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Protein

Aspartic proteinase yapsin-6

Gene

YPS6

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Cleaves proteins C-terminally to mono- and paired-basic residues (By similarity). Required for cell wall integrity.By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei85PROSITE-ProRule annotation1
Active sitei324PROSITE-ProRule annotation1

GO - Molecular functioni

  • aspartic-type endopeptidase activity Source: SGD

GO - Biological processi

  • fungal-type cell wall organization Source: SGD
  • protein catabolic process Source: GO_Central
  • proteolysis Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Aspartyl protease, Hydrolase, Protease

Enzyme and pathway databases

BioCyciYEAST:G3O-31451-MONOMER.

Protein family/group databases

MEROPSiA01.A62.

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartic proteinase yapsin-6 (EC:3.4.23.-)
Gene namesi
Name:YPS6
Ordered Locus Names:YIR039C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IX

Organism-specific databases

EuPathDBiFungiDB:YIR039C.
SGDiS000001478. YPS6.

Subcellular locationi

  • Cell membrane 1 Publication; Lipid-anchorGPI-anchor 1 Publication

GO - Cellular componenti

  • anchored component of membrane Source: UniProtKB-KW
  • fungal-type cell wall Source: SGD
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
PropeptideiPRO_000002584425 – 52Sequence analysisAdd BLAST28
ChainiPRO_000002584553 – 515Aspartic proteinase yapsin-6Add BLAST463
PropeptideiPRO_0000025846516 – 537Removed in mature formSequence analysisAdd BLAST22

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi57N-linked (GlcNAc...)Sequence analysis1
Glycosylationi149N-linked (GlcNAc...)Sequence analysis1
Glycosylationi156N-linked (GlcNAc...)Sequence analysis1
Glycosylationi161N-linked (GlcNAc...)Sequence analysis1
Glycosylationi183N-linked (GlcNAc...)Sequence analysis1
Glycosylationi195N-linked (GlcNAc...)Sequence analysis1
Glycosylationi311N-linked (GlcNAc...)Sequence analysis1
Glycosylationi363N-linked (GlcNAc...)Sequence analysis1
Glycosylationi375N-linked (GlcNAc...)Sequence analysis1
Glycosylationi379N-linked (GlcNAc...)Sequence analysis1
Glycosylationi472N-linked (GlcNAc...)Sequence analysis1
Lipidationi515GPI-anchor amidated asparagineSequence analysis1

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein, GPI-anchor, Lipoprotein, Zymogen

Proteomic databases

MaxQBiP40583.
PRIDEiP40583.

Interactioni

Protein-protein interaction databases

BioGridi35030. 10 interactors.
DIPiDIP-2688N.
IntActiP40583. 2 interactors.
MINTiMINT-512020.

Structurei

3D structure databases

ProteinModelPortaliP40583.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini67 – 426Peptidase A1PROSITE-ProRule annotationAdd BLAST360

Sequence similaritiesi

Belongs to the peptidase A1 family.Curated
Contains 1 peptidase A1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00550000075429.
HOGENOMiHOG000248646.
InParanoidiP40583.
OMAiANTNFNS.
OrthoDBiEOG092C3KPP.

Family and domain databases

CDDicd05474. SAP_like. 1 hit.
Gene3Di2.40.70.10. 2 hits.
InterProiIPR001461. Aspartic_peptidase_A1.
IPR001969. Aspartic_peptidase_AS.
IPR033121. PEPTIDASE_A1.
IPR021109. Peptidase_aspartic_dom.
IPR033876. SAP-like.
[Graphical view]
PANTHERiPTHR13683. PTHR13683. 3 hits.
PfamiPF00026. Asp. 1 hit.
[Graphical view]
PRINTSiPR00792. PEPSIN.
SUPFAMiSSF50630. SSF50630. 2 hits.
PROSITEiPS00141. ASP_PROTEASE. 1 hit.
PS51767. PEPTIDASE_A1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P40583-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLISILSLL SSLMCSLTVL GSSASSYVKF PVQKLADIIN ICTQDVSTVF
60 70 80 90 100
KRNEVLNTTV INGIGVYVVK MEIGTPPQTL YLQLDTGSSD MIVNNADIAY
110 120 130 140 150
CKSMSDGSDY ASTDNYELTA TFNGLPSTTI SSEAYNTLCS YWGTFDASNS
160 170 180 190 200
STFENNATFF NNTYGDGTYY AGTYGTDVVS FENITLNDFT FGVSNDTIGN
210 220 230 240 250
PSGILGISLP IAEFTDGIEY ALALNRTPFI YDNFPMELKN QGKINKIAYS
260 270 280 290 300
LFLNGPDAHF GSILFGAVDK SKYTGQLYTL PMLQAFNTLG SNPGMIITAQ
310 320 330 340 350
SVAILDSESG NKTVSDIQFP VMLDSGTTFS YLPTEIAEAI GKSFDGEYSS
360 370 380 390 400
DDQGYIFDCS KVNDTLLSVD FGGFNISANI SNFVTSAKDR CVLNVKQSES
410 420 430 440 450
TYMLGDAFLV DAYVVYDLEN YEISIAQASF NNQEEDIEVI SDTVPGATPA
460 470 480 490 500
PGYFSTWVYK PGSPIGTGDF INVSWTSYSE FSQYKSLLAT AAQSDDASSF
510 520 530
SSSGGSSEST TKKQNAGYKY RSSFSFSLLS FISYFLL
Length:537
Mass (Da):58,214
Last modified:February 1, 1995 - v1
Checksum:i80C14D25D49D32CE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z38061 Genomic DNA. Translation: CAA86199.1.
Z46902 Genomic DNA. Translation: CAA86998.1.
BK006942 Genomic DNA. Translation: DAA08586.1.
PIRiS50344.
RefSeqiNP_012305.3. NM_001179561.3.

Genome annotation databases

EnsemblFungiiYIR039C; YIR039C; YIR039C.
GeneIDi854857.
KEGGisce:YIR039C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z38061 Genomic DNA. Translation: CAA86199.1.
Z46902 Genomic DNA. Translation: CAA86998.1.
BK006942 Genomic DNA. Translation: DAA08586.1.
PIRiS50344.
RefSeqiNP_012305.3. NM_001179561.3.

3D structure databases

ProteinModelPortaliP40583.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35030. 10 interactors.
DIPiDIP-2688N.
IntActiP40583. 2 interactors.
MINTiMINT-512020.

Protein family/group databases

MEROPSiA01.A62.

Proteomic databases

MaxQBiP40583.
PRIDEiP40583.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYIR039C; YIR039C; YIR039C.
GeneIDi854857.
KEGGisce:YIR039C.

Organism-specific databases

EuPathDBiFungiDB:YIR039C.
SGDiS000001478. YPS6.

Phylogenomic databases

GeneTreeiENSGT00550000075429.
HOGENOMiHOG000248646.
InParanoidiP40583.
OMAiANTNFNS.
OrthoDBiEOG092C3KPP.

Enzyme and pathway databases

BioCyciYEAST:G3O-31451-MONOMER.

Miscellaneous databases

PROiP40583.

Family and domain databases

CDDicd05474. SAP_like. 1 hit.
Gene3Di2.40.70.10. 2 hits.
InterProiIPR001461. Aspartic_peptidase_A1.
IPR001969. Aspartic_peptidase_AS.
IPR033121. PEPTIDASE_A1.
IPR021109. Peptidase_aspartic_dom.
IPR033876. SAP-like.
[Graphical view]
PANTHERiPTHR13683. PTHR13683. 3 hits.
PfamiPF00026. Asp. 1 hit.
[Graphical view]
PRINTSiPR00792. PEPSIN.
SUPFAMiSSF50630. SSF50630. 2 hits.
PROSITEiPS00141. ASP_PROTEASE. 1 hit.
PS51767. PEPTIDASE_A1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiYPS6_YEAST
AccessioniPrimary (citable) accession number: P40583
Secondary accession number(s): D6VVX0, E9PAD7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 30, 2016
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome IX
    Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.