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Protein

Ribosome biogenesis protein RLP7

Gene

RLP7

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the biogenesis of the 60S ribosomal subunit. May act as a specificity factor that binds precursor rRNAs and tethers the enzymes that carry out the early 5' to 3' exonucleolytic reactions that generate the mature rRNAs.1 Publication

Miscellaneous

Present with 7720 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • rRNA binding Source: SGD
  • structural constituent of ribosome Source: GO_Central

GO - Biological processi

  • cytoplasmic translation Source: GO_Central
  • exonucleolytic trimming to generate mature 5'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
  • maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
  • ribosomal large subunit biogenesis Source: SGD

Keywordsi

Molecular functionRNA-binding
Biological processRibosome biogenesis

Enzyme and pathway databases

BioCyciYEAST:G3O-33044-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosome biogenesis protein RLP7
Alternative name(s):
Ribosomal protein L7-like
Gene namesi
Name:RLP7
Synonyms:RPL7
Ordered Locus Names:YNL002C
ORF Names:N2014
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNL002C
SGDiS000004947 RLP7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001046582 – 322Ribosome biogenesis protein RLP7Add BLAST321

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei14PhosphoserineCombined sources1
Modified residuei120PhosphothreonineCombined sources1
Modified residuei278PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP40693
PaxDbiP40693
PRIDEiP40693

PTM databases

iPTMnetiP40693

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi35823, 431 interactors
DIPiDIP-6476N
IntActiP40693, 42 interactors
MINTiP40693
STRINGi4932.YNL002C

Structurei

Secondary structure

1322
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi58 – 86Combined sources29
Beta strandi99 – 104Combined sources6
Beta strandi129 – 134Combined sources6
Beta strandi140 – 146Combined sources7
Helixi157 – 165Combined sources9
Beta strandi170 – 179Combined sources10
Helixi183 – 187Combined sources5
Turni191 – 193Combined sources3
Beta strandi194 – 196Combined sources3
Helixi201 – 208Combined sources8
Beta strandi219 – 221Combined sources3
Helixi234 – 237Combined sources4
Helixi247 – 255Combined sources9
Helixi261 – 265Combined sources5
Helixi282 – 298Combined sources17
Beta strandi309 – 311Combined sources3
Helixi314 – 321Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3JCTelectron microscopy3.08t1-322[»]
4V7Felectron microscopy8.70r/s1-322[»]
5Z3Gelectron microscopy3.65D1-322[»]
6C0Felectron microscopy3.70t1-322[»]
6CB1electron microscopy4.60t1-322[»]
6ELZelectron microscopy3.30t1-322[»]
6EM1electron microscopy3.60t1-322[»]
6EM3electron microscopy3.20t1-322[»]
6EM4electron microscopy4.10t1-322[»]
6EM5electron microscopy4.30t1-322[»]
ProteinModelPortaliP40693
SMRiP40693
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000170917
InParanoidiP40693
KOiK02937
OMAiQSNTMVE
OrthoDBiEOG092C4MAX

Family and domain databases

CDDicd01657 Ribosomal_L7_archeal_euk, 1 hit
Gene3Di1.10.15.30, 1 hit
3.30.1390.20, 2 hits
InterProiView protein in InterPro
IPR036919 L30_ferredoxin-like_sf
IPR023106 Ribosomal_L30_central_dom_arc
IPR018038 Ribosomal_L30_CS
IPR016082 Ribosomal_L30_ferredoxin-like
IPR035808 Ribosomal_L7_euk_arc
PfamiView protein in Pfam
PF00327 Ribosomal_L30, 1 hit
SUPFAMiSSF55129 SSF55129, 1 hit
PROSITEiView protein in PROSITE
PS00634 RIBOSOMAL_L30, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P40693-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSTQDSKAQ TLNSNPEILL RKRRNADRTR IERQELAKKK REEQIKKKRS
60 70 80 90 100
NKNKFVRAES IVAKTLATSR EKERIKRVSI LEDKKAKNET QHIASGKDFI
110 120 130 140 150
LKITEKANGA EENSVDLEET EEEEDDGLIR EKTTYDGKPA LLFIVRVRGP
160 170 180 190 200
LAVNIPNKAF KILSLLRLVE TNTGVFVKLT KNVYPLLKVI APYVVIGKPS
210 220 230 240 250
LSSIRSLIQK RGRIIYKGEN EAEPHEIVLN DNNIVEEQLG DHGIICVEDI
260 270 280 290 300
IHEIATMGES FSVCNFFLQP FKLNREVSGF GSLNRLRKIK QREAESRTRQ
310 320
FSNAATAPVI EVDIDSLLAK LN
Length:322
Mass (Da):36,559
Last modified:February 1, 1995 - v1
Checksum:i64714DDFAFB90B5D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19167 Genomic DNA Translation: AAA34982.1
X77114 Genomic DNA Translation: CAA54376.1
Z71278 Genomic DNA Translation: CAA95861.1
AY693031 Genomic DNA Translation: AAT93050.1
BK006947 Genomic DNA Translation: DAA10541.1
PIRiS38194
RefSeqiNP_014396.3, NM_001182841.3

Genome annotation databases

EnsemblFungiiYNL002C; YNL002C; YNL002C
GeneIDi855730
KEGGisce:YNL002C

Similar proteinsi

Entry informationi

Entry nameiRLP7_YEAST
AccessioniPrimary (citable) accession number: P40693
Secondary accession number(s): D6W1H5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 23, 2018
This is version 160 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  5. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

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