MSL1

Protein namesⁱ	Recommended name: U2 small nuclear ribonucleoprotein B'' Short name: U2 snRNP B''
Gene namesⁱ	Name:MSL1 Ordered Locus Names:YIR009W ORF Names:YIB9W
Organismⁱ	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifierⁱ	559292 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae
Proteomesⁱ	UP000002311 Componentⁱ: Chromosome IX

Organism-specific databases

EuPathDBⁱ	FungiDB:YIR009W.
Saccharomyces Genome Database More...SGDⁱ	S000001448. MSL1.

Subcellular locationⁱ

Nucleus

GO - Cellular componentⁱ

U2 snRNP
Source: SGD
Traceable author statementⁱ
- 11804584
U2-type prespliceosome
Source: SGD
Inferred from direct assayⁱ
- 16618970

Complete GO annotation...

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000081895	1 – 111	U2 small nuclear ribonucleoprotein B''Add BLAST		111

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P40567.
PRIDEⁱ	P40567.

Interactionⁱ

Subunit structureⁱ

Belongs to the CWC complex (or CEF1-associated complex), a spliceosome sub-complex reminiscent of a late-stage spliceosome composed of the U2, U5 and U6 snRNAs and at least BUD13, BUD31, BRR2, CDC40, CEF1, CLF1, CUS1, CWC2, CWC15, CWC21, CWC22, CWC23, CWC24, CWC25, CWC27, ECM2, HSH155, IST3, ISY1, LEA1, MSL1, NTC20, PRP8, PRP9, PRP11, PRP19, PRP21, PRP22, PRP45, PRP46, SLU7, SMB1, SMD1, SMD2, SMD3, SMX2, SMX3, SNT309, SNU114, SPP2, SYF1, SYF2, RSE1 and YJU2. Interacts with RDS3. Interacts with LEA1.2 Publications

Protein-protein interaction databases

BioGridⁱ	35001. 74 interactors.
Database of interacting proteins More...DIPⁱ	DIP-816N.
IntActⁱ	P40567. 10 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-572508.
STRINGⁱ	4932.YIR009W.

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Show more details

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	30 – 34	Combined sources	5
Helixⁱ	41 – 53	Combined sources	13
Turnⁱ	66 – 70	Combined sources	5
Beta strandⁱ	72 – 74	Combined sources	3
Helixⁱ	79 – 88	Combined sources	10
Beta strandⁱ	100 – 103	Combined sources	4

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	5GMK	electron microscopy	3.40	a	1-111	[»]
	5LJ3	electron microscopy	3.80	Y	1-111	[»]
	5LJ5	electron microscopy	3.80	Y	1-111	[»]
	5MQ0	electron microscopy	4.17	Y	1-111	[»]
	5WSG	electron microscopy	4.00	X	1-111	[»]
ProteinModelPortalⁱ	P40567.
SMRⁱ	P40567.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	28 – 106	RRMPROSITE-ProRule annotationAdd BLAST		79

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000007046.
HOGENOMⁱ	HOG000000973.
OMAⁱ	FFDKPLV.
Database of Orthologous Groups More...OrthoDBⁱ	EOG092C5A64.

Family and domain databases

InterProⁱ	View protein in InterPro IPR000504. RRM_dom.
SMARTⁱ	View protein in SMART SM00360. RRM. 1 hit.
SUPFAMⁱ	SSF54928. SSF54928. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50102. RRM. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

P40567-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MVEPARKKQR IDRDTHHTVA EPVTEAKNTL YVSQLNEKIN MQRLRVNLFL 
        60         70         80         90        100
LFATFGEVLK VSMNFKKQRG QAFITMRTID QASLAQISLN GERFFGKPLK 
       110 
VEFSKSETKT L

Length:111

Mass (Da):12,830

Last modified:February 1, 1995 - v1

Checksum:ⁱ8FB0974FC30994AE

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X79743 Genomic DNA. No translation available. Z37996 Genomic DNA. Translation: CAA86079.1. AY558237 Genomic DNA. Translation: AAS56563.1. BK006942 Genomic DNA. Translation: DAA08555.1.
PIRⁱ	S48353.
NCBI Reference Sequences More...RefSeqⁱ	NP_012274.1. NM_001179531.1.

Genome annotation databases

EnsemblFungiⁱ	YIR009W; YIR009W; YIR009W.
GeneIDⁱ	854826.
KEGGⁱ	sce:YIR009W.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X79743 Genomic DNA. No translation available. Z37996 Genomic DNA. Translation: CAA86079.1. AY558237 Genomic DNA. Translation: AAS56563.1. BK006942 Genomic DNA. Translation: DAA08555.1.
PIRⁱ	S48353.
NCBI Reference Sequences More...RefSeqⁱ	NP_012274.1. NM_001179531.1.

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	5GMK	electron microscopy	3.40	a	1-111	[»]
	5LJ3	electron microscopy	3.80	Y	1-111	[»]
	5LJ5	electron microscopy	3.80	Y	1-111	[»]
	5MQ0	electron microscopy	4.17	Y	1-111	[»]
	5WSG	electron microscopy	4.00	X	1-111	[»]
ProteinModelPortalⁱ	P40567.
SMRⁱ	P40567.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	35001. 74 interactors.
Database of interacting proteins More...DIPⁱ	DIP-816N.
IntActⁱ	P40567. 10 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-572508.
STRINGⁱ	4932.YIR009W.

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P40567.
PRIDEⁱ	P40567.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblFungiⁱ	YIR009W; YIR009W; YIR009W.
GeneIDⁱ	854826.
KEGGⁱ	sce:YIR009W.

Organism-specific databases

EuPathDBⁱ	FungiDB:YIR009W.
Saccharomyces Genome Database More...SGDⁱ	S000001448. MSL1.

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000007046.
HOGENOMⁱ	HOG000000973.
OMAⁱ	FFDKPLV.
Database of Orthologous Groups More...OrthoDBⁱ	EOG092C5A64.

Enzyme and pathway databases

BioCycⁱ	YEAST:G3O-31430-MONOMER.

BioCycⁱ

YEAST:G3O-31430-MONOMER.

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P40567.

PROⁱ

PR:P40567.

Family and domain databases

InterProⁱ	View protein in InterPro IPR000504. RRM_dom.
SMARTⁱ	View protein in SMART SM00360. RRM. 1 hit.
SUPFAMⁱ	SSF54928. SSF54928. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50102. RRM. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MSL1_YEAST
Accessionⁱ	P40567Primary (citable) accession number: P40567 Secondary accession number(s): D6VVT9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
	Last sequence update:	February 1, 1995
	Last modified:	July 5, 2017
	This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Fungal Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
Yeast chromosome IX
Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P40567 (MSL1_YEAST)

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U2 small nuclear ribonucleoprotein B''

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ