P40625 (HMG_TETPY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
High mobility group protein

Alternative name(s):
Non-histone chromosomal protein

Gene names

Name:

HMG

Organism

Tetrahymena pyriformis

Taxonomic identifier

5908 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Alveolata › Ciliophora › Intramacronucleata › Oligohymenophorea › Hymenostomatida › Tetrahymenina › Tetrahymenidae › Tetrahymena

Protein attributes

Sequence length	99 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Nucleus. Chromosome.
Post-translational modification	Phosphorylated at two positions (Ser-16 and Thr-42 or Ser-43), each 6-7%. Ref.1
Sequence similarities	Contains 1 HMG box DNA-binding domain.

Ontologies

Keywords
Cellular component	Chromosome Nucleus
Ligand	DNA-binding
PTM	Phosphoprotein
Technical term	Direct protein sequencing
Gene Ontology (GO)
Cellular_component	chromosome Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 99	99	High mobility group protein		PRO_0000048560
Regions
	DNA binding	11 – 79	69	HMG box
Amino acid modifications
	Modified residue	16	1	Phosphoserine Ref.1
	Modified residue	42	1	Phosphothreonine Probable
	Modified residue	43	1	Phosphoserine Probable

Sequences

	Sequence		Length	Mass (Da)
	P40625 [UniParc]. Last modified February 1, 1995. Version 1. Checksum: 93BFB012A2D3D7FF	FASTA	99	11,627
	10 20 30 40 50 60 GKVKDDKPAP PKRPLSAFFL FKQHNYDQVK KENPNAKITE LTSMIAEKWK HVTEKEKKKY 70 80 90 EGLQQEAKAK YEKDMQAYEK KYGKPEKVKK IKKSKKGSK

References

[1]

"Tetrahymena HMG nonhistone chromosomal protein. Isolation and amino acid sequence lacking the N- and C-terminal domains of vertebrate HMG 1." Hayashi T., Hayashi H., Iwai K. J. Biochem. 105:577-581(1989) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE, PHOSPHORYLATION AT SER-16; THR-42 AND SER-43. Strain: GL.

Cross-references

Sequence databases
PIR	JU0038.
3D structure databases
ProteinModelPortal	P40625.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	1.10.30.10. 1 hit.
InterPro	IPR009071. HMG_box_dom. [Graphical view]
Pfam	PF00505. HMG_box. 1 hit. [Graphical view]
SMART	SM00398. HMG. 1 hit. [Graphical view]
SUPFAM	SSF47095. HMG-box. 1 hit.
PROSITE	PS50118. HMG_BOX_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HMG_TETPY

Accession

Primary (citable) accession number: P40625

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	May 1, 2013
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)