ID   HMG_TETPY               Reviewed;          99 AA.
AC   P40625;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   03-MAY-2023, entry version 80.
DE   RecName: Full=High mobility group protein;
DE   AltName: Full=Non-histone chromosomal protein;
GN   Name=HMG;
OS   Tetrahymena pyriformis.
OC   Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC   Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC   Tetrahymena.
OX   NCBI_TaxID=5908;
RN   [1]
RP   PROTEIN SEQUENCE, AND PHOSPHORYLATION AT SER-16; THR-42 AND SER-43.
RC   STRAIN=GL;
RX   PubMed=2760016; DOI=10.1093/oxfordjournals.jbchem.a122707;
RA   Hayashi T., Hayashi H., Iwai K.;
RT   "Tetrahymena HMG nonhistone chromosomal protein. Isolation and amino acid
RT   sequence lacking the N- and C-terminal domains of vertebrate HMG 1.";
RL   J. Biochem. 105:577-581(1989).
CC   -!- SUBCELLULAR LOCATION: Nucleus. Chromosome.
CC   -!- PTM: Phosphorylated at two positions (Ser-16 and Thr-42 or Ser-43),
CC       each 6-7%. {ECO:0000269|PubMed:2760016}.
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DR   PIR; JU0038; JU0038.
DR   AlphaFoldDB; P40625; -.
DR   SMR; P40625; -.
DR   iPTMnet; P40625; -.
DR   GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.30.10; High mobility group box domain; 1.
DR   InterPro; IPR009071; HMG_box_dom.
DR   InterPro; IPR036910; HMG_box_dom_sf.
DR   PANTHER; PTHR48112; HIGH MOBILITY GROUP PROTEIN DSP1; 1.
DR   PANTHER; PTHR48112:SF32; HIGH MOBILITY GROUP PROTEIN DSP1; 1.
DR   Pfam; PF00505; HMG_box; 1.
DR   PRINTS; PR00886; HIGHMOBLTY12.
DR   SMART; SM00398; HMG; 1.
DR   SUPFAM; SSF47095; HMG-box; 1.
DR   PROSITE; PS50118; HMG_BOX_2; 1.
PE   1: Evidence at protein level;
KW   Chromosome; Direct protein sequencing; DNA-binding; Nucleus;
KW   Phosphoprotein.
FT   CHAIN           1..99
FT                   /note="High mobility group protein"
FT                   /id="PRO_0000048560"
FT   DNA_BIND        11..79
FT                   /note="HMG box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
FT   MOD_RES         16
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000269|PubMed:2760016"
FT   MOD_RES         42
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000305|PubMed:2760016"
FT   MOD_RES         43
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000305|PubMed:2760016"
SQ   SEQUENCE   99 AA;  11627 MW;  93BFB012A2D3D7FF CRC64;
     GKVKDDKPAP PKRPLSAFFL FKQHNYDQVK KENPNAKITE LTSMIAEKWK HVTEKEKKKY
     EGLQQEAKAK YEKDMQAYEK KYGKPEKVKK IKKSKKGSK
//