Sox7

Functionⁱ

Binds to and activates the CDH5 promoter, hence plays a role in the transcriptional regulation of genes expressed in the hemogenic endothelium and blocks further differentiation into blood precursors. May be required for the survival of both hematopoietic and endothelial precursors during specification. May play a role in skeletal myogenesis and up-regulate the expression of muscle markers, such as PAX3/PAX7 and Meox1. Competes with GATA4 for binding and activation of the FGF3 promoter. Represses Wnt/beta-catenin-stimulated transcription. Probably acts by targeting CTNNB1 to proteasomal degradation. Binds the DNA sequence 5'-AACAAT-3'.6 Publications

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	45 – 113	HMG boxPROSITE-ProRule annotationAdd BLAST		69

GO - Molecular functionⁱ

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

endoderm formation Source: MGI
negative regulation of cell proliferation Source: MGI
negative regulation of transcription, DNA-templated Source: MGI
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: MGI
positive regulation of transcription, DNA-templated
Source: MGI
Inferred from direct assayⁱ
- 19515696
- 15220343
regulation of canonical Wnt signaling pathway Source: MGI
regulation of transcription by RNA polymerase II
Source: MGI
Inferred from direct assayⁱ
- 15082719
transcription, DNA-templated Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding
Biological process	Transcription, Transcription regulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Transcription factor SOX-7 Short name: mSOX7
Gene namesⁱ	Name:Sox7 Synonyms:Sox-7
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 14

Organism-specific databases

MGIⁱ	MGI:98369. Sox7.

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	323 – 328	Missing : Loss of beta-catenin-binding. 1 Publication		6

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000048732	1 – 380	Transcription factor SOX-7Add BLAST		380

Proteomic databases

PaxDbⁱ	P40646.
PRIDEⁱ	P40646.

PTM databases

PhosphoSitePlusⁱ	P40646.

PhosphoSitePlusⁱ

P40646.

Expressionⁱ

Tissue specificityⁱ

Predominantly expressed in ovary, lung and heart. In the ovary, restricted to oocytes (at protein level). Present both in mesenchymal and epithelial cells in some adult tissues, including ear.2 Publications

Developmental stageⁱ

Expressed at least from 7.6 until 17.5 dpc. At 7.5 dpc, expressed in the yolk sac, as well as in the parietal and visceral endoderm and the embryonic mesoderm. At 8 dpc, expressed in somites and head region. At 9.5 dpc, expressed throughout vasculature. At 11.5 dpc, primarily expressed in the intersomitic vasculature. At 17.5 dpc, predominant expression in heart and lung. At that stage, also expressed in brain, cochlea, tongue, cartilage, lung, liver and vertebrae. During hemangioblast differentiation, transiently expressed in hemogenic endothelium cells and down-regulated in nascent blood precursors. May be expressed during the precursor stage of myogenic differentiation.4 Publications

Inductionⁱ

Up-regulated by VEGFA.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000063060.
CleanExⁱ	MM_SOX7.
ExpressionAtlasⁱ	P40646. baseline and differential.
Genevisibleⁱ	P40646. MM.

Interactionⁱ

Subunit structureⁱ

Interacts with CTNNB1/beta-catenin; this interaction may lead to the proteasomal degradation of active CTNNB1 and thus inhibition of Wnt/beta-catenin-stimulated transcription.By similarity

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000078597.

STRINGⁱ

10090.ENSMUSP00000078597.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P40646.
SMRⁱ	P40646.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	260 – 380	Sox C-terminalPROSITE-ProRule annotationAdd BLAST		121

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	323 – 328	Required for beta-catenin-binding		6

Phylogenomic databases

eggNOGⁱ	ENOG410IPZD. Eukaryota. ENOG410XP3W. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118988.
HOGENOMⁱ	HOG000069999.
HOVERGENⁱ	HBG000517.
InParanoidⁱ	P40646.
KEGG Orthology (KO) More...KOⁱ	K09270.
OMAⁱ	PQKRPYV.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0CYU.
PhylomeDBⁱ	P40646.

Family and domain databases

Gene3Dⁱ	1.10.30.10. 1 hit.
InterProⁱ	View protein in InterPro IPR009071. HMG_box_dom. IPR036910. HMG_box_dom_sf. IPR033392. Sox7/17/18_central. IPR021934. Sox_C.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00505. HMG_box. 1 hit. PF12067. Sox17_18_mid. 1 hit.
SMARTⁱ	View protein in SMART SM00398. HMG. 1 hit.
SUPFAMⁱ	SSF47095. SSF47095. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50118. HMG_BOX_2. 1 hit. PS51516. SOX_C. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

P40646-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MASLLGAYPW TEGLECPALE AELSDGLSPP AVPRPSGDKS SESRIRRPMN 
        60         70         80         90        100
AFMVWAKDER KRLAVQNPDL HNAELSKMLG KSWKALTLSQ KRPYVDEAER 
       110        120        130        140        150
LRLQHMQDYP NYKYRPRRKK QGKRLCKRVD PGFLLSSLSR DQNTLPEKNG 
       160        170        180        190        200
IGRGEKEDRG EYSPGATLPG LHSCYREGAA AAPGSVDTYP YGLPTPPEMS 
       210        220        230        240        250
PLDALEPEQT FFSSSCQEEH GHPHHLPHLP GPPYSPEFTP SPLHCSHPLG 
       260        270        280        290        300
SLALGQSPGV SMMSSVSGCP PSPAYYSHAT YHPLHPNLQA HLGQLSPPPE 
       310        320        330        340        350
HPGFDTLDQL SQVELLGDMD RNEFDQYLNT PGHPDSAAGV GTLTGHVPLS 
       360        370        380
QGTPTGPTET SLISVLADAT ATYYNSYSVS

Length:380

Mass (Da):41,489

Last modified:May 10, 2002 - v2

Checksum:ⁱBE780D7234CB895C

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB023419 mRNA. Translation: BAA78765.1. X65660 mRNA. Translation: CAA46611.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS27206.1.
PIRⁱ	S22945.
NCBI Reference Sequences More...RefSeqⁱ	NP_035576.1. NM_011446.1.
UniGeneⁱ	Mm.42162.

Genome annotation databases

Ensemblⁱ	ENSMUST00000079652; ENSMUSP00000078597; ENSMUSG00000063060.
GeneIDⁱ	20680.
KEGGⁱ	mmu:20680.
UCSC genome browser More...UCSCⁱ	uc007uhy.1. mouse.

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
P40646	Q3U1W5	Mus musculus (Mouse)	380	UniRef100_P40646	Cluster: Transcription factor SOX-7	2

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
P40646	Q3U1W5 UPI0003331DA9 UPI00042AB3E7 UPI000B4ECD74 D3ZTE1 A0A1A6GLK0 A0A1U7QBA4 UPI00038BF624 UPI0004ED1D9A Q3U0W9 +5	Mus musculus (Mouse) Jaculus jaculus (Lesser Egyptian jerboa) Peromyscus maniculatus bairdii (Prairie deer mouse) Meriones unguiculatus (Mongolian jird) (Mongolian gerbil) Rattus norvegicus (Rat) Neotoma lepida (Desert woodrat) Mesocricetus auratus (Golden hamster) Microtus ochrogaster (Prairie vole) Nannospalax galili (Northern Israeli blind subterranean mole rat) (Spalax galili) Mus pahari (Gairdner's shrew-mouse) (Coelomys pahari) And more	380	UniRef90_P40646	Cluster: Transcription factor SOX-7	16

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
P40646	Q9BT81 UPI0004BDCF6D UPI0007EE847E G3QS49 A0A2K6CKJ3 A0A2K5M610 A0A2K6QKA0 A0A096MZ97 A0A2I3S8Z2 UPI000C2A0A50 +126	Homo sapiens (Human) Equus przewalskii (Przewalski's horse) (Equus caballus przewalskii) Oryctolagus cuniculus (Rabbit) Gorilla gorilla gorilla (Western lowland gorilla) Macaca nemestrina (Pig-tailed macaque) Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys) Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana) Papio anubis (Olive baboon) Pan troglodytes (Chimpanzee) Piliocolobus tephrosceles (Ugandan red Colobus) And more	388	UniRef50_Q9BT81	Cluster: Transcription factor SOX-7	137

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB023419 mRNA. Translation: BAA78765.1. X65660 mRNA. Translation: CAA46611.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS27206.1.
PIRⁱ	S22945.
NCBI Reference Sequences More...RefSeqⁱ	NP_035576.1. NM_011446.1.
UniGeneⁱ	Mm.42162.

3D structure databases

ProteinModelPortalⁱ	P40646.
SMRⁱ	P40646.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000078597.

STRINGⁱ

10090.ENSMUSP00000078597.

PTM databases

PhosphoSitePlusⁱ	P40646.

PhosphoSitePlusⁱ

P40646.

Proteomic databases

PaxDbⁱ	P40646.
PRIDEⁱ	P40646.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000079652; ENSMUSP00000078597; ENSMUSG00000063060.
GeneIDⁱ	20680.
KEGGⁱ	mmu:20680.
UCSC genome browser More...UCSCⁱ	uc007uhy.1. mouse.

Organism-specific databases

CTDⁱ	83595.
MGIⁱ	MGI:98369. Sox7.

Phylogenomic databases

eggNOGⁱ	ENOG410IPZD. Eukaryota. ENOG410XP3W. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118988.
HOGENOMⁱ	HOG000069999.
HOVERGENⁱ	HBG000517.
InParanoidⁱ	P40646.
KEGG Orthology (KO) More...KOⁱ	K09270.
OMAⁱ	PQKRPYV.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0CYU.
PhylomeDBⁱ	P40646.

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P40646.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000063060.
CleanExⁱ	MM_SOX7.
ExpressionAtlasⁱ	P40646. baseline and differential.
Genevisibleⁱ	P40646. MM.

Family and domain databases

Gene3Dⁱ	1.10.30.10. 1 hit.
InterProⁱ	View protein in InterPro IPR009071. HMG_box_dom. IPR036910. HMG_box_dom_sf. IPR033392. Sox7/17/18_central. IPR021934. Sox_C.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00505. HMG_box. 1 hit. PF12067. Sox17_18_mid. 1 hit.
SMARTⁱ	View protein in SMART SM00398. HMG. 1 hit.
SUPFAMⁱ	SSF47095. SSF47095. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50118. HMG_BOX_2. 1 hit. PS51516. SOX_C. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SOX7_MOUSE
Accessionⁱ	P40646Primary (citable) accession number: P40646 Secondary accession number(s): Q9R1T6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
	Last sequence update:	May 10, 2002
	Last modified:	March 28, 2018
	This is version 131 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P40646 (SOX7_MOUSE)

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Transcription factor SOX-7

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Nucleus

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ