P40570 (YIT4_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative uncharacterized protein YIR014W

Gene names

Ordered Locus Names:

YIR014W

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	242 AA.
Sequence status	Complete.
Protein existence	Predicted

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence caution	The sequence AAT92745.1 differs from that shown. Reason: Erroneous initiation. The sequence CAA86084.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	fungal-type vacuole Inferred from direct assay PubMed 14562095. Source: SGD integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 242	242	Putative uncharacterized protein YIR014W		PRO_0000203004
Regions
	Transmembrane	128 – 148	21	Helical; Potential
	Transmembrane	152 – 172	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	P40570 [UniParc]. Last modified December 6, 2005. Version 2. Checksum: D81202C770462809	FASTA	242	27,600
	10 20 30 40 50 60 MLHLEDDNGR QRSVIANLQK FVYCCLYLRF IKDGSLFLIL LGWIISSLCD FIQELTLRYL 70 80 90 100 110 120 KKNYLEVGRD NDQEDDESLA IRGLETPIVR MIINKAIRYY QGLILLETAY CIVYHIRLDV 130 140 150 160 170 180 SRDICSKPYG FVIMLLIREF TCPVPTAFPS KLLLVLLDIL LLFCQIVIIN GSLSSSLQNV 190 200 210 220 230 240 KLIVKELNAE EEGALNILKL NTWHMDATGP ELIVLKNHDK SIPQQADGDD ATEITPLLNI AE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome IX." Churcher C.M., Bowman S., Badcock K., Bankier A.T., Brown D., Chillingworth T., Connor R., Devlin K., Gentles S., Hamlin N., Harris D.E., Horsnell T., Hunt S., Jagels K., Jones M., Lye G., Moule S., Odell C. , Pearson D., Rajandream M.A., Rice P., Rowley N., Skelton J., Smith V., Walsh S.V., Whitehead S., Barrell B.G. Nature 387:84-87(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J. Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[4]	"Sequencing and comparison of yeast species to identify genes and regulatory elements." Kellis M., Patterson N., Endrizzi M., Birren B.W., Lander E.S. Nature 423:241-254(2003) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION OF PROBABLE INITIATION SITE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z37996 Genomic DNA. Translation: CAA86084.1. Different initiation. AY692726 Genomic DNA. Translation: AAT92745.1. Different initiation. BK006942 Genomic DNA. Translation: DAA08560.1.
PIR	S48358.
RefSeq	NP_012279.4. NM_001179536.3.
3D structure databases
ProteinModelPortal	P40570.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-2640N.
IntAct	P40570. 2 interactions.
MINT	MINT-425416.
STRING	4932.YIR014W.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YIR014W; YIR014W; YIR014W.
GeneID	854831.
KEGG	sce:YIR014W.
Organism-specific databases
CYGD	YIR014w.
SGD	S000001453. YIR014W.
Phylogenomic databases
eggNOG	NOG83059.
OMA	VINIERD.
OrthoDB	EOG4Z65ZG.
Enzyme and pathway databases
BioCyc	YEAST:G3O-31435-MONOMER.
Gene expression databases
Genevestigator	P40570.
GermOnline	YIR014W. Saccharomyces cerevisiae.
Family and domain databases
ProtoNet	Search...
Other
NextBio	977698.

Entry information

Entry name

YIT4_YEAST

Accession

Primary (citable) accession number: P40570
Secondary accession number(s): D6VVU4

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	December 6, 2005
Last modified:	May 29, 2013
This is version 82 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program