Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

U2 small nuclear ribonucleoprotein B''

Gene

MSL1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in pre-mRNA splicing. This protein is associated with snRNP U2. It binds stem loop IV of U2 snRNA.1 Publication

Miscellaneous

Present with 504 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • U2 snRNA binding Source: SGD

GO - Biological processi

  • mRNA splicing, via spliceosome Source: SGD

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding
Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

BioCyciYEAST:G3O-31430-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
U2 small nuclear ribonucleoprotein B''
Short name:
U2 snRNP B''
Gene namesi
Name:MSL1
Ordered Locus Names:YIR009W
ORF Names:YIB9W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IX

Organism-specific databases

EuPathDBiFungiDB:YIR009W
SGDiS000001448 MSL1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000818951 – 111U2 small nuclear ribonucleoprotein B''Add BLAST111

Proteomic databases

MaxQBiP40567
PaxDbiP40567
PRIDEiP40567

Interactioni

Subunit structurei

Belongs to the CWC complex (or CEF1-associated complex), a spliceosome sub-complex reminiscent of a late-stage spliceosome composed of the U2, U5 and U6 snRNAs and at least BUD13, BUD31, BRR2, CDC40, CEF1, CLF1, CUS1, CWC2, CWC15, CWC21, CWC22, CWC23, CWC24, CWC25, CWC27, ECM2, HSH155, IST3, ISY1, LEA1, MSL1, NTC20, PRP8, PRP9, PRP11, PRP19, PRP21, PRP22, PRP45, PRP46, SLU7, SMB1, SMD1, SMD2, SMD3, SMX2, SMX3, SNT309, SNU114, SPP2, SYF1, SYF2, RSE1 and YJU2. Interacts with RDS3. Interacts with LEA1.2 Publications

Protein-protein interaction databases

BioGridi35001, 79 interactors
ComplexPortaliCPX-1651 PRP19-associated complex
CPX-26 U2 snRNP
DIPiDIP-816N
IntActiP40567, 10 interactors
MINTiP40567
STRINGi4932.YIR009W

Structurei

Secondary structure

1111
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi30 – 32Combined sources3
Beta strandi37 – 39Combined sources3
Helixi41 – 52Combined sources12
Turni53 – 55Combined sources3
Turni66 – 70Combined sources5
Beta strandi72 – 74Combined sources3
Helixi79 – 88Combined sources10
Turni89 – 91Combined sources3
Beta strandi100 – 103Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5GMKelectron microscopy3.40a1-111[»]
5LJ3electron microscopy3.80Y1-111[»]
5LJ5electron microscopy3.80Y1-111[»]
5MQ0electron microscopy4.17Y1-111[»]
5NRLelectron microscopy7.20Y1-111[»]
5WSGelectron microscopy4.00X1-111[»]
6BK8electron microscopy3.30r1-111[»]
6EXNelectron microscopy3.70Y1-111[»]
ProteinModelPortaliP40567
SMRiP40567
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 106RRMPROSITE-ProRule annotationAdd BLAST79

Phylogenomic databases

GeneTreeiENSGT00390000007046
HOGENOMiHOG000000973
OMAiEPKQTLY
OrthoDBiEOG092C5A64

Family and domain databases

Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit

Sequencei

Sequence statusi: Complete.

P40567-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVEPARKKQR IDRDTHHTVA EPVTEAKNTL YVSQLNEKIN MQRLRVNLFL
60 70 80 90 100
LFATFGEVLK VSMNFKKQRG QAFITMRTID QASLAQISLN GERFFGKPLK
110
VEFSKSETKT L
Length:111
Mass (Da):12,830
Last modified:February 1, 1995 - v1
Checksum:i8FB0974FC30994AE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X79743 Genomic DNA No translation available.
Z37996 Genomic DNA Translation: CAA86079.1
AY558237 Genomic DNA Translation: AAS56563.1
BK006942 Genomic DNA Translation: DAA08555.1
PIRiS48353
RefSeqiNP_012274.1, NM_001179531.1

Genome annotation databases

EnsemblFungiiYIR009W; YIR009W; YIR009W
GeneIDi854826
KEGGisce:YIR009W

Similar proteinsi

Entry informationi

Entry nameiMSL1_YEAST
AccessioniPrimary (citable) accession number: P40567
Secondary accession number(s): D6VVT9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: June 20, 2018
This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IX
    Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health