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Protein

Transcription factor SOX-7

Gene

Sox7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds to and activates the CDH5 promoter, hence plays a role in the transcriptional regulation of genes expressed in the hemogenic endothelium and blocks further differentiation into blood precursors. May be required for the survival of both hematopoietic and endothelial precursors during specification. May play a role in skeletal myogenesis and up-regulate the expression of muscel markers, such as PAX3/PAX7 and Meox1. Competes with GATA4 for binding and activation of the FGF3 promoter. Represses Wnt/beta-catenin-stimulated transcription. Probably acts by targeting CTNNB1 to proteasomal degradation. Binds the DNA sequence 5'-AACAAT-3'.6 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi45 – 11369HMG boxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • sequence-specific DNA binding Source: MGI
  • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding Source: MGI
  • transcription factor activity, sequence-specific DNA binding Source: MGI
  • transcription regulatory region DNA binding Source: BHF-UCL

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiR-MMU-3769402. Deactivation of the beta-catenin transactivating complex.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor SOX-7
Short name:
mSOX7
Gene namesi
Name:Sox7
Synonyms:Sox-7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:98369. Sox7.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi323 – 3286Missing : Loss of beta-catenin-binding. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 380380Transcription factor SOX-7PRO_0000048732Add
BLAST

Proteomic databases

PaxDbiP40646.
PRIDEiP40646.

PTM databases

PhosphoSiteiP40646.

Expressioni

Tissue specificityi

Predominantly expressed in ovary, lung and heart. In the ovary, restricted to oocytes (at protein level). Present both in mesenchymal and epithelial cells in some adult tissues, including ear.2 Publications

Developmental stagei

Expressed at least from 7.6 until 17.5 dpc. At 7.5 dpc, expressed in the yolk sac, as well as in the parietal and visceral endoderm and the embryonic mesoderm. At 8 dpc, expressed in somites and head region. At 9.5 dpc, expressed throughout vasculature. At 11.5 dpc, primarily expressed in the intersomitic vasculature. At 17.5 dpc, predominant expression in heart and lung. At that stage, also expressed in brain, cochlea, tongue, cartilage, lung, liver and vertebrae. During hemangioblast differentiation, transiently expressed in hemogenic endothelium cells and down-regulated in nascent blood precursors. May be expressed during the precursor stage of myogenic differentiation.4 Publications

Inductioni

Up-regulated by VEGFA.1 Publication

Gene expression databases

BgeeiP40646.
CleanExiMM_SOX7.
ExpressionAtlasiP40646. baseline and differential.
GenevisibleiP40646. MM.

Interactioni

Subunit structurei

Interacts with CTNNB1/beta-catenin; this interaction may lead to the proteasomal degradation of active CTNNB1 and thus inhibition of Wnt/beta-catenin-stimulated transcription.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000078597.

Structurei

3D structure databases

ProteinModelPortaliP40646.
SMRiP40646. Positions 45-118.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini260 – 380121Sox C-terminalPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni323 – 3286Required for beta-catenin-binding

Sequence similaritiesi

Contains 1 HMG box DNA-binding domain.PROSITE-ProRule annotation
Contains 1 Sox C-terminal domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IPZD. Eukaryota.
ENOG410XP3W. LUCA.
HOGENOMiHOG000069999.
HOVERGENiHBG000517.
InParanoidiP40646.
KOiK09270.
OMAiPRRKKQL.
OrthoDBiEOG7QC7VG.
PhylomeDBiP40646.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
IPR033392. Sox7/17/18_central.
IPR021934. Sox_C.
[Graphical view]
PfamiPF00505. HMG_box. 1 hit.
PF12067. Sox17_18_mid. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
PS51516. SOX_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P40646-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASLLGAYPW TEGLECPALE AELSDGLSPP AVPRPSGDKS SESRIRRPMN
60 70 80 90 100
AFMVWAKDER KRLAVQNPDL HNAELSKMLG KSWKALTLSQ KRPYVDEAER
110 120 130 140 150
LRLQHMQDYP NYKYRPRRKK QGKRLCKRVD PGFLLSSLSR DQNTLPEKNG
160 170 180 190 200
IGRGEKEDRG EYSPGATLPG LHSCYREGAA AAPGSVDTYP YGLPTPPEMS
210 220 230 240 250
PLDALEPEQT FFSSSCQEEH GHPHHLPHLP GPPYSPEFTP SPLHCSHPLG
260 270 280 290 300
SLALGQSPGV SMMSSVSGCP PSPAYYSHAT YHPLHPNLQA HLGQLSPPPE
310 320 330 340 350
HPGFDTLDQL SQVELLGDMD RNEFDQYLNT PGHPDSAAGV GTLTGHVPLS
360 370 380
QGTPTGPTET SLISVLADAT ATYYNSYSVS
Length:380
Mass (Da):41,489
Last modified:May 10, 2002 - v2
Checksum:iBE780D7234CB895C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023419 mRNA. Translation: BAA78765.1.
X65660 mRNA. Translation: CAA46611.1.
CCDSiCCDS27206.1.
PIRiS22945.
RefSeqiNP_035576.1. NM_011446.1.
UniGeneiMm.42162.

Genome annotation databases

EnsembliENSMUST00000079652; ENSMUSP00000078597; ENSMUSG00000063060.
GeneIDi20680.
KEGGimmu:20680.
UCSCiuc007uhy.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023419 mRNA. Translation: BAA78765.1.
X65660 mRNA. Translation: CAA46611.1.
CCDSiCCDS27206.1.
PIRiS22945.
RefSeqiNP_035576.1. NM_011446.1.
UniGeneiMm.42162.

3D structure databases

ProteinModelPortaliP40646.
SMRiP40646. Positions 45-118.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000078597.

PTM databases

PhosphoSiteiP40646.

Proteomic databases

PaxDbiP40646.
PRIDEiP40646.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000079652; ENSMUSP00000078597; ENSMUSG00000063060.
GeneIDi20680.
KEGGimmu:20680.
UCSCiuc007uhy.1. mouse.

Organism-specific databases

CTDi83595.
MGIiMGI:98369. Sox7.

Phylogenomic databases

eggNOGiENOG410IPZD. Eukaryota.
ENOG410XP3W. LUCA.
HOGENOMiHOG000069999.
HOVERGENiHBG000517.
InParanoidiP40646.
KOiK09270.
OMAiPRRKKQL.
OrthoDBiEOG7QC7VG.
PhylomeDBiP40646.

Enzyme and pathway databases

ReactomeiR-MMU-3769402. Deactivation of the beta-catenin transactivating complex.

Miscellaneous databases

PROiP40646.
SOURCEiSearch...

Gene expression databases

BgeeiP40646.
CleanExiMM_SOX7.
ExpressionAtlasiP40646. baseline and differential.
GenevisibleiP40646. MM.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
IPR033392. Sox7/17/18_central.
IPR021934. Sox_C.
[Graphical view]
PfamiPF00505. HMG_box. 1 hit.
PF12067. Sox17_18_mid. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
PS51516. SOX_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Isolation and characterization of a mouse SRY-related cDNA, mSox7."
    Taniguchi K., Hiraoka Y., Ogawa M., Sakai Y., Kido S., Aiso S.
    Biochim. Biophys. Acta 1445:225-231(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DNA-BINDING, TISSUE SPECIFICITY.
  2. "A conserved family of genes related to the testis determining gene, SRY."
    Denny P., Swift S., Brand N., Dabhade N., Barton P., Ashworth A.
    Nucleic Acids Res. 20:2887-2887(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 56-109.
    Strain: Parkes.
    Tissue: Brain and Testis.
  3. "SOX7 transcription factor: sequence, chromosomal localisation, expression, transactivation and interference with Wnt signalling."
    Takash W., Canizares J., Bonneaud N., Poulat F., Mattei M.-G., Jay P., Berta P.
    Nucleic Acids Res. 29:4274-4283(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, MUTAGENESIS OF 323-GLU--LEU-328.
  4. "SOX7 and GATA-4 are competitive activators of Fgf-3 transcription."
    Murakami A., Shen H., Ishida S., Dickson C.
    J. Biol. Chem. 279:28564-28573(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN FGF3 PROMOTER ACTIVATION.
  5. "Sox7-sustained expression alters the balance between proliferation and differentiation of hematopoietic progenitors at the onset of blood specification."
    Gandillet A., Serrano A.G., Pearson S., Lie-A-Ling M., Lacaud G., Kouskoff V.
    Blood 114:4813-4822(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN HEMOPOIETIC DEVELOPMENT, DEVELOPMENTAL STAGE.
  6. "SOX15 and SOX7 differentially regulate the myogenic program in P19 cells."
    Savage J., Conley A.J., Blais A., Skerjanc I.S.
    Stem Cells 27:1231-1243(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN MYOGENIC DIFFERENTIATION, DEVELOPMENTAL STAGE.
  7. "SOX7 regulates the expression of VE-cadherin in the haemogenic endothelium at the onset of haematopoietic development."
    Costa G., Mazan A., Gandillet A., Pearson S., Lacaud G., Kouskoff V.
    Development 139:1587-1598(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN HEMOPOIETIC DEVELOPMENT, INDUCTION, DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiSOX7_MOUSE
AccessioniPrimary (citable) accession number: P40646
Secondary accession number(s): Q9R1T6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: May 10, 2002
Last modified: June 8, 2016
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.