UniProtKB - P40568 (DSN1_YEAST)
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Protein
Kinetochore-associated protein DSN1
Gene
DSN1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Acts as essential component of the kinetochore MIND complex, which is required for the spindle checkpoint and kinetochore integrity. MIND plays a role in establishing a bipolar spindle-kinetochore interaction by joining kinetochore subunits contacting DNA to those contacting microtubules.2 Publications
Miscellaneous
Present with 1310 molecules/cell in log phase SD medium.1 Publication
GO - Biological processi
- attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation Source: SGD
- cell division Source: UniProtKB-KW
- chromosome segregation Source: SGD
- mitotic sister chromatid segregation Source: GO_Central
Keywordsi
Biological process | Cell cycle, Cell division, Mitosis |
Enzyme and pathway databases
BioCyci | YEAST:G3O-31431-MONOMER. |
Names & Taxonomyi
Protein namesi | Recommended name: Kinetochore-associated protein DSN1 |
Gene namesi | Name:DSN1 Ordered Locus Names:YIR010W ORF Names:YIB10W |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | FungiDB:YIR010W. |
SGDi | S000001449. DSN1. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000080024 | 1 – 576 | Kinetochore-associated protein DSN1Add BLAST | 576 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 250 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | P40568. |
PaxDbi | P40568. |
PRIDEi | P40568. |
PTM databases
iPTMneti | P40568. |
Interactioni
Subunit structurei
Component of the MIND kinetochore complex, which is composed of at least MTW1, NNF1, NSL1 and DSN1.3 Publications
Binary interactionsi
Protein-protein interaction databases
BioGridi | 35002. 640 interactors. |
DIPi | DIP-4794N. |
IntActi | P40568. 39 interactors. |
MINTi | P40568. |
STRINGi | 4932.YIR010W. |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more detailsFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Helixi | 561 – 570 | Combined sources | 10 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5T6J | X-ray | 1.75 | C | 560-572 | [»] | |
ProteinModelPortali | P40568. | |||||
SMRi | P40568. | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Family & Domainsi
Phylogenomic databases
HOGENOMi | HOG000112286. |
InParanoidi | P40568. |
KOi | K11560. |
OMAi | IISPHKD. |
OrthoDBi | EOG092C5AKJ. |
Family and domain databases
InterProi | View protein in InterPro IPR013218. Dsn1/Mis13. IPR018247. EF_Hand_1_Ca_BS. |
PANTHERi | PTHR14778. PTHR14778. 1 hit. |
Pfami | View protein in Pfam PF08202. MIS13. 1 hit. |
i Sequence
Sequence statusi: Complete.
P40568-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSLEPTQTVS GTPPMLHQRT HKQVYPLRME TIPILESDSK ATLQSNEPTQ
60 70 80 90 100
KDEEETEYFE NKQSVSNLSP DLKFKRHKNK HIQGFPTLGE RLDNLQDIKK
110 120 130 140 150
AKRVENFNSS APIADDNHSG DATANATANA TANATANVNA SAMPAPYMPY
160 170 180 190 200
YYYYHPMNAP TPAMIPYPGS PMHSIMPNSS LQPFYSQPTA AGGPDMTTPQ
210 220 230 240 250
NISSSQQLLP APQLFPYGSF HQQQLQQPHY IQRTRERKKS IGSQRGRRLS
260 270 280 290 300
MLASQANGGS TIISPHKDIP EEDFYTVVGN ASFGKNLQIR QLFNWCLMRS
310 320 330 340 350
LHKLELKAKN QEEEGELEHL TKKSKLESTK AETDYVDPKR LAMVIIKEFV
360 370 380 390 400
DDLKKDHIAI DWEDEEKYED EDEEKILDNT ENYDDTELRQ LFQENDDDDD
410 420 430 440 450
DDDEVDYSEI QRSRRKFSER RKALPKEPKK LLPNSKNVEN TKNLSILTSK
460 470 480 490 500
VNAIKNEVKE WAVTLDTSRP DLEWQELTSF SSQPLEPLSD TEEPDLAIAD
510 520 530 540 550
VETKLETKVD ELRYQSHILN SHSLALNEIT NSKVNKLNIE TMRKISSETD
560 570
DDHSQVINPQ QLLKGLSLSF SKKLDL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X79743 Genomic DNA. No translation available. Z37996 Genomic DNA. Translation: CAA86080.1. BK006942 Genomic DNA. Translation: DAA08556.1. |
PIRi | S48354. |
RefSeqi | NP_012275.3. NM_001179532.3. |
Genome annotation databases
EnsemblFungii | YIR010W; YIR010W; YIR010W. |
GeneIDi | 854827. |
KEGGi | sce:YIR010W. |
Similar proteinsi
Entry informationi
Entry namei | DSN1_YEAST | |
Accessioni | P40568Primary (citable) accession number: P40568 Secondary accession number(s): D6VVU0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1995 |
Last sequence update: | February 1, 1995 | |
Last modified: | March 28, 2018 | |
This is version 136 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |