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Protein

Protein swallow

Gene

swa

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Has a role in localizing bicoid mRNA at the anterior margin of the oocyte during oogenesis, and a poorly characterized role in nuclear divisions in early embryogenesis.1 Publication

GO - Molecular functioni

  • dynein complex binding Source: FlyBase
  • mRNA binding Source: FlyBase

GO - Biological processi

  • actin filament organization Source: FlyBase
  • anterior/posterior axis specification, embryo Source: FlyBase
  • bicoid mRNA localization Source: FlyBase
  • cell cycle Source: UniProtKB-KW
  • cell division Source: UniProtKB-KW
  • pole plasm mRNA localization Source: FlyBase
  • regulation of pole plasm oskar mRNA localization Source: FlyBase

Keywordsi

Molecular functionDevelopmental protein
Biological processCell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
Protein swallow
Gene namesi
Name:swa
ORF Names:CG3429
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0003655. swa.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000723421 – 548Protein swallowAdd BLAST548

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei362Phosphoserine1 Publication1
Modified residuei368Phosphoserine1 Publication1
Modified residuei463Phosphoserine1 Publication1
Modified residuei471Phosphoserine1 Publication1
Modified residuei475Phosphoserine1 Publication1
Modified residuei483Phosphoserine1 Publication1
Modified residuei485Phosphoserine1 Publication1
Modified residuei487Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP40688.
PRIDEiP40688.

PTM databases

iPTMnetiP40688.

Expressioni

Developmental stagei

Expressed both maternally and zygotically.1 Publication

Gene expression databases

BgeeiFBgn0003655.
ExpressionAtlasiP40688. differential.
GenevisibleiP40688. DM.

Interactioni

Subunit structurei

May be a homo- or heterodimer.1 Publication

GO - Molecular functioni

  • dynein complex binding Source: FlyBase

Protein-protein interaction databases

BioGridi58067. 6 interactors.
DIPiDIP-17669N.
ELMiP40688.
IntActiP40688. 3 interactors.
MINTiMINT-280485.
STRINGi7227.FBpp0070884.

Structurei

Secondary structure

1548
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi288 – 294Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3BRLX-ray1.90C287-296[»]
3E2BX-ray2.00C281-296[»]
SMRiP40688.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP40688.

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410KC2M. Eukaryota.
ENOG4110MNQ. LUCA.
InParanoidiP40688.
OMAiELSDCQQ.
OrthoDBiEOG091G05GJ.
PhylomeDBiP40688.

Sequencei

Sequence statusi: Complete.

P40688-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLQDESFPT DELFDQLNNL SSSGARNTWF AEHHKPAVFE RDTAPFLEIC
60 70 80 90 100
YADPDFDADG DVANKSAKTC VSDPVGRDQE DEDDYDEDVD GDDHKLGCEK
110 120 130 140 150
APLGSGRSSK AVSYQDIHSA YTKRRFQHVT SKVGQYIAEI QAQDQKRRNV
160 170 180 190 200
KFAGFQRVNS MPESLTPTLQ QVYVHDGDFK VDKNCQTHSN SDSNYNSNSN
210 220 230 240 250
NSSSSFDRLL AENESLQQKI NSLRVEAKRL QGFNEYVQER LDRKTDDFVK
260 270 280 290 300
MKCNFETLRT ELSECQQKLR RQQDNSQHHF MYHIRSATSA KATQTDFLVD
310 320 330 340 350
TIPASGNVLV TPHPLGDLTY NSSKGSIELA LLSVAPSARV AQNPVQVQRA
360 370 380 390 400
IHPQSLDFSS VSTEADGSGS GEHRVETSSR ALVRRTPAPN NSETSQPSSN
410 420 430 440 450
DSAIEVEAHE EERPSSRRQW EQQGELISPR QWGQHEGMYY FDKRNNRVIE
460 470 480 490 500
VMGFNISQGR NQSHDTIHNQ SINDSQTRLL VHSMSMSHLE AHDHFRSKRT
510 520 530 540
TLGSRMLRFL GPCVRCRNGD PLNRSNVTYK DGLPAMPEEE FVDQRNQR
Length:548
Mass (Da):62,070
Last modified:February 1, 1995 - v1
Checksum:iB8E0351C7B005159
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56023 Genomic DNA. Translation: CAA39500.1.
AE014298 Genomic DNA. Translation: AAF46160.3.
AY069487 mRNA. Translation: AAL39632.1.
PIRiS20806.
RefSeqiNP_511060.2. NM_078505.4.
UniGeneiDm.7242.

Genome annotation databases

EnsemblMetazoaiFBtr0070922; FBpp0070884; FBgn0003655.
GeneIDi31580.
KEGGidme:Dmel_CG3429.
UCSCiCG3429-RA. d. melanogaster.

Similar proteinsi

Entry informationi

Entry nameiSWA_DROME
AccessioniPrimary (citable) accession number: P40688
Secondary accession number(s): Q9W400
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: October 25, 2017
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references