Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P40720

- FUMA_SALTY

UniProt

P40720 - FUMA_SALTY

Protein

Fumarate hydratase class I, aerobic

Gene

fumA

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    It functions as an aerobic enzyme in the citric acid cycle. It accounts for about 80% of the fumarase activity when the bacteria grows aerobically By similarity.By similarity

    Catalytic activityi

    (S)-malate = fumarate + H2O.

    Cofactori

    Binds 1 4Fe-4S cluster.

    Enzyme regulationi

    Subject to aerobic respiratory control and catabolite repression.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi318 – 3181Iron-sulfur (4Fe-4S)By similarity
    Active sitei397 – 3971Sequence Analysis
    Binding sitei463 – 4631SubstrateSequence Analysis

    GO - Molecular functioni

    1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
    2. fumarate hydratase activity Source: UniProtKB-EC
    3. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. tricarboxylic acid cycle Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Tricarboxylic acid cycle

    Keywords - Ligandi

    4Fe-4S, Iron, Iron-sulfur, Metal-binding

    Enzyme and pathway databases

    BioCyciSENT99287:GCTI-1478-MONOMER.
    UniPathwayiUPA00223; UER01007.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fumarate hydratase class I, aerobic (EC:4.2.1.2)
    Short name:
    Fumarase
    Gene namesi
    Name:fumA
    Ordered Locus Names:STM1468
    OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
    Taxonomic identifieri99287 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
    ProteomesiUP000001014: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 580579Fumarate hydratase class I, aerobicPRO_0000195659Add
    BLAST

    Proteomic databases

    PaxDbiP40720.
    PRIDEiP40720.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi99287.STM1468.

    Structurei

    3D structure databases

    ProteinModelPortaliP40720.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class-I fumarase family.Curated

    Phylogenomic databases

    eggNOGiCOG1838.
    HOGENOMiHOG000009338.
    KOiK01676.
    OMAiTCVEYPE.
    OrthoDBiEOG6TXR10.
    PhylomeDBiP40720.

    Family and domain databases

    Gene3Di3.20.130.10. 1 hit.
    InterProiIPR004646. Fe-S_hydro-lyase_TtdA-typ_cat.
    IPR004647. Fe-S_hydro-lyase_TtdB-typ_cat.
    IPR011167. Fe_dep_fumarate_hydratase.
    IPR020557. Fumarate_lyase_CS.
    [Graphical view]
    PfamiPF05681. Fumerase. 1 hit.
    PF05683. Fumerase_C. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001394. Fe_dep_fumar_hy. 1 hit.
    SUPFAMiSSF117457. SSF117457. 1 hit.
    TIGRFAMsiTIGR00722. ttdA_fumA_fumB. 1 hit.
    TIGR00723. ttdB_fumA_fumB. 1 hit.
    PROSITEiPS00163. FUMARATE_LYASES. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P40720-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSNKPFFYQD PFPLKKDDTE YYLLTSEHVS VAEFEGQEIL KVAPEALTLL    50
    ARQAFHDASF MLRPAHQQQV ADILRDPQAS ENDKYVALQF LRNSDIAAKG 100
    VLPTCQDTGT AIIVGKKGQR VWTGGGDEAA LARGVYNTYI EDNLRYSQNA 150
    ALDMYKEVNT GTNLPAQIDL YSVDGDEYKF LCIAKGGGSA NKTYLYQETK 200
    ALLTPGKLKN YLVDKMRTLG TAACPPYHIA FVIGGTSAEA NLKTVKLASA 250
    KYYDALPTEG NEHGQAFRDI ELEKELLLEA QNLGLGAQFG GKYFAHDIRV 300
    IRLPRHGASC PVGMGVSCSA DRNIKAKINR DGIWIEKLER NPGKYIPEAL 350
    RQAGEGEAVR VDLNRPMSEI LQQLSQYPVS TRLSLNGTII VGRDIAHAKL 400
    KERMDRGEGL PQYIKDHPIY YAGPAKTPEG YASGSLGPTT AGRMDSYVDQ 450
    LQSQGGSMIM LAKGNRSQQV TDACKKHGGF YLGSIGGPAA VLAQGSIKRL 500
    ECVEYPELGM EAIWKIEVED FPAFILVDDK GNDFFQQIQS SQCGAALSNV 550
    AALRGGNMIR YFAGERRKRL IRSTPLCCYR 580
    Length:580
    Mass (Da):63,825
    Last modified:January 23, 2007 - v3
    Checksum:iDF36C9E67D6FBE39
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006468 Genomic DNA. Translation: AAL20388.1.
    X57117 Genomic DNA. No translation available.
    RefSeqiNP_460429.1. NC_003197.1.
    WP_000066602.1. NC_003197.1.

    Genome annotation databases

    EnsemblBacteriaiAAL20388; AAL20388; STM1468.
    GeneIDi1252986.
    KEGGistm:STM1468.
    PATRICi32381419. VBISalEnt20916_1550.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006468 Genomic DNA. Translation: AAL20388.1 .
    X57117 Genomic DNA. No translation available.
    RefSeqi NP_460429.1. NC_003197.1.
    WP_000066602.1. NC_003197.1.

    3D structure databases

    ProteinModelPortali P40720.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 99287.STM1468.

    Proteomic databases

    PaxDbi P40720.
    PRIDEi P40720.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL20388 ; AAL20388 ; STM1468 .
    GeneIDi 1252986.
    KEGGi stm:STM1468.
    PATRICi 32381419. VBISalEnt20916_1550.

    Phylogenomic databases

    eggNOGi COG1838.
    HOGENOMi HOG000009338.
    KOi K01676.
    OMAi TCVEYPE.
    OrthoDBi EOG6TXR10.
    PhylomeDBi P40720.

    Enzyme and pathway databases

    UniPathwayi UPA00223 ; UER01007 .
    BioCyci SENT99287:GCTI-1478-MONOMER.

    Family and domain databases

    Gene3Di 3.20.130.10. 1 hit.
    InterProi IPR004646. Fe-S_hydro-lyase_TtdA-typ_cat.
    IPR004647. Fe-S_hydro-lyase_TtdB-typ_cat.
    IPR011167. Fe_dep_fumarate_hydratase.
    IPR020557. Fumarate_lyase_CS.
    [Graphical view ]
    Pfami PF05681. Fumerase. 1 hit.
    PF05683. Fumerase_C. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001394. Fe_dep_fumar_hy. 1 hit.
    SUPFAMi SSF117457. SSF117457. 1 hit.
    TIGRFAMsi TIGR00722. ttdA_fumA_fumB. 1 hit.
    TIGR00723. ttdB_fumA_fumB. 1 hit.
    PROSITEi PS00163. FUMARATE_LYASES. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: LT2 / SGSC1412 / ATCC 700720.
    2. "Sequence of the phosphomannose isomerase-encoding gene of Salmonella typhimurium."
      Collins L.V., Hackett J.
      Gene 103:135-136(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-39.
      Strain: C5.

    Entry informationi

    Entry nameiFUMA_SALTY
    AccessioniPrimary (citable) accession number: P40720
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 101 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3