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Protein

Glutathione S-transferase 1

Gene

GTT1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

GO - Molecular functioni

  • glutathione peroxidase activity Source: SGD
  • glutathione transferase activity Source: SGD

GO - Biological processi

  • glutathione metabolic process Source: SGD
  • protein glutathionylation Source: SGD

Keywordsi

Molecular functionTransferase

Enzyme and pathway databases

BioCyciYEAST:YIR038C-MONOMER.
SABIO-RKiP40582.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase 1 (EC:2.5.1.18)
Alternative name(s):
GST-I
Gene namesi
Name:GTT1
Ordered Locus Names:YIR038C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IX

Organism-specific databases

EuPathDBiFungiDB:YIR038C.
SGDiS000001477. GTT1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001859871 – 234Glutathione S-transferase 1Add BLAST234

Proteomic databases

MaxQBiP40582.
PRIDEiP40582.

PTM databases

iPTMnetiP40582.

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

BioGridi35029. 100 interactors.
DIPiDIP-2103N.
IntActiP40582. 69 interactors.
MINTiMINT-566298.
STRINGi4932.YIR038C.

Structurei

3D structure databases

ProteinModelPortaliP40582.
SMRiP40582.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 90GST N-terminalAdd BLAST88
Domaini96 – 234GST C-terminalAdd BLAST139

Sequence similaritiesi

Belongs to the GST superfamily.Curated

Phylogenomic databases

HOGENOMiHOG000125753.
InParanoidiP40582.
KOiK00799.
OMAiADVQMSF.
OrthoDBiEOG092C40MQ.

Family and domain databases

InterProiView protein in InterPro
IPR010987. Glutathione-S-Trfase_C-like.
IPR036282. Glutathione-S-Trfase_C_sf.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR036249. Thioredoxin-like_sf.
PfamiView protein in Pfam
PF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiView protein in PROSITE
PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.

Sequencei

Sequence statusi: Complete.

P40582-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLPIIKVHW LDHSRAFRLL WLLDHLNLEY EIVPYKRDAN FRAPPELKKI
60 70 80 90 100
HPLGRSPLLE VQDRETGKKK ILAESGFIFQ YVLQHFDHSH VLMSEDADIA
110 120 130 140 150
DQINYYLFYV EGSLQPPLMI EFILSKVKDS GMPFPISYLA RKVADKISQA
160 170 180 190 200
YSSGEVKNQF DFVEGEISKN NGYLVDGKLS GADILMSFPL QMAFERKFAA
210 220 230
PEDYPAISKW LKTITSEESY AASKEKARAL GSNF
Length:234
Mass (Da):26,795
Last modified:February 1, 1995 - v1
Checksum:i3C07D40D29F60DFF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z38061 Genomic DNA. Translation: CAA86198.1.
BK006942 Genomic DNA. Translation: DAA08585.1.
PIRiS48500.
RefSeqiNP_012304.1. NM_001179560.1.

Genome annotation databases

EnsemblFungiiYIR038C; YIR038C; YIR038C.
GeneIDi854856.
KEGGisce:YIR038C.

Similar proteinsi

Entry informationi

Entry nameiGST1_YEAST
AccessioniPrimary (citable) accession number: P40582
Secondary accession number(s): D6VVW9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: October 25, 2017
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IX
    Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names