AP-1-like transcription factor YAP5 - Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

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P40574 (YAP5_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 111. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
AP-1-like transcription factor YAP5

Gene names

Name:	YAP5
Ordered Locus Names:	YIR018W

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›

Protein attributes

Sequence length	245 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Transcription activator involved in the regulation of genes expressed in response to environmental changes and metabolic requirements. According to genome-wide promoter binding and gene expression studies it is a coregulator for the expression of ribosomal genes, while its own expression is induced by the cell cycle specific activator SBF (SWI4-SWI6). Ref.5 Ref.6 Ref.7
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm. Nucleus Ref.8.
Miscellaneous	One of 8 closely related fungi-specific YAP proteins (YAP1 to YAP8), which all seem to be transcription activators of the environmental stress response and metabolism control pathways and to have similar but not identical DNA binding specificities. Present with 238 molecules/cell in log phase SD medium.
Sequence similarities	Belongs to the bZIP family. YAP subfamily. Contains 1 bZIP (basic-leucine zipper) domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Cytoplasm Nucleus
Ligand	DNA-binding
Molecular function	Activator
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	negative regulation of chromatin silencing at telomere Inferred from mutant phenotype PubMed 21206489. Source: SGD negative regulation of transcription from RNA polymerase II promoter Inferred from mutant phenotype PubMed 18287073. Source: SGD positive regulation of transcription from RNA polymerase II promoter in response to iron Inferred from mutant phenotype PubMed 18070921. Source: SGD
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nuclear chromatin Inferred from direct assay Ref.6. Source: SGD
Molecular_function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding RNA polymerase II transcription factor activity Inferred from direct assay PubMed 18287073. Source: SGD
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 245

245

AP-1-like transcription factor YAP5

PRO_0000076525

Regions

Domain

58 – 121

bZIP

Region

63 – 82

Basic motif By similarity

Region

86 – 114

Leucine-zipper By similarity

Experimental info

Sequence conflict

173

P → S in AAC49426. Ref.1

Sequences

Sequence

Length

Mass (Da)

Tools

P40574 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: 02F78E1963982E0D
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FASTA

245

28,386

        10         20         30         40         50         60 
MALPLIKPKE SEESHLALLS KIHVSKNWKL PPRLPHRAAQ RRKRVHRLHE DYETEENDEE 

        70         80         90        100        110        120 
LQKKKRQNRD AQRAYRERKN NKLQVLEETI ESLSKVVKNY ETKLNRLQNE LQAKESENHA 

       130        140        150        160        170        180 
LKQKLETLTL KQASVPAQDP ILQNLIENFK PMKAIPIKYN TAIKRHQHST ELPSSVKCGF 

       190        200        210        220        230        240 
CNDNTTCVCK ELETDHRKSD DGVATEQKDM SMPHAECNNK DNPNGLCSNC TNIDKSCIDI 


RSIIH

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A heteromeric complex containing the centromere binding factor 1 and two basic leucine zipper factors, Met4 and Met28, mediates the transcription activation of yeast sulfur metabolism." Kuras L., Cherest H., Surdin-Kerjan Y., Thomas D. EMBO J. 15:2519-2529(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 28383 / FL100 / VTT C-80102.
[2]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome IX." Churcher C.M., Bowman S., Badcock K., Bankier A.T., Brown D., Chillingworth T., Connor R., Devlin K., Gentles S., Hamlin N., Harris D.E., Horsnell T., Hunt S., Jagels K., Jones M., Lye G., Moule S., Odell C. Barrell B.G. Nature 387:84-87(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[3]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[4]	"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. LaBaer J. Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[5]	"Yap, a novel family of eight bZIP proteins in Saccharomyces cerevisiae with distinct biological functions." Fernandes L., Rodrigues-Pousada C., Struhl K. Mol. Cell. Biol. 17:6982-6993(1997) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, ISOLATION OF YAP FAMILY PROTEINS.
[6]	"Complex transcriptional circuitry at the G1/S transition in Saccharomyces cerevisiae." Horak C.E., Luscombe N.M., Qian J., Bertone P., Piccirrillo S., Gerstein M., Snyder M. Genes Dev. 16:3017-3033(2002) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, CELL CYCLE ACTIVATION.
[7]	"Computational discovery of gene modules and regulatory networks." Bar-Joseph Z., Gerber G.K., Lee T.I., Rinaldi N.J., Yoo J.Y., Robert F., Gordon D.B., Fraenkel E., Jaakkola T.S., Young R.A., Gifford D.K. Nat. Biotechnol. 21:1337-1342(2003) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, REGULATORY TRANSCRIPTION MODULES.
[8]	"Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[9]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U17015 Genomic DNA. Translation: AAC49426.1. Z37996 Genomic DNA. Translation: CAA86089.1. AY558238 Genomic DNA. Translation: AAS56564.1. BK006942 Genomic DNA. Translation: DAA08564.1.
PIR	S48363.
RefSeq	NP_012283.1. NM_001179540.1.
3D structure databases
ProteinModelPortal	P40574.
SMR	P40574. Positions 63-108.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-2994N.
IntAct	P40574. 5 interactions.
MINT	MINT-401990.
STRING	4932.YIR018W.
Proteomic databases
PaxDb	P40574.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YIR018W; YIR018W; YIR018W.
GeneID	854835.
KEGG	sce:YIR018W.
Organism-specific databases
CYGD	YIR018w.
SGD	S000001457. YAP5.
Phylogenomic databases
eggNOG	NOG73431.
GeneTree	ENSGT00530000069245.
OMA	GFCNDNT.
OrthoDB	EOG44XNS4.
Gene expression databases
Genevestigator	P40574.
GermOnline	YIR018W. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR004827. bZIP. [Graphical view]
Pfam	PF00170. bZIP_1. 1 hit. [Graphical view]
SMART	SM00338. BRLZ. 1 hit. [Graphical view]
PROSITE	PS50217. BZIP. 1 hit. PS00036. BZIP_BASIC. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	977710.

Entry information

Entry name

YAP5_YEAST

Accession

Primary (citable) accession number: P40574
Secondary accession number(s): D6VVU8

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	May 1, 2013
This is version 111 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome IX

Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents