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P40720

- FUMA_SALTY

UniProt

P40720 - FUMA_SALTY

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Protein

Fumarate hydratase class I, aerobic

Gene

fumA

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the reversible hydration of fumarate to (S)-malate. Functions as an aerobic enzyme in the direction of malate formation as part of the citric acid cycle. Accounts for about 80% of the fumarase activity when the bacteria grow aerobically. To a lesser extent, also displays D-tartrate dehydratase activity in vitro, but is not able to convert (R)-malate, L-tartrate or meso-tartrate. Can also catalyze the isomerization of enol- to keto-oxaloacetate.By similarity

Catalytic activityi

(S)-malate = fumarate + H2O.By similarity
Keto-oxaloacetate = enol-oxaloacetate.By similarity

Cofactori

[4Fe-4S] clusterBy similarityNote: Binds 1 [4Fe-4S] cluster per subunit.By similarity

Pathwayi

GO - Molecular functioni

  1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  2. fumarate hydratase activity Source: UniProtKB-EC
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. tricarboxylic acid cycle Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Lyase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

4Fe-4S, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

BioCyciSENT99287:GCTI-1478-MONOMER.
UniPathwayiUPA00223; UER01007.

Names & Taxonomyi

Protein namesi
Recommended name:
Fumarate hydratase class I, aerobicBy similarity (EC:4.2.1.2By similarity)
Alternative name(s):
Fumarase ABy similarity
Oxaloacetate keto--enol-isomeraseBy similarity
Short name:
OAAKE isomeraseBy similarity
Oxaloacetate tautomeraseBy similarity (EC:5.3.2.2By similarity)
Gene namesi
Name:fumABy similarity
Ordered Locus Names:STM1468
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000001014: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 580580Fumarate hydratase class I, aerobicPRO_0000195659Add
BLAST

Proteomic databases

PaxDbiP40720.
PRIDEiP40720.

Expressioni

Inductioni

Is expressed under aerobic conditions. Is repressed by glucose and anaerobiosis.By similarity

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi99287.STM1468.

Structurei

3D structure databases

ProteinModelPortaliP40720.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-I fumarase family.Curated

Phylogenomic databases

eggNOGiCOG1838.
HOGENOMiHOG000009338.
KOiK01676.
OMAiTCVEYPE.
OrthoDBiEOG6TXR10.
PhylomeDBiP40720.

Family and domain databases

Gene3Di3.20.130.10. 1 hit.
InterProiIPR004646. Fe-S_hydro-lyase_TtdA-typ_cat.
IPR004647. Fe-S_hydro-lyase_TtdB-typ_cat.
IPR011167. Fe_dep_fumarate_hydratase.
IPR020557. Fumarate_lyase_CS.
[Graphical view]
PfamiPF05681. Fumerase. 1 hit.
PF05683. Fumerase_C. 1 hit.
[Graphical view]
PIRSFiPIRSF001394. Fe_dep_fumar_hy. 1 hit.
SUPFAMiSSF117457. SSF117457. 1 hit.
TIGRFAMsiTIGR00722. ttdA_fumA_fumB. 1 hit.
TIGR00723. ttdB_fumA_fumB. 1 hit.
PROSITEiPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P40720-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSNKPFFYQD PFPLKKDDTE YYLLTSEHVS VAEFEGQEIL KVAPEALTLL
60 70 80 90 100
ARQAFHDASF MLRPAHQQQV ADILRDPQAS ENDKYVALQF LRNSDIAAKG
110 120 130 140 150
VLPTCQDTGT AIIVGKKGQR VWTGGGDEAA LARGVYNTYI EDNLRYSQNA
160 170 180 190 200
ALDMYKEVNT GTNLPAQIDL YSVDGDEYKF LCIAKGGGSA NKTYLYQETK
210 220 230 240 250
ALLTPGKLKN YLVDKMRTLG TAACPPYHIA FVIGGTSAEA NLKTVKLASA
260 270 280 290 300
KYYDALPTEG NEHGQAFRDI ELEKELLLEA QNLGLGAQFG GKYFAHDIRV
310 320 330 340 350
IRLPRHGASC PVGMGVSCSA DRNIKAKINR DGIWIEKLER NPGKYIPEAL
360 370 380 390 400
RQAGEGEAVR VDLNRPMSEI LQQLSQYPVS TRLSLNGTII VGRDIAHAKL
410 420 430 440 450
KERMDRGEGL PQYIKDHPIY YAGPAKTPEG YASGSLGPTT AGRMDSYVDQ
460 470 480 490 500
LQSQGGSMIM LAKGNRSQQV TDACKKHGGF YLGSIGGPAA VLAQGSIKRL
510 520 530 540 550
ECVEYPELGM EAIWKIEVED FPAFILVDDK GNDFFQQIQS SQCGAALSNV
560 570 580
AALRGGNMIR YFAGERRKRL IRSTPLCCYR
Length:580
Mass (Da):63,825
Last modified:January 23, 2007 - v3
Checksum:iDF36C9E67D6FBE39
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006468 Genomic DNA. Translation: AAL20388.1.
X57117 Genomic DNA. No translation available.
RefSeqiNP_460429.1. NC_003197.1.
WP_000066602.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL20388; AAL20388; STM1468.
GeneIDi1252986.
KEGGistm:STM1468.
PATRICi32381419. VBISalEnt20916_1550.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006468 Genomic DNA. Translation: AAL20388.1 .
X57117 Genomic DNA. No translation available.
RefSeqi NP_460429.1. NC_003197.1.
WP_000066602.1. NC_003197.1.

3D structure databases

ProteinModelPortali P40720.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 99287.STM1468.

Proteomic databases

PaxDbi P40720.
PRIDEi P40720.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL20388 ; AAL20388 ; STM1468 .
GeneIDi 1252986.
KEGGi stm:STM1468.
PATRICi 32381419. VBISalEnt20916_1550.

Phylogenomic databases

eggNOGi COG1838.
HOGENOMi HOG000009338.
KOi K01676.
OMAi TCVEYPE.
OrthoDBi EOG6TXR10.
PhylomeDBi P40720.

Enzyme and pathway databases

UniPathwayi UPA00223 ; UER01007 .
BioCyci SENT99287:GCTI-1478-MONOMER.

Family and domain databases

Gene3Di 3.20.130.10. 1 hit.
InterProi IPR004646. Fe-S_hydro-lyase_TtdA-typ_cat.
IPR004647. Fe-S_hydro-lyase_TtdB-typ_cat.
IPR011167. Fe_dep_fumarate_hydratase.
IPR020557. Fumarate_lyase_CS.
[Graphical view ]
Pfami PF05681. Fumerase. 1 hit.
PF05683. Fumerase_C. 1 hit.
[Graphical view ]
PIRSFi PIRSF001394. Fe_dep_fumar_hy. 1 hit.
SUPFAMi SSF117457. SSF117457. 1 hit.
TIGRFAMsi TIGR00722. ttdA_fumA_fumB. 1 hit.
TIGR00723. ttdB_fumA_fumB. 1 hit.
PROSITEi PS00163. FUMARATE_LYASES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LT2 / SGSC1412 / ATCC 700720.
  2. "Sequence of the phosphomannose isomerase-encoding gene of Salmonella typhimurium."
    Collins L.V., Hackett J.
    Gene 103:135-136(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-39.
    Strain: C5.

Entry informationi

Entry nameiFUMA_SALTY
AccessioniPrimary (citable) accession number: P40720
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: January 23, 2007
Last modified: November 26, 2014
This is version 103 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3