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Protein

Sensor protein QseC

Gene

qseC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Member of a two-component regulatory system QseB/QseC. Activates the flagella regulon by activating transcription of FlhDC. May activate QseB by phosphorylation.1 Publication

Catalytic activityi

ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Two-component regulatory system

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEcoCyc:EG12658-MONOMER.
ECOL316407:JW2994-MONOMER.
BRENDAi2.7.13.3. 2026.

Names & Taxonomyi

Protein namesi
Recommended name:
Sensor protein QseC (EC:2.7.13.3)
Gene namesi
Name:qseC
Synonyms:ygiY
Ordered Locus Names:b3026, JW2994
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13027. qseC.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 12CytoplasmicSequence analysisAdd BLAST12
Transmembranei13 – 33HelicalSequence analysisAdd BLAST21
Topological domaini34 – 156PeriplasmicSequence analysisAdd BLAST123
Transmembranei157 – 177HelicalSequence analysisAdd BLAST21
Topological domaini178 – 449CytoplasmicSequence analysisAdd BLAST272

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • intracellular Source: GOC
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000747031 – 449Sensor protein QseCAdd BLAST449

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei246Phosphohistidine; by autocatalysisPROSITE-ProRule annotation1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP40719.
PRIDEiP40719.

Expressioni

Inductioni

By the signal autoinducer AI-2, through MqsR.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4259459. 14 interactors.
IntActiP40719. 6 interactors.
STRINGi511145.b3026.

Structurei

Secondary structure

1449
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni3 – 5Combined sources3
Helixi14 – 32Combined sources19
Beta strandi156 – 158Combined sources3
Helixi159 – 182Combined sources24
Helixi283 – 297Combined sources15
Beta strandi309 – 312Combined sources4
Helixi313 – 330Combined sources18
Beta strandi334 – 341Combined sources8
Beta strandi345 – 348Combined sources4
Helixi350 – 366Combined sources17
Beta strandi373 – 378Combined sources6
Beta strandi380 – 386Combined sources7
Helixi419 – 428Combined sources10
Beta strandi432 – 434Combined sources3
Beta strandi441 – 448Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KSENMR-A2-185[»]
3JZ3X-ray2.50A/B236-449[»]
ProteinModelPortaliP40719.
SMRiP40719.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP40719.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini243 – 449Histidine kinasePROSITE-ProRule annotationAdd BLAST207

Sequence similaritiesi

Contains 1 histidine kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105DHQ. Bacteria.
ENOG410XS4R. LUCA.
HOGENOMiHOG000223178.
InParanoidiP40719.
KOiK07645.
OMAiFGQMWIW.
PhylomeDBiP40719.

Family and domain databases

Gene3Di1.10.287.130. 1 hit.
3.30.565.10. 1 hit.
InterProiIPR013727. 2CSK_N.
IPR003594. HATPase_C.
IPR005467. His_kinase_dom.
IPR003661. HisK_dim/P.
IPR004358. Sig_transdc_His_kin-like_C.
[Graphical view]
PfamiPF08521. 2CSK_N. 1 hit.
PF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
[Graphical view]
PRINTSiPR00344. BCTRLSENSOR.
SMARTiSM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
[Graphical view]
SUPFAMiSSF47384. SSF47384. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiPS50109. HIS_KIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P40719-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFTQRLSLR VRLTLIFLIL ASVTWLLSSF VAWKQTTDNV DELFDTQLML
60 70 80 90 100
FAKRLSTLDL NEINAADRMA QTPNRLKHGH VDDDALTFAI FTHDGRMVLN
110 120 130 140 150
DGDNGEDIPY SYQREGFADG QLVGEDDPWR FVWMTSPDGK YRIVVGQEWE
160 170 180 190 200
YREDMALAIV AGQLIPWLVA LPIMLIIMMV LLGRELAPLN KLALALRMRD
210 220 230 240 250
PDSEKPLNAT GVPSEVRPLV ESLNQLFART HAMMVRERRF TSDAAHELRS
260 270 280 290 300
PLTALKVQTE VAQLSDDDPQ ARKKALLQLH SGIDRATRLV DQLLTLSRLD
310 320 330 340 350
SLDNLQDVAE IPLEDLLQSS VMDIYHTAQQ AKIDVRLTLN AHSIKRTGQP
360 370 380 390 400
LLLSLLVRNL LDNAVRYSPQ GSVVDVTLNA DNFIVRDNGP GVTPEALARI
410 420 430 440
GERFYRPPGQ TATGSGLGLS IVQRIAKLHG MNVEFGNAEQ GGFEAKVSW
Length:449
Mass (Da):50,282
Last modified:October 1, 1996 - v2
Checksum:i9F00CB507FDFA715
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28377 Genomic DNA. Translation: AAA69194.1.
U00096 Genomic DNA. Translation: AAC76062.1.
AP009048 Genomic DNA. Translation: BAE77082.1.
U18656 Genomic DNA. No translation available.
PIRiH65089.
RefSeqiNP_417498.1. NC_000913.3.
WP_000673402.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76062; AAC76062; b3026.
BAE77082; BAE77082; BAE77082.
GeneIDi947174.
KEGGiecj:JW2994.
eco:b3026.
PATRICi32121464. VBIEscCol129921_3119.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28377 Genomic DNA. Translation: AAA69194.1.
U00096 Genomic DNA. Translation: AAC76062.1.
AP009048 Genomic DNA. Translation: BAE77082.1.
U18656 Genomic DNA. No translation available.
PIRiH65089.
RefSeqiNP_417498.1. NC_000913.3.
WP_000673402.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KSENMR-A2-185[»]
3JZ3X-ray2.50A/B236-449[»]
ProteinModelPortaliP40719.
SMRiP40719.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259459. 14 interactors.
IntActiP40719. 6 interactors.
STRINGi511145.b3026.

Proteomic databases

PaxDbiP40719.
PRIDEiP40719.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76062; AAC76062; b3026.
BAE77082; BAE77082; BAE77082.
GeneIDi947174.
KEGGiecj:JW2994.
eco:b3026.
PATRICi32121464. VBIEscCol129921_3119.

Organism-specific databases

EchoBASEiEB2845.
EcoGeneiEG13027. qseC.

Phylogenomic databases

eggNOGiENOG4105DHQ. Bacteria.
ENOG410XS4R. LUCA.
HOGENOMiHOG000223178.
InParanoidiP40719.
KOiK07645.
OMAiFGQMWIW.
PhylomeDBiP40719.

Enzyme and pathway databases

BioCyciEcoCyc:EG12658-MONOMER.
ECOL316407:JW2994-MONOMER.
BRENDAi2.7.13.3. 2026.

Miscellaneous databases

EvolutionaryTraceiP40719.
PROiP40719.

Family and domain databases

Gene3Di1.10.287.130. 1 hit.
3.30.565.10. 1 hit.
InterProiIPR013727. 2CSK_N.
IPR003594. HATPase_C.
IPR005467. His_kinase_dom.
IPR003661. HisK_dim/P.
IPR004358. Sig_transdc_His_kin-like_C.
[Graphical view]
PfamiPF08521. 2CSK_N. 1 hit.
PF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
[Graphical view]
PRINTSiPR00344. BCTRLSENSOR.
SMARTiSM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
[Graphical view]
SUPFAMiSSF47384. SSF47384. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiPS50109. HIS_KIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQSEC_ECOLI
AccessioniPrimary (citable) accession number: P40719
Secondary accession number(s): Q2M9H4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 144 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.