UniProtKB - P40567 (MSL1_YEAST)
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Protein
U2 small nuclear ribonucleoprotein B''
Gene
MSL1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Involved in pre-mRNA splicing. This protein is associated with snRNP U2. It binds stem loop IV of U2 snRNA.1 Publication
Miscellaneous
Present with 504 molecules/cell in log phase SD medium.1 Publication
GO - Molecular functioni
- U2 snRNA binding Source: SGD
GO - Biological processi
- mRNA splicing, via spliceosome Source: SGD
Keywordsi
Molecular function | Ribonucleoprotein, RNA-binding |
Biological process | mRNA processing, mRNA splicing |
Enzyme and pathway databases
BioCyci | YEAST:G3O-31430-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: U2 small nuclear ribonucleoprotein B''Short name: U2 snRNP B'' |
Gene namesi | Name:MSL1 Ordered Locus Names:YIR009W ORF Names:YIB9W |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | FungiDB:YIR009W |
SGDi | S000001448 MSL1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000081895 | 1 – 111 | U2 small nuclear ribonucleoprotein B''Add BLAST | 111 |
Proteomic databases
MaxQBi | P40567 |
PaxDbi | P40567 |
PRIDEi | P40567 |
Interactioni
Subunit structurei
Belongs to the CWC complex (or CEF1-associated complex), a spliceosome sub-complex reminiscent of a late-stage spliceosome composed of the U2, U5 and U6 snRNAs and at least BUD13, BUD31, BRR2, CDC40, CEF1, CLF1, CUS1, CWC2, CWC15, CWC21, CWC22, CWC23, CWC24, CWC25, CWC27, ECM2, HSH155, IST3, ISY1, LEA1, MSL1, NTC20, PRP8, PRP9, PRP11, PRP19, PRP21, PRP22, PRP45, PRP46, SLU7, SMB1, SMD1, SMD2, SMD3, SMX2, SMX3, SNT309, SNU114, SPP2, SYF1, SYF2, RSE1 and YJU2. Interacts with RDS3. Interacts with LEA1.2 Publications
Binary interactionsi
Protein-protein interaction databases
BioGridi | 3500178 interactors. |
DIPi | DIP-816N |
IntActi | P40567 14 interactors. |
MINTi | P40567 |
STRINGi | 4932.YIR009W |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more detailsFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Beta strandi | 30 – 34 | Combined sources | 5 | |
Helixi | 41 – 53 | Combined sources | 13 | |
Turni | 66 – 70 | Combined sources | 5 | |
Beta strandi | 72 – 74 | Combined sources | 3 | |
Helixi | 79 – 88 | Combined sources | 10 | |
Beta strandi | 100 – 103 | Combined sources | 4 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5GMK | electron microscopy | 3.40 | a | 1-111 | [»] | |
5LJ3 | electron microscopy | 3.80 | Y | 1-111 | [»] | |
5LJ5 | electron microscopy | 3.80 | Y | 1-111 | [»] | |
5MQ0 | electron microscopy | 4.17 | Y | 1-111 | [»] | |
5NRL | electron microscopy | 7.20 | Y | 1-111 | [»] | |
5WSG | electron microscopy | 4.00 | X | 1-111 | [»] | |
6BK8 | electron microscopy | 3.30 | r | 1-111 | [»] | |
6EXN | electron microscopy | 3.70 | Y | 1-111 | [»] | |
ProteinModelPortali | P40567 | |||||
SMRi | P40567 | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 28 – 106 | RRMPROSITE-ProRule annotationAdd BLAST | 79 |
Phylogenomic databases
GeneTreei | ENSGT00390000007046 |
HOGENOMi | HOG000000973 |
OMAi | EPKQTLY |
OrthoDBi | EOG092C5A64 |
Family and domain databases
Gene3Di | 3.30.70.3301 hit |
InterProi | View protein in InterPro IPR012677 Nucleotide-bd_a/b_plait_sf IPR035979 RBD_domain_sf IPR000504 RRM_dom |
SMARTi | View protein in SMART SM00360 RRM, 1 hit |
SUPFAMi | SSF54928 SSF54928, 1 hit |
PROSITEi | View protein in PROSITE PS50102 RRM, 1 hit |
i Sequence
Sequence statusi: Complete.
P40567-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVEPARKKQR IDRDTHHTVA EPVTEAKNTL YVSQLNEKIN MQRLRVNLFL
60 70 80 90 100
LFATFGEVLK VSMNFKKQRG QAFITMRTID QASLAQISLN GERFFGKPLK
110
VEFSKSETKT L
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X79743 Genomic DNA No translation available. Z37996 Genomic DNA Translation: CAA86079.1 AY558237 Genomic DNA Translation: AAS56563.1 BK006942 Genomic DNA Translation: DAA08555.1 |
PIRi | S48353 |
RefSeqi | NP_012274.1, NM_001179531.1 |
Genome annotation databases
EnsemblFungii | YIR009W; YIR009W; YIR009W |
GeneIDi | 854826 |
KEGGi | sce:YIR009W |
Similar proteinsi
Entry informationi
Entry namei | MSL1_YEAST | |
Accessioni | P40567Primary (citable) accession number: P40567 Secondary accession number(s): D6VVT9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1995 |
Last sequence update: | February 1, 1995 | |
Last modified: | April 25, 2018 | |
This is version 146 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |