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Protein

Sensor protein QseC

Gene

qseC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Member of a two-component regulatory system QseB/QseC. Activates the flagella regulon by activating transcription of FlhDC. May activate QseB by phosphorylation.1 Publication

Catalytic activityi

ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Two-component regulatory system

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEcoCyc:EG12658-MONOMER.
ECOL316407:JW2994-MONOMER.
BRENDAi2.7.13.3. 2026.

Names & Taxonomyi

Protein namesi
Recommended name:
Sensor protein QseC (EC:2.7.13.3)
Gene namesi
Name:qseC
Synonyms:ygiY
Ordered Locus Names:b3026, JW2994
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13027. qseC.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1212CytoplasmicSequence analysisAdd
BLAST
Transmembranei13 – 3321HelicalSequence analysisAdd
BLAST
Topological domaini34 – 156123PeriplasmicSequence analysisAdd
BLAST
Transmembranei157 – 17721HelicalSequence analysisAdd
BLAST
Topological domaini178 – 449272CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • intracellular Source: GOC
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 449449Sensor protein QseCPRO_0000074703Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei246 – 2461Phosphohistidine; by autocatalysisPROSITE-ProRule annotation

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP40719.
PRIDEiP40719.

Expressioni

Inductioni

By the signal autoinducer AI-2, through MqsR.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4259459. 14 interactions.
IntActiP40719. 6 interactions.
STRINGi511145.b3026.

Structurei

Secondary structure

1
449
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni3 – 53Combined sources
Helixi14 – 3219Combined sources
Beta strandi156 – 1583Combined sources
Helixi159 – 18224Combined sources
Helixi283 – 29715Combined sources
Beta strandi309 – 3124Combined sources
Helixi313 – 33018Combined sources
Beta strandi334 – 3418Combined sources
Beta strandi345 – 3484Combined sources
Helixi350 – 36617Combined sources
Beta strandi373 – 3786Combined sources
Beta strandi380 – 3867Combined sources
Helixi419 – 42810Combined sources
Beta strandi432 – 4343Combined sources
Beta strandi441 – 4488Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2KSENMR-A2-185[»]
3JZ3X-ray2.50A/B236-449[»]
ProteinModelPortaliP40719.
SMRiP40719. Positions 2-55, 149-185, 240-449.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP40719.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini243 – 449207Histidine kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 histidine kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105DHQ. Bacteria.
ENOG410XS4R. LUCA.
HOGENOMiHOG000223178.
InParanoidiP40719.
KOiK07645.
OMAiFGQMWIW.
OrthoDBiEOG6G4VQG.
PhylomeDBiP40719.

Family and domain databases

Gene3Di1.10.287.130. 1 hit.
3.30.565.10. 1 hit.
InterProiIPR013727. 2CSK_N.
IPR003594. HATPase_C.
IPR005467. His_kinase_dom.
IPR003661. HisK_dim/P.
IPR004358. Sig_transdc_His_kin-like_C.
[Graphical view]
PfamiPF08521. 2CSK_N. 1 hit.
PF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
[Graphical view]
PRINTSiPR00344. BCTRLSENSOR.
SMARTiSM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
[Graphical view]
SUPFAMiSSF47384. SSF47384. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiPS50109. HIS_KIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P40719-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFTQRLSLR VRLTLIFLIL ASVTWLLSSF VAWKQTTDNV DELFDTQLML
60 70 80 90 100
FAKRLSTLDL NEINAADRMA QTPNRLKHGH VDDDALTFAI FTHDGRMVLN
110 120 130 140 150
DGDNGEDIPY SYQREGFADG QLVGEDDPWR FVWMTSPDGK YRIVVGQEWE
160 170 180 190 200
YREDMALAIV AGQLIPWLVA LPIMLIIMMV LLGRELAPLN KLALALRMRD
210 220 230 240 250
PDSEKPLNAT GVPSEVRPLV ESLNQLFART HAMMVRERRF TSDAAHELRS
260 270 280 290 300
PLTALKVQTE VAQLSDDDPQ ARKKALLQLH SGIDRATRLV DQLLTLSRLD
310 320 330 340 350
SLDNLQDVAE IPLEDLLQSS VMDIYHTAQQ AKIDVRLTLN AHSIKRTGQP
360 370 380 390 400
LLLSLLVRNL LDNAVRYSPQ GSVVDVTLNA DNFIVRDNGP GVTPEALARI
410 420 430 440
GERFYRPPGQ TATGSGLGLS IVQRIAKLHG MNVEFGNAEQ GGFEAKVSW
Length:449
Mass (Da):50,282
Last modified:October 1, 1996 - v2
Checksum:i9F00CB507FDFA715
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28377 Genomic DNA. Translation: AAA69194.1.
U00096 Genomic DNA. Translation: AAC76062.1.
AP009048 Genomic DNA. Translation: BAE77082.1.
U18656 Genomic DNA. No translation available.
PIRiH65089.
RefSeqiNP_417498.1. NC_000913.3.
WP_000673402.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76062; AAC76062; b3026.
BAE77082; BAE77082; BAE77082.
GeneIDi947174.
KEGGiecj:JW2994.
eco:b3026.
PATRICi32121464. VBIEscCol129921_3119.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28377 Genomic DNA. Translation: AAA69194.1.
U00096 Genomic DNA. Translation: AAC76062.1.
AP009048 Genomic DNA. Translation: BAE77082.1.
U18656 Genomic DNA. No translation available.
PIRiH65089.
RefSeqiNP_417498.1. NC_000913.3.
WP_000673402.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2KSENMR-A2-185[»]
3JZ3X-ray2.50A/B236-449[»]
ProteinModelPortaliP40719.
SMRiP40719. Positions 2-55, 149-185, 240-449.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259459. 14 interactions.
IntActiP40719. 6 interactions.
STRINGi511145.b3026.

Proteomic databases

PaxDbiP40719.
PRIDEiP40719.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76062; AAC76062; b3026.
BAE77082; BAE77082; BAE77082.
GeneIDi947174.
KEGGiecj:JW2994.
eco:b3026.
PATRICi32121464. VBIEscCol129921_3119.

Organism-specific databases

EchoBASEiEB2845.
EcoGeneiEG13027. qseC.

Phylogenomic databases

eggNOGiENOG4105DHQ. Bacteria.
ENOG410XS4R. LUCA.
HOGENOMiHOG000223178.
InParanoidiP40719.
KOiK07645.
OMAiFGQMWIW.
OrthoDBiEOG6G4VQG.
PhylomeDBiP40719.

Enzyme and pathway databases

BioCyciEcoCyc:EG12658-MONOMER.
ECOL316407:JW2994-MONOMER.
BRENDAi2.7.13.3. 2026.

Miscellaneous databases

EvolutionaryTraceiP40719.
PROiP40719.

Family and domain databases

Gene3Di1.10.287.130. 1 hit.
3.30.565.10. 1 hit.
InterProiIPR013727. 2CSK_N.
IPR003594. HATPase_C.
IPR005467. His_kinase_dom.
IPR003661. HisK_dim/P.
IPR004358. Sig_transdc_His_kin-like_C.
[Graphical view]
PfamiPF08521. 2CSK_N. 1 hit.
PF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
[Graphical view]
PRINTSiPR00344. BCTRLSENSOR.
SMARTiSM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
[Graphical view]
SUPFAMiSSF47384. SSF47384. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiPS50109. HIS_KIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  2. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  3. Chatterjee P.K., Sternberg N.L.
    Submitted (DEC-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 317-449.
  4. "Quorum sensing Escherichia coli regulators B and C (QseBC): a novel two-component regulatory system involved in the regulation of flagella and motility by quorum sensing in E. coli."
    Sperandio V., Torres A.G., Kaper J.B.
    Mol. Microbiol. 43:809-821(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
    Strain: K12 and O157:H7.
  5. "Global topology analysis of the Escherichia coli inner membrane proteome."
    Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
    Science 308:1321-1323(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: K12 / MG1655 / ATCC 47076.
  6. "Autoinducer 2 controls biofilm formation in Escherichia coli through a novel motility quorum-sensing regulator (MqsR, B3022)."
    Gonzalez Barrios A.F., Zuo R., Hashimoto Y., Yang L., Bentley W.E., Wood T.K.
    J. Bacteriol. 188:305-316(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION BY AI-2 AND MQSR.
    Strain: K12 / ATCC 25404 / DSM 5698 / NCIMB 11290, K12 / DH5-alpha and K12 / W3110 / ATCC 27325 / DSM 5911.

Entry informationi

Entry nameiQSEC_ECOLI
AccessioniPrimary (citable) accession number: P40719
Secondary accession number(s): Q2M9H4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: October 1, 1996
Last modified: February 17, 2016
This is version 141 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.