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P40720

- FUMA_SALTY

UniProt

P40720 - FUMA_SALTY

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Protein
Fumarate hydratase class I, aerobic
Gene
fumA, STM1468
Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

It functions as an aerobic enzyme in the citric acid cycle. It accounts for about 80% of the fumarase activity when the bacteria grows aerobically By similarity.

Catalytic activityi

(S)-malate = fumarate + H2O.

Cofactori

Binds 1 4Fe-4S cluster.

Enzyme regulationi

Subject to aerobic respiratory control and catabolite repression By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi318 – 3181Iron-sulfur (4Fe-4S) By similarity
Active sitei397 – 3971 Reviewed prediction
Binding sitei463 – 4631Substrate Reviewed prediction

GO - Molecular functioni

  1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  2. fumarate hydratase activity Source: UniProtKB-EC
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. tricarboxylic acid cycle Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

4Fe-4S, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

BioCyciSENT99287:GCTI-1478-MONOMER.
UniPathwayiUPA00223; UER01007.

Names & Taxonomyi

Protein namesi
Recommended name:
Fumarate hydratase class I, aerobic (EC:4.2.1.2)
Short name:
Fumarase
Gene namesi
Name:fumA
Ordered Locus Names:STM1468
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000001014: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 580579Fumarate hydratase class I, aerobic
PRO_0000195659Add
BLAST

Proteomic databases

PaxDbiP40720.
PRIDEiP40720.

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

STRINGi99287.STM1468.

Structurei

3D structure databases

ProteinModelPortaliP40720.

Family & Domainsi

Sequence similaritiesi

Belongs to the class-I fumarase family.

Phylogenomic databases

eggNOGiCOG1838.
HOGENOMiHOG000009338.
KOiK01676.
OMAiTCVEYPE.
OrthoDBiEOG6TXR10.
PhylomeDBiP40720.

Family and domain databases

Gene3Di3.20.130.10. 1 hit.
InterProiIPR004646. Fe-S_hydro-lyase_TtdA-typ_cat.
IPR004647. Fe-S_hydro-lyase_TtdB-typ_cat.
IPR011167. Fe_dep_fumarate_hydratase.
IPR020557. Fumarate_lyase_CS.
[Graphical view]
PfamiPF05681. Fumerase. 1 hit.
PF05683. Fumerase_C. 1 hit.
[Graphical view]
PIRSFiPIRSF001394. Fe_dep_fumar_hy. 1 hit.
SUPFAMiSSF117457. SSF117457. 1 hit.
TIGRFAMsiTIGR00722. ttdA_fumA_fumB. 1 hit.
TIGR00723. ttdB_fumA_fumB. 1 hit.
PROSITEiPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P40720-1 [UniParc]FASTAAdd to Basket

« Hide

MSNKPFFYQD PFPLKKDDTE YYLLTSEHVS VAEFEGQEIL KVAPEALTLL    50
ARQAFHDASF MLRPAHQQQV ADILRDPQAS ENDKYVALQF LRNSDIAAKG 100
VLPTCQDTGT AIIVGKKGQR VWTGGGDEAA LARGVYNTYI EDNLRYSQNA 150
ALDMYKEVNT GTNLPAQIDL YSVDGDEYKF LCIAKGGGSA NKTYLYQETK 200
ALLTPGKLKN YLVDKMRTLG TAACPPYHIA FVIGGTSAEA NLKTVKLASA 250
KYYDALPTEG NEHGQAFRDI ELEKELLLEA QNLGLGAQFG GKYFAHDIRV 300
IRLPRHGASC PVGMGVSCSA DRNIKAKINR DGIWIEKLER NPGKYIPEAL 350
RQAGEGEAVR VDLNRPMSEI LQQLSQYPVS TRLSLNGTII VGRDIAHAKL 400
KERMDRGEGL PQYIKDHPIY YAGPAKTPEG YASGSLGPTT AGRMDSYVDQ 450
LQSQGGSMIM LAKGNRSQQV TDACKKHGGF YLGSIGGPAA VLAQGSIKRL 500
ECVEYPELGM EAIWKIEVED FPAFILVDDK GNDFFQQIQS SQCGAALSNV 550
AALRGGNMIR YFAGERRKRL IRSTPLCCYR 580
Length:580
Mass (Da):63,825
Last modified:January 23, 2007 - v3
Checksum:iDF36C9E67D6FBE39
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006468 Genomic DNA. Translation: AAL20388.1.
X57117 Genomic DNA. No translation available.
RefSeqiNP_460429.1. NC_003197.1.
WP_000066602.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL20388; AAL20388; STM1468.
GeneIDi1252986.
KEGGistm:STM1468.
PATRICi32381419. VBISalEnt20916_1550.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006468 Genomic DNA. Translation: AAL20388.1 .
X57117 Genomic DNA. No translation available.
RefSeqi NP_460429.1. NC_003197.1.
WP_000066602.1. NC_003197.1.

3D structure databases

ProteinModelPortali P40720.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 99287.STM1468.

Proteomic databases

PaxDbi P40720.
PRIDEi P40720.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL20388 ; AAL20388 ; STM1468 .
GeneIDi 1252986.
KEGGi stm:STM1468.
PATRICi 32381419. VBISalEnt20916_1550.

Phylogenomic databases

eggNOGi COG1838.
HOGENOMi HOG000009338.
KOi K01676.
OMAi TCVEYPE.
OrthoDBi EOG6TXR10.
PhylomeDBi P40720.

Enzyme and pathway databases

UniPathwayi UPA00223 ; UER01007 .
BioCyci SENT99287:GCTI-1478-MONOMER.

Family and domain databases

Gene3Di 3.20.130.10. 1 hit.
InterProi IPR004646. Fe-S_hydro-lyase_TtdA-typ_cat.
IPR004647. Fe-S_hydro-lyase_TtdB-typ_cat.
IPR011167. Fe_dep_fumarate_hydratase.
IPR020557. Fumarate_lyase_CS.
[Graphical view ]
Pfami PF05681. Fumerase. 1 hit.
PF05683. Fumerase_C. 1 hit.
[Graphical view ]
PIRSFi PIRSF001394. Fe_dep_fumar_hy. 1 hit.
SUPFAMi SSF117457. SSF117457. 1 hit.
TIGRFAMsi TIGR00722. ttdA_fumA_fumB. 1 hit.
TIGR00723. ttdB_fumA_fumB. 1 hit.
PROSITEi PS00163. FUMARATE_LYASES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LT2 / SGSC1412 / ATCC 700720.
  2. "Sequence of the phosphomannose isomerase-encoding gene of Salmonella typhimurium."
    Collins L.V., Hackett J.
    Gene 103:135-136(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-39.
    Strain: C5.

Entry informationi

Entry nameiFUMA_SALTY
AccessioniPrimary (citable) accession number: P40720
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 100 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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