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Protein

Surface presentation of antigens protein SpaS

Gene

spaS

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Involved in a secretory pathway responsible for the surface presentation of determinants needed for the entry of Salmonella species into mammalian cells.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Virulence

Protein family/group databases

MEROPSiN06.002.

Names & Taxonomyi

Protein namesi
Recommended name:
Surface presentation of antigens protein SpaS
Gene namesi
Name:spaS
Ordered Locus Names:STM2887
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000001014 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei29 – 49HelicalSequence analysisAdd BLAST21
Transmembranei72 – 92HelicalSequence analysisAdd BLAST21
Transmembranei132 – 152HelicalSequence analysisAdd BLAST21
Transmembranei179 – 199HelicalSequence analysisAdd BLAST21
Transmembranei261 – 281HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001809561 – 356Surface presentation of antigens protein SpaSAdd BLAST356

Proteomic databases

PaxDbiP40702.
PRIDEiP40702.

Interactioni

Protein-protein interaction databases

DIPiDIP-59558N.
STRINGi99287.STM2887.

Structurei

Secondary structure

1356
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi243 – 250Combined sources8
Beta strandi253 – 257Combined sources5
Beta strandi262 – 267Combined sources6
Turni270 – 272Combined sources3
Beta strandi277 – 283Combined sources7
Helixi284 – 297Combined sources14
Beta strandi301 – 303Combined sources3
Helixi305 – 314Combined sources10
Helixi323 – 342Combined sources20

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3C01X-ray2.60A/B/C/D211-258[»]
E/F/G/H259-356[»]
ProteinModelPortaliP40702.
SMRiP40702.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP40702.

Family & Domainsi

Sequence similaritiesi

Belongs to the type III secretion exporter family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4108M6W. Bacteria.
COG1377. LUCA.
HOGENOMiHOG000253898.
KOiK03229.
OMAiQPNPGAY.
PhylomeDBiP40702.

Family and domain databases

Gene3Di3.40.1690.10. 1 hit.
InterProiIPR006307. BsaZ.
IPR006135. T3SS_substrate_exporter.
IPR029025. T3SS_substrate_exporter_C.
[Graphical view]
PANTHERiPTHR30531. PTHR30531. 1 hit.
PfamiPF01312. Bac_export_2. 1 hit.
[Graphical view]
PRINTSiPR00950. TYPE3IMSPROT.
SUPFAMiSSF160544. SSF160544. 1 hit.
TIGRFAMsiTIGR01404. FlhB_rel_III. 1 hit.

Sequencei

Sequence statusi: Complete.

P40702-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSNKTEKPT KKRLEDSAKK GQSFKSKDLI IACLTLGGIA YLVSYGSFNE
60 70 80 90 100
FMGIIKIIIA DNFDQSMADY SLAVFGIGLK YLIPFMLLCL VCSALPALLQ
110 120 130 140 150
AGFVLATEAL KPNLSALNPV EGAKKLFSMR TVKDTVKTLL YLSSFVVAAI
160 170 180 190 200
ICWKKYKVEI FSQLNGNIVG IAVIWRELLL ALVLTCLACA LIVLLLDAIA
210 220 230 240 250
EYFLTMKDMK MDKEEVKREM KEQEGNPEVK SKRREVHMEI LSEQVKSDIE
260 270 280 290 300
NSRLIVANPT HITIGIYFKP ELMPIPMISV YETNQRALAV RAYAEKVGVP
310 320 330 340 350
VIVDIKLARS LFKTHRRYDL VSLEEIDEVL RLLVWLEEVE NAGKDVIQPQ

ENEVRH
Length:356
Mass (Da):40,093
Last modified:February 1, 1995 - v1
Checksum:i5860259314317CF8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X73525 Genomic DNA. Translation: CAA51927.1.
AE006468 Genomic DNA. Translation: AAL21767.1.
PIRiS37356.
RefSeqiNP_461808.1. NC_003197.1.
WP_000097719.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL21767; AAL21767; STM2887.
GeneIDi1254410.
KEGGistm:STM2887.
PATRICi32384462. VBISalEnt20916_3043.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X73525 Genomic DNA. Translation: CAA51927.1.
AE006468 Genomic DNA. Translation: AAL21767.1.
PIRiS37356.
RefSeqiNP_461808.1. NC_003197.1.
WP_000097719.1. NC_003197.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3C01X-ray2.60A/B/C/D211-258[»]
E/F/G/H259-356[»]
ProteinModelPortaliP40702.
SMRiP40702.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-59558N.
STRINGi99287.STM2887.

Protein family/group databases

MEROPSiN06.002.

Proteomic databases

PaxDbiP40702.
PRIDEiP40702.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL21767; AAL21767; STM2887.
GeneIDi1254410.
KEGGistm:STM2887.
PATRICi32384462. VBISalEnt20916_3043.

Phylogenomic databases

eggNOGiENOG4108M6W. Bacteria.
COG1377. LUCA.
HOGENOMiHOG000253898.
KOiK03229.
OMAiQPNPGAY.
PhylomeDBiP40702.

Miscellaneous databases

EvolutionaryTraceiP40702.

Family and domain databases

Gene3Di3.40.1690.10. 1 hit.
InterProiIPR006307. BsaZ.
IPR006135. T3SS_substrate_exporter.
IPR029025. T3SS_substrate_exporter_C.
[Graphical view]
PANTHERiPTHR30531. PTHR30531. 1 hit.
PfamiPF01312. Bac_export_2. 1 hit.
[Graphical view]
PRINTSiPR00950. TYPE3IMSPROT.
SUPFAMiSSF160544. SSF160544. 1 hit.
TIGRFAMsiTIGR01404. FlhB_rel_III. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSPAS_SALTY
AccessioniPrimary (citable) accession number: P40702
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 2, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.