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P40625 (HMG_TETPY) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
High mobility group protein
Alternative name(s):
Non-histone chromosomal protein
Gene names
Name:HMG
OrganismTetrahymena pyriformis
Taxonomic identifier5908 [NCBI]
Taxonomic lineageEukaryotaAlveolataCiliophoraIntramacronucleataOligohymenophoreaHymenostomatidaTetrahymeninaTetrahymenidaeTetrahymena

Protein attributes

Sequence length99 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Nucleus. Chromosome.

Post-translational modification

Phosphorylated at two positions (Ser-16 and Thr-42 or Ser-43), each 6-7%. Ref.1

Sequence similarities

Contains 1 HMG box DNA-binding domain.

Ontologies

Keywords
   Cellular componentChromosome
Nucleus
   LigandDNA-binding
   PTMPhosphoprotein
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Cellular_componentchromosome

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 9999High mobility group protein
PRO_0000048560

Regions

DNA binding11 – 7969HMG box

Amino acid modifications

Modified residue161Phosphoserine Ref.1
Modified residue421Phosphothreonine Probable
Modified residue431Phosphoserine Probable

Sequences

Sequence LengthMass (Da)Tools
P40625 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: 93BFB012A2D3D7FF

FASTA9911,627
        10         20         30         40         50         60 
GKVKDDKPAP PKRPLSAFFL FKQHNYDQVK KENPNAKITE LTSMIAEKWK HVTEKEKKKY 

        70         80         90 
EGLQQEAKAK YEKDMQAYEK KYGKPEKVKK IKKSKKGSK 

« Hide

References

[1]"Tetrahymena HMG nonhistone chromosomal protein. Isolation and amino acid sequence lacking the N- and C-terminal domains of vertebrate HMG 1."
Hayashi T., Hayashi H., Iwai K.
J. Biochem. 105:577-581(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE, PHOSPHORYLATION AT SER-16; THR-42 AND SER-43.
Strain: GL.

Cross-references

Sequence databases

PIRJU0038.

3D structure databases

ProteinModelPortalP40625.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.10.30.10. 1 hit.
InterProIPR009071. HMG_box_dom.
[Graphical view]
PfamPF00505. HMG_box. 1 hit.
[Graphical view]
SMARTSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMSSF47095. SSF47095. 1 hit.
PROSITEPS50118. HMG_BOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHMG_TETPY
AccessionPrimary (citable) accession number: P40625
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: October 16, 2013
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families