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P40720 (FUMA_SALTY) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Fumarate hydratase class I, aerobic

Short name=Fumarase
EC=4.2.1.2
Gene names
Name:fumA
Ordered Locus Names:STM1468
OrganismSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) [Reference proteome] [HAMAP]
Taxonomic identifier99287 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella

Protein attributes

Sequence length580 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

It functions as an aerobic enzyme in the citric acid cycle. It accounts for about 80% of the fumarase activity when the bacteria grows aerobically By similarity.

Catalytic activity

(S)-malate = fumarate + H2O.

Cofactor

Binds 1 4Fe-4S cluster.

Enzyme regulation

Subject to aerobic respiratory control and catabolite repression By similarity.

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; (S)-malate from fumarate: step 1/1.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the class-I fumarase family.

Ontologies

Keywords
   Biological processTricarboxylic acid cycle
   Ligand4Fe-4S
Iron
Iron-sulfur
Metal-binding
   Molecular functionLyase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtricarboxylic acid cycle

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_function4 iron, 4 sulfur cluster binding

Inferred from electronic annotation. Source: UniProtKB-KW

fumarate hydratase activity

Inferred from electronic annotation. Source: UniProtKB-EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 580579Fumarate hydratase class I, aerobic
PRO_0000195659

Sites

Active site3971 Potential
Metal binding3181Iron-sulfur (4Fe-4S) By similarity
Binding site4631Substrate Potential

Sequences

Sequence LengthMass (Da)Tools
P40720 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: DF36C9E67D6FBE39

FASTA58063,825
        10         20         30         40         50         60 
MSNKPFFYQD PFPLKKDDTE YYLLTSEHVS VAEFEGQEIL KVAPEALTLL ARQAFHDASF 

        70         80         90        100        110        120 
MLRPAHQQQV ADILRDPQAS ENDKYVALQF LRNSDIAAKG VLPTCQDTGT AIIVGKKGQR 

       130        140        150        160        170        180 
VWTGGGDEAA LARGVYNTYI EDNLRYSQNA ALDMYKEVNT GTNLPAQIDL YSVDGDEYKF 

       190        200        210        220        230        240 
LCIAKGGGSA NKTYLYQETK ALLTPGKLKN YLVDKMRTLG TAACPPYHIA FVIGGTSAEA 

       250        260        270        280        290        300 
NLKTVKLASA KYYDALPTEG NEHGQAFRDI ELEKELLLEA QNLGLGAQFG GKYFAHDIRV 

       310        320        330        340        350        360 
IRLPRHGASC PVGMGVSCSA DRNIKAKINR DGIWIEKLER NPGKYIPEAL RQAGEGEAVR 

       370        380        390        400        410        420 
VDLNRPMSEI LQQLSQYPVS TRLSLNGTII VGRDIAHAKL KERMDRGEGL PQYIKDHPIY 

       430        440        450        460        470        480 
YAGPAKTPEG YASGSLGPTT AGRMDSYVDQ LQSQGGSMIM LAKGNRSQQV TDACKKHGGF 

       490        500        510        520        530        540 
YLGSIGGPAA VLAQGSIKRL ECVEYPELGM EAIWKIEVED FPAFILVDDK GNDFFQQIQS 

       550        560        570        580 
SQCGAALSNV AALRGGNMIR YFAGERRKRL IRSTPLCCYR 

« Hide

References

« Hide 'large scale' references
[1]"Complete genome sequence of Salmonella enterica serovar Typhimurium LT2."
McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P., Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D., Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E. expand/collapse author list , Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R., Wilson R.K.
Nature 413:852-856(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: LT2 / SGSC1412 / ATCC 700720.
[2]"Sequence of the phosphomannose isomerase-encoding gene of Salmonella typhimurium."
Collins L.V., Hackett J.
Gene 103:135-136(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-39.
Strain: C5.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE006468 Genomic DNA. Translation: AAL20388.1.
X57117 Genomic DNA. No translation available.
RefSeqNP_460429.1. NC_003197.1.

3D structure databases

ProteinModelPortalP40720.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING99287.STM1468.

Proteomic databases

PaxDbP40720.
PRIDEP40720.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAL20388; AAL20388; STM1468.
GeneID1252986.
KEGGstm:STM1468.
PATRIC32381419. VBISalEnt20916_1550.

Phylogenomic databases

eggNOGCOG1838.
HOGENOMHOG000009338.
KOK01676.
OMATCVEYPE.
OrthoDBEOG6TXR10.
PhylomeDBP40720.

Enzyme and pathway databases

BioCycSENT99287:GCTI-1478-MONOMER.
UniPathwayUPA00223; UER01007.

Family and domain databases

Gene3D3.20.130.10. 1 hit.
InterProIPR004646. Fe-S_hydro-lyase_TtdA-typ_cat.
IPR004647. Fe-S_hydro-lyase_TtdB-typ_cat.
IPR011167. Fe_dep_fumarate_hydratase.
IPR020557. Fumarate_lyase_CS.
[Graphical view]
PfamPF05681. Fumerase. 1 hit.
PF05683. Fumerase_C. 1 hit.
[Graphical view]
PIRSFPIRSF001394. Fe_dep_fumar_hy. 1 hit.
SUPFAMSSF117457. SSF117457. 1 hit.
TIGRFAMsTIGR00722. ttdA_fumA_fumB. 1 hit.
TIGR00723. ttdB_fumA_fumB. 1 hit.
PROSITEPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFUMA_SALTY
AccessionPrimary (citable) accession number: P40720
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 99 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways