P40612 (SPAM_SALTY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Surface presentation of antigens protein SpaM

Alternative name(s):
Invasion protein InvI

Gene names

Name:	spaM
Synonyms:	invI
Ordered Locus Names:	STM2893

Organism

Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) [Reference proteome] [HAMAP]

Taxonomic identifier

99287 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella › Salmonella choleraesuis › Salmonella enterica I › Salmonella typhimurium

Protein attributes

Sequence length	147 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in a secretory pathway responsible for the surface presentation of determinants needed for the entry of Salmonella species into mammalian cells.
Sequence similarities	Belongs to the SpaM family.

Ontologies

Keywords
Biological process	Virulence
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	pathogenesis Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 147	147	Surface presentation of antigens protein SpaM		PRO_0000180934

Sequences

	Sequence		Length	Mass (Da)
	P40612 [UniParc]. Last modified February 1, 1995. Version 1. Checksum: D0872251FC1A6982	FASTA	147	18,089
	10 20 30 40 50 60 MHSLTRIKVL QRRCTVFHSQ CESILLRYQD EDRGLQAEEE AILEQIAGLK LLLDTLRAEN 70 80 90 100 110 120 RQLSREEIYT LLRKQSIVRR QIKDLELQII QIQEKRSELE KKREEFQKKS KYWLRKEGNY 130 140 QRWIIRQKRF YIQREIQQEE AESEEII

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cognate gene clusters govern invasion of host epithelial cells by Salmonella typhimurium and Shigella flexneri." Groisman E.A., Ochman H. EMBO J. 12:3779-3787(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Functional analysis of the Salmonella typhimurium invasion genes invl and invJ and identification of a target of the protein secretion apparatus encoded in the inv locus." Collazo C., Zierler M.K., Galan J.E. Mol. Microbiol. 15:25-38(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: SR-11.
[3]	Boyd E.F., Li J., Nelson K., Ochman H., Selander R.K. Submitted (JAN-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: S4194.
[4]	"Complete genome sequence of Salmonella enterica serovar Typhimurium LT2." McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P., Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D., Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E. , Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R., Wilson R.K. Nature 413:852-856(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: LT2 / SGSC1412 / ATCC 700720.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U10872 Genomic DNA. Translation: AAA83430.1. X73525 Genomic DNA. Translation: CAA51922.1. U43300 Genomic DNA. Translation: AAC44990.1. AE006468 Genomic DNA. Translation: AAL21773.1.
PIR	S37305.
RefSeq	NP_461814.1. NC_003197.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	99287.STM2893.
Proteomic databases
PRIDE	P40612.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAL21773; AAL21773; STM2893.
GeneID	1254416.
KEGG	stm:STM2893.
PATRIC	32384474. VBISalEnt20916_3049.
Phylogenomic databases
eggNOG	NOG40270.
HOGENOM	HOG000028228.
OMA	CEASLQK.
ProtClustDB	PRK15335.
Family and domain databases
InterPro	IPR002954. Salm_SPAgM. [Graphical view]
Pfam	PF02090. SPAM. 1 hit. [Graphical view]
PRINTS	PR01227. SSPAMPROTEIN.
ProtoNet	Search...

Entry information

Entry name

SPAM_SALTY

Accession

Primary (citable) accession number: P40612

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	May 1, 2013
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program