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Protein

Ribonuclease P protein subunit RPR2

Gene

RPR2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.1 Publication

Miscellaneous

Present with 2070 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi90ZincBy similarity1
Metal bindingi93ZincBy similarity1
Metal bindingi115ZincBy similarity1
Metal bindingi117ZincBy similarity1

GO - Molecular functioni

GO - Biological processi

  • intronic box C/D snoRNA processing Source: SGD
  • tRNA processing Source: SGD

Keywordsi

Molecular functionHydrolase
Biological processtRNA processing
LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:YIR015W-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease P protein subunit RPR2 (EC:3.1.26.5)
Alternative name(s):
RNA-processing protein RPR2
RNase P 16.4 kDa subunit
Gene namesi
Name:RPR2
Ordered Locus Names:YIR015W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IX

Organism-specific databases

EuPathDBiFungiDB:YIR015W
SGDiS000001454 RPR2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001538471 – 144Ribonuclease P protein subunit RPR2Add BLAST144

Proteomic databases

MaxQBiP40571
PaxDbiP40571

Interactioni

Subunit structurei

Component of nuclear RNase P. RNase P consists of an RNA moiety and at least 9 protein subunits including POP1, POP3, POP4, POP5, POP6, POP7, POP8, RPP1 and RPR2, many of which are shared with the RNase MPR complex.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi35007, 18 interactors
IntActiP40571, 7 interactors
MINTiP40571
STRINGi4932.YIR015W

Structurei

3D structure databases

ProteinModelPortaliP40571
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000231207
InParanoidiP40571
KOiK03540
OMAiPRTIANQ
OrthoDBiEOG092C5WX8

Family and domain databases

InterProiView protein in InterPro
IPR007175 Rpr2
PfamiView protein in Pfam
PF04032 Rpr2, 1 hit

Sequencei

Sequence statusi: Complete.

P40571-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKKAHGGKM KPEIDENGTL LVPPPRTIAN QDHFHRLNYL YQISAYQTRA
60 70 80 90 100
RQKARTDAHT PLARNYIKSM DLISKKTKTS LLPTIKRTIC KKCHRLLWTP
110 120 130 140
KKLEITSDGA LSVMCGCGTV KRFNIGADPN YRTYSEREGN LLNS
Length:144
Mass (Da):16,344
Last modified:February 1, 1995 - v1
Checksum:i91AEF14F80D76148
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z37996 Genomic DNA Translation: CAA86085.1
AY557849 Genomic DNA Translation: AAS56175.1
BK006942 Genomic DNA Translation: DAA08561.1
PIRiS48359
RefSeqiNP_012280.1, NM_001179537.1

Genome annotation databases

EnsemblFungiiYIR015W; YIR015W; YIR015W
GeneIDi854832
KEGGisce:YIR015W

Similar proteinsi

Entry informationi

Entry nameiRPR2_YEAST
AccessioniPrimary (citable) accession number: P40571
Secondary accession number(s): D6VVU5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: March 28, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health