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Protein

Flagellar biosynthetic protein FlhB

Gene

flhB

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Bacterial flagellum biogenesis, Bacterial flagellum protein export, Protein transport, Transport

Enzyme and pathway databases

BioCyciSENT99287:GCTI-1926-MONOMER.

Protein family/group databases

TCDBi3.A.6.2.1. the type iii (virulence-related) secretory pathway (iiisp) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Flagellar biosynthetic protein FlhB
Gene namesi
Name:flhB
Ordered Locus Names:STM1914
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000001014 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3232PeriplasmicSequence analysisAdd
BLAST
Transmembranei33 – 5321HelicalSequence analysisAdd
BLAST
Topological domaini54 – 7421CytoplasmicSequence analysisAdd
BLAST
Transmembranei75 – 9521HelicalSequence analysisAdd
BLAST
Transmembranei96 – 11621HelicalSequence analysisAdd
BLAST
Topological domaini117 – 14529CytoplasmicSequence analysisAdd
BLAST
Transmembranei146 – 16621HelicalSequence analysisAdd
BLAST
Topological domaini167 – 19024PeriplasmicSequence analysisAdd
BLAST
Transmembranei191 – 21121HelicalSequence analysisAdd
BLAST
Topological domaini212 – 383172CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 383383Flagellar biosynthetic protein FlhBPRO_0000180950Add
BLAST

Proteomic databases

PaxDbiP40727.
PRIDEiP40727.

Interactioni

Protein-protein interaction databases

IntActiP40727. 1 interaction.
STRINGi99287.STM1914.

Structurei

Secondary structure

1
383
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi230 – 2367Combined sources
Helixi238 – 25821Combined sources
Helixi259 – 2624Combined sources
Beta strandi264 – 2696Combined sources
Beta strandi273 – 2786Combined sources
Beta strandi288 – 2936Combined sources
Helixi296 – 30712Combined sources
Beta strandi312 – 3143Combined sources
Helixi316 – 32510Combined sources
Helixi334 – 3363Combined sources
Helixi337 – 35014Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3B0ZX-ray2.45A219-269[»]
B270-383[»]
ProteinModelPortaliP40727.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the type III secretion exporter family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105D00. Bacteria.
COG1377. LUCA.
HOGENOMiHOG000253899.
KOiK02401.
OMAiNLKMSKQ.
OrthoDBiEOG6FRD1F.
PhylomeDBiP40727.

Family and domain databases

Gene3Di3.40.1690.10. 1 hit.
InterProiIPR006136. FlhB.
IPR006135. T3SS_substrate_exporter.
IPR029025. T3SS_substrate_exporter_C.
[Graphical view]
PANTHERiPTHR30531. PTHR30531. 1 hit.
PfamiPF01312. Bac_export_2. 1 hit.
[Graphical view]
PRINTSiPR00950. TYPE3IMSPROT.
SUPFAMiSSF160544. SSF160544. 1 hit.
TIGRFAMsiTIGR00328. flhB. 1 hit.

Sequencei

Sequence statusi: Complete.

P40727-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEESDDDKT EAPTPHRLEK AREEGQIPRS RELTSLLILL VGVCIIWFGG
60 70 80 90 100
ESLARQLAGM LSAGLHFDHR MVNDPNLILG QIILLIKAAM MALLPLIAGV
110 120 130 140 150
VLVALISPVM LGGLIFSGKS LQPKFSKLNP LPGIKRMFSA QTGAELLKAV
160 170 180 190 200
LKSTLVGCVT GFYLWHHWPQ MMRLMAESPI VAMGNALDLV GLCALLVVLG
210 220 230 240 250
VIPMVGFDVF FQIFSHLKKL RMSRQDIRDE FKESEGDPHV KGKIRQMQRA
260 270 280 290 300
AAQRRMMEDV PKADVIVTNP THYSVALQYD ENKMSAPKVV AKGAGLIALR
310 320 330 340 350
IREIGAEHRV PTLEAPPLAR ALYRHAEIGQ QIPGQLYAAV AEVLAWVWQL
360 370 380
KRWRLAGGQR PPQPENLPVP EALDFMNEKN TDG
Length:383
Mass (Da):42,355
Last modified:February 1, 1995 - v1
Checksum:i742BA0BBED9DF238
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D32203 Genomic DNA. Translation: BAA06902.1.
AE006468 Genomic DNA. Translation: AAL20830.1.
M16691 Genomic DNA. Translation: AAD15121.1.
PIRiA55546.
RefSeqiNP_460871.1. NC_003197.1.
WP_000797081.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL20830; AAL20830; STM1914.
GeneIDi1253435.
KEGGistm:STM1914.
PATRICi32382383. VBISalEnt20916_2030.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D32203 Genomic DNA. Translation: BAA06902.1.
AE006468 Genomic DNA. Translation: AAL20830.1.
M16691 Genomic DNA. Translation: AAD15121.1.
PIRiA55546.
RefSeqiNP_460871.1. NC_003197.1.
WP_000797081.1. NC_003197.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3B0ZX-ray2.45A219-269[»]
B270-383[»]
ProteinModelPortaliP40727.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP40727. 1 interaction.
STRINGi99287.STM1914.

Protein family/group databases

TCDBi3.A.6.2.1. the type iii (virulence-related) secretory pathway (iiisp) family.

Proteomic databases

PaxDbiP40727.
PRIDEiP40727.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL20830; AAL20830; STM1914.
GeneIDi1253435.
KEGGistm:STM1914.
PATRICi32382383. VBISalEnt20916_2030.

Phylogenomic databases

eggNOGiENOG4105D00. Bacteria.
COG1377. LUCA.
HOGENOMiHOG000253899.
KOiK02401.
OMAiNLKMSKQ.
OrthoDBiEOG6FRD1F.
PhylomeDBiP40727.

Enzyme and pathway databases

BioCyciSENT99287:GCTI-1926-MONOMER.

Family and domain databases

Gene3Di3.40.1690.10. 1 hit.
InterProiIPR006136. FlhB.
IPR006135. T3SS_substrate_exporter.
IPR029025. T3SS_substrate_exporter_C.
[Graphical view]
PANTHERiPTHR30531. PTHR30531. 1 hit.
PfamiPF01312. Bac_export_2. 1 hit.
[Graphical view]
PRINTSiPR00950. TYPE3IMSPROT.
SUPFAMiSSF160544. SSF160544. 1 hit.
TIGRFAMsiTIGR00328. flhB. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular characterization of the Salmonella typhimurium flhB operon and its protein products."
    Minamino T., Iino T., Kutsukake K.
    J. Bacteriol. 176:7630-7637(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: KK1004.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LT2 / SGSC1412 / ATCC 700720.
  3. "Purification and characterization of the CheZ protein of bacterial chemotaxis."
    Stock A.M., Stock J.B.
    J. Bacteriol. 169:3301-3311(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-213.

Entry informationi

Entry nameiFLHB_SALTY
AccessioniPrimary (citable) accession number: P40727
Secondary accession number(s): Q6LDV3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: December 9, 2015
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.