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Protein

Putative transcription factor SOX-14

Gene

Sox14

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi187 – 255HMG boxPROSITE-ProRule annotationAdd BLAST69

GO - Molecular functioni

  • DNA binding, bending Source: FlyBase
  • sequence-specific DNA binding Source: FlyBase

GO - Biological processi

  • dendrite morphogenesis Source: FlyBase
  • metamorphosis Source: FlyBase
  • neuron remodeling Source: FlyBase
  • regulation of neuron remodeling Source: FlyBase
  • regulation of transcription by RNA polymerase II Source: FlyBase
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-DME-3769402 Deactivation of the beta-catenin transactivating complex

Names & Taxonomyi

Protein namesi
Recommended name:
Putative transcription factor SOX-14
Gene namesi
Name:Sox14
ORF Names:CG3090
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0005612 Sox14

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000488031 – 669Putative transcription factor SOX-14Add BLAST669

Proteomic databases

PaxDbiP40656
PRIDEiP40656

Expressioni

Gene expression databases

BgeeiFBgn0005612
ExpressionAtlasiP40656 differential
GenevisibleiP40656 DM

Interactioni

Protein-protein interaction databases

BioGridi63408, 3 interactors
IntActiP40656, 1 interactor
STRINGi7227.FBpp0072066

Structurei

3D structure databases

ProteinModelPortaliP40656
SMRiP40656
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi99 – 102Poly-Ala4
Compositional biasi286 – 289Poly-Asn4

Phylogenomic databases

eggNOGiENOG410IPZC Eukaryota
ENOG4111PMB LUCA
GeneTreeiENSGT00760000118988
InParanoidiP40656
KOiK09268
OMAiDGGHTFQ
OrthoDBiEOG091G0FFO
PhylomeDBiP40656

Family and domain databases

Gene3Di1.10.30.10, 1 hit
InterProiView protein in InterPro
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
PfamiView protein in Pfam
PF00505 HMG_box, 1 hit
SMARTiView protein in SMART
SM00398 HMG, 1 hit
SUPFAMiSSF47095 SSF47095, 1 hit
PROSITEiView protein in PROSITE
PS50118 HMG_BOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

P40656-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIAKPNQATT EPPLSLRPGT VPTVPATTPA RPATITIQRR HPAPKADSTP
60 70 80 90 100
HTLPPFSPSP SPASSPSPAP AQTPGAQKTQ SQAAITHPAA VASPSAPVAA
110 120 130 140 150
AAPKTPKTPE PRSTHTHTHT HSQHFSPPPR ESEMDGERSP SHSGHEMTLS
160 170 180 190 200
MDGIDSSLVF GSARVPVNSS TPYSDATRTK KHSPGHIKRP MNAFMVWSQM
210 220 230 240 250
ERRKICERTP DLHNAEISKE LGRRWQLLSK DDKQPYIIEA EKLRKLHMIE
260 270 280 290 300
YPNYKYRPQK KQTRSPGSLK PNQDADGCEA RNDTTNNNNS LTTLAINGTT
310 320 330 340 350
TAGRKSKRST STCQSGSASK RLRNDSGDTS SKPKYEVKME SAEQLNSADI
360 370 380 390 400
ILPSADNLIS YQSSEYLPLS TLSNADCDEK LHSELSSGPL ESRENLSEVV
410 420 430 440 450
NRFLPLFLGG NEDSQLGVSS LTQSQHNQSD PTAGLMDNIS DISPINDREE
460 470 480 490 500
LTEEVMRYLP YLEVNPSSDG LTLKVESSSL LGKPLNEPVF DSEDNIVNDA
510 520 530 540 550
NLHSASHQIP PYVPDSHDCF AEDCGGDSSS HQVEFEVVRP QTVTMTMTCT
560 570 580 590 600
LPYGGPDAGH TTFQADDFNA IPSAAEDSEC SILTTSNSPQ IGFNGSSFVE
610 620 630 640 650
ADAIGSTCTY AQQDYTGSVI ETHNDLNYAA HDNNGALLAY TFEDLPPQPT
660
GSHLEFNTNK YEFASYYKM
Length:669
Mass (Da):72,742
Last modified:June 13, 2006 - v3
Checksum:i4C748614764B1E64
GO

Sequence cautioni

The sequence CAB64387 differs from that shown. Reason: Frameshift at position 457.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti102 – 110APKTPKTPE → STEDPQDPG in CAB64387 (Ref. 3) Curated9
Sequence conflicti120 – 121Missing in CAB64387 (Ref. 3) Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAM68286.1
AJ252125 mRNA Translation: CAB64387.1 Frameshift.
X65667 mRNA Translation: CAA46618.1
PIRiS22935
RefSeqiNP_001286801.1, NM_001299872.1
NP_476894.1, NM_057546.3
NP_599117.1, NM_134290.1
UniGeneiDm.760

Genome annotation databases

EnsemblMetazoaiFBtr0072157; FBpp0072066; FBgn0005612
FBtr0072158; FBpp0072067; FBgn0005612
FBtr0343282; FBpp0309947; FBgn0005612
GeneIDi37822
KEGGidme:Dmel_CG3090

Similar proteinsi

Entry informationi

Entry nameiSOX14_DROME
AccessioniPrimary (citable) accession number: P40656
Secondary accession number(s): Q2MGM9
, Q9U1H4, Q9W1E2, Q9W1E3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: June 13, 2006
Last modified: March 28, 2018
This is version 145 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health