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Protein

Glutathione S-transferase 1

Gene

GTT1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

GO - Molecular functioni

  • glutathione peroxidase activity Source: SGD
  • glutathione transferase activity Source: SGD

GO - Biological processi

  • glutathione metabolic process Source: SGD
  • protein glutathionylation Source: SGD

Keywordsi

Molecular functionTransferase

Enzyme and pathway databases

BioCyciYEAST:YIR038C-MONOMER
SABIO-RKiP40582

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase 1 (EC:2.5.1.18)
Alternative name(s):
GST-I
Gene namesi
Name:GTT1
Ordered Locus Names:YIR038C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IX

Organism-specific databases

EuPathDBiFungiDB:YIR038C
SGDiS000001477 GTT1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001859871 – 234Glutathione S-transferase 1Add BLAST234

Proteomic databases

MaxQBiP40582
PaxDbiP40582
PRIDEiP40582

PTM databases

iPTMnetiP40582

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

BioGridi35029, 103 interactors
DIPiDIP-2103N
IntActiP40582, 69 interactors
MINTiP40582
STRINGi4932.YIR038C

Structurei

3D structure databases

ProteinModelPortaliP40582
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 90GST N-terminalAdd BLAST88
Domaini96 – 234GST C-terminalAdd BLAST139

Sequence similaritiesi

Belongs to the GST superfamily.Curated

Phylogenomic databases

HOGENOMiHOG000125753
InParanoidiP40582
KOiK00799
OMAiRAQRIVW
OrthoDBiEOG092C40MQ

Family and domain databases

InterProiView protein in InterPro
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR004045 Glutathione_S-Trfase_N
IPR004046 GST_C
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF00043 GST_C, 1 hit
PF02798 GST_N, 1 hit
SUPFAMiSSF47616 SSF47616, 1 hit
SSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS50405 GST_CTER, 1 hit
PS50404 GST_NTER, 1 hit

Sequencei

Sequence statusi: Complete.

P40582-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLPIIKVHW LDHSRAFRLL WLLDHLNLEY EIVPYKRDAN FRAPPELKKI
60 70 80 90 100
HPLGRSPLLE VQDRETGKKK ILAESGFIFQ YVLQHFDHSH VLMSEDADIA
110 120 130 140 150
DQINYYLFYV EGSLQPPLMI EFILSKVKDS GMPFPISYLA RKVADKISQA
160 170 180 190 200
YSSGEVKNQF DFVEGEISKN NGYLVDGKLS GADILMSFPL QMAFERKFAA
210 220 230
PEDYPAISKW LKTITSEESY AASKEKARAL GSNF
Length:234
Mass (Da):26,795
Last modified:February 1, 1995 - v1
Checksum:i3C07D40D29F60DFF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z38061 Genomic DNA Translation: CAA86198.1
BK006942 Genomic DNA Translation: DAA08585.1
PIRiS48500
RefSeqiNP_012304.1, NM_001179560.1

Genome annotation databases

EnsemblFungiiYIR038C; YIR038C; YIR038C
GeneIDi854856
KEGGisce:YIR038C

Similar proteinsi

Entry informationi

Entry nameiGST1_YEAST
AccessioniPrimary (citable) accession number: P40582
Secondary accession number(s): D6VVW9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: March 28, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health