Reviewed, UniProtKB/Swiss-Prot P40617 (ARL4A_HUMAN)

Names and origin

Protein names

Recommended name:
    ADP-ribosylation factor-like protein 4A

Gene names

Name:	ARL4A
Synonyms:	ARL4

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	200 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Does not act as an allosteric activator of the cholera toxin catalytic subunit By similarity.
Subcellular location	Nucleus.
Sequence similarities	Belongs to the small GTPase superfamily. Arf family.

Ontologies

Keywords
Cellular component	Nucleus
Coding sequence diversity	Polymorphism
Ligand	GTP-binding Nucleotide-binding
PTM	Lipoprotein Myristate
Gene Ontology (GO)
Biological process	small GTPase mediated signal transduction Inferred from electronic annotation. Source: InterPro
Cellular component	nucleus Ref.5 Traceable author statement. Source: ProtInc
Molecular function	GTP binding Inferred from electronic annotation. Source: InterPro GTPase activity Ref.5 Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Potential
	Chain	2 – 200	199	ADP-ribosylation factor-like protein 4A		PRO_0000207459
Regions
	Nucleotide binding	27 – 34	8	GTP By similarity
	Nucleotide binding	75 – 79	5	GTP By similarity
	Nucleotide binding	134 – 137	4	GTP By similarity
Amino acid modifications
	Lipidation	2	1	N-myristoyl glycine Potential
Natural variations
	Natural variant	139	1	R → K: dbSNP rs2953325.		VAR_024367

Sequences

	Sequence		Length	Mass (Da)
	P40617-1 [UniParc]. Last modified November 1, 1995. Version 2. Checksum: 8D93A8C003BD16CF	FASTA	200	22,615
	10 20 30 40 50 60 MGNGLSDQTS ILSNLPSFQS FHIVILGLDC AGKTTVLYRL QFNEFVNTVP TKGFNTEKIK 70 80 90 100 110 120 VTLGNSKTVT FHFWDVGGQE KLRPLWKSYT RCTDGIVFVV DSVDVERMEE AKTELHKITR 130 140 150 160 170 180 ISENQGVPVL IVANKQDLRN SLSLSEIEKL LAMGELSSST PWHLQPTCAI IGDGLKEGLE 190 200 KLHDMIIKRR KMLRQQKKKR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Rosenwald A.G., Kahn R.A. Submitted (JAN-1995) to UniProtKB Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Umbilical vein endothelial cell.
[2]	Choe I. Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver.
[3]	"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." Puhl H.L. III, Ikeda S.R., Aronstam R.S. Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Skin and Testis.
[5]	"ADP-ribosylation factor (ARF)-like 4, 6, and 7 represent a subgroup of the ARF family characterization by rapid nucleotide exchange and a nuclear localization signal." Jacobs S., Schilf C., Fliegert F., Koling S., Weber Y., Schurmann A., Joost H.-G. FEBS Lett. 456:384-388(1999) [PubMed: 10462049] [Abstract] Cited for: SUBCELLULAR LOCATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U73960 mRNA. Translation: AAB39713.1. AF493890 mRNA. Translation: AAM12604.1. BC001111 mRNA. Translation: AAH01111.1. BC003027 mRNA. Translation: AAH03027.1. BC039123 mRNA. Translation: AAH39123.1.
RefSeq	NP_001032241.1. NP_005729.1. NP_997625.1.
UniGene	Hs.245540
3D structure databases
HSSP	HSSP built from PDB template 1MOZ based on UniProtKB P38116.
ModBase	Search...
Genome annotation databases
Ensembl	ENSG00000122644. Homo sapiens. [Contig view]
GeneID	10124.
KEGG	hsa:10124.
Organism-specific databases
H-InvDB	HIX0006491.
HGNC	HGNC:695. ARL4A.
MIM	604786. gene.
PharmGKB	PA24988.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOGENOM	P40617.
HOVERGEN	P40617.
Gene expression databases
ArrayExpress	P40617.
CleanEx	HS_ARL4A.
GermOnline	ENSG00000122644. Homo sapiens.
Family and domain databases
InterPro	IPR006688. ARF. IPR006689. ARF/SAR. IPR001806. Ras_trnsfrmng. IPR005225. Small_GTP_bd. [Graphical view]
PANTHER	PTHR11711. ARF/SAR. 1 hit.
Pfam	PF00025. Arf. 1 hit. [Graphical view]
PRINTS	PR00449. RASTRNSFRMNG. PR00328. SAR1GTPBP.
SMART	SM00177. ARF. 1 hit. [Graphical view]
TIGRFAMs	TIGR00231. small_GTP. 1 hit.
PROSITE	PS01019. ARF. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
LinkHub	P40617.
NextBio	38291.
SOURCE	Search...

Entry information

Entry name

ARL4A_HUMAN

Accession

Primary (citable) accession number: P40617
Secondary accession number(s): P80418, Q49AF5

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	November 1, 1995
Last modified:	November 25, 2008
This is version 79 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)