Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

ADP-ribosylation factor-like protein 4A

Gene

ARL4A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi27 – 34GTPBy similarity8
Nucleotide bindingi75 – 79GTPBy similarity5
Nucleotide bindingi134 – 137GTPBy similarity4

GO - Molecular functioni

  • GTP binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000122644-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosylation factor-like protein 4A
Gene namesi
Name:ARL4A
Synonyms:ARL4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:695. ARL4A.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: HPA
  • nucleolus Source: UniProtKB
  • nucleoplasm Source: HPA
  • nucleus Source: UniProtKB
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi34T → N: Inhibits relocalization of CYTH2 to the plasma membrane. Strongly localized in the nucleolus. 2 Publications1
Mutagenesisi79Q → L: Localized in the nucleus and nucleolus. 2 Publications1

Organism-specific databases

DisGeNETi10124.
OpenTargetsiENSG00000122644.
PharmGKBiPA24988.

Polymorphism and mutation databases

BioMutaiARL4A.
DMDMi1168495.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedSequence analysis
ChainiPRO_00002074592 – 200ADP-ribosylation factor-like protein 4AAdd BLAST199

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineSequence analysis1

Post-translational modificationi

Myristoylated.1 Publication

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

EPDiP40617.
PaxDbiP40617.
PeptideAtlasiP40617.
PRIDEiP40617.

PTM databases

iPTMnetiP40617.
PhosphoSitePlusiP40617.

Expressioni

Gene expression databases

BgeeiENSG00000122644.
CleanExiHS_ARL4A.
ExpressionAtlasiP40617. baseline and differential.
GenevisibleiP40617. HS.

Organism-specific databases

HPAiHPA064513.

Interactioni

Subunit structurei

Interacts with CYTH2. Interacts with KPNA2; the interaction is direct. Does not interacts with ARL4A.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CCDC102BA1A4H13EBI-2875746,EBI-10171570
CCDC57Q2TAC23EBI-2875746,EBI-2808286
GOLGA2Q083793EBI-2875746,EBI-618309
SPATC1LQ9H0A93EBI-2875746,EBI-372911

Protein-protein interaction databases

BioGridi115428. 6 interactors.
IntActiP40617. 9 interactors.
STRINGi9606.ENSP00000349250.

Structurei

3D structure databases

ProteinModelPortaliP40617.
SMRiP40617.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Arf family.Curated

Phylogenomic databases

eggNOGiKOG0070. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00840000129731.
HOGENOMiHOG000163691.
HOVERGENiHBG002073.
InParanoidiP40617.
KOiK07945.
OMAiCFHIVIL.
OrthoDBiEOG091G0LK5.
PhylomeDBiP40617.
TreeFamiTF105464.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR024156. Small_GTPase_ARF.
IPR006689. Small_GTPase_ARF/SAR.
[Graphical view]
PfamiPF00025. Arf. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51417. ARF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P40617-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNGLSDQTS ILSNLPSFQS FHIVILGLDC AGKTTVLYRL QFNEFVNTVP
60 70 80 90 100
TKGFNTEKIK VTLGNSKTVT FHFWDVGGQE KLRPLWKSYT RCTDGIVFVV
110 120 130 140 150
DSVDVERMEE AKTELHKITR ISENQGVPVL IVANKQDLRN SLSLSEIEKL
160 170 180 190 200
LAMGELSSST PWHLQPTCAI IGDGLKEGLE KLHDMIIKRR KMLRQQKKKR
Length:200
Mass (Da):22,615
Last modified:November 1, 1995 - v2
Checksum:i8D93A8C003BD16CF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U73960 mRNA. Translation: AAB39713.1.
AK313233 mRNA. Translation: BAG36044.1.
AF493890 mRNA. Translation: AAM12604.1.
CH236948 Genomic DNA. Translation: EAL24295.1.
CH471073 Genomic DNA. Translation: EAW93650.1.
BC001111 mRNA. Translation: AAH01111.1.
BC003027 mRNA. Translation: AAH03027.1.
CCDSiCCDS5359.1.
RefSeqiNP_001032241.1. NM_001037164.2.
NP_001182325.1. NM_001195396.1.
NP_005729.1. NM_005738.4.
NP_997625.1. NM_212460.3.
UniGeneiHs.245540.

Genome annotation databases

EnsembliENST00000356797; ENSP00000349250; ENSG00000122644.
ENST00000396662; ENSP00000379897; ENSG00000122644.
ENST00000396663; ENSP00000379898; ENSG00000122644.
ENST00000396664; ENSP00000379899; ENSG00000122644.
ENST00000404894; ENSP00000385236; ENSG00000122644.
GeneIDi10124.
KEGGihsa:10124.
UCSCiuc003ssp.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U73960 mRNA. Translation: AAB39713.1.
AK313233 mRNA. Translation: BAG36044.1.
AF493890 mRNA. Translation: AAM12604.1.
CH236948 Genomic DNA. Translation: EAL24295.1.
CH471073 Genomic DNA. Translation: EAW93650.1.
BC001111 mRNA. Translation: AAH01111.1.
BC003027 mRNA. Translation: AAH03027.1.
CCDSiCCDS5359.1.
RefSeqiNP_001032241.1. NM_001037164.2.
NP_001182325.1. NM_001195396.1.
NP_005729.1. NM_005738.4.
NP_997625.1. NM_212460.3.
UniGeneiHs.245540.

3D structure databases

ProteinModelPortaliP40617.
SMRiP40617.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115428. 6 interactors.
IntActiP40617. 9 interactors.
STRINGi9606.ENSP00000349250.

PTM databases

iPTMnetiP40617.
PhosphoSitePlusiP40617.

Polymorphism and mutation databases

BioMutaiARL4A.
DMDMi1168495.

Proteomic databases

EPDiP40617.
PaxDbiP40617.
PeptideAtlasiP40617.
PRIDEiP40617.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000356797; ENSP00000349250; ENSG00000122644.
ENST00000396662; ENSP00000379897; ENSG00000122644.
ENST00000396663; ENSP00000379898; ENSG00000122644.
ENST00000396664; ENSP00000379899; ENSG00000122644.
ENST00000404894; ENSP00000385236; ENSG00000122644.
GeneIDi10124.
KEGGihsa:10124.
UCSCiuc003ssp.4. human.

Organism-specific databases

CTDi10124.
DisGeNETi10124.
GeneCardsiARL4A.
HGNCiHGNC:695. ARL4A.
HPAiHPA064513.
MIMi604786. gene.
neXtProtiNX_P40617.
OpenTargetsiENSG00000122644.
PharmGKBiPA24988.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0070. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00840000129731.
HOGENOMiHOG000163691.
HOVERGENiHBG002073.
InParanoidiP40617.
KOiK07945.
OMAiCFHIVIL.
OrthoDBiEOG091G0LK5.
PhylomeDBiP40617.
TreeFamiTF105464.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000122644-MONOMER.

Miscellaneous databases

GeneWikiiARL4A.
GenomeRNAii10124.
PROiP40617.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000122644.
CleanExiHS_ARL4A.
ExpressionAtlasiP40617. baseline and differential.
GenevisibleiP40617. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR024156. Small_GTPase_ARF.
IPR006689. Small_GTPase_ARF/SAR.
[Graphical view]
PfamiPF00025. Arf. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51417. ARF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiARL4A_HUMAN
AccessioniPrimary (citable) accession number: P40617
Secondary accession number(s): A4D119, P80418, Q49AF5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: November 1, 1995
Last modified: November 30, 2016
This is version 153 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.