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Protein

Benzil reductase ((S)-benzoin forming) IRC24

Gene

IRC24

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Reduces benzil stereospecifically to (S)-benzoin. Is probably involved in a pathway contributing to genomic integrity.

Miscellaneous

Present with 1620 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

(S)-benzoin + NADP+ = benzil + NADPH.1 Publication

Kineticsi

  1. KM=207 µM for benzil1 Publication
  2. KM=29 µM for 1-phenyl-1,2-propanedione1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Binding sitei144SubstrateBy similarity1
    Active sitei157Proton acceptorPROSITE-ProRule annotation1

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Nucleotide bindingi6 – 30NADPBy similarityAdd BLAST25

    GO - Molecular functioni

    Keywordsi

    Molecular functionOxidoreductase
    LigandNADP

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31450-MONOMER

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Benzil reductase ((S)-benzoin forming) IRC24 (EC:1.1.1.320)
    Alternative name(s):
    Increased recombination centers protein 24
    Gene namesi
    Name:IRC24
    Ordered Locus Names:YIR036C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    Proteomesi
    • UP000002311 Componenti: Chromosome IX

    Organism-specific databases

    EuPathDBiFungiDB:YIR036C
    SGDiS000001475 IRC24

    Pathology & Biotechi

    Disruption phenotypei

    Displays increased levels of spontaneous RAD52 foci in proliferating diploid cells.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    ChainiPRO_00000548711 – 263Benzil reductase ((S)-benzoin forming) IRC24Add BLAST263

    Proteomic databases

    MaxQBiP40580
    PaxDbiP40580
    PRIDEiP40580

    Expressioni

    Inductioni

    By single-strand DNA damage.1 Publication

    Interactioni

    Protein-protein interaction databases

    BioGridi35027, 25 interactors
    DIPiDIP-4707N
    STRINGi4932.YIR036C

    Structurei

    3D structure databases

    ProteinModelPortaliP40580
    SMRiP40580
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    InParanoidiP40580
    KOiK16216
    OMAiWGGYGAS
    OrthoDBiEOG092C4ECY

    Family and domain databases

    InterProiView protein in InterPro
    IPR036291 NAD(P)-bd_dom_sf
    IPR020904 Sc_DH/Rdtase_CS
    IPR002347 SDR_fam
    PfamiView protein in Pfam
    PF00106 adh_short, 1 hit
    PRINTSiPR00081 GDHRDH
    SUPFAMiSSF51735 SSF51735, 1 hit
    PROSITEiView protein in PROSITE
    PS00061 ADH_SHORT, 1 hit

    Sequencei

    Sequence statusi: Complete.

    P40580-1 [UniParc]FASTAAdd to basket

    « Hide

            10         20         30         40         50
    MGKVILITGA SRGIGLQLVK TVIEEDDECI VYGVARTEAG LQSLQREYGA
    60 70 80 90 100
    DKFVYRVLDI TDRSRMEALV EEIRQKHGKL DGIVANAGML EPVKSISQSN
    110 120 130 140 150
    SEHDIKQWER LFDVNFFSIV SLVALCLPLL KSSPFVGNIV FVSSGASVKP
    160 170 180 190 200
    YNGWSAYGCS KAALNHFAMD IASEEPSDKV RAVCIAPGVV DTQMQKDIRE
    210 220 230 240 250
    TLGPQGMTPK ALERFTQLYK TSSLLDPKVP AAVLAQLVLK GIPDSLNGQY
    260
    LRYNDERLGP VQG
    Length:263
    Mass (Da):28,804
    Last modified:February 1, 1995 - v1
    Checksum:i53DE25425AAC946F
    GO

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    Z38061 Genomic DNA Translation: CAA86196.1
    AY558240 Genomic DNA Translation: AAS56566.1
    AB052924 Genomic DNA Translation: BAB86002.1
    BK006942 Genomic DNA Translation: DAA08583.1
    PIRiS48498
    RefSeqiNP_012302.3, NM_001179558.3

    Genome annotation databases

    EnsemblFungiiYIR036C; YIR036C; YIR036C
    GeneIDi854854
    KEGGisce:YIR036C

    Similar proteinsi

    Entry informationi

    Entry nameiBZRD_YEAST
    AccessioniPrimary (citable) accession number: P40580
    Secondary accession number(s): D6VVW7, Q54AB5
    Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: May 23, 2018
    This is version 144 of the entry and version 1 of the sequence. See complete history.
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome
    UniProt is an ELIXIR core data resource
    Main funding by: National Institutes of Health