DSN1

Functionⁱ

Acts as essential component of the kinetochore MIND complex, which is required for the spindle checkpoint and kinetochore integrity. MIND plays a role in establishing a bipolar spindle-kinetochore interaction by joining kinetochore subunits contacting DNA to those contacting microtubules.2 Publications

Miscellaneous

Present with 1310 molecules/cell in log phase SD medium.1 Publication

GO - Biological processⁱ

attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation
Source: SGD
Inferred from genetic interactionⁱ
- 23861669
cell division Source: UniProtKB-KW
chromosome segregation
Source: SGD
Inferred from direct assayⁱ
- 12455957
mitotic sister chromatid segregation Source: GO_Central

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Cell cycle, Cell division, Mitosis

Biological process

Cell cycle, Cell division, Mitosis

Enzyme and pathway databases

BioCycⁱ	YEAST:G3O-31431-MONOMER.

BioCycⁱ

YEAST:G3O-31431-MONOMER.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Kinetochore-associated protein DSN1
Gene namesⁱ	Name:DSN1 Ordered Locus Names:YIR010W ORF Names:YIB10W
Organismⁱ	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifierⁱ	559292 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae
Proteomesⁱ	UP000002311 Componentⁱ: Chromosome IX

Organism-specific databases

EuPathDBⁱ	FungiDB:YIR010W.
Saccharomyces Genome Database More...SGDⁱ	S000001449. DSN1.

Keywords - Cellular componentⁱ

Centromere, Chromosome, Kinetochore, Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000080024	1 – 576	Kinetochore-associated protein DSN1Add BLAST		576

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	250	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P40568.
PaxDbⁱ	P40568.
PRIDEⁱ	P40568.

PTM databases

iPTMnetⁱ	P40568.

iPTMnetⁱ

P40568.

Interactionⁱ

Subunit structureⁱ

Component of the MIND kinetochore complex, which is composed of at least MTW1, NNF1, NSL1 and DSN1.3 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
CSM1	P25651	3	EBI-25398,EBI-22001
MTW1	P39731	15	EBI-25398,EBI-11606
NNF1	P47149	15	EBI-25398,EBI-12098
NSL1	Q12143	19	EBI-25398,EBI-33666

Show more details

Protein-protein interaction databases

BioGridⁱ	35002. 640 interactors.
Database of interacting proteins More...DIPⁱ	DIP-4794N.
IntActⁱ	P40568. 39 interactors.
Molecular INTeraction database More...MINTⁱ	P40568.
STRINGⁱ	4932.YIR010W.

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Show more details

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Helixⁱ	561 – 570	Combined sources		10

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	5T6J	X-ray	1.75	C	560-572	[»]
ProteinModelPortalⁱ	P40568.
SMRⁱ	P40568.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Phylogenomic databases

HOGENOMⁱ	HOG000112286.
InParanoidⁱ	P40568.
KEGG Orthology (KO) More...KOⁱ	K11560.
OMAⁱ	IISPHKD.
Database of Orthologous Groups More...OrthoDBⁱ	EOG092C5AKJ.

Family and domain databases

InterProⁱ	View protein in InterPro IPR013218. Dsn1/Mis13. IPR018247. EF_Hand_1_Ca_BS.
PANTHERⁱ	PTHR14778. PTHR14778. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08202. MIS13. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

P40568-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSLEPTQTVS GTPPMLHQRT HKQVYPLRME TIPILESDSK ATLQSNEPTQ 
        60         70         80         90        100
KDEEETEYFE NKQSVSNLSP DLKFKRHKNK HIQGFPTLGE RLDNLQDIKK 
       110        120        130        140        150
AKRVENFNSS APIADDNHSG DATANATANA TANATANVNA SAMPAPYMPY 
       160        170        180        190        200
YYYYHPMNAP TPAMIPYPGS PMHSIMPNSS LQPFYSQPTA AGGPDMTTPQ 
       210        220        230        240        250
NISSSQQLLP APQLFPYGSF HQQQLQQPHY IQRTRERKKS IGSQRGRRLS 
       260        270        280        290        300
MLASQANGGS TIISPHKDIP EEDFYTVVGN ASFGKNLQIR QLFNWCLMRS 
       310        320        330        340        350
LHKLELKAKN QEEEGELEHL TKKSKLESTK AETDYVDPKR LAMVIIKEFV 
       360        370        380        390        400
DDLKKDHIAI DWEDEEKYED EDEEKILDNT ENYDDTELRQ LFQENDDDDD 
       410        420        430        440        450
DDDEVDYSEI QRSRRKFSER RKALPKEPKK LLPNSKNVEN TKNLSILTSK 
       460        470        480        490        500
VNAIKNEVKE WAVTLDTSRP DLEWQELTSF SSQPLEPLSD TEEPDLAIAD 
       510        520        530        540        550
VETKLETKVD ELRYQSHILN SHSLALNEIT NSKVNKLNIE TMRKISSETD 
       560        570 
DDHSQVINPQ QLLKGLSLSF SKKLDL

Length:576

Mass (Da):65,692

Last modified:February 1, 1995 - v1

Checksum:ⁱF859D3547378C072

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X79743 Genomic DNA. No translation available. Z37996 Genomic DNA. Translation: CAA86080.1. BK006942 Genomic DNA. Translation: DAA08556.1.
PIRⁱ	S48354.
NCBI Reference Sequences More...RefSeqⁱ	NP_012275.3. NM_001179532.3.

Genome annotation databases

EnsemblFungiⁱ	YIR010W; YIR010W; YIR010W.
GeneIDⁱ	854827.
KEGGⁱ	sce:YIR010W.

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
P40568	N1P0Q8 B5VKU3 UPI0007622749 H9TYP0	Saccharomyces cerevisiae (strain CEN.PK113-7D) (Baker's yeast) Saccharomyces cerevisiae (strain AWRI1631) (Baker's yeast) Marmota marmota marmota (Alpine marmot) Saccharomyces cerevisiae (Baker's yeast)	576	UniRef100_P40568	Cluster: Kinetochore-associated protein DSN1	5

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
P40568	N1P0Q8 B5VKU3 UPI0007622749 H9TYP0 C8ZAQ9 H9TYV4 B3LTJ9 A0A0L8VNV5 A0A1L4A9Z4 C7GJG2 +6	Saccharomyces cerevisiae (strain CEN.PK113-7D) (Baker's yeast) Saccharomyces cerevisiae (strain AWRI1631) (Baker's yeast) Marmota marmota marmota (Alpine marmot) Saccharomyces cerevisiae (Baker's yeast) Saccharomyces cerevisiae (strain Lalvin EC1118 / Prise de mousse) (Baker's yeast) Saccharomyces cerevisiae (strain RM11-1a) (Baker's yeast) Saccharomyces sp. 'boulardii' Saccharomyces cerevisiae (strain JAY291) (Baker's yeast) Saccharomyces cerevisiae (strain YJM789) (Baker's yeast) Saccharomyces paradoxus (Yeast) (Saccharomyces douglasii) And more	576	UniRef90_P40568	Cluster: Kinetochore-associated protein DSN1	17

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
P40568	N1P0Q8 B5VKU3 UPI0007622749 H9TYP0 B3LTJ9 A0A0L8VNV5 C8ZAQ9 H9TYV4 A0A1L4A9Z4 C7GJG2 +17	Saccharomyces cerevisiae (strain CEN.PK113-7D) (Baker's yeast) Saccharomyces cerevisiae (strain AWRI1631) (Baker's yeast) Marmota marmota marmota (Alpine marmot) Saccharomyces cerevisiae (Baker's yeast) Saccharomyces cerevisiae (strain RM11-1a) (Baker's yeast) Saccharomyces sp. 'boulardii' Saccharomyces cerevisiae (strain Lalvin EC1118 / Prise de mousse) (Baker's yeast) Saccharomyces cerevisiae (strain JAY291) (Baker's yeast) Saccharomyces cerevisiae (strain YJM789) (Baker's yeast) Saccharomyces paradoxus (Yeast) (Saccharomyces douglasii) And more	576	UniRef50_P40568	Cluster: Kinetochore-associated protein DSN1	28

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X79743 Genomic DNA. No translation available. Z37996 Genomic DNA. Translation: CAA86080.1. BK006942 Genomic DNA. Translation: DAA08556.1.
PIRⁱ	S48354.
NCBI Reference Sequences More...RefSeqⁱ	NP_012275.3. NM_001179532.3.

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	5T6J	X-ray	1.75	C	560-572	[»]
ProteinModelPortalⁱ	P40568.
SMRⁱ	P40568.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	35002. 640 interactors.
Database of interacting proteins More...DIPⁱ	DIP-4794N.
IntActⁱ	P40568. 39 interactors.
Molecular INTeraction database More...MINTⁱ	P40568.
STRINGⁱ	4932.YIR010W.

PTM databases

iPTMnetⁱ	P40568.

iPTMnetⁱ

P40568.

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P40568.
PaxDbⁱ	P40568.
PRIDEⁱ	P40568.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblFungiⁱ	YIR010W; YIR010W; YIR010W.
GeneIDⁱ	854827.
KEGGⁱ	sce:YIR010W.

Organism-specific databases

EuPathDBⁱ	FungiDB:YIR010W.
Saccharomyces Genome Database More...SGDⁱ	S000001449. DSN1.

Phylogenomic databases

HOGENOMⁱ	HOG000112286.
InParanoidⁱ	P40568.
KEGG Orthology (KO) More...KOⁱ	K11560.
OMAⁱ	IISPHKD.
Database of Orthologous Groups More...OrthoDBⁱ	EOG092C5AKJ.

Enzyme and pathway databases

BioCycⁱ	YEAST:G3O-31431-MONOMER.

BioCycⁱ

YEAST:G3O-31431-MONOMER.

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P40568.

PROⁱ

PR:P40568.

Family and domain databases

InterProⁱ	View protein in InterPro IPR013218. Dsn1/Mis13. IPR018247. EF_Hand_1_Ca_BS.
PANTHERⁱ	PTHR14778. PTHR14778. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08202. MIS13. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	DSN1_YEAST
Accessionⁱ	P40568Primary (citable) accession number: P40568 Secondary accession number(s): D6VVU0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
	Last sequence update:	February 1, 1995
	Last modified:	March 28, 2018
	This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Fungal Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

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Supporting data

UniProtKB - P40568 (DSN1_YEAST)

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Kinetochore-associated protein DSN1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Cytoskeleton

Nucleus

Other locations

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ