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Protein

Putative transcription factor SOX-14

Gene

Sox14

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi187 – 25569HMG boxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • DNA binding, bending Source: FlyBase
  • sequence-specific DNA binding Source: FlyBase

GO - Biological processi

  • dendrite morphogenesis Source: FlyBase
  • metamorphosis Source: FlyBase
  • neuron remodeling Source: FlyBase
  • regulation of neuron remodeling Source: FlyBase
  • regulation of transcription from RNA polymerase II promoter Source: FlyBase
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiR-DME-3769402. Deactivation of the beta-catenin transactivating complex.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative transcription factor SOX-14
Gene namesi
Name:Sox14
ORF Names:CG3090
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0005612. Sox14.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  • nucleus Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 669669Putative transcription factor SOX-14PRO_0000048803Add
BLAST

Proteomic databases

PaxDbiP40656.

Expressioni

Gene expression databases

BgeeiP40656.
ExpressionAtlasiP40656. differential.
GenevisibleiP40656. DM.

Interactioni

Protein-protein interaction databases

BioGridi63408. 1 interaction.
IntActiP40656. 1 interaction.
MINTiMINT-791196.
STRINGi7227.FBpp0072066.

Structurei

3D structure databases

ProteinModelPortaliP40656.
SMRiP40656. Positions 185-260.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi99 – 1024Poly-Ala
Compositional biasi286 – 2894Poly-Asn

Sequence similaritiesi

Contains 1 HMG box DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IPZC. Eukaryota.
ENOG4111PMB. LUCA.
GeneTreeiENSGT00760000118988.
InParanoidiP40656.
KOiK09268.
OMAiDGGHTFQ.
OrthoDBiEOG78PV8K.
PhylomeDBiP40656.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
[Graphical view]
PfamiPF00505. HMG_box. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P40656-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIAKPNQATT EPPLSLRPGT VPTVPATTPA RPATITIQRR HPAPKADSTP
60 70 80 90 100
HTLPPFSPSP SPASSPSPAP AQTPGAQKTQ SQAAITHPAA VASPSAPVAA
110 120 130 140 150
AAPKTPKTPE PRSTHTHTHT HSQHFSPPPR ESEMDGERSP SHSGHEMTLS
160 170 180 190 200
MDGIDSSLVF GSARVPVNSS TPYSDATRTK KHSPGHIKRP MNAFMVWSQM
210 220 230 240 250
ERRKICERTP DLHNAEISKE LGRRWQLLSK DDKQPYIIEA EKLRKLHMIE
260 270 280 290 300
YPNYKYRPQK KQTRSPGSLK PNQDADGCEA RNDTTNNNNS LTTLAINGTT
310 320 330 340 350
TAGRKSKRST STCQSGSASK RLRNDSGDTS SKPKYEVKME SAEQLNSADI
360 370 380 390 400
ILPSADNLIS YQSSEYLPLS TLSNADCDEK LHSELSSGPL ESRENLSEVV
410 420 430 440 450
NRFLPLFLGG NEDSQLGVSS LTQSQHNQSD PTAGLMDNIS DISPINDREE
460 470 480 490 500
LTEEVMRYLP YLEVNPSSDG LTLKVESSSL LGKPLNEPVF DSEDNIVNDA
510 520 530 540 550
NLHSASHQIP PYVPDSHDCF AEDCGGDSSS HQVEFEVVRP QTVTMTMTCT
560 570 580 590 600
LPYGGPDAGH TTFQADDFNA IPSAAEDSEC SILTTSNSPQ IGFNGSSFVE
610 620 630 640 650
ADAIGSTCTY AQQDYTGSVI ETHNDLNYAA HDNNGALLAY TFEDLPPQPT
660
GSHLEFNTNK YEFASYYKM
Length:669
Mass (Da):72,742
Last modified:June 13, 2006 - v3
Checksum:i4C748614764B1E64
GO

Sequence cautioni

The sequence CAB64387.1 differs from that shown. Reason: Frameshift at position 457. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti102 – 1109APKTPKTPE → STEDPQDPG in CAB64387 (Ref. 3) Curated
Sequence conflicti120 – 1212Missing in CAB64387 (Ref. 3) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA. Translation: AAM68286.1.
AJ252125 mRNA. Translation: CAB64387.1. Frameshift.
X65667 mRNA. Translation: CAA46618.1.
PIRiS22935.
RefSeqiNP_001286801.1. NM_001299872.1.
NP_476894.1. NM_057546.3.
NP_599117.1. NM_134290.1.
UniGeneiDm.760.

Genome annotation databases

EnsemblMetazoaiFBtr0072157; FBpp0072066; FBgn0005612.
FBtr0072158; FBpp0072067; FBgn0005612.
FBtr0343282; FBpp0309947; FBgn0005612.
GeneIDi37822.
KEGGidme:Dmel_CG3090.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA. Translation: AAM68286.1.
AJ252125 mRNA. Translation: CAB64387.1. Frameshift.
X65667 mRNA. Translation: CAA46618.1.
PIRiS22935.
RefSeqiNP_001286801.1. NM_001299872.1.
NP_476894.1. NM_057546.3.
NP_599117.1. NM_134290.1.
UniGeneiDm.760.

3D structure databases

ProteinModelPortaliP40656.
SMRiP40656. Positions 185-260.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi63408. 1 interaction.
IntActiP40656. 1 interaction.
MINTiMINT-791196.
STRINGi7227.FBpp0072066.

Proteomic databases

PaxDbiP40656.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0072157; FBpp0072066; FBgn0005612.
FBtr0072158; FBpp0072067; FBgn0005612.
FBtr0343282; FBpp0309947; FBgn0005612.
GeneIDi37822.
KEGGidme:Dmel_CG3090.

Organism-specific databases

CTDi8403.
FlyBaseiFBgn0005612. Sox14.

Phylogenomic databases

eggNOGiENOG410IPZC. Eukaryota.
ENOG4111PMB. LUCA.
GeneTreeiENSGT00760000118988.
InParanoidiP40656.
KOiK09268.
OMAiDGGHTFQ.
OrthoDBiEOG78PV8K.
PhylomeDBiP40656.

Enzyme and pathway databases

ReactomeiR-DME-3769402. Deactivation of the beta-catenin transactivating complex.

Miscellaneous databases

GenomeRNAii37822.
PROiP40656.

Gene expression databases

BgeeiP40656.
ExpressionAtlasiP40656. differential.
GenevisibleiP40656. DM.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
[Graphical view]
PfamiPF00505. HMG_box. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  2. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  3. "Cloning of Sox14, a new Drosophila sox gene."
    Cremazy F., Berta P., Girard F.
    Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-542.
  4. "A conserved family of genes related to the testis determining gene, SRY."
    Denny P., Swift S., Brand N., Dabhade N., Barton P., Ashworth A.
    Nucleic Acids Res. 20:2887-2887(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 198-251.
    Strain: Canton-S.
    Tissue: Embryo.

Entry informationi

Entry nameiSOX14_DROME
AccessioniPrimary (citable) accession number: P40656
Secondary accession number(s): Q2MGM9
, Q9U1H4, Q9W1E2, Q9W1E3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: June 13, 2006
Last modified: June 8, 2016
This is version 131 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.