SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P40571

- RPR2_YEAST

UniProt

P40571 - RPR2_YEAST

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Ribonuclease P protein subunit RPR2
Gene
RPR2, YIR015W
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.1 Publication

Catalytic activityi

Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.

Cofactori

Binds 1 zinc ion per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi90 – 901Zinc By similarity
Metal bindingi93 – 931Zinc By similarity
Metal bindingi115 – 1151Zinc By similarity
Metal bindingi117 – 1171Zinc By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. ribonuclease P activity Source: UniProtKB-EC

GO - Biological processi

  1. RNA phosphodiester bond hydrolysis Source: GOC
  2. RNA phosphodiester bond hydrolysis, endonucleolytic Source: GOC
  3. intronic box C/D snoRNA processing Source: SGD
  4. tRNA processing Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:YIR015W-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease P protein subunit RPR2 (EC:3.1.26.5)
Alternative name(s):
RNA-processing protein RPR2
RNase P 16.4 kDa subunit
Gene namesi
Name:RPR2
Ordered Locus Names:YIR015W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome IX

Organism-specific databases

CYGDiYIR015w.
SGDiS000001454. RPR2.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. nucleolar ribonuclease P complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 144144Ribonuclease P protein subunit RPR2
PRO_0000153847Add
BLAST

Proteomic databases

MaxQBiP40571.
PaxDbiP40571.

Expressioni

Gene expression databases

GenevestigatoriP40571.

Interactioni

Subunit structurei

Component of nuclear RNase P. RNase P consists of an RNA moiety and at least 9 protein subunits including POP1, POP3, POP4, POP5, POP6, POP7, POP8, RPP1 and RPR2, many of which are shared with the RNase MPR complex.1 Publication

Protein-protein interaction databases

BioGridi35007. 14 interactions.
IntActiP40571. 3 interactions.
MINTiMINT-2786613.
STRINGi4932.YIR015W.

Structurei

3D structure databases

ProteinModelPortaliP40571.
SMRiP40571. Positions 35-127.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2023.
HOGENOMiHOG000231207.
KOiK03540.
OMAiRTIANQD.
OrthoDBiEOG7W6X08.

Family and domain databases

InterProiIPR007175. Rpr2.
[Graphical view]
PANTHERiPTHR14742. PTHR14742. 1 hit.
PfamiPF04032. Rpr2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P40571-1 [UniParc]FASTAAdd to Basket

« Hide

MGKKAHGGKM KPEIDENGTL LVPPPRTIAN QDHFHRLNYL YQISAYQTRA    50
RQKARTDAHT PLARNYIKSM DLISKKTKTS LLPTIKRTIC KKCHRLLWTP 100
KKLEITSDGA LSVMCGCGTV KRFNIGADPN YRTYSEREGN LLNS 144
Length:144
Mass (Da):16,344
Last modified:February 1, 1995 - v1
Checksum:i91AEF14F80D76148
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z37996 Genomic DNA. Translation: CAA86085.1.
AY557849 Genomic DNA. Translation: AAS56175.1.
BK006942 Genomic DNA. Translation: DAA08561.1.
PIRiS48359.
RefSeqiNP_012280.1. NM_001179537.1.

Genome annotation databases

EnsemblFungiiYIR015W; YIR015W; YIR015W.
GeneIDi854832.
KEGGisce:YIR015W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z37996 Genomic DNA. Translation: CAA86085.1 .
AY557849 Genomic DNA. Translation: AAS56175.1 .
BK006942 Genomic DNA. Translation: DAA08561.1 .
PIRi S48359.
RefSeqi NP_012280.1. NM_001179537.1.

3D structure databases

ProteinModelPortali P40571.
SMRi P40571. Positions 35-127.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 35007. 14 interactions.
IntActi P40571. 3 interactions.
MINTi MINT-2786613.
STRINGi 4932.YIR015W.

Proteomic databases

MaxQBi P40571.
PaxDbi P40571.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YIR015W ; YIR015W ; YIR015W .
GeneIDi 854832.
KEGGi sce:YIR015W.

Organism-specific databases

CYGDi YIR015w.
SGDi S000001454. RPR2.

Phylogenomic databases

eggNOGi COG2023.
HOGENOMi HOG000231207.
KOi K03540.
OMAi RTIANQD.
OrthoDBi EOG7W6X08.

Enzyme and pathway databases

BioCyci YEAST:YIR015W-MONOMER.

Miscellaneous databases

NextBioi 977701.
PROi P40571.

Gene expression databases

Genevestigatori P40571.

Family and domain databases

InterProi IPR007175. Rpr2.
[Graphical view ]
PANTHERi PTHR14742. PTHR14742. 1 hit.
Pfami PF04032. Rpr2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. "Purification and characterization of the nuclear RNase P holoenzyme complex reveals extensive subunit overlap with RNase MRP."
    Chamberlain J.R., Lee Y., Lane W.S., Engelke D.R.
    Genes Dev. 12:1678-1690(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, IDENTIFICATION IN THE RNASE P COMPLEX BY MASS SPECTROMETRY.
  5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRPR2_YEAST
AccessioniPrimary (citable) accession number: P40571
Secondary accession number(s): D6VVU5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: July 9, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 2070 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IX
    Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

External Data

Dasty 3

Similar proteinsi