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P40571

- RPR2_YEAST

UniProt

P40571 - RPR2_YEAST

Protein

Ribonuclease P protein subunit RPR2

Gene

RPR2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.1 Publication

    Catalytic activityi

    Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.

    Cofactori

    Binds 1 zinc ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi90 – 901ZincBy similarity
    Metal bindingi93 – 931ZincBy similarity
    Metal bindingi115 – 1151ZincBy similarity
    Metal bindingi117 – 1171ZincBy similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. ribonuclease P activity Source: UniProtKB-EC

    GO - Biological processi

    1. intronic box C/D snoRNA processing Source: SGD
    2. RNA phosphodiester bond hydrolysis Source: GOC
    3. RNA phosphodiester bond hydrolysis, endonucleolytic Source: GOC
    4. tRNA processing Source: SGD

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciYEAST:YIR015W-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribonuclease P protein subunit RPR2 (EC:3.1.26.5)
    Alternative name(s):
    RNA-processing protein RPR2
    RNase P 16.4 kDa subunit
    Gene namesi
    Name:RPR2
    Ordered Locus Names:YIR015W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome IX

    Organism-specific databases

    CYGDiYIR015w.
    SGDiS000001454. RPR2.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. nucleolar ribonuclease P complex Source: SGD

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 144144Ribonuclease P protein subunit RPR2PRO_0000153847Add
    BLAST

    Proteomic databases

    MaxQBiP40571.
    PaxDbiP40571.

    Expressioni

    Gene expression databases

    GenevestigatoriP40571.

    Interactioni

    Subunit structurei

    Component of nuclear RNase P. RNase P consists of an RNA moiety and at least 9 protein subunits including POP1, POP3, POP4, POP5, POP6, POP7, POP8, RPP1 and RPR2, many of which are shared with the RNase MPR complex.1 Publication

    Protein-protein interaction databases

    BioGridi35007. 14 interactions.
    IntActiP40571. 3 interactions.
    MINTiMINT-2786613.
    STRINGi4932.YIR015W.

    Structurei

    3D structure databases

    ProteinModelPortaliP40571.
    SMRiP40571. Positions 35-127.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG2023.
    HOGENOMiHOG000231207.
    KOiK03540.
    OMAiRTIANQD.
    OrthoDBiEOG7W6X08.

    Family and domain databases

    InterProiIPR007175. Rpr2.
    [Graphical view]
    PANTHERiPTHR14742. PTHR14742. 1 hit.
    PfamiPF04032. Rpr2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P40571-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGKKAHGGKM KPEIDENGTL LVPPPRTIAN QDHFHRLNYL YQISAYQTRA    50
    RQKARTDAHT PLARNYIKSM DLISKKTKTS LLPTIKRTIC KKCHRLLWTP 100
    KKLEITSDGA LSVMCGCGTV KRFNIGADPN YRTYSEREGN LLNS 144
    Length:144
    Mass (Da):16,344
    Last modified:February 1, 1995 - v1
    Checksum:i91AEF14F80D76148
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z37996 Genomic DNA. Translation: CAA86085.1.
    AY557849 Genomic DNA. Translation: AAS56175.1.
    BK006942 Genomic DNA. Translation: DAA08561.1.
    PIRiS48359.
    RefSeqiNP_012280.1. NM_001179537.1.

    Genome annotation databases

    EnsemblFungiiYIR015W; YIR015W; YIR015W.
    GeneIDi854832.
    KEGGisce:YIR015W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z37996 Genomic DNA. Translation: CAA86085.1 .
    AY557849 Genomic DNA. Translation: AAS56175.1 .
    BK006942 Genomic DNA. Translation: DAA08561.1 .
    PIRi S48359.
    RefSeqi NP_012280.1. NM_001179537.1.

    3D structure databases

    ProteinModelPortali P40571.
    SMRi P40571. Positions 35-127.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 35007. 14 interactions.
    IntActi P40571. 3 interactions.
    MINTi MINT-2786613.
    STRINGi 4932.YIR015W.

    Proteomic databases

    MaxQBi P40571.
    PaxDbi P40571.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YIR015W ; YIR015W ; YIR015W .
    GeneIDi 854832.
    KEGGi sce:YIR015W.

    Organism-specific databases

    CYGDi YIR015w.
    SGDi S000001454. RPR2.

    Phylogenomic databases

    eggNOGi COG2023.
    HOGENOMi HOG000231207.
    KOi K03540.
    OMAi RTIANQD.
    OrthoDBi EOG7W6X08.

    Enzyme and pathway databases

    BioCyci YEAST:YIR015W-MONOMER.

    Miscellaneous databases

    NextBioi 977701.
    PROi P40571.

    Gene expression databases

    Genevestigatori P40571.

    Family and domain databases

    InterProi IPR007175. Rpr2.
    [Graphical view ]
    PANTHERi PTHR14742. PTHR14742. 1 hit.
    Pfami PF04032. Rpr2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    4. "Purification and characterization of the nuclear RNase P holoenzyme complex reveals extensive subunit overlap with RNase MRP."
      Chamberlain J.R., Lee Y., Lane W.S., Engelke D.R.
      Genes Dev. 12:1678-1690(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, IDENTIFICATION IN THE RNASE P COMPLEX BY MASS SPECTROMETRY.
    5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiRPR2_YEAST
    AccessioniPrimary (citable) accession number: P40571
    Secondary accession number(s): D6VVU5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 2070 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome IX
      Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

    External Data

    Dasty 3