UniProtKB - P40646 (SOX7_MOUSE)
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Protein
Transcription factor SOX-7
Gene
Sox7
Organism
Mus musculus (Mouse)
Status
Functioni
Binds to and activates the CDH5 promoter, hence plays a role in the transcriptional regulation of genes expressed in the hemogenic endothelium and blocks further differentiation into blood precursors. May be required for the survival of both hematopoietic and endothelial precursors during specification. May play a role in skeletal myogenesis and up-regulate the expression of muscle markers, such as PAX3/PAX7 and Meox1. Competes with GATA4 for binding and activation of the FGF3 promoter. Represses Wnt/beta-catenin-stimulated transcription. Probably acts by targeting CTNNB1 to proteasomal degradation. Binds the DNA sequence 5'-AACAAT-3'.6 Publications
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 45 – 113 | HMG boxPROSITE-ProRule annotationAdd BLAST | 69 |
GO - Molecular functioni
- DNA binding transcription factor activity Source: MGI
- sequence-specific DNA binding Source: MGI
- transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding Source: MGI
- transcription regulatory region DNA binding Source: BHF-UCL
GO - Biological processi
- endoderm formation Source: MGI
- negative regulation of cell proliferation Source: MGI
- negative regulation of transcription, DNA-templated Source: MGI
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: MGI
- positive regulation of transcription, DNA-templated Source: MGI
- regulation of canonical Wnt signaling pathway Source: MGI
- regulation of transcription by RNA polymerase II Source: MGI
- transcription, DNA-templated Source: UniProtKB-KW
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Transcription factor SOX-7Short name: mSOX7 |
Gene namesi | Name:Sox7 Synonyms:Sox-7 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:98369. Sox7. |
Pathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 323 – 328 | Missing : Loss of beta-catenin-binding. 1 Publication | 6 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000048732 | 1 – 380 | Transcription factor SOX-7Add BLAST | 380 |
Proteomic databases
PaxDbi | P40646. |
PRIDEi | P40646. |
PTM databases
PhosphoSitePlusi | P40646. |
Expressioni
Tissue specificityi
Predominantly expressed in ovary, lung and heart. In the ovary, restricted to oocytes (at protein level). Present both in mesenchymal and epithelial cells in some adult tissues, including ear.2 Publications
Developmental stagei
Expressed at least from 7.6 until 17.5 dpc. At 7.5 dpc, expressed in the yolk sac, as well as in the parietal and visceral endoderm and the embryonic mesoderm. At 8 dpc, expressed in somites and head region. At 9.5 dpc, expressed throughout vasculature. At 11.5 dpc, primarily expressed in the intersomitic vasculature. At 17.5 dpc, predominant expression in heart and lung. At that stage, also expressed in brain, cochlea, tongue, cartilage, lung, liver and vertebrae. During hemangioblast differentiation, transiently expressed in hemogenic endothelium cells and down-regulated in nascent blood precursors. May be expressed during the precursor stage of myogenic differentiation.4 Publications
Inductioni
Up-regulated by VEGFA.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000063060. |
CleanExi | MM_SOX7. |
ExpressionAtlasi | P40646. baseline and differential. |
Genevisiblei | P40646. MM. |
Interactioni
Subunit structurei
Interacts with CTNNB1/beta-catenin; this interaction may lead to the proteasomal degradation of active CTNNB1 and thus inhibition of Wnt/beta-catenin-stimulated transcription.By similarity
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000078597. |
Structurei
3D structure databases
ProteinModelPortali | P40646. |
SMRi | P40646. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 260 – 380 | Sox C-terminalPROSITE-ProRule annotationAdd BLAST | 121 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 323 – 328 | Required for beta-catenin-binding | 6 |
Phylogenomic databases
eggNOGi | ENOG410IPZD. Eukaryota. ENOG410XP3W. LUCA. |
GeneTreei | ENSGT00760000118988. |
HOGENOMi | HOG000069999. |
HOVERGENi | HBG000517. |
InParanoidi | P40646. |
KOi | K09270. |
OMAi | PQKRPYV. |
OrthoDBi | EOG091G0CYU. |
PhylomeDBi | P40646. |
Family and domain databases
Gene3Di | 1.10.30.10. 1 hit. |
InterProi | View protein in InterPro IPR009071. HMG_box_dom. IPR036910. HMG_box_dom_sf. IPR033392. Sox7/17/18_central. IPR021934. Sox_C. |
Pfami | View protein in Pfam PF00505. HMG_box. 1 hit. PF12067. Sox17_18_mid. 1 hit. |
SMARTi | View protein in SMART SM00398. HMG. 1 hit. |
SUPFAMi | SSF47095. SSF47095. 1 hit. |
PROSITEi | View protein in PROSITE PS50118. HMG_BOX_2. 1 hit. PS51516. SOX_C. 1 hit. |
i Sequence
Sequence statusi: Complete.
P40646-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASLLGAYPW TEGLECPALE AELSDGLSPP AVPRPSGDKS SESRIRRPMN
60 70 80 90 100
AFMVWAKDER KRLAVQNPDL HNAELSKMLG KSWKALTLSQ KRPYVDEAER
110 120 130 140 150
LRLQHMQDYP NYKYRPRRKK QGKRLCKRVD PGFLLSSLSR DQNTLPEKNG
160 170 180 190 200
IGRGEKEDRG EYSPGATLPG LHSCYREGAA AAPGSVDTYP YGLPTPPEMS
210 220 230 240 250
PLDALEPEQT FFSSSCQEEH GHPHHLPHLP GPPYSPEFTP SPLHCSHPLG
260 270 280 290 300
SLALGQSPGV SMMSSVSGCP PSPAYYSHAT YHPLHPNLQA HLGQLSPPPE
310 320 330 340 350
HPGFDTLDQL SQVELLGDMD RNEFDQYLNT PGHPDSAAGV GTLTGHVPLS
360 370 380
QGTPTGPTET SLISVLADAT ATYYNSYSVS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB023419 mRNA. Translation: BAA78765.1. X65660 mRNA. Translation: CAA46611.1. |
CCDSi | CCDS27206.1. |
PIRi | S22945. |
RefSeqi | NP_035576.1. NM_011446.1. |
UniGenei | Mm.42162. |
Genome annotation databases
Ensembli | ENSMUST00000079652; ENSMUSP00000078597; ENSMUSG00000063060. |
GeneIDi | 20680. |
KEGGi | mmu:20680. |
UCSCi | uc007uhy.1. mouse. |
Similar proteinsi
Entry informationi
Entry namei | SOX7_MOUSE | |
Accessioni | P40646Primary (citable) accession number: P40646 Secondary accession number(s): Q9R1T6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1995 |
Last sequence update: | May 10, 2002 | |
Last modified: | March 28, 2018 | |
This is version 131 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |