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Protein

Protein MGA2

Gene

MGA2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • cellular response to cold Source: SGD
  • chromatin silencing at silent mating-type cassette Source: SGD
  • mRNA stabilization Source: SGD
  • positive regulation of transcription from RNA polymerase II promoter Source: SGD
  • positive regulation of transcription from RNA polymerase II promoter in response to cobalt ion Source: SGD
  • positive regulation of transcription from RNA polymerase II promoter in response to hypoxia Source: SGD
  • positive regulation of unsaturated fatty acid biosynthetic process by positive regulation of transcription from RNA polymerase II promoter Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-31448-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein MGA2
Gene namesi
Name:MGA2
Ordered Locus Names:YIR033W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IX

Organism-specific databases

EuPathDBiFungiDB:YIR033W.
SGDiS000001472. MGA2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1037 – 1054HelicalSequence analysisAdd BLAST18

GO - Cellular componenti

  • integral component of endoplasmic reticulum membrane Source: SGD
  • nucleus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000670741 – 1113Protein MGA2Add BLAST1113

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei255PhosphoserineCombined sources1
Modified residuei467PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP40578.
PRIDEiP40578.

PTM databases

iPTMnetiP40578.

Interactioni

Protein-protein interaction databases

BioGridi35024. 226 interactors.
DIPiDIP-6689N.
IntActiP40578. 21 interactors.
MINTiMINT-655593.

Structurei

3D structure databases

ProteinModelPortaliP40578.
SMRiP40578.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini530 – 610IPT/TIGAdd BLAST81
Repeati719 – 748ANK 1Add BLAST30
Repeati752 – 781ANK 2Add BLAST30

Sequence similaritiesi

Contains 2 ANK repeats.PROSITE-ProRule annotation
Contains 1 IPT/TIG domain.Curated

Keywords - Domaini

ANK repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00530000067551.
HOGENOMiHOG000113576.
InParanoidiP40578.
KOiK06867.
OMAiLLHIPQD.
OrthoDBiEOG092C06NJ.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
2.60.40.10. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
PF01833. TIG. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 2 hits.
SM00429. IPT. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF81296. SSF81296. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P40578-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQQNSEFLTE TPGSDPHISQ LHANSVMESQ LLDDFLLNGS PMYQDDSMAH
60 70 80 90 100
INIDEGANFQ NFIKTDEGDS PNLLSFEGIG NNTHVNQNVS TPLEEEMESN
110 120 130 140 150
RALKEEEEDE HENKVFNEKN IGNPAHDEIV FGRKETIQSV YINPLDYLKV
160 170 180 190 200
NAAQLPLDVE VSGLPQVSRV ENQLKLKVKI TSETPLNQSM LYLPSDSISR
210 220 230 240 250
EKFYLKKNIE DFSEDFKKNL LYINAFVLCA VSNRTTNVCT KCVKREQRRA
260 270 280 290 300
ARRKSGIADN LLWCNNINRR LVVFNNKQVF PIMKTFDNVK EFELTTRLVC
310 320 330 340 350
YCRHHKANNG FVILFTITDW QNRLLGKFTT TPIMITDRKP ANMDTTKFNN
360 370 380 390 400
TTTSSRRQLT EEESTTEYYS TDNNQLSKDE NMPFQYTYQH NPYDNDSQMN
410 420 430 440 450
NIPLKDKNVP FPYSISQQTD LLQNNNLSLN LSLPNQHIPS PTSMSEEGSE
460 470 480 490 500
SFNYHHRDND NPVRTISLTN IEQQSQLNQR KRARNNLEND IGKPLFKHSF
510 520 530 540 550
SNSISATNTM NPALHSMQDF SMKNNNNNLP SINRVIPSQG PINGGIEVTL
560 570 580 590 600
LGCNFKDGLS VKFGSNLALS TQCWSETTIV TYLPPAAYAG QVFVSITDTN
610 620 630 640 650
NENNNDDLPQ EIEINDNKKA IFTYVDDTDR QLIELALQIV GLKMNGKLED
660 670 680 690 700
ARNIAKRIVG NDSPDSGTNG NSCSKSTGPS PNQHSMNLNT SVLYSDEVLI
710 720 730 740 750
QKVIKSLNIN SNISICDSLG RTLLHLACLK NYSSLVYTLI KKGARVNDID
760 770 780 790 800
SFGLTPLHFA CISGDPKIIK MLLNCKVNYS LRSHNGLTAR EVFIANHIHS
810 820 830 840 850
KEIDKKQDNR DNHKFVHNDT YISEVLSLFE EFQNGTKFTD SVETDSNYSI
860 870 880 890 900
SRKYSQSSFN SSLLDNESLN ENLFESQSMI NPTSMEIQHP TLQLFENSSY
910 920 930 940 950
SEYDQSDFEE DGDEDLFVTD EVEKPGVACR EEQSELLDIG SSANEPEEDN
960 970 980 990 1000
GSTSLWNRVL HRINDDLPKY EDLFPLSWGK DDKLKTTNQD SIVEQSASNI
1010 1020 1030 1040 1050
ENSENSEEED YEEEEEFLKK QFNRFFQNKQ NFRNDKMLIF FWIPLTLLLL
1060 1070 1080 1090 1100
TWFIMYKFGN QDSSINHISE LISEYLRIAL AKFLLGNERM KTAFRSKLSN
1110
LQTTRMLNDL IVS
Length:1,113
Mass (Da):127,055
Last modified:February 1, 1995 - v1
Checksum:iEC8A6D46C01CF917
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z38061 Genomic DNA. Translation: CAA86193.1.
BK006942 Genomic DNA. Translation: DAA08580.1.
PIRiS48495.
RefSeqiNP_012299.1. NM_001179555.1.

Genome annotation databases

EnsemblFungiiYIR033W; YIR033W; YIR033W.
GeneIDi854851.
KEGGisce:YIR033W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z38061 Genomic DNA. Translation: CAA86193.1.
BK006942 Genomic DNA. Translation: DAA08580.1.
PIRiS48495.
RefSeqiNP_012299.1. NM_001179555.1.

3D structure databases

ProteinModelPortaliP40578.
SMRiP40578.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35024. 226 interactors.
DIPiDIP-6689N.
IntActiP40578. 21 interactors.
MINTiMINT-655593.

PTM databases

iPTMnetiP40578.

Proteomic databases

MaxQBiP40578.
PRIDEiP40578.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYIR033W; YIR033W; YIR033W.
GeneIDi854851.
KEGGisce:YIR033W.

Organism-specific databases

EuPathDBiFungiDB:YIR033W.
SGDiS000001472. MGA2.

Phylogenomic databases

GeneTreeiENSGT00530000067551.
HOGENOMiHOG000113576.
InParanoidiP40578.
KOiK06867.
OMAiLLHIPQD.
OrthoDBiEOG092C06NJ.

Enzyme and pathway databases

BioCyciYEAST:G3O-31448-MONOMER.

Miscellaneous databases

PROiP40578.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
2.60.40.10. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
PF01833. TIG. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 2 hits.
SM00429. IPT. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF81296. SSF81296. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMGA2_YEAST
AccessioniPrimary (citable) accession number: P40578
Secondary accession number(s): D6VVW4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 2, 2016
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 300 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IX
    Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.