P40688 (SWA_DROME) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein swallow

Gene names

Name:	swa
ORF Names:	CG3429

Organism

Drosophila melanogaster (Fruit fly) [Reference proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Eremoneura › Cyclorrhapha › Schizophora › Acalyptratae › Ephydroidea › Drosophilidae › Drosophilinae › Drosophilini › Drosophilina › Drosophiliti › Drosophila › Sophophora › melanogaster group › melanogaster subgroup

Protein attributes

Sequence length	548 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Has a role in localizing bicoid mRNA at the anterior margin of the oocyte during oogenesis, and a poorly characterized role in nuclear divisions in early embryogenesis. Ref.1
Subunit structure	May be a homo- or heterodimer. Ref.1
Subcellular location	Nucleus. Note: Uniformly distributed in eggs, becomes localized to the nuclei during early mitotic divisions in early embryogenesis. Enters each nucleus at the beginning of mitosis, occupies a position complementary to that of condensed chromatin, and leaves each nucleus at the end of mitosis. Ref.1 Ref.5
Developmental stage	Expressed both maternally and zygotically. Ref.1

Ontologies

Keywords
Biological process	Cell cycle Cell division Mitosis
Cellular component	Nucleus
Molecular function	Developmental protein
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	bicoid mRNA localization Non-traceable author statement PubMed 10449356PubMed 12446149. Source: FlyBase cell division Inferred from electronic annotation. Source: UniProtKB-KW mitosis Inferred from electronic annotation. Source: UniProtKB-KW pole plasm mRNA localization Inferred from mutant phenotype PubMed 7681599. Source: FlyBase regulation of pole plasm oskar mRNA localization Inferred from genetic interaction PubMed 16905128. Source: FlyBase
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	dynein binding Traceable author statement PubMed 12446149. Source: FlyBase mRNA binding Inferred from sequence or structural similarity PubMed 10908586. Source: FlyBase
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 548

548

Protein swallow

PRO_0000072342

Amino acid modifications

Modified residue

362

1

Phosphoserine Ref.6

Modified residue

368

1

Phosphoserine Ref.6

Modified residue

463

1

Phosphoserine Ref.6

Modified residue

471

1

Phosphoserine Ref.6

Modified residue

475

1

Phosphoserine Ref.6

Modified residue

483

1

Phosphoserine Ref.6

Modified residue

485

1

Phosphoserine Ref.6

Modified residue

487

1

Phosphoserine Ref.6

Secondary structure

1

.

.

.

548

Helix Strand Turn

Details...

Beta strand

288 – 294

7

Sequences

	Sequence		Length	Mass (Da)
	P40688 [UniParc]. Last modified February 1, 1995. Version 1. Checksum: B8E0351C7B005159	FASTA	548	62,070
	10 20 30 40 50 60 MSLQDESFPT DELFDQLNNL SSSGARNTWF AEHHKPAVFE RDTAPFLEIC YADPDFDADG 70 80 90 100 110 120 DVANKSAKTC VSDPVGRDQE DEDDYDEDVD GDDHKLGCEK APLGSGRSSK AVSYQDIHSA 130 140 150 160 170 180 YTKRRFQHVT SKVGQYIAEI QAQDQKRRNV KFAGFQRVNS MPESLTPTLQ QVYVHDGDFK 190 200 210 220 230 240 VDKNCQTHSN SDSNYNSNSN NSSSSFDRLL AENESLQQKI NSLRVEAKRL QGFNEYVQER 250 260 270 280 290 300 LDRKTDDFVK MKCNFETLRT ELSECQQKLR RQQDNSQHHF MYHIRSATSA KATQTDFLVD 310 320 330 340 350 360 TIPASGNVLV TPHPLGDLTY NSSKGSIELA LLSVAPSARV AQNPVQVQRA IHPQSLDFSS 370 380 390 400 410 420 VSTEADGSGS GEHRVETSSR ALVRRTPAPN NSETSQPSSN DSAIEVEAHE EERPSSRRQW 430 440 450 460 470 480 EQQGELISPR QWGQHEGMYY FDKRNNRVIE VMGFNISQGR NQSHDTIHNQ SINDSQTRLL 490 500 510 520 530 540 VHSMSMSHLE AHDHFRSKRT TLGSRMLRFL GPCVRCRNGD PLNRSNVTYK DGLPAMPEEE FVDQRNQR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence of swallow, a gene required for the localization of bicoid message in Drosophila eggs." Chao Y.-C., Donahue K.M., Pokrywka N.J., Stephenson E.C. Dev. Genet. 12:333-341(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE, FUNCTION, SUBUNIT, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE. Strain: Canton-S.
[2]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[3]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed] [Europe PMC] [Abstract] Cited for: GENOME REANNOTATION. Strain: Berkeley.
[4]	"A Drosophila full-length cDNA resource." Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E. Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Berkeley. Tissue: Embryo.
[5]	"Distribution of swallow protein in egg chambers and embryos of Drosophila melanogaster." Hegde J., Stephenson E.C. Development 119:457-470(1993) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION.
[6]	"Phosphoproteome analysis of Drosophila melanogaster embryos." Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P. J. Proteome Res. 7:1675-1682(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-362; SER-368; SER-463; SER-471; SER-475; SER-483; SER-485 AND SER-487, MASS SPECTROMETRY. Tissue: Embryo.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

X56023 Genomic DNA. Translation: CAA39500.1.
AE014298 Genomic DNA. Translation: AAF46160.3.
AY069487 mRNA. Translation: AAL39632.1.

PIR

S20806.

RefSeq

NP_511060.2. NM_078505.3.

UniGene

Dm.7242.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3BRL	X-ray	1.90	C	287-296	[»]
3E2B	X-ray	2.00	C	281-296	[»]

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-17669N.

IntAct

P40688. 3 interactions.

MINT

MINT-280485.

STRING

7227.FBpp0070884.

Proteomic databases

PaxDb

P40688.

PRIDE

P40688.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblMetazoa

FBtr0070922; FBpp0070884; FBgn0003655.

GeneID

31580.

KEGG

dme:Dmel_CG3429.

UCSC

CG3429-RA. d. melanogaster.

Organism-specific databases

CTD

31580.

FlyBase

FBgn0003655. swa.

Phylogenomic databases

eggNOG

NOG313358.

InParanoid

P40688.

OMA

SFPADEL.

OrthoDB

EOG4TB2SS.

PhylomeDB

P40688.

Gene expression databases

Bgee

P40688.

GermOnline

CG3429. Drosophila melanogaster.

Family and domain databases

ProtoNet

Search...

Other

EvolutionaryTrace

P40688.

GenomeRNAi

31580.

NextBio

774289.

Entry information

Entry name

SWA_DROME

Accession

Primary (citable) accession number: P40688
Secondary accession number(s): Q9W400

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	April 3, 2013
This is version 96 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Drosophila annotation project