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P40582

- GST1_YEAST

UniProt

P40582 - GST1_YEAST

Protein

Glutathione S-transferase 1

Gene

GTT1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    RX + glutathione = HX + R-S-glutathione.

    GO - Molecular functioni

    1. glutathione peroxidase activity Source: SGD
    2. glutathione transferase activity Source: SGD

    GO - Biological processi

    1. glutathione metabolic process Source: SGD
    2. oxidation-reduction process Source: GOC

    Keywords - Molecular functioni

    Transferase

    Enzyme and pathway databases

    BioCyciYEAST:YIR038C-MONOMER.
    SABIO-RKP40582.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutathione S-transferase 1 (EC:2.5.1.18)
    Alternative name(s):
    GST-I
    Gene namesi
    Name:GTT1
    Ordered Locus Names:YIR038C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome IX

    Organism-specific databases

    CYGDiYIR038c.
    SGDiS000001477. GTT1.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum Source: SGD
    2. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 234234Glutathione S-transferase 1PRO_0000185987Add
    BLAST

    Proteomic databases

    MaxQBiP40582.
    PaxDbiP40582.

    Expressioni

    Gene expression databases

    GenevestigatoriP40582.

    Interactioni

    Subunit structurei

    Homodimer.

    Protein-protein interaction databases

    BioGridi35029. 88 interactions.
    DIPiDIP-2103N.
    IntActiP40582. 64 interactions.
    MINTiMINT-566298.
    STRINGi4932.YIR038C.

    Structurei

    3D structure databases

    ProteinModelPortaliP40582.
    SMRiP40582. Positions 5-226.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini3 – 9088GST N-terminalAdd
    BLAST
    Domaini96 – 234139GST C-terminalAdd
    BLAST

    Sequence similaritiesi

    Belongs to the GST superfamily.Curated
    Contains 1 GST C-terminal domain.Curated
    Contains 1 GST N-terminal domain.Curated

    Phylogenomic databases

    eggNOGiCOG0625.
    HOGENOMiHOG000125753.
    KOiK00799.
    OMAiDIQMSFI.
    OrthoDBiEOG7BZW43.

    Family and domain databases

    Gene3Di1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProiIPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR004046. GST_C.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view]
    PfamiPF00043. GST_C. 1 hit.
    PF02798. GST_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEiPS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P40582-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSLPIIKVHW LDHSRAFRLL WLLDHLNLEY EIVPYKRDAN FRAPPELKKI    50
    HPLGRSPLLE VQDRETGKKK ILAESGFIFQ YVLQHFDHSH VLMSEDADIA 100
    DQINYYLFYV EGSLQPPLMI EFILSKVKDS GMPFPISYLA RKVADKISQA 150
    YSSGEVKNQF DFVEGEISKN NGYLVDGKLS GADILMSFPL QMAFERKFAA 200
    PEDYPAISKW LKTITSEESY AASKEKARAL GSNF 234
    Length:234
    Mass (Da):26,795
    Last modified:February 1, 1995 - v1
    Checksum:i3C07D40D29F60DFF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z38061 Genomic DNA. Translation: CAA86198.1.
    BK006942 Genomic DNA. Translation: DAA08585.1.
    PIRiS48500.
    RefSeqiNP_012304.1. NM_001179560.1.

    Genome annotation databases

    EnsemblFungiiYIR038C; YIR038C; YIR038C.
    GeneIDi854856.
    KEGGisce:YIR038C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z38061 Genomic DNA. Translation: CAA86198.1 .
    BK006942 Genomic DNA. Translation: DAA08585.1 .
    PIRi S48500.
    RefSeqi NP_012304.1. NM_001179560.1.

    3D structure databases

    ProteinModelPortali P40582.
    SMRi P40582. Positions 5-226.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 35029. 88 interactions.
    DIPi DIP-2103N.
    IntActi P40582. 64 interactions.
    MINTi MINT-566298.
    STRINGi 4932.YIR038C.

    Proteomic databases

    MaxQBi P40582.
    PaxDbi P40582.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YIR038C ; YIR038C ; YIR038C .
    GeneIDi 854856.
    KEGGi sce:YIR038C.

    Organism-specific databases

    CYGDi YIR038c.
    SGDi S000001477. GTT1.

    Phylogenomic databases

    eggNOGi COG0625.
    HOGENOMi HOG000125753.
    KOi K00799.
    OMAi DIQMSFI.
    OrthoDBi EOG7BZW43.

    Enzyme and pathway databases

    BioCyci YEAST:YIR038C-MONOMER.
    SABIO-RK P40582.

    Miscellaneous databases

    NextBioi 977767.

    Gene expression databases

    Genevestigatori P40582.

    Family and domain databases

    Gene3Di 1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProi IPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR004046. GST_C.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    Pfami PF00043. GST_C. 1 hit.
    PF02798. GST_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEi PS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. "A novel membrane-bound glutathione S-transferase functions in the stationary phase of the yeast Saccharomyces cerevisiae."
      Choi J.H., Lou W., Vancura A.
      J. Biol. Chem. 273:29915-29922(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.

    Entry informationi

    Entry nameiGST1_YEAST
    AccessioniPrimary (citable) accession number: P40582
    Secondary accession number(s): D6VVW9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 119 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome IX
      Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

    External Data

    Dasty 3