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UniProtKB - P40646 (SOX7_MOUSE)

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Protein

Transcription factor SOX-7

Gene

Sox7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds to and activates the CDH5 promoter, hence plays a role in the transcriptional regulation of genes expressed in the hemogenic endothelium and blocks further differentiation into blood precursors. May be required for the survival of both hematopoietic and endothelial precursors during specification. May play a role in skeletal myogenesis and up-regulate the expression of muscel markers, such as PAX3/PAX7 and Meox1. Competes with GATA4 for binding and activation of the FGF3 promoter. Represses Wnt/beta-catenin-stimulated transcription. Probably acts by targeting CTNNB1 to proteasomal degradation. Binds the DNA sequence 5'-AACAAT-3'.6 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi45 – 113HMG boxPROSITE-ProRule annotationAdd BLAST69

GO - Molecular functioni

  • sequence-specific DNA binding Source: MGI
  • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding Source: MGI
  • transcription factor activity, sequence-specific DNA binding Source: MGI
  • transcription regulatory region DNA binding Source: BHF-UCL
Complete GO annotation...

GO - Biological processi

Complete GO annotation...

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-3769402. Deactivation of the beta-catenin transactivating complex.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor SOX-7
Short name:
mSOX7
Gene namesi
Name:Sox7
Synonyms:Sox-7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:98369. Sox7.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi323 – 328Missing : Loss of beta-catenin-binding. 1 Publication6

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000487321 – 380Transcription factor SOX-7Add BLAST380

Proteomic databases

PaxDbiP40646.
PRIDEiP40646.

PTM databases

PhosphoSitePlusiP40646.

Expressioni

Tissue specificityi

Predominantly expressed in ovary, lung and heart. In the ovary, restricted to oocytes (at protein level). Present both in mesenchymal and epithelial cells in some adult tissues, including ear.2 Publications

Developmental stagei

Expressed at least from 7.6 until 17.5 dpc. At 7.5 dpc, expressed in the yolk sac, as well as in the parietal and visceral endoderm and the embryonic mesoderm. At 8 dpc, expressed in somites and head region. At 9.5 dpc, expressed throughout vasculature. At 11.5 dpc, primarily expressed in the intersomitic vasculature. At 17.5 dpc, predominant expression in heart and lung. At that stage, also expressed in brain, cochlea, tongue, cartilage, lung, liver and vertebrae. During hemangioblast differentiation, transiently expressed in hemogenic endothelium cells and down-regulated in nascent blood precursors. May be expressed during the precursor stage of myogenic differentiation.4 Publications

Inductioni

Up-regulated by VEGFA.1 Publication

Gene expression databases

BgeeiENSMUSG00000063060.
CleanExiMM_SOX7.
ExpressionAtlasiP40646. baseline and differential.
GenevisibleiP40646. MM.

Interactioni

Subunit structurei

Interacts with CTNNB1/beta-catenin; this interaction may lead to the proteasomal degradation of active CTNNB1 and thus inhibition of Wnt/beta-catenin-stimulated transcription.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000078597.

Structurei

3D structure databases

ProteinModelPortaliP40646.
SMRiP40646.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini260 – 380Sox C-terminalPROSITE-ProRule annotationAdd BLAST121

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni323 – 328Required for beta-catenin-binding6

Phylogenomic databases

eggNOGiENOG410IPZD. Eukaryota.
ENOG410XP3W. LUCA.
GeneTreeiENSGT00760000118988.
HOGENOMiHOG000069999.
HOVERGENiHBG000517.
InParanoidiP40646.
KOiK09270.
OMAiPQKRPYV.
OrthoDBiEOG091G0CYU.
PhylomeDBiP40646.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiView protein in InterPro
IPR009071. HMG_box_dom.
IPR033392. Sox7/17/18_central.
IPR021934. Sox_C.
PfamiView protein in Pfam
PF00505. HMG_box. 1 hit.
PF12067. Sox17_18_mid. 1 hit.
SMARTiView protein in SMART
SM00398. HMG. 1 hit.
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiView protein in PROSITE
PS50118. HMG_BOX_2. 1 hit.
PS51516. SOX_C. 1 hit.

Sequencei

Sequence statusi: Complete.

P40646-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASLLGAYPW TEGLECPALE AELSDGLSPP AVPRPSGDKS SESRIRRPMN 
        60         70         80         90        100
AFMVWAKDER KRLAVQNPDL HNAELSKMLG KSWKALTLSQ KRPYVDEAER 
       110        120        130        140        150
LRLQHMQDYP NYKYRPRRKK QGKRLCKRVD PGFLLSSLSR DQNTLPEKNG 
       160        170        180        190        200
IGRGEKEDRG EYSPGATLPG LHSCYREGAA AAPGSVDTYP YGLPTPPEMS 
       210        220        230        240        250
PLDALEPEQT FFSSSCQEEH GHPHHLPHLP GPPYSPEFTP SPLHCSHPLG 
       260        270        280        290        300
SLALGQSPGV SMMSSVSGCP PSPAYYSHAT YHPLHPNLQA HLGQLSPPPE 
       310        320        330        340        350
HPGFDTLDQL SQVELLGDMD RNEFDQYLNT PGHPDSAAGV GTLTGHVPLS 
       360        370        380
QGTPTGPTET SLISVLADAT ATYYNSYSVS
Length:380
Mass (Da):41,489
Last modified:May 10, 2002 - v2
Checksum:iBE780D7234CB895C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023419 mRNA. Translation: BAA78765.1.
X65660 mRNA. Translation: CAA46611.1.
CCDSiCCDS27206.1.
PIRiS22945.
RefSeqiNP_035576.1. NM_011446.1.
UniGeneiMm.42162.

Genome annotation databases

EnsembliENSMUST00000079652; ENSMUSP00000078597; ENSMUSG00000063060.
GeneIDi20680.
KEGGimmu:20680.
UCSCiuc007uhy.1. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiSOX7_MOUSE
AccessioniPrimary (citable) accession number: P40646
Secondary accession number(s): Q9R1T6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: May 10, 2002
Last modified: June 7, 2017
This is version 127 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot