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Protein

Glutathione S-transferase 1

Gene

GTT1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

GO - Molecular functioni

  1. glutathione peroxidase activity Source: SGD
  2. glutathione transferase activity Source: SGD

GO - Biological processi

  1. glutathione metabolic process Source: SGD
  2. oxidation-reduction process Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Enzyme and pathway databases

BioCyciYEAST:YIR038C-MONOMER.
SABIO-RKP40582.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase 1 (EC:2.5.1.18)
Alternative name(s):
GST-I
Gene namesi
Name:GTT1
Ordered Locus Names:YIR038C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome IX

Organism-specific databases

CYGDiYIR038c.
SGDiS000001477. GTT1.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: SGD
  2. endoplasmic reticulum membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 234234Glutathione S-transferase 1PRO_0000185987Add
BLAST

Proteomic databases

MaxQBiP40582.
PaxDbiP40582.

Expressioni

Gene expression databases

GenevestigatoriP40582.

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

BioGridi35029. 87 interactions.
DIPiDIP-2103N.
IntActiP40582. 64 interactions.
MINTiMINT-566298.
STRINGi4932.YIR038C.

Structurei

3D structure databases

ProteinModelPortaliP40582.
SMRiP40582. Positions 5-226.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 9088GST N-terminalAdd
BLAST
Domaini96 – 234139GST C-terminalAdd
BLAST

Sequence similaritiesi

Belongs to the GST superfamily.Curated
Contains 1 GST C-terminal domain.Curated
Contains 1 GST N-terminal domain.Curated

Phylogenomic databases

eggNOGiCOG0625.
HOGENOMiHOG000125753.
InParanoidiP40582.
KOiK00799.
OMAiADVQMSF.
OrthoDBiEOG7BZW43.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P40582-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLPIIKVHW LDHSRAFRLL WLLDHLNLEY EIVPYKRDAN FRAPPELKKI
60 70 80 90 100
HPLGRSPLLE VQDRETGKKK ILAESGFIFQ YVLQHFDHSH VLMSEDADIA
110 120 130 140 150
DQINYYLFYV EGSLQPPLMI EFILSKVKDS GMPFPISYLA RKVADKISQA
160 170 180 190 200
YSSGEVKNQF DFVEGEISKN NGYLVDGKLS GADILMSFPL QMAFERKFAA
210 220 230
PEDYPAISKW LKTITSEESY AASKEKARAL GSNF
Length:234
Mass (Da):26,795
Last modified:February 1, 1995 - v1
Checksum:i3C07D40D29F60DFF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z38061 Genomic DNA. Translation: CAA86198.1.
BK006942 Genomic DNA. Translation: DAA08585.1.
PIRiS48500.
RefSeqiNP_012304.1. NM_001179560.1.

Genome annotation databases

EnsemblFungiiYIR038C; YIR038C; YIR038C.
GeneIDi854856.
KEGGisce:YIR038C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z38061 Genomic DNA. Translation: CAA86198.1.
BK006942 Genomic DNA. Translation: DAA08585.1.
PIRiS48500.
RefSeqiNP_012304.1. NM_001179560.1.

3D structure databases

ProteinModelPortaliP40582.
SMRiP40582. Positions 5-226.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35029. 87 interactions.
DIPiDIP-2103N.
IntActiP40582. 64 interactions.
MINTiMINT-566298.
STRINGi4932.YIR038C.

Proteomic databases

MaxQBiP40582.
PaxDbiP40582.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYIR038C; YIR038C; YIR038C.
GeneIDi854856.
KEGGisce:YIR038C.

Organism-specific databases

CYGDiYIR038c.
SGDiS000001477. GTT1.

Phylogenomic databases

eggNOGiCOG0625.
HOGENOMiHOG000125753.
InParanoidiP40582.
KOiK00799.
OMAiADVQMSF.
OrthoDBiEOG7BZW43.

Enzyme and pathway databases

BioCyciYEAST:YIR038C-MONOMER.
SABIO-RKP40582.

Miscellaneous databases

NextBioi977767.

Gene expression databases

GenevestigatoriP40582.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "A novel membrane-bound glutathione S-transferase functions in the stationary phase of the yeast Saccharomyces cerevisiae."
    Choi J.H., Lou W., Vancura A.
    J. Biol. Chem. 273:29915-29922(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.

Entry informationi

Entry nameiGST1_YEAST
AccessioniPrimary (citable) accession number: P40582
Secondary accession number(s): D6VVW9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: March 4, 2015
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IX
    Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.