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Reviewed, UniProtKB/Swiss-Prot P40582 (GST1_YEAST)

Last modified June 16, 2009. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Glutathione S-transferase 1
    EC=2.5.1.18
Alternative name(s):
    GST-I
Gene names
Name: GTT1
Ordered Locus Names: YIR038C
OrganismSaccharomyces cerevisiae (Baker's yeast) [Complete proteome]
Taxonomic identifier4932 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

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Protein attributes

Sequence length234 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Catalytic activity

RX + glutathione = HX + R-S-glutathione.

Subunit structure

Homodimer.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein.

Sequence similarities

Belongs to the GST superfamily.

Contains 1 GST C-terminal domain.

Contains 1 GST N-terminal domain.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 234234Glutathione S-transferase 1
PRO_0000185987

Regions

Domain3 – 9088GST N-terminal
Domain96 – 234139GST C-terminal

Amino acid modifications

Modified residue561Phosphoserine Ref.3

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Sequences

Sequence LengthMass (Da)Tools
P40582-1 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: 3C07D40D29F60DFF

FASTA23426,795
        10         20         30         40         50         60 
MSLPIIKVHW LDHSRAFRLL WLLDHLNLEY EIVPYKRDAN FRAPPELKKI HPLGRSPLLE 

        70         80         90        100        110        120 
VQDRETGKKK ILAESGFIFQ YVLQHFDHSH VLMSEDADIA DQINYYLFYV EGSLQPPLMI 

       130        140        150        160        170        180 
EFILSKVKDS GMPFPISYLA RKVADKISQA YSSGEVKNQF DFVEGEISKN NGYLVDGKLS 

       190        200        210        220        230 
GADILMSFPL QMAFERKFAA PEDYPAISKW LKTITSEESY AASKEKARAL GSNF

« Hide

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References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome IX."
Churcher C.M., Bowman S., Badcock K., Bankier A.T., Brown D., Chillingworth T., Connor R., Devlin K., Gentles S., Hamlin N., Harris D.E., Horsnell T., Hunt S., Jagels K., Jones M., Lye G., Moule S., Odell C. expand/collapse author list , Pearson D., Rajandream M.A., Rice P., Rowley N., Skelton J., Smith V., Walsh S.V., Whitehead S., Barrell B.G.
Nature 387:84-87(1997) [PubMed: 9169870] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204511 / S288c / AB972.
[2]"A novel membrane-bound glutathione S-transferase functions in the stationary phase of the yeast Saccharomyces cerevisiae."
Choi J.H., Lou W., Vancura A.
J. Biol. Chem. 273:29915-29922(1998) [PubMed: 9792709] [Abstract]
Cited for: CHARACTERIZATION.
[3]"A multidimensional chromatography technology for in-depth phosphoproteome analysis."
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed: 18407956] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-56, MASS SPECTROMETRY.
+Additional computationally mapped references.

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Cross-references

Sequence databases

Z38061 Genomic DNA. Translation: CAA86198.1.
PIRS48500.
RefSeqNP_012304.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

DIPDIP:2103N.
IntActP40582. 81 interactions.

Genome annotation databases

EnsemblYIR038C. Saccharomyces cerevisiae. [Contig view]
GeneID854856.
GenomeReviewsGene locus YIR038C in contig Z47047_GR.
KEGGsce:YIR038C.
NMPDRfig|4932.3.peg.1849.

Organism-specific databases

CYGDYIR038c.
SGDS000001477. GTT1.
Yeast-GFPSearch...

Phylogenomic databases

HOGENOMP40582.
OMAP40582. SHRILWL.

Enzyme and pathway databases

BRENDA2.5.1.18. 250.

Gene expression databases

ArrayExpressP40582.
GermOnlineYIR038C. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR004045. Glutathione_S-Trfase_N.
IPR017933. Glutathione_S_Trfase/Cl_chnl_C.
IPR004046. GST_C.
IPR012335. Thioredoxin_fold.
[Graphical view]
Gene3DG3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
PfamPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
PROSITEPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio977767.

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Entry information

Entry nameGST1_YEAST
AccessionPrimary (citable) accession number: P40582
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: June 16, 2009
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome IX

Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents