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Protein

ADP-ribosylation factor-like protein 4A

Gene

ARL4A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi27 – 34GTPBy similarity8
Nucleotide bindingi75 – 79GTPBy similarity5
Nucleotide bindingi134 – 137GTPBy similarity4

GO - Molecular functioni

  • GTP binding Source: UniProtKB

GO - Biological processi

Keywordsi

LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosylation factor-like protein 4A
Gene namesi
Name:ARL4A
Synonyms:ARL4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:695. ARL4A.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: HPA
  • nucleolus Source: UniProtKB
  • nucleoplasm Source: HPA
  • nucleus Source: UniProtKB
  • plasma membrane Source: UniProtKB

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi34T → N: Inhibits relocalization of CYTH2 to the plasma membrane. Strongly localized in the nucleolus. 2 Publications1
Mutagenesisi79Q → L: Localized in the nucleus and nucleolus. 2 Publications1

Organism-specific databases

DisGeNETi10124.
OpenTargetsiENSG00000122644.
PharmGKBiPA24988.

Polymorphism and mutation databases

BioMutaiARL4A.
DMDMi1168495.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedSequence analysis
ChainiPRO_00002074592 – 200ADP-ribosylation factor-like protein 4AAdd BLAST199

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineSequence analysis1

Post-translational modificationi

Myristoylated.1 Publication

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

EPDiP40617.
PaxDbiP40617.
PeptideAtlasiP40617.
PRIDEiP40617.

PTM databases

iPTMnetiP40617.
PhosphoSitePlusiP40617.

Expressioni

Gene expression databases

BgeeiENSG00000122644.
CleanExiHS_ARL4A.
ExpressionAtlasiP40617. baseline and differential.
GenevisibleiP40617. HS.

Organism-specific databases

HPAiHPA064513.

Interactioni

Subunit structurei

Interacts with CYTH2. Interacts with KPNA2; the interaction is direct. Does not interacts with ARL4A.2 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi115428. 11 interactors.
IntActiP40617. 9 interactors.
STRINGi9606.ENSP00000349250.

Structurei

3D structure databases

ProteinModelPortaliP40617.
SMRiP40617.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Arf family.Curated

Phylogenomic databases

eggNOGiKOG0070. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00780000121855.
HOGENOMiHOG000163691.
HOVERGENiHBG002073.
InParanoidiP40617.
KOiK07945.
OMAiCFHIVIL.
OrthoDBiEOG091G0LK5.
PhylomeDBiP40617.
TreeFamiTF105464.

Family and domain databases

InterProiView protein in InterPro
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR024156. Small_GTPase_ARF.
IPR006689. Small_GTPase_ARF/SAR.
PfamiView protein in Pfam
PF00025. Arf. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiView protein in PROSITE
PS51417. ARF. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P40617-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNGLSDQTS ILSNLPSFQS FHIVILGLDC AGKTTVLYRL QFNEFVNTVP
60 70 80 90 100
TKGFNTEKIK VTLGNSKTVT FHFWDVGGQE KLRPLWKSYT RCTDGIVFVV
110 120 130 140 150
DSVDVERMEE AKTELHKITR ISENQGVPVL IVANKQDLRN SLSLSEIEKL
160 170 180 190 200
LAMGELSSST PWHLQPTCAI IGDGLKEGLE KLHDMIIKRR KMLRQQKKKR
Length:200
Mass (Da):22,615
Last modified:November 1, 1995 - v2
Checksum:i8D93A8C003BD16CF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U73960 mRNA. Translation: AAB39713.1.
AK313233 mRNA. Translation: BAG36044.1.
AF493890 mRNA. Translation: AAM12604.1.
CH236948 Genomic DNA. Translation: EAL24295.1.
CH471073 Genomic DNA. Translation: EAW93650.1.
BC001111 mRNA. Translation: AAH01111.1.
BC003027 mRNA. Translation: AAH03027.1.
CCDSiCCDS5359.1.
RefSeqiNP_001032241.1. NM_001037164.2.
NP_001182325.1. NM_001195396.1.
NP_005729.1. NM_005738.4.
NP_997625.1. NM_212460.3.
UniGeneiHs.245540.

Genome annotation databases

EnsembliENST00000356797; ENSP00000349250; ENSG00000122644.
ENST00000396662; ENSP00000379897; ENSG00000122644.
ENST00000396663; ENSP00000379898; ENSG00000122644.
ENST00000396664; ENSP00000379899; ENSG00000122644.
ENST00000404894; ENSP00000385236; ENSG00000122644.
GeneIDi10124.
KEGGihsa:10124.
UCSCiuc003ssp.4. human.

Similar proteinsi

Entry informationi

Entry nameiARL4A_HUMAN
AccessioniPrimary (citable) accession number: P40617
Secondary accession number(s): A4D119, P80418, Q49AF5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: November 1, 1995
Last modified: August 30, 2017
This is version 159 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families