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Protein

Uncharacterized oxidoreductase YIR035C

Gene

YIR035C

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei137SubstrateBy similarity1
Active sitei150Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi6 – 30NAD or NADPBy similarityAdd BLAST25

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciYEAST:G3O-31449-MONOMER.
ReactomeiR-SCE-1474151. Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized oxidoreductase YIR035C (EC:1.-.-.-)
Gene namesi
Ordered Locus Names:YIR035C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IX

Organism-specific databases

EuPathDBiFungiDB:YIR035C.
SGDiS000001474. YIR035C.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000548701 – 254Uncharacterized oxidoreductase YIR035CAdd BLAST254

Proteomic databases

MaxQBiP40579.
PRIDEiP40579.

PTM databases

iPTMnetiP40579.

Interactioni

Protein-protein interaction databases

BioGridi35026. 16 interactors.
DIPiDIP-4612N.
IntActiP40579. 3 interactors.
MINTiMINT-492719.

Structurei

Secondary structure

1254
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 7Combined sources4
Helixi13 – 25Combined sources13
Beta strandi30 – 36Combined sources7
Helixi38 – 48Combined sources11
Helixi49 – 51Combined sources3
Beta strandi52 – 57Combined sources6
Helixi62 – 76Combined sources15
Beta strandi81 – 85Combined sources5
Turni93 – 96Combined sources4
Helixi100 – 110Combined sources11
Helixi112 – 128Combined sources17
Beta strandi131 – 135Combined sources5
Helixi148 – 155Combined sources8
Helixi157 – 167Combined sources11
Beta strandi171 – 177Combined sources7
Turni195 – 197Combined sources3
Helixi200 – 210Combined sources11
Helixi219 – 231Combined sources13
Helixi235 – 237Combined sources3
Beta strandi241 – 243Combined sources3
Helixi247 – 252Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3KZVX-ray2.00A1-254[»]
ProteinModelPortaliP40579.
SMRiP40579.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP40579.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00440000033609.
InParanoidiP40579.
OMAiQVQFIAG.
OrthoDBiEOG092C4ECY.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P40579-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKVILVTGV SRGIGKSIVD VLFSLDKDTV VYGVARSEAP LKKLKEKYGD
60 70 80 90 100
RFFYVVGDIT EDSVLKQLVN AAVKGHGKID SLVANAGVLE PVQNVNEIDV
110 120 130 140 150
NAWKKLYDIN FFSIVSLVGI ALPELKKTNG NVVFVSSDAC NMYFSSWGAY
160 170 180 190 200
GSSKAALNHF AMTLANEERQ VKAIAVAPGI VDTDMQVNIR ENVGPSSMSA
210 220 230 240 250
EQLKMFRGLK ENNQLLDSSV PATVYAKLAL HGIPDGVNGQ YLSYNDPALA

DFMP
Length:254
Mass (Da):27,481
Last modified:February 1, 1995 - v1
Checksum:i916A5A460BE59F78
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z38061 Genomic DNA. Translation: CAA86195.1.
AY692591 Genomic DNA. Translation: AAT92610.1.
BK006942 Genomic DNA. Translation: DAA08582.1.
PIRiS48497.
RefSeqiNP_012301.3. NM_001179557.3.

Genome annotation databases

EnsemblFungiiYIR035C; YIR035C; YIR035C.
GeneIDi854853.
KEGGisce:YIR035C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z38061 Genomic DNA. Translation: CAA86195.1.
AY692591 Genomic DNA. Translation: AAT92610.1.
BK006942 Genomic DNA. Translation: DAA08582.1.
PIRiS48497.
RefSeqiNP_012301.3. NM_001179557.3.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3KZVX-ray2.00A1-254[»]
ProteinModelPortaliP40579.
SMRiP40579.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35026. 16 interactors.
DIPiDIP-4612N.
IntActiP40579. 3 interactors.
MINTiMINT-492719.

PTM databases

iPTMnetiP40579.

Proteomic databases

MaxQBiP40579.
PRIDEiP40579.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYIR035C; YIR035C; YIR035C.
GeneIDi854853.
KEGGisce:YIR035C.

Organism-specific databases

EuPathDBiFungiDB:YIR035C.
SGDiS000001474. YIR035C.

Phylogenomic databases

GeneTreeiENSGT00440000033609.
InParanoidiP40579.
OMAiQVQFIAG.
OrthoDBiEOG092C4ECY.

Enzyme and pathway databases

BioCyciYEAST:G3O-31449-MONOMER.
ReactomeiR-SCE-1474151. Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation.

Miscellaneous databases

EvolutionaryTraceiP40579.
PROiP40579.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiYIV5_YEAST
AccessioniPrimary (citable) accession number: P40579
Secondary accession number(s): D6VVW6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 2, 2016
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 2370 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome IX
    Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.