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P40571

- RPR2_YEAST

UniProt

P40571 - RPR2_YEAST

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Protein

Ribonuclease P protein subunit RPR2

Gene

RPR2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.1 Publication

Catalytic activityi

Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.

Cofactori

Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi90 – 901ZincBy similarity
Metal bindingi93 – 931ZincBy similarity
Metal bindingi115 – 1151ZincBy similarity
Metal bindingi117 – 1171ZincBy similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. ribonuclease P activity Source: UniProtKB-EC

GO - Biological processi

  1. intronic box C/D snoRNA processing Source: SGD
  2. RNA phosphodiester bond hydrolysis Source: GOC
  3. RNA phosphodiester bond hydrolysis, endonucleolytic Source: GOC
  4. tRNA processing Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:YIR015W-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease P protein subunit RPR2 (EC:3.1.26.5)
Alternative name(s):
RNA-processing protein RPR2
RNase P 16.4 kDa subunit
Gene namesi
Name:RPR2
Ordered Locus Names:YIR015W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome IX

Organism-specific databases

CYGDiYIR015w.
SGDiS000001454. RPR2.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. nucleolar ribonuclease P complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 144144Ribonuclease P protein subunit RPR2PRO_0000153847Add
BLAST

Proteomic databases

MaxQBiP40571.
PaxDbiP40571.

Expressioni

Gene expression databases

GenevestigatoriP40571.

Interactioni

Subunit structurei

Component of nuclear RNase P. RNase P consists of an RNA moiety and at least 9 protein subunits including POP1, POP3, POP4, POP5, POP6, POP7, POP8, RPP1 and RPR2, many of which are shared with the RNase MPR complex.1 Publication

Protein-protein interaction databases

BioGridi35007. 14 interactions.
IntActiP40571. 3 interactions.
MINTiMINT-2786613.
STRINGi4932.YIR015W.

Structurei

3D structure databases

ProteinModelPortaliP40571.
SMRiP40571. Positions 35-127.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2023.
HOGENOMiHOG000231207.
InParanoidiP40571.
KOiK03540.
OMAiRTIANQD.
OrthoDBiEOG7W6X08.

Family and domain databases

InterProiIPR007175. Rpr2.
[Graphical view]
PANTHERiPTHR14742. PTHR14742. 1 hit.
PfamiPF04032. Rpr2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P40571-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGKKAHGGKM KPEIDENGTL LVPPPRTIAN QDHFHRLNYL YQISAYQTRA
60 70 80 90 100
RQKARTDAHT PLARNYIKSM DLISKKTKTS LLPTIKRTIC KKCHRLLWTP
110 120 130 140
KKLEITSDGA LSVMCGCGTV KRFNIGADPN YRTYSEREGN LLNS
Length:144
Mass (Da):16,344
Last modified:February 1, 1995 - v1
Checksum:i91AEF14F80D76148
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z37996 Genomic DNA. Translation: CAA86085.1.
AY557849 Genomic DNA. Translation: AAS56175.1.
BK006942 Genomic DNA. Translation: DAA08561.1.
PIRiS48359.
RefSeqiNP_012280.1. NM_001179537.1.

Genome annotation databases

EnsemblFungiiYIR015W; YIR015W; YIR015W.
GeneIDi854832.
KEGGisce:YIR015W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z37996 Genomic DNA. Translation: CAA86085.1 .
AY557849 Genomic DNA. Translation: AAS56175.1 .
BK006942 Genomic DNA. Translation: DAA08561.1 .
PIRi S48359.
RefSeqi NP_012280.1. NM_001179537.1.

3D structure databases

ProteinModelPortali P40571.
SMRi P40571. Positions 35-127.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 35007. 14 interactions.
IntActi P40571. 3 interactions.
MINTi MINT-2786613.
STRINGi 4932.YIR015W.

Proteomic databases

MaxQBi P40571.
PaxDbi P40571.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YIR015W ; YIR015W ; YIR015W .
GeneIDi 854832.
KEGGi sce:YIR015W.

Organism-specific databases

CYGDi YIR015w.
SGDi S000001454. RPR2.

Phylogenomic databases

eggNOGi COG2023.
HOGENOMi HOG000231207.
InParanoidi P40571.
KOi K03540.
OMAi RTIANQD.
OrthoDBi EOG7W6X08.

Enzyme and pathway databases

BioCyci YEAST:YIR015W-MONOMER.

Miscellaneous databases

NextBioi 977701.
PROi P40571.

Gene expression databases

Genevestigatori P40571.

Family and domain databases

InterProi IPR007175. Rpr2.
[Graphical view ]
PANTHERi PTHR14742. PTHR14742. 1 hit.
Pfami PF04032. Rpr2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. "Purification and characterization of the nuclear RNase P holoenzyme complex reveals extensive subunit overlap with RNase MRP."
    Chamberlain J.R., Lee Y., Lane W.S., Engelke D.R.
    Genes Dev. 12:1678-1690(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, IDENTIFICATION IN THE RNASE P COMPLEX BY MASS SPECTROMETRY.
  5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRPR2_YEAST
AccessioniPrimary (citable) accession number: P40571
Secondary accession number(s): D6VVU5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: October 29, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 2070 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IX
    Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

External Data

Dasty 3