P40720FUMA_SALTYFumarate hydratase class I, aerobic4.2.1.2Fumarase AOxaloacetate keto--enol-isomeraseOAAKE isomeraseOxaloacetate tautomerase5.3.2.2fumASTM1468Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)BacteriaPseudomonadotaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonellaComplete genome sequence of Salmonella enterica serovar Typhimurium LT2.NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]Sequence of the phosphomannose isomerase-encoding gene of Salmonella typhimurium.NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-39Catalyzes the reversible hydration of fumarate to (S)-malate. Functions as an aerobic enzyme in the direction of malate formation as part of the citric acid cycle. Accounts for about 80% of the fumarase activity when the bacteria grow aerobically. To a lesser extent, also displays D-tartrate dehydratase activity in vitro, but is not able to convert (R)-malate, L-tartrate or meso-tartrate. Can also catalyze the isomerization of enol- to keto-oxaloacetate.(S)-malate = fumarate + H2Ooxaloacetate = enol-oxaloacetate[4Fe-4S] clusterBinds 1 [4Fe-4S] cluster per subunit.Carbohydrate metabolism; tricarboxylic acid cycle; (S)-malate from fumarate: step 1/1.Homodimer.Is expressed under aerobic conditions. Is repressed by glucose and anaerobiosis.Belongs to the class-I fumarase family.4Fe-4SIronIron-sulfurIsomeraseLyaseMetal-bindingReference proteomeTricarboxylic acid cycle[4Fe-4S] cluster[4Fe-4S] cluster[4Fe-4S] clusterMSNKPFFYQDPFPLKKDDTEYYLLTSEHVSVAEFEGQEILKVAPEALTLLARQAFHDASFMLRPAHQQQVADILRDPQASENDKYVALQFLRNSDIAAKGVLPTCQDTGTAIIVGKKGQRVWTGGGDEAALARGVYNTYIEDNLRYSQNAALDMYKEVNTGTNLPAQIDLYSVDGDEYKFLCIAKGGGSANKTYLYQETKALLTPGKLKNYLVDKMRTLGTAACPPYHIAFVIGGTSAEANLKTVKLASAKYYDALPTEGNEHGQAFRDIELEKELLLEAQNLGLGAQFGGKYFAHDIRVIRLPRHGASCPVGMGVSCSADRNIKAKINRDGIWIEKLERNPGKYIPEALRQAGEGEAVRVDLNRPMSEILQQLSQYPVSTRLSLNGTIIVGRDIAHAKLKERMDRGEGLPQYIKDHPIYYAGPAKTPEGYASGSLGPTTAGRMDSYVDQLQSQGGSMIMLAKGNRSQQVTDACKKHGGFYLGSIGGPAAVLAQGSIKRLECVEYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQQIQSSQCGAALSNVAALRGGNMIRYFAGERRKRLIRSTPLCCYR
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