Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P40645

- SOX6_MOUSE

UniProt

P40645 - SOX6_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Transcription factor SOX-6

Gene

Sox6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Transcriptional activator. Binds specifically to the DNA sequence 5'-AACAAT-3'. Plays a key role in several developmental processes, including neurogenesis and skeleton formation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi620 – 68869HMG boxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. protein heterodimerization activity Source: MGI
  3. sequence-specific DNA binding Source: MGI
  4. sequence-specific DNA binding transcription factor activity Source: MGI
  5. transcription regulatory region DNA binding Source: MGI

GO - Biological processi

  1. astrocyte differentiation Source: Ensembl
  2. cardiac muscle cell differentiation Source: MGI
  3. cartilage development Source: MGI
  4. cell fate commitment Source: MGI
  5. cell morphogenesis Source: MGI
  6. cellular response to transforming growth factor beta stimulus Source: Ensembl
  7. erythrocyte development Source: MGI
  8. erythrocyte differentiation Source: MGI
  9. gene silencing Source: MGI
  10. hemopoiesis Source: MGI
  11. in utero embryonic development Source: MGI
  12. muscle cell differentiation Source: MGI
  13. negative regulation of transcription, DNA-templated Source: MGI
  14. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  15. oligodendrocyte cell fate specification Source: MGI
  16. oligodendrocyte differentiation Source: MGI
  17. positive regulation of cartilage development Source: Ensembl
  18. positive regulation of chondrocyte differentiation Source: UniProtKB
  19. positive regulation of mesenchymal stem cell differentiation Source: Ensembl
  20. positive regulation of transcription, DNA-templated Source: MGI
  21. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  22. post-embryonic development Source: MGI
  23. regulation of gene expression Source: MGI
  24. regulation of transcription, DNA-templated Source: MGI
  25. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor SOX-6
Alternative name(s):
SOX-LZ
Gene namesi
Name:Sox6
Synonyms:Sox-6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:98368. Sox6.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: MGI
  2. transcription factor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 827827Transcription factor SOX-6PRO_0000048730Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki404 – 404Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity
Cross-linki417 – 417Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity

Post-translational modificationi

Sumoylation inhibits the transcriptional activity.By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiP40645.
PRIDEiP40645.

PTM databases

PhosphoSiteiP40645.

Expressioni

Tissue specificityi

Highly expressed in testis.

Gene expression databases

BgeeiP40645.
CleanExiMM_SOX6.
ExpressionAtlasiP40645. baseline and differential.
GenevestigatoriP40645.

Interactioni

Subunit structurei

Interacts with DAZAP2. May interact with CENPK.1 Publication

Protein-protein interaction databases

BioGridi203410. 5 interactions.
IntActiP40645. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP40645.
SMRiP40645. Positions 618-687.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili184 – 26279Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi233 – 26129Gln-richAdd
BLAST
Compositional biasi240 – 2434Poly-Gln
Compositional biasi280 – 2856Poly-Ala
Compositional biasi313 – 3175Poly-Ala
Compositional biasi514 – 5174Poly-Gln

Sequence similaritiesi

Contains 1 HMG box DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG253815.
HOGENOMiHOG000056455.
HOVERGENiHBG003915.
InParanoidiP40645.
KOiK09269.
OMAiFENLGPQ.
OrthoDBiEOG70087H.
PhylomeDBiP40645.
TreeFamiTF320471.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
IPR027153. SOX-6.
[Graphical view]
PANTHERiPTHR10270:SF89. PTHR10270:SF89. 1 hit.
PfamiPF00505. HMG_box. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: P40645-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSKQATSPF ACTADGEEAM TQDLTSREKE EGSDQHPASH LPLHPIMHNK
60 70 80 90 100
PHSEELPTLV STIQQDADWD SVLSSQQRME SENNKLCSLY SFRNTSTSPH
110 120 130 140 150
KPDEGSRERE IMNSVTFGTP ERRKGSLADV VDTLKQKKLE EMTRTEQEDS
160 170 180 190 200
SCMEKLLSKD WKEKMERLNT SELLGEIKGT PESLAEKERQ LSTMITQLIS
210 220 230 240 250
LREQLLAAHD EQKKLAASQI EKQRQQMDLA RQQQEQIARQ QQQLLQQQHK
260 270 280 290 300
INLLQQQIQV QGHMPPLMIP IFPHDQRTLA AAAAAQQGFL FPPGITYKPG
310 320 330 340 350
DNYPVQFIPS TMAAAAASGL SPLQLQKGHV SHPQINPRLK GISDRFGRNL
360 370 380 390 400
DPSEHGGGHS YNHRQIEQLY AAQLASMQVS PGAKMPSTPQ PPNSAGAVSP
410 420 430 440 450
TGIKNEKRGT SPVTQVKDET TAQPLNLSSR PKTAEPVKSP TSPTQNLFPA
460 470 480 490 500
SKTSPVNLPN KSSIPSPIGG SLGRGSSLDI LSSLNSPALF GDQDTVMKAI
510 520 530 540 550
QEARKMREQI QREQQQQPHG VDGKLSSMNN MGLSNCRTEK ERTRFENLGP
560 570 580 590 600
QLTGKSSEDG KLGPGVIDLT RPEDAEGSKA MNGSAAKLQQ YYCWPTGGAT
610 620 630 640 650
VAEARVYRDA RGRASSEPHI KRPMNAFMVW AKDERRKILQ AFPDMHNSNI
660 670 680 690 700
SKILGSRWKS MSNQEKQPYY EEQARLSKIH LEKYPNYKYK PRPKRTCIVD
710 720 730 740 750
GKKLRIGEYK QLMRSRRQEM RQFFTVGQQP QMPITTGTGV VYPGAITMAT
760 770 780 790 800
TTPSPQMTSD CSSTSASPEP SLPVIQSTYG MKMDGASLAG NDMINGEDEM
810 820
EAYDDYEDDP KSDYSSENEA PEPVSAN
Length:827
Mass (Da):91,803
Last modified:February 1, 1996 - v2
Checksum:iF777BAB7CFB1E93B
GO
Isoform 2 (identifier: P40645-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     327-367: Missing.

Show »
Length:786
Mass (Da):87,192
Checksum:iEFC8E350AEC84653
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti312 – 3132MA → SS in BAA09618. (PubMed:7791783)Curated
Sequence conflicti632 – 6321K → R in CAA46610. (PubMed:1614875)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei327 – 36741Missing in isoform 2. 1 PublicationVSP_002198Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U32614 mRNA. Translation: AAC52263.1.
D61689 mRNA. Translation: BAA09618.1.
AJ010605 mRNA. Translation: CAA09270.1.
X65659 mRNA. Translation: CAA46610.1.
CCDSiCCDS40098.1. [P40645-1]
PIRiS22944.
S59121.
RefSeqiNP_001264255.1. NM_001277326.1. [P40645-1]
NP_001264257.1. NM_001277328.1. [P40645-2]
NP_035575.1. NM_011445.4. [P40645-1]
XP_006507569.1. XM_006507506.1. [P40645-1]
XP_006507570.1. XM_006507507.1. [P40645-1]
XP_006507573.1. XM_006507510.1. [P40645-2]
XP_006507574.1. XM_006507511.1. [P40645-2]
UniGeneiMm.323365.
Mm.487065.

Genome annotation databases

EnsembliENSMUST00000072804; ENSMUSP00000072583; ENSMUSG00000051910. [P40645-1]
ENSMUST00000166207; ENSMUSP00000129027; ENSMUSG00000051910. [P40645-1]
GeneIDi20679.
KEGGimmu:20679.
UCSCiuc009jin.1. mouse. [P40645-2]
uc009jip.1. mouse. [P40645-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U32614 mRNA. Translation: AAC52263.1 .
D61689 mRNA. Translation: BAA09618.1 .
AJ010605 mRNA. Translation: CAA09270.1 .
X65659 mRNA. Translation: CAA46610.1 .
CCDSi CCDS40098.1. [P40645-1 ]
PIRi S22944.
S59121.
RefSeqi NP_001264255.1. NM_001277326.1. [P40645-1 ]
NP_001264257.1. NM_001277328.1. [P40645-2 ]
NP_035575.1. NM_011445.4. [P40645-1 ]
XP_006507569.1. XM_006507506.1. [P40645-1 ]
XP_006507570.1. XM_006507507.1. [P40645-1 ]
XP_006507573.1. XM_006507510.1. [P40645-2 ]
XP_006507574.1. XM_006507511.1. [P40645-2 ]
UniGenei Mm.323365.
Mm.487065.

3D structure databases

ProteinModelPortali P40645.
SMRi P40645. Positions 618-687.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 203410. 5 interactions.
IntActi P40645. 1 interaction.

PTM databases

PhosphoSitei P40645.

Proteomic databases

MaxQBi P40645.
PRIDEi P40645.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000072804 ; ENSMUSP00000072583 ; ENSMUSG00000051910 . [P40645-1 ]
ENSMUST00000166207 ; ENSMUSP00000129027 ; ENSMUSG00000051910 . [P40645-1 ]
GeneIDi 20679.
KEGGi mmu:20679.
UCSCi uc009jin.1. mouse. [P40645-2 ]
uc009jip.1. mouse. [P40645-1 ]

Organism-specific databases

CTDi 55553.
MGIi MGI:98368. Sox6.

Phylogenomic databases

eggNOGi NOG253815.
HOGENOMi HOG000056455.
HOVERGENi HBG003915.
InParanoidi P40645.
KOi K09269.
OMAi FENLGPQ.
OrthoDBi EOG70087H.
PhylomeDBi P40645.
TreeFami TF320471.

Miscellaneous databases

ChiTaRSi SOX6. mouse.
NextBioi 299177.
PROi P40645.
SOURCEi Search...

Gene expression databases

Bgeei P40645.
CleanExi MM_SOX6.
ExpressionAtlasi P40645. baseline and differential.
Genevestigatori P40645.

Family and domain databases

Gene3Di 1.10.30.10. 1 hit.
InterProi IPR009071. HMG_box_dom.
IPR027153. SOX-6.
[Graphical view ]
PANTHERi PTHR10270:SF89. PTHR10270:SF89. 1 hit.
Pfami PF00505. HMG_box. 1 hit.
[Graphical view ]
SMARTi SM00398. HMG. 1 hit.
[Graphical view ]
SUPFAMi SSF47095. SSF47095. 1 hit.
PROSITEi PS50118. HMG_BOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The Sry-related HMG box-containing gene Sox6 is expressed in the adult testis and developing nervous system of the mouse."
    Connor F., Wright E., Denny P., Koopman P., Ashworth A.
    Nucleic Acids Res. 23:3365-3372(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Testis.
  2. "A gene that is related to SRY and is expressed in the testes encodes a leucine zipper-containing protein."
    Takamatsu N., Kanda H., Tsuchiya I., Yamada S., Ito M., Kabeno S., Shiba T., Yamashita S.
    Mol. Cell. Biol. 15:3759-3766(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Strain: C57BL/6.
    Tissue: Testis.
  3. "A new long form of Sox5 (L-Sox5), Sox6 and Sox9 are coexpressed in chondrogenesis and cooperatively activate the type II collagen gene."
    Lefebvre V., Li P., de Crombrugghe B.
    EMBO J. 17:5718-5733(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 519-827.
  4. "A conserved family of genes related to the testis determining gene, SRY."
    Denny P., Swift S., Brand N., Dabhade N., Barton P., Ashworth A.
    Nucleic Acids Res. 20:2887-2887(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 631-684.
    Strain: Parkes.
    Tissue: Brain and Testis.
  5. Lubec G., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 660-666, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: OF1.
    Tissue: Hippocampus.
  6. "Characterization of Solt, a novel SoxLZ/Sox6 binding protein expressed in adult mouse testis."
    Yamashita A., Ito M., Takamatsu N., Shiba T.
    FEBS Lett. 481:147-151(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: POSSIBLE INTERACTION WITH CENPK.
  7. Cited for: INTERACTION WITH DAZAP2.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiSOX6_MOUSE
AccessioniPrimary (citable) accession number: P40645
Secondary accession number(s): Q62250, Q9QWS5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1996
Last modified: October 29, 2014
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3