAGRIAE
160 170 180 190 200
VGARFVLDGM PGKQMAIDAD LNAGLIGEDE AKKRRSEVTQ EADFYGSMDG
210 220 230 240 250
ASKFVRGDAI AGILIMVINV VGGLLVGVLQ HGMSIGSAAE SYTLLTIGDG
260 270 280 290 300
LVAQIPALVI STAAGVIVTR VSTDQDVGEQ MVGQLFSNPR VMLLAAAVLG
310 320 330 340 350
LLGMVPGMPN LVFLLFTAAL LGLAWWLRGR EEKAPEEPQP VKMPENNSVV
360 370 380 390 400
EATWNDVQLE DSLGMEVGYR LIPMVDFQQD GELLGRIRSI RKKFAQDMGF
410 420 430 440 450
LPPVVHIRDN MDLQPARYRI LMKGVEIGSG DAYPGRWLAI NPGTAAGTLP
460 470 480 490 500
GEKTVDPAFG LDAIWIESAL KEQAQIQGFT VVEASTVVAT HLNHLIGQFS
510 520 530 540 550
AELFGRQEAQ QLLDRVSQEM PKLTEDLVPG VVTLTTLHKV LQNLLAEKVP
560 570 580 590 600
IRDMRTILET LAEHAPLQSD PHELTAVVRV ALGRAITQQW FPGNEEVQVI
610 620 630 640 650
GLDTALERLL LQALQGGGGL EPGLADRLLA QTQEALSRQE MLGAPPVLLV
660 670 680 690
NHALRPLLSR FLRRSLPQLV VLSNLELSDN RHIRMTATIG GK
Length:692
Mass (Da):74,849
Last modified:February 1, 1995 - v1
Checksum:i8E0D65026DE84B47
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D32203 Genomic DNA. Translation: BAA06903.1.
AE006468 Genomic DNA. Translation: AAL20829.1.
PIRiB55546.
RefSeqiNP_460870.1. NC_003197.1.
WP_000002386.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL20829; AAL20829; STM1913.
GeneIDi1253434.
KEGGistm:STM1913.
PATRICi32382381. VBISalEnt20916_2029.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D32203 Genomic DNA. Translation: BAA06903.1.
AE006468 Genomic DNA. Translation: AAL20829.1.
PIRiB55546.
RefSeqiNP_460870.1. NC_003197.1.
WP_000002386.1. NC_003197.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3A5IX-ray2.80A/B328-692[»]
SMRiP40729.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP40729. 4 interactors.
STRINGi99287.STM1913.

Protein family/group databases

TCDBi3.A.6.2.1. the type iii (virulence-related) secretory pathway (iiisp) family.

Proteomic databases

PaxDbiP40729.
PRIDEiP40729.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL20829; AAL20829; STM1913.
GeneIDi1253434.
KEGGistm:STM1913.
PATRICi32382381. VBISalEnt20916_2029.

Phylogenomic databases

eggNOGiENOG4105D7B. Bacteria.
COG1298. LUCA.
HOGENOMiHOG000254014.
KOiK02400.
OMAiETKELGW.
PhylomeDBiP40729.

Miscellaneous databases

EvolutionaryTraceiP40729.

Family and domain databases

InterProiIPR025505. FHIPEP_CS.
IPR006301. FlhA.
IPR001712. T3SS_FHIPEP.
[Graphical view]
PfamiPF00771. FHIPEP. 1 hit.
[Graphical view]
PIRSFiPIRSF005419. FlhA. 1 hit.
PRINTSiPR00949. TYPE3IMAPROT.
TIGRFAMsiTIGR01398. FlhA. 1 hit.
PROSITEiPS00994. FHIPEP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFLHA_SALTY
AccessioniPrimary (citable) accession number: P40729
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 2, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.