Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P40571 (RPR2_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ribonuclease P protein subunit RPR2

EC=3.1.26.5
Alternative name(s):
RNA-processing protein RPR2
RNase P 16.4 kDa subunit
Gene names
Name:RPR2
Ordered Locus Names:YIR015W
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length144 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Ref.4

Catalytic activity

Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.

Cofactor

Binds 1 zinc ion per subunit By similarity.

Subunit structure

Component of nuclear RNase P. RNase P consists of an RNA moiety and at least 9 protein subunits including POP1, POP3, POP4, POP5, POP6, POP7, POP8, RPP1 and RPR2, many of which are shared with the RNase MPR complex. Ref.4

Subcellular location

Nucleus Ref.5.

Miscellaneous

Present with 2070 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the eukaryotic/archaeal RNase P protein component 4 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 144144Ribonuclease P protein subunit RPR2
PRO_0000153847

Sites

Metal binding901Zinc By similarity
Metal binding931Zinc By similarity
Metal binding1151Zinc By similarity
Metal binding1171Zinc By similarity

Sequences

Sequence LengthMass (Da)Tools
P40571 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: 91AEF14F80D76148

FASTA14416,344
        10         20         30         40         50         60 
MGKKAHGGKM KPEIDENGTL LVPPPRTIAN QDHFHRLNYL YQISAYQTRA RQKARTDAHT 

        70         80         90        100        110        120 
PLARNYIKSM DLISKKTKTS LLPTIKRTIC KKCHRLLWTP KKLEITSDGA LSVMCGCGTV 

       130        140 
KRFNIGADPN YRTYSEREGN LLNS 

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome IX."
Churcher C.M., Bowman S., Badcock K., Bankier A.T., Brown D., Chillingworth T., Connor R., Devlin K., Gentles S., Hamlin N., Harris D.E., Horsnell T., Hunt S., Jagels K., Jones M., Lye G., Moule S., Odell C. expand/collapse author list , Pearson D., Rajandream M.A., Rice P., Rowley N., Skelton J., Smith V., Walsh S.V., Whitehead S., Barrell B.G.
Nature 387:84-87(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[4]"Purification and characterization of the nuclear RNase P holoenzyme complex reveals extensive subunit overlap with RNase MRP."
Chamberlain J.R., Lee Y., Lane W.S., Engelke D.R.
Genes Dev. 12:1678-1690(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, IDENTIFICATION IN THE RNASE P COMPLEX BY MASS SPECTROMETRY.
[5]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[6]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z37996 Genomic DNA. Translation: CAA86085.1.
AY557849 Genomic DNA. Translation: AAS56175.1.
BK006942 Genomic DNA. Translation: DAA08561.1.
PIRS48359.
RefSeqNP_012280.1. NM_001179537.1.

3D structure databases

ProteinModelPortalP40571.
SMRP40571. Positions 35-127.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid35007. 14 interactions.
IntActP40571. 3 interactions.
MINTMINT-2786613.
STRING4932.YIR015W.

Proteomic databases

MaxQBP40571.
PaxDbP40571.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYIR015W; YIR015W; YIR015W.
GeneID854832.
KEGGsce:YIR015W.

Organism-specific databases

CYGDYIR015w.
SGDS000001454. RPR2.

Phylogenomic databases

eggNOGCOG2023.
HOGENOMHOG000231207.
KOK03540.
OMARTIANQD.
OrthoDBEOG7W6X08.

Enzyme and pathway databases

BioCycYEAST:YIR015W-MONOMER.

Gene expression databases

GenevestigatorP40571.

Family and domain databases

InterProIPR007175. Rpr2.
[Graphical view]
PANTHERPTHR14742. PTHR14742. 1 hit.
PfamPF04032. Rpr2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio977701.
PROP40571.

Entry information

Entry nameRPR2_YEAST
AccessionPrimary (citable) accession number: P40571
Secondary accession number(s): D6VVU5
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: July 9, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome IX

Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families