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P40693

- RLP7_YEAST

UniProt

P40693 - RLP7_YEAST

Protein

Ribosome biogenesis protein RLP7

Gene

RLP7

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 124 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Involved in the biogenesis of the 60S ribosomal subunit. May act as a specificity factor that binds precursor rRNAs and tethers the enzymes that carry out the early 5' to 3' exonucleolytic reactions that generate the mature rRNAs.1 Publication

    GO - Molecular functioni

    1. rRNA binding Source: SGD

    GO - Biological processi

    1. exonucleolytic trimming to generate mature 5'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
    2. maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
    3. ribosomal large subunit biogenesis Source: SGD

    Keywords - Biological processi

    Ribosome biogenesis

    Keywords - Ligandi

    RNA-binding

    Enzyme and pathway databases

    BioCyciYEAST:G3O-33044-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribosome biogenesis protein RLP7
    Alternative name(s):
    Ribosomal protein L7-like
    Gene namesi
    Name:RLP7
    Synonyms:RPL7
    Ordered Locus Names:YNL002C
    ORF Names:N2014
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XIV

    Organism-specific databases

    CYGDiYNL002c.
    SGDiS000004947. RLP7.

    Subcellular locationi

    Nucleusnucleolus 1 Publication

    GO - Cellular componenti

    1. nucleolus Source: SGD
    2. preribosome, large subunit precursor Source: SGD

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 322321Ribosome biogenesis protein RLP7PRO_0000104658Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserine1 Publication
    Modified residuei14 – 141Phosphoserine1 Publication
    Modified residuei120 – 1201Phosphothreonine3 Publications
    Modified residuei278 – 2781Phosphoserine2 Publications

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiP40693.
    PaxDbiP40693.
    PeptideAtlasiP40693.

    Expressioni

    Gene expression databases

    GenevestigatoriP40693.

    Interactioni

    Protein-protein interaction databases

    BioGridi35823. 373 interactions.
    DIPiDIP-6476N.
    IntActiP40693. 34 interactions.
    MINTiMINT-8285428.
    STRINGi4932.YNL002C.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3J65electron microscopy8.70r1-322[»]
    3J66electron microscopy8.70s1-322[»]
    ProteinModelPortaliP40693.
    SMRiP40693. Positions 1-322.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein L30P family.Curated

    Phylogenomic databases

    eggNOGiCOG1841.
    HOGENOMiHOG000170917.
    KOiK02937.
    OMAiPFKLNRE.
    OrthoDBiEOG7TBCCW.

    Family and domain databases

    Gene3Di3.30.1390.20. 2 hits.
    InterProiIPR018038. Ribosomal_L30_CS.
    IPR016082. Ribosomal_L30_ferredoxin-like.
    [Graphical view]
    PfamiPF00327. Ribosomal_L30. 1 hit.
    [Graphical view]
    SUPFAMiSSF55129. SSF55129. 1 hit.
    PROSITEiPS00634. RIBOSOMAL_L30. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P40693-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSTQDSKAQ TLNSNPEILL RKRRNADRTR IERQELAKKK REEQIKKKRS    50
    NKNKFVRAES IVAKTLATSR EKERIKRVSI LEDKKAKNET QHIASGKDFI 100
    LKITEKANGA EENSVDLEET EEEEDDGLIR EKTTYDGKPA LLFIVRVRGP 150
    LAVNIPNKAF KILSLLRLVE TNTGVFVKLT KNVYPLLKVI APYVVIGKPS 200
    LSSIRSLIQK RGRIIYKGEN EAEPHEIVLN DNNIVEEQLG DHGIICVEDI 250
    IHEIATMGES FSVCNFFLQP FKLNREVSGF GSLNRLRKIK QREAESRTRQ 300
    FSNAATAPVI EVDIDSLLAK LN 322
    Length:322
    Mass (Da):36,559
    Last modified:February 1, 1995 - v1
    Checksum:i64714DDFAFB90B5D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L19167 Genomic DNA. Translation: AAA34982.1.
    X77114 Genomic DNA. Translation: CAA54376.1.
    Z71278 Genomic DNA. Translation: CAA95861.1.
    AY693031 Genomic DNA. Translation: AAT93050.1.
    BK006947 Genomic DNA. Translation: DAA10541.1.
    PIRiS38194.
    RefSeqiNP_014396.3. NM_001182841.3.

    Genome annotation databases

    EnsemblFungiiYNL002C; YNL002C; YNL002C.
    GeneIDi855730.
    KEGGisce:YNL002C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L19167 Genomic DNA. Translation: AAA34982.1 .
    X77114 Genomic DNA. Translation: CAA54376.1 .
    Z71278 Genomic DNA. Translation: CAA95861.1 .
    AY693031 Genomic DNA. Translation: AAT93050.1 .
    BK006947 Genomic DNA. Translation: DAA10541.1 .
    PIRi S38194.
    RefSeqi NP_014396.3. NM_001182841.3.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3J65 electron microscopy 8.70 r 1-322 [» ]
    3J66 electron microscopy 8.70 s 1-322 [» ]
    ProteinModelPortali P40693.
    SMRi P40693. Positions 1-322.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 35823. 373 interactions.
    DIPi DIP-6476N.
    IntActi P40693. 34 interactions.
    MINTi MINT-8285428.
    STRINGi 4932.YNL002C.

    Proteomic databases

    MaxQBi P40693.
    PaxDbi P40693.
    PeptideAtlasi P40693.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YNL002C ; YNL002C ; YNL002C .
    GeneIDi 855730.
    KEGGi sce:YNL002C.

    Organism-specific databases

    CYGDi YNL002c.
    SGDi S000004947. RLP7.

    Phylogenomic databases

    eggNOGi COG1841.
    HOGENOMi HOG000170917.
    KOi K02937.
    OMAi PFKLNRE.
    OrthoDBi EOG7TBCCW.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-33044-MONOMER.

    Miscellaneous databases

    NextBioi 980111.

    Gene expression databases

    Genevestigatori P40693.

    Family and domain databases

    Gene3Di 3.30.1390.20. 2 hits.
    InterProi IPR018038. Ribosomal_L30_CS.
    IPR016082. Ribosomal_L30_ferredoxin-like.
    [Graphical view ]
    Pfami PF00327. Ribosomal_L30. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55129. SSF55129. 1 hit.
    PROSITEi PS00634. RIBOSOMAL_L30. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Two yeast chromosomes are related by a fossil duplication of their centromeric regions."
      Lalo D., Stettler S., Mariotte S., Slonimski P.P., Thuriaux P.
      C. R. Acad. Sci. III, Sci. Vie 316:367-373(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: S288c / GRF88.
    2. "Two distinct yeast proteins are related to the mammalian ribosomal polypeptide L7."
      Lalo D., Mariotte S., Thuriaux P.
      Yeast 9:1085-1091(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: S288c / GRF88.
    3. "Organization of the centromeric region of chromosome XIV in Saccharomyces cerevisiae."
      Lalo D., Stettler S., Mariotte S., Gendreau E., Thuriaux P.
      Yeast 10:523-533(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: S288c / GRF88.
    4. "Nucleotide sequence analysis of an 8887 bp region of the left arm of yeast chromosome XIV, encompassing the centromere sequence."
      Verhasselt P., Aert R., Voet M., Volckaert G.
      Yeast 10:945-951(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 96604 / S288c / FY1679.
    5. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
      Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J.
      , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
      Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    6. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    7. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    8. "A nucleolar protein related to ribosomal protein L7 is required for an early step in large ribosomal subunit biogenesis."
      Dunbar D.A., Dragon F., Lee S.J., Baserga S.J.
      Proc. Natl. Acad. Sci. U.S.A. 97:13027-13032(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    9. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    10. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
      Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
      J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-120, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Strain: ADR376.
    11. "Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry."
      Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L., Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.
      Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-278, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-14; THR-120 AND SER-278, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-120, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    14. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiRLP7_YEAST
    AccessioniPrimary (citable) accession number: P40693
    Secondary accession number(s): D6W1H5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 124 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 7720 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. Ribosomal proteins
      Ribosomal proteins families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families
    4. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    5. Yeast chromosome XIV
      Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

    External Data

    Dasty 3