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P40693

- RLP7_YEAST

UniProt

P40693 - RLP7_YEAST

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Protein
Ribosome biogenesis protein RLP7
Gene
RLP7, RPL7, YNL002C, N2014
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in the biogenesis of the 60S ribosomal subunit. May act as a specificity factor that binds precursor rRNAs and tethers the enzymes that carry out the early 5' to 3' exonucleolytic reactions that generate the mature rRNAs.1 Publication

GO - Molecular functioni

  1. rRNA binding Source: SGD

GO - Biological processi

  1. exonucleolytic trimming to generate mature 5'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
  2. maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
  3. ribosomal large subunit biogenesis Source: SGD
Complete GO annotation...

Keywords - Biological processi

Ribosome biogenesis

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-33044-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosome biogenesis protein RLP7
Alternative name(s):
Ribosomal protein L7-like
Gene namesi
Name:RLP7
Synonyms:RPL7
Ordered Locus Names:YNL002C
ORF Names:N2014
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XIV

Organism-specific databases

CYGDiYNL002c.
SGDiS000004947. RLP7.

Subcellular locationi

Nucleusnucleolus 1 Publication

GO - Cellular componenti

  1. nucleolus Source: SGD
  2. preribosome, large subunit precursor Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 322321Ribosome biogenesis protein RLP7
PRO_0000104658Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine1 Publication
Modified residuei14 – 141Phosphoserine1 Publication
Modified residuei120 – 1201Phosphothreonine3 Publications
Modified residuei278 – 2781Phosphoserine2 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP40693.
PaxDbiP40693.
PeptideAtlasiP40693.

Expressioni

Gene expression databases

GenevestigatoriP40693.

Interactioni

Protein-protein interaction databases

BioGridi35823. 373 interactions.
DIPiDIP-6476N.
IntActiP40693. 34 interactions.
MINTiMINT-8285428.
STRINGi4932.YNL002C.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3J65electron microscopy8.70r1-322[»]
3J66electron microscopy8.70s1-322[»]
ProteinModelPortaliP40693.
SMRiP40693. Positions 1-322.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1841.
HOGENOMiHOG000170917.
KOiK02937.
OMAiPFKLNRE.
OrthoDBiEOG7TBCCW.

Family and domain databases

Gene3Di3.30.1390.20. 2 hits.
InterProiIPR018038. Ribosomal_L30_CS.
IPR016082. Ribosomal_L30_ferredoxin-like.
[Graphical view]
PfamiPF00327. Ribosomal_L30. 1 hit.
[Graphical view]
SUPFAMiSSF55129. SSF55129. 1 hit.
PROSITEiPS00634. RIBOSOMAL_L30. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P40693-1 [UniParc]FASTAAdd to Basket

« Hide

MSSTQDSKAQ TLNSNPEILL RKRRNADRTR IERQELAKKK REEQIKKKRS    50
NKNKFVRAES IVAKTLATSR EKERIKRVSI LEDKKAKNET QHIASGKDFI 100
LKITEKANGA EENSVDLEET EEEEDDGLIR EKTTYDGKPA LLFIVRVRGP 150
LAVNIPNKAF KILSLLRLVE TNTGVFVKLT KNVYPLLKVI APYVVIGKPS 200
LSSIRSLIQK RGRIIYKGEN EAEPHEIVLN DNNIVEEQLG DHGIICVEDI 250
IHEIATMGES FSVCNFFLQP FKLNREVSGF GSLNRLRKIK QREAESRTRQ 300
FSNAATAPVI EVDIDSLLAK LN 322
Length:322
Mass (Da):36,559
Last modified:February 1, 1995 - v1
Checksum:i64714DDFAFB90B5D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L19167 Genomic DNA. Translation: AAA34982.1.
X77114 Genomic DNA. Translation: CAA54376.1.
Z71278 Genomic DNA. Translation: CAA95861.1.
AY693031 Genomic DNA. Translation: AAT93050.1.
BK006947 Genomic DNA. Translation: DAA10541.1.
PIRiS38194.
RefSeqiNP_014396.3. NM_001182841.3.

Genome annotation databases

EnsemblFungiiYNL002C; YNL002C; YNL002C.
GeneIDi855730.
KEGGisce:YNL002C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L19167 Genomic DNA. Translation: AAA34982.1 .
X77114 Genomic DNA. Translation: CAA54376.1 .
Z71278 Genomic DNA. Translation: CAA95861.1 .
AY693031 Genomic DNA. Translation: AAT93050.1 .
BK006947 Genomic DNA. Translation: DAA10541.1 .
PIRi S38194.
RefSeqi NP_014396.3. NM_001182841.3.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3J65 electron microscopy 8.70 r 1-322 [» ]
3J66 electron microscopy 8.70 s 1-322 [» ]
ProteinModelPortali P40693.
SMRi P40693. Positions 1-322.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 35823. 373 interactions.
DIPi DIP-6476N.
IntActi P40693. 34 interactions.
MINTi MINT-8285428.
STRINGi 4932.YNL002C.

Proteomic databases

MaxQBi P40693.
PaxDbi P40693.
PeptideAtlasi P40693.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YNL002C ; YNL002C ; YNL002C .
GeneIDi 855730.
KEGGi sce:YNL002C.

Organism-specific databases

CYGDi YNL002c.
SGDi S000004947. RLP7.

Phylogenomic databases

eggNOGi COG1841.
HOGENOMi HOG000170917.
KOi K02937.
OMAi PFKLNRE.
OrthoDBi EOG7TBCCW.

Enzyme and pathway databases

BioCyci YEAST:G3O-33044-MONOMER.

Miscellaneous databases

NextBioi 980111.

Gene expression databases

Genevestigatori P40693.

Family and domain databases

Gene3Di 3.30.1390.20. 2 hits.
InterProi IPR018038. Ribosomal_L30_CS.
IPR016082. Ribosomal_L30_ferredoxin-like.
[Graphical view ]
Pfami PF00327. Ribosomal_L30. 1 hit.
[Graphical view ]
SUPFAMi SSF55129. SSF55129. 1 hit.
PROSITEi PS00634. RIBOSOMAL_L30. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Two yeast chromosomes are related by a fossil duplication of their centromeric regions."
    Lalo D., Stettler S., Mariotte S., Slonimski P.P., Thuriaux P.
    C. R. Acad. Sci. III, Sci. Vie 316:367-373(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: S288c / GRF88.
  2. "Two distinct yeast proteins are related to the mammalian ribosomal polypeptide L7."
    Lalo D., Mariotte S., Thuriaux P.
    Yeast 9:1085-1091(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: S288c / GRF88.
  3. "Organization of the centromeric region of chromosome XIV in Saccharomyces cerevisiae."
    Lalo D., Stettler S., Mariotte S., Gendreau E., Thuriaux P.
    Yeast 10:523-533(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: S288c / GRF88.
  4. "Nucleotide sequence analysis of an 8887 bp region of the left arm of yeast chromosome XIV, encompassing the centromere sequence."
    Verhasselt P., Aert R., Voet M., Volckaert G.
    Yeast 10:945-951(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 96604 / S288c / FY1679.
  5. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
    Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J.
    , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
    Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  6. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  7. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  8. "A nucleolar protein related to ribosomal protein L7 is required for an early step in large ribosomal subunit biogenesis."
    Dunbar D.A., Dragon F., Lee S.J., Baserga S.J.
    Proc. Natl. Acad. Sci. U.S.A. 97:13027-13032(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  9. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  10. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
    Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
    J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-120, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ADR376.
  11. "Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry."
    Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L., Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.
    Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-278, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-14; THR-120 AND SER-278, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-120, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRLP7_YEAST
AccessioniPrimary (citable) accession number: P40693
Secondary accession number(s): D6W1H5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: June 11, 2014
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 7720 molecules/cell in log phase SD medium.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  5. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

External Data

Dasty 3

Similar proteinsi