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Protein

Flagellar biosynthesis protein FlhA

Gene

flhA

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Bacterial flagellum biogenesis, Bacterial flagellum protein export, Protein transport, Transport

Enzyme and pathway databases

BioCyciSENT99287:GCTI-1925-MONOMER.

Protein family/group databases

TCDBi3.A.6.2.1. the type iii (virulence-related) secretory pathway (iiisp) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Flagellar biosynthesis protein FlhA
Gene namesi
Name:flhA
Ordered Locus Names:STM1913
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000001014 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei24 – 4421HelicalSequence analysisAdd
BLAST
Transmembranei46 – 6621HelicalSequence analysisAdd
BLAST
Transmembranei71 – 9121HelicalSequence analysisAdd
BLAST
Transmembranei95 – 11521HelicalSequence analysisAdd
BLAST
Transmembranei121 – 14121HelicalSequence analysisAdd
BLAST
Transmembranei209 – 22921HelicalSequence analysisAdd
BLAST
Transmembranei247 – 26721HelicalSequence analysisAdd
BLAST
Transmembranei296 – 31621HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 692692Flagellar biosynthesis protein FlhAPRO_0000190017Add
BLAST

Proteomic databases

PaxDbiP40729.
PRIDEiP40729.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
fliHP159342EBI-6410261,EBI-6410310

Protein-protein interaction databases

IntActiP40729. 4 interactions.
STRINGi99287.STM1913.

Structurei

Secondary structure

1
692
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi354 – 3563Combined sources
Beta strandi362 – 3676Combined sources
Helixi369 – 3713Combined sources
Turni372 – 3754Combined sources
Beta strandi377 – 3793Combined sources
Helixi382 – 39716Combined sources
Beta strandi405 – 4095Combined sources
Beta strandi417 – 4226Combined sources
Beta strandi425 – 4317Combined sources
Beta strandi436 – 4405Combined sources
Beta strandi450 – 4556Combined sources
Beta strandi457 – 4593Combined sources
Beta strandi462 – 4687Combined sources
Helixi471 – 4766Combined sources
Beta strandi480 – 4834Combined sources
Helixi484 – 49815Combined sources
Turni499 – 5035Combined sources
Helixi506 – 51712Combined sources
Helixi521 – 5255Combined sources
Turni526 – 5316Combined sources
Helixi534 – 54613Combined sources
Helixi554 – 56411Combined sources
Helixi565 – 5673Combined sources
Helixi571 – 58111Combined sources
Helixi583 – 5908Combined sources
Helixi606 – 61510Combined sources
Beta strandi616 – 6183Combined sources
Helixi624 – 64219Combined sources
Beta strandi647 – 6504Combined sources
Turni652 – 6543Combined sources
Helixi655 – 6628Combined sources
Turni663 – 6653Combined sources
Beta strandi670 – 6734Combined sources
Turni674 – 6763Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3A5IX-ray2.80A/B328-692[»]
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP40729.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105D7B. Bacteria.
COG1298. LUCA.
HOGENOMiHOG000254014.
KOiK02400.
OMAiETKELGW.
PhylomeDBiP40729.

Family and domain databases

InterProiIPR025505. FHIPEP_CS.
IPR006301. FlhA.
IPR001712. T3SS_FHIPEP.
[Graphical view]
PfamiPF00771. FHIPEP. 1 hit.
[Graphical view]
PIRSFiPIRSF005419. FlhA. 1 hit.
PRINTSiPR00949. TYPE3IMAPROT.
TIGRFAMsiTIGR01398. FlhA. 1 hit.
PROSITEiPS00994. FHIPEP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P40729-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANLVAMLRL PSNLKSTQWQ ILAGPILILL ILSMMVLPLP AFILDLLFTF
60 70 80 90 100
NIALSIMVLL VAMFTQRTLD FAAFPTILLF TTLLRLALNV ASTRIILMEG
110 120 130 140 150
HTGAAAAGKV VEAFGHFLVG GNFAIGIVVF IILVIINFMV ITKGAGRIAE
160 170 180 190 200
VGARFVLDGM PGKQMAIDAD LNAGLIGEDE AKKRRSEVTQ EADFYGSMDG
210 220 230 240 250
ASKFVRGDAI AGILIMVINV VGGLLVGVLQ HGMSIGSAAE SYTLLTIGDG
260 270 280 290 300
LVAQIPALVI STAAGVIVTR VSTDQDVGEQ MVGQLFSNPR VMLLAAAVLG
310 320 330 340 350
LLGMVPGMPN LVFLLFTAAL LGLAWWLRGR EEKAPEEPQP VKMPENNSVV
360 370 380 390 400
EATWNDVQLE DSLGMEVGYR LIPMVDFQQD GELLGRIRSI RKKFAQDMGF
410 420 430 440 450
LPPVVHIRDN MDLQPARYRI LMKGVEIGSG DAYPGRWLAI NPGTAAGTLP
460 470 480 490 500
GEKTVDPAFG LDAIWIESAL KEQAQIQGFT VVEASTVVAT HLNHLIGQFS
510 520 530 540 550
AELFGRQEAQ QLLDRVSQEM PKLTEDLVPG VVTLTTLHKV LQNLLAEKVP
560 570 580 590 600
IRDMRTILET LAEHAPLQSD PHELTAVVRV ALGRAITQQW FPGNEEVQVI
610 620 630 640 650
GLDTALERLL LQALQGGGGL EPGLADRLLA QTQEALSRQE MLGAPPVLLV
660 670 680 690
NHALRPLLSR FLRRSLPQLV VLSNLELSDN RHIRMTATIG GK
Length:692
Mass (Da):74,849
Last modified:February 1, 1995 - v1
Checksum:i8E0D65026DE84B47
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D32203 Genomic DNA. Translation: BAA06903.1.
AE006468 Genomic DNA. Translation: AAL20829.1.
PIRiB55546.
RefSeqiNP_460870.1. NC_003197.1.
WP_000002386.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL20829; AAL20829; STM1913.
GeneIDi1253434.
KEGGistm:STM1913.
PATRICi32382381. VBISalEnt20916_2029.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D32203 Genomic DNA. Translation: BAA06903.1.
AE006468 Genomic DNA. Translation: AAL20829.1.
PIRiB55546.
RefSeqiNP_460870.1. NC_003197.1.
WP_000002386.1. NC_003197.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3A5IX-ray2.80A/B328-692[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP40729. 4 interactions.
STRINGi99287.STM1913.

Protein family/group databases

TCDBi3.A.6.2.1. the type iii (virulence-related) secretory pathway (iiisp) family.

Proteomic databases

PaxDbiP40729.
PRIDEiP40729.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL20829; AAL20829; STM1913.
GeneIDi1253434.
KEGGistm:STM1913.
PATRICi32382381. VBISalEnt20916_2029.

Phylogenomic databases

eggNOGiENOG4105D7B. Bacteria.
COG1298. LUCA.
HOGENOMiHOG000254014.
KOiK02400.
OMAiETKELGW.
PhylomeDBiP40729.

Enzyme and pathway databases

BioCyciSENT99287:GCTI-1925-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP40729.

Family and domain databases

InterProiIPR025505. FHIPEP_CS.
IPR006301. FlhA.
IPR001712. T3SS_FHIPEP.
[Graphical view]
PfamiPF00771. FHIPEP. 1 hit.
[Graphical view]
PIRSFiPIRSF005419. FlhA. 1 hit.
PRINTSiPR00949. TYPE3IMAPROT.
TIGRFAMsiTIGR01398. FlhA. 1 hit.
PROSITEiPS00994. FHIPEP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFLHA_SALTY
AccessioniPrimary (citable) accession number: P40729
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: September 7, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.