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P40645

- SOX6_MOUSE

UniProt

P40645 - SOX6_MOUSE

Protein

Transcription factor SOX-6

Gene

Sox6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 124 (01 Oct 2014)
      Sequence version 2 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Transcriptional activator. Binds specifically to the DNA sequence 5'-AACAAT-3'. Plays a key role in several developmental processes, including neurogenesis and skeleton formation.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi620 – 68869HMG boxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: MGI
    2. protein binding Source: MGI
    3. protein heterodimerization activity Source: MGI
    4. sequence-specific DNA binding Source: MGI
    5. sequence-specific DNA binding transcription factor activity Source: MGI
    6. transcription regulatory region DNA binding Source: MGI

    GO - Biological processi

    1. astrocyte differentiation Source: Ensembl
    2. cardiac muscle cell differentiation Source: MGI
    3. cartilage development Source: MGI
    4. cell fate commitment Source: MGI
    5. cell morphogenesis Source: MGI
    6. cellular response to transforming growth factor beta stimulus Source: Ensembl
    7. erythrocyte development Source: MGI
    8. erythrocyte differentiation Source: MGI
    9. gene silencing Source: MGI
    10. hemopoiesis Source: MGI
    11. in utero embryonic development Source: MGI
    12. muscle cell differentiation Source: MGI
    13. negative regulation of transcription, DNA-templated Source: MGI
    14. negative regulation of transcription from RNA polymerase II promoter Source: MGI
    15. oligodendrocyte cell fate specification Source: MGI
    16. oligodendrocyte differentiation Source: MGI
    17. positive regulation of cartilage development Source: Ensembl
    18. positive regulation of chondrocyte differentiation Source: UniProtKB
    19. positive regulation of mesenchymal stem cell differentiation Source: Ensembl
    20. positive regulation of transcription, DNA-templated Source: MGI
    21. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    22. post-embryonic development Source: MGI
    23. regulation of gene expression Source: MGI
    24. regulation of transcription, DNA-templated Source: MGI
    25. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator, Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription factor SOX-6
    Alternative name(s):
    SOX-LZ
    Gene namesi
    Name:Sox6
    Synonyms:Sox-6
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:98368. Sox6.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: MGI
    2. transcription factor complex Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 827827Transcription factor SOX-6PRO_0000048730Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki404 – 404Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity
    Cross-linki417 – 417Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity

    Post-translational modificationi

    Sumoylation inhibits the transcriptional activity.By similarity

    Keywords - PTMi

    Isopeptide bond, Ubl conjugation

    Proteomic databases

    MaxQBiP40645.
    PRIDEiP40645.

    PTM databases

    PhosphoSiteiP40645.

    Expressioni

    Tissue specificityi

    Highly expressed in testis.

    Gene expression databases

    ArrayExpressiP40645.
    BgeeiP40645.
    CleanExiMM_SOX6.
    GenevestigatoriP40645.

    Interactioni

    Subunit structurei

    Interacts with DAZAP2. May interact with CENPK.1 Publication

    Protein-protein interaction databases

    BioGridi203410. 5 interactions.
    IntActiP40645. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliP40645.
    SMRiP40645. Positions 618-687.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili184 – 26279Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi233 – 26129Gln-richAdd
    BLAST
    Compositional biasi240 – 2434Poly-Gln
    Compositional biasi280 – 2856Poly-Ala
    Compositional biasi313 – 3175Poly-Ala
    Compositional biasi514 – 5174Poly-Gln

    Sequence similaritiesi

    Contains 1 HMG box DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG253815.
    HOGENOMiHOG000056455.
    HOVERGENiHBG003915.
    InParanoidiP40645.
    KOiK09269.
    OMAiFENLGPQ.
    OrthoDBiEOG70087H.
    PhylomeDBiP40645.
    TreeFamiTF320471.

    Family and domain databases

    Gene3Di1.10.30.10. 1 hit.
    InterProiIPR009071. HMG_box_dom.
    IPR027153. SOX-6.
    [Graphical view]
    PANTHERiPTHR10270:SF89. PTHR10270:SF89. 1 hit.
    PfamiPF00505. HMG_box. 1 hit.
    [Graphical view]
    SMARTiSM00398. HMG. 1 hit.
    [Graphical view]
    SUPFAMiSSF47095. SSF47095. 1 hit.
    PROSITEiPS50118. HMG_BOX_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Note: Additional isoforms seem to exist.

    Isoform 1 (identifier: P40645-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSSKQATSPF ACTADGEEAM TQDLTSREKE EGSDQHPASH LPLHPIMHNK    50
    PHSEELPTLV STIQQDADWD SVLSSQQRME SENNKLCSLY SFRNTSTSPH 100
    KPDEGSRERE IMNSVTFGTP ERRKGSLADV VDTLKQKKLE EMTRTEQEDS 150
    SCMEKLLSKD WKEKMERLNT SELLGEIKGT PESLAEKERQ LSTMITQLIS 200
    LREQLLAAHD EQKKLAASQI EKQRQQMDLA RQQQEQIARQ QQQLLQQQHK 250
    INLLQQQIQV QGHMPPLMIP IFPHDQRTLA AAAAAQQGFL FPPGITYKPG 300
    DNYPVQFIPS TMAAAAASGL SPLQLQKGHV SHPQINPRLK GISDRFGRNL 350
    DPSEHGGGHS YNHRQIEQLY AAQLASMQVS PGAKMPSTPQ PPNSAGAVSP 400
    TGIKNEKRGT SPVTQVKDET TAQPLNLSSR PKTAEPVKSP TSPTQNLFPA 450
    SKTSPVNLPN KSSIPSPIGG SLGRGSSLDI LSSLNSPALF GDQDTVMKAI 500
    QEARKMREQI QREQQQQPHG VDGKLSSMNN MGLSNCRTEK ERTRFENLGP 550
    QLTGKSSEDG KLGPGVIDLT RPEDAEGSKA MNGSAAKLQQ YYCWPTGGAT 600
    VAEARVYRDA RGRASSEPHI KRPMNAFMVW AKDERRKILQ AFPDMHNSNI 650
    SKILGSRWKS MSNQEKQPYY EEQARLSKIH LEKYPNYKYK PRPKRTCIVD 700
    GKKLRIGEYK QLMRSRRQEM RQFFTVGQQP QMPITTGTGV VYPGAITMAT 750
    TTPSPQMTSD CSSTSASPEP SLPVIQSTYG MKMDGASLAG NDMINGEDEM 800
    EAYDDYEDDP KSDYSSENEA PEPVSAN 827
    Length:827
    Mass (Da):91,803
    Last modified:February 1, 1996 - v2
    Checksum:iF777BAB7CFB1E93B
    GO
    Isoform 2 (identifier: P40645-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         327-367: Missing.

    Show »
    Length:786
    Mass (Da):87,192
    Checksum:iEFC8E350AEC84653
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti312 – 3132MA → SS in BAA09618. (PubMed:7791783)Curated
    Sequence conflicti632 – 6321K → R in CAA46610. (PubMed:1614875)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei327 – 36741Missing in isoform 2. 1 PublicationVSP_002198Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U32614 mRNA. Translation: AAC52263.1.
    D61689 mRNA. Translation: BAA09618.1.
    AJ010605 mRNA. Translation: CAA09270.1.
    X65659 mRNA. Translation: CAA46610.1.
    CCDSiCCDS40098.1. [P40645-1]
    PIRiS22944.
    S59121.
    RefSeqiNP_001264255.1. NM_001277326.1. [P40645-1]
    NP_001264257.1. NM_001277328.1. [P40645-2]
    NP_035575.1. NM_011445.4. [P40645-1]
    XP_006507569.1. XM_006507506.1. [P40645-1]
    XP_006507570.1. XM_006507507.1. [P40645-1]
    XP_006507573.1. XM_006507510.1. [P40645-2]
    XP_006507574.1. XM_006507511.1. [P40645-2]
    UniGeneiMm.323365.
    Mm.487065.

    Genome annotation databases

    EnsembliENSMUST00000072804; ENSMUSP00000072583; ENSMUSG00000051910. [P40645-1]
    ENSMUST00000166207; ENSMUSP00000129027; ENSMUSG00000051910. [P40645-1]
    GeneIDi20679.
    KEGGimmu:20679.
    UCSCiuc009jin.1. mouse. [P40645-2]
    uc009jip.1. mouse. [P40645-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U32614 mRNA. Translation: AAC52263.1 .
    D61689 mRNA. Translation: BAA09618.1 .
    AJ010605 mRNA. Translation: CAA09270.1 .
    X65659 mRNA. Translation: CAA46610.1 .
    CCDSi CCDS40098.1. [P40645-1 ]
    PIRi S22944.
    S59121.
    RefSeqi NP_001264255.1. NM_001277326.1. [P40645-1 ]
    NP_001264257.1. NM_001277328.1. [P40645-2 ]
    NP_035575.1. NM_011445.4. [P40645-1 ]
    XP_006507569.1. XM_006507506.1. [P40645-1 ]
    XP_006507570.1. XM_006507507.1. [P40645-1 ]
    XP_006507573.1. XM_006507510.1. [P40645-2 ]
    XP_006507574.1. XM_006507511.1. [P40645-2 ]
    UniGenei Mm.323365.
    Mm.487065.

    3D structure databases

    ProteinModelPortali P40645.
    SMRi P40645. Positions 618-687.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 203410. 5 interactions.
    IntActi P40645. 1 interaction.

    PTM databases

    PhosphoSitei P40645.

    Proteomic databases

    MaxQBi P40645.
    PRIDEi P40645.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000072804 ; ENSMUSP00000072583 ; ENSMUSG00000051910 . [P40645-1 ]
    ENSMUST00000166207 ; ENSMUSP00000129027 ; ENSMUSG00000051910 . [P40645-1 ]
    GeneIDi 20679.
    KEGGi mmu:20679.
    UCSCi uc009jin.1. mouse. [P40645-2 ]
    uc009jip.1. mouse. [P40645-1 ]

    Organism-specific databases

    CTDi 55553.
    MGIi MGI:98368. Sox6.

    Phylogenomic databases

    eggNOGi NOG253815.
    HOGENOMi HOG000056455.
    HOVERGENi HBG003915.
    InParanoidi P40645.
    KOi K09269.
    OMAi FENLGPQ.
    OrthoDBi EOG70087H.
    PhylomeDBi P40645.
    TreeFami TF320471.

    Miscellaneous databases

    ChiTaRSi SOX6. mouse.
    NextBioi 299177.
    PROi P40645.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P40645.
    Bgeei P40645.
    CleanExi MM_SOX6.
    Genevestigatori P40645.

    Family and domain databases

    Gene3Di 1.10.30.10. 1 hit.
    InterProi IPR009071. HMG_box_dom.
    IPR027153. SOX-6.
    [Graphical view ]
    PANTHERi PTHR10270:SF89. PTHR10270:SF89. 1 hit.
    Pfami PF00505. HMG_box. 1 hit.
    [Graphical view ]
    SMARTi SM00398. HMG. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47095. SSF47095. 1 hit.
    PROSITEi PS50118. HMG_BOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The Sry-related HMG box-containing gene Sox6 is expressed in the adult testis and developing nervous system of the mouse."
      Connor F., Wright E., Denny P., Koopman P., Ashworth A.
      Nucleic Acids Res. 23:3365-3372(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Testis.
    2. "A gene that is related to SRY and is expressed in the testes encodes a leucine zipper-containing protein."
      Takamatsu N., Kanda H., Tsuchiya I., Yamada S., Ito M., Kabeno S., Shiba T., Yamashita S.
      Mol. Cell. Biol. 15:3759-3766(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Strain: C57BL/6.
      Tissue: Testis.
    3. "A new long form of Sox5 (L-Sox5), Sox6 and Sox9 are coexpressed in chondrogenesis and cooperatively activate the type II collagen gene."
      Lefebvre V., Li P., de Crombrugghe B.
      EMBO J. 17:5718-5733(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 519-827.
    4. "A conserved family of genes related to the testis determining gene, SRY."
      Denny P., Swift S., Brand N., Dabhade N., Barton P., Ashworth A.
      Nucleic Acids Res. 20:2887-2887(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 631-684.
      Strain: Parkes.
      Tissue: Brain and Testis.
    5. Lubec G., Sunyer B., Chen W.-Q.
      Submitted (JAN-2009) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 660-666, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: OF1.
      Tissue: Hippocampus.
    6. "Characterization of Solt, a novel SoxLZ/Sox6 binding protein expressed in adult mouse testis."
      Yamashita A., Ito M., Takamatsu N., Shiba T.
      FEBS Lett. 481:147-151(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: POSSIBLE INTERACTION WITH CENPK.
    7. Cited for: INTERACTION WITH DAZAP2.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiSOX6_MOUSE
    AccessioniPrimary (citable) accession number: P40645
    Secondary accession number(s): Q62250, Q9QWS5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 124 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3