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P40688 (SWA_DROME) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein swallow
Gene names
Name:swa
ORF Names:CG3429
OrganismDrosophila melanogaster (Fruit fly)
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryotaMetazoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Protein attributes

Sequence length548 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Has a role in localizing bicoid mRNA at the anterior margin of the oocyte during oogenesis, and a poorly characterized role in nuclear divisions in early embryogenesis. Ref.1

Subunit structure

May be a homo- or heterodimer. Ref.1

Subcellular location

Nucleus. Note: Uniformly distributed in eggs, becomes localized to the nuclei during early mitotic divisions in early embryogenesis. Enters each nucleus at the beginning of mitosis, occupies a position complementary to that of condensed chromatin, and leaves each nucleus at the end of mitosis. Ref.1 Ref.5

Developmental stage

Expressed both maternally and zygotically. Ref.1

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 548548Protein swallow
PRO_0000072342

Amino acid modifications

Modified residue3621Phosphoserine Ref.6
Modified residue3681Phosphoserine Ref.6
Modified residue4631Phosphoserine Ref.6
Modified residue4711Phosphoserine Ref.6
Modified residue4751Phosphoserine Ref.6
Modified residue4831Phosphoserine Ref.6
Modified residue4851Phosphoserine Ref.6
Modified residue4871Phosphoserine Ref.6

Secondary structure

... 548
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P40688 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: B8E0351C7B005159

FASTA54862,070
        10         20         30         40         50         60 
MSLQDESFPT DELFDQLNNL SSSGARNTWF AEHHKPAVFE RDTAPFLEIC YADPDFDADG 

        70         80         90        100        110        120 
DVANKSAKTC VSDPVGRDQE DEDDYDEDVD GDDHKLGCEK APLGSGRSSK AVSYQDIHSA 

       130        140        150        160        170        180 
YTKRRFQHVT SKVGQYIAEI QAQDQKRRNV KFAGFQRVNS MPESLTPTLQ QVYVHDGDFK 

       190        200        210        220        230        240 
VDKNCQTHSN SDSNYNSNSN NSSSSFDRLL AENESLQQKI NSLRVEAKRL QGFNEYVQER 

       250        260        270        280        290        300 
LDRKTDDFVK MKCNFETLRT ELSECQQKLR RQQDNSQHHF MYHIRSATSA KATQTDFLVD 

       310        320        330        340        350        360 
TIPASGNVLV TPHPLGDLTY NSSKGSIELA LLSVAPSARV AQNPVQVQRA IHPQSLDFSS 

       370        380        390        400        410        420 
VSTEADGSGS GEHRVETSSR ALVRRTPAPN NSETSQPSSN DSAIEVEAHE EERPSSRRQW 

       430        440        450        460        470        480 
EQQGELISPR QWGQHEGMYY FDKRNNRVIE VMGFNISQGR NQSHDTIHNQ SINDSQTRLL 

       490        500        510        520        530        540 
VHSMSMSHLE AHDHFRSKRT TLGSRMLRFL GPCVRCRNGD PLNRSNVTYK DGLPAMPEEE 


FVDQRNQR 

« Hide

References

« Hide 'large scale' references
[1]"Sequence of swallow, a gene required for the localization of bicoid message in Drosophila eggs."
Chao Y.-C., Donahue K.M., Pokrywka N.J., Stephenson E.C.
Dev. Genet. 12:333-341(1991) [PubMed: 1806330] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE, FUNCTION, SUBUNIT, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE.
Strain: Canton-S.
[2]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[3]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: Berkeley.
[4]"A Drosophila full-length cDNA resource."
Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E.
Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed: 12537569] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Berkeley.
Tissue: Embryo.
[5]"Distribution of swallow protein in egg chambers and embryos of Drosophila melanogaster."
Hegde J., Stephenson E.C.
Development 119:457-470(1993) [PubMed: 7507030] [Abstract]
Cited for: SUBCELLULAR LOCATION.
[6]"Phosphoproteome analysis of Drosophila melanogaster embryos."
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.
J. Proteome Res. 7:1675-1682(2008) [PubMed: 18327897] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-362; SER-368; SER-463; SER-471; SER-475; SER-483; SER-485 AND SER-487, MASS SPECTROMETRY.
Tissue: Embryo.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X56023 Genomic DNA. Translation: CAA39500.1.
AE014298 Genomic DNA. Translation: AAF46160.3.
AY069487 mRNA. Translation: AAL39632.1.
PIRS20806.
RefSeqNP_511060.2. NM_078505.3.
UniGeneDm.7242.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3BRLX-ray1.90C287-296[»]
3E2BX-ray2.00C281-296[»]
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-17669N.
IntActP40688. 3 interactions.
MINTMINT-280485.
STRINGP40688.

Proteomic databases

PRIDEP40688.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0070922; FBpp0070884; FBgn0003655.
GeneID31580.
KEGGdme:Dmel_CG3429.
NMPDRfig|7227.3.peg.16720.
UCSCCG3429-RA. d. melanogaster.

Organism-specific databases

CTD31580.
FlyBaseFBgn0003655. swa.

Phylogenomic databases

GeneTreeEMGT00050000022720.
InParanoidP40688.
OMAVSYQDIH.
OrthoDBEOG4TB2SS.
PhylomeDBP40688.

Gene expression databases

BgeeP40688.
GermOnlineCG3429. Drosophila melanogaster.

Family and domain databases

ProtoNetSearch...

Other

NextBio774289.

Entry information

Entry nameSWA_DROME
AccessionPrimary (citable) accession number: P40688
Secondary accession number(s): Q9W400
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: January 25, 2012
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase

PDB cross-references

Index of Protein Data Bank (PDB) cross-references