MSL1

Protein namesⁱ	Recommended name: U2 small nuclear ribonucleoprotein B'' Short name: U2 snRNP B''
Gene namesⁱ	Name:MSL1 Ordered Locus Names:YIR009W ORF Names:YIB9W
Organismⁱ	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifierⁱ	559292 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae
Proteomesⁱ	UP000002311 Componentⁱ: Chromosome IX

Organism-specific databases

EuPathDBⁱ	FungiDB:YIR009W
Saccharomyces Genome Database More...SGDⁱ	S000001448 MSL1

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000081895	1 – 111	U2 small nuclear ribonucleoprotein B''Add BLAST		111

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P40567
PaxDbⁱ	P40567
PRIDEⁱ	P40567

Interactionⁱ

Subunit structureⁱ

Belongs to the CWC complex (or CEF1-associated complex), a spliceosome sub-complex reminiscent of a late-stage spliceosome composed of the U2, U5 and U6 snRNAs and at least BUD13, BUD31, BRR2, CDC40, CEF1, CLF1, CUS1, CWC2, CWC15, CWC21, CWC22, CWC23, CWC24, CWC25, CWC27, ECM2, HSH155, IST3, ISY1, LEA1, MSL1, NTC20, PRP8, PRP9, PRP11, PRP19, PRP21, PRP22, PRP45, PRP46, SLU7, SMB1, SMD1, SMD2, SMD3, SMX2, SMX3, SNT309, SNU114, SPP2, SYF1, SYF2, RSE1 and YJU2. Interacts with RDS3. Interacts with LEA1.2 Publications

Protein-protein interaction databases

BioGridⁱ	35001, 79 interactors
ComplexPortalⁱ	CPX-1651 PRP19-associated complex CPX-26 U2 snRNP
Database of interacting proteins More...DIPⁱ	DIP-816N
IntActⁱ	P40567, 10 interactors
Molecular INTeraction database More...MINTⁱ	P40567
STRINGⁱ	4932.YIR009W

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Show more details

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	30 – 32	Combined sources	3
Beta strandⁱ	37 – 39	Combined sources	3
Helixⁱ	41 – 52	Combined sources	12
Turnⁱ	53 – 55	Combined sources	3
Turnⁱ	66 – 70	Combined sources	5
Beta strandⁱ	72 – 74	Combined sources	3
Helixⁱ	79 – 88	Combined sources	10
Turnⁱ	89 – 91	Combined sources	3
Beta strandⁱ	100 – 103	Combined sources	4

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	5GMK	electron microscopy	3.40	a	1-111	[»]
	5LJ3	electron microscopy	3.80	Y	1-111	[»]
	5LJ5	electron microscopy	3.80	Y	1-111	[»]
	5MQ0	electron microscopy	4.17	Y	1-111	[»]
	5NRL	electron microscopy	7.20	Y	1-111	[»]
	5WSG	electron microscopy	4.00	X	1-111	[»]
	6BK8	electron microscopy	3.30	r	1-111	[»]
	6EXN	electron microscopy	3.70	Y	1-111	[»]
ProteinModelPortalⁱ	P40567
SMRⁱ	P40567
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	28 – 106	RRMPROSITE-ProRule annotationAdd BLAST		79

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000007046
HOGENOMⁱ	HOG000000973
OMAⁱ	EPKQTLY
Database of Orthologous Groups More...OrthoDBⁱ	EOG092C5A64

Family and domain databases

Gene3Dⁱ	3.30.70.330, 1 hit
InterProⁱ	View protein in InterPro IPR012677 Nucleotide-bd_a/b_plait_sf IPR035979 RBD_domain_sf IPR000504 RRM_dom
SMARTⁱ	View protein in SMART SM00360 RRM, 1 hit
SUPFAMⁱ	SSF54928 SSF54928, 1 hit
PROSITEⁱ	View protein in PROSITE PS50102 RRM, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P40567-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MVEPARKKQR IDRDTHHTVA EPVTEAKNTL YVSQLNEKIN MQRLRVNLFL 
        60         70         80         90        100
LFATFGEVLK VSMNFKKQRG QAFITMRTID QASLAQISLN GERFFGKPLK 
       110 
VEFSKSETKT L

Length:111

Mass (Da):12,830

Last modified:February 1, 1995 - v1

Checksum:ⁱ8FB0974FC30994AE

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X79743 Genomic DNA No translation available. Z37996 Genomic DNA Translation: CAA86079.1 AY558237 Genomic DNA Translation: AAS56563.1 BK006942 Genomic DNA Translation: DAA08555.1
PIRⁱ	S48353
NCBI Reference Sequences More...RefSeqⁱ	NP_012274.1, NM_001179531.1

Genome annotation databases

EnsemblFungiⁱ	YIR009W; YIR009W; YIR009W
GeneIDⁱ	854826
KEGGⁱ	sce:YIR009W

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
P40567	U2 snRNP component		YEAS1		111
K7_Msl1p		YEASK		111
Msl1p		YEASA		111
Msl1p		SACCK		111
Msl1p		YEASC		111
+5

Protein	Similar proteins		Species	Score	Length
P40567	U2 snRNP component		YEAS1		111
K7_Msl1p		YEASK		111
Msl1p		YEASA		111
Msl1p		SACCK		111
Msl1p		YEASC		111
+12

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X79743 Genomic DNA No translation available. Z37996 Genomic DNA Translation: CAA86079.1 AY558237 Genomic DNA Translation: AAS56563.1 BK006942 Genomic DNA Translation: DAA08555.1
PIRⁱ	S48353
NCBI Reference Sequences More...RefSeqⁱ	NP_012274.1, NM_001179531.1

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	5GMK	electron microscopy	3.40	a	1-111	[»]
	5LJ3	electron microscopy	3.80	Y	1-111	[»]
	5LJ5	electron microscopy	3.80	Y	1-111	[»]
	5MQ0	electron microscopy	4.17	Y	1-111	[»]
	5NRL	electron microscopy	7.20	Y	1-111	[»]
	5WSG	electron microscopy	4.00	X	1-111	[»]
	6BK8	electron microscopy	3.30	r	1-111	[»]
	6EXN	electron microscopy	3.70	Y	1-111	[»]
ProteinModelPortalⁱ	P40567
SMRⁱ	P40567
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	35001, 79 interactors
ComplexPortalⁱ	CPX-1651 PRP19-associated complex CPX-26 U2 snRNP
Database of interacting proteins More...DIPⁱ	DIP-816N
IntActⁱ	P40567, 10 interactors
Molecular INTeraction database More...MINTⁱ	P40567
STRINGⁱ	4932.YIR009W

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P40567
PaxDbⁱ	P40567
PRIDEⁱ	P40567

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblFungiⁱ	YIR009W; YIR009W; YIR009W
GeneIDⁱ	854826
KEGGⁱ	sce:YIR009W

Organism-specific databases

EuPathDBⁱ	FungiDB:YIR009W
Saccharomyces Genome Database More...SGDⁱ	S000001448 MSL1

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000007046
HOGENOMⁱ	HOG000000973
OMAⁱ	EPKQTLY
Database of Orthologous Groups More...OrthoDBⁱ	EOG092C5A64

Enzyme and pathway databases

BioCycⁱ	YEAST:G3O-31430-MONOMER

BioCycⁱ

YEAST:G3O-31430-MONOMER

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P40567

PROⁱ

PR:P40567

Family and domain databases

Gene3Dⁱ	3.30.70.330, 1 hit
InterProⁱ	View protein in InterPro IPR012677 Nucleotide-bd_a/b_plait_sf IPR035979 RBD_domain_sf IPR000504 RRM_dom
SMARTⁱ	View protein in SMART SM00360 RRM, 1 hit
SUPFAMⁱ	SSF54928 SSF54928, 1 hit
PROSITEⁱ	View protein in PROSITE PS50102 RRM, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MSL1_YEAST
Accessionⁱ	P40567Primary (citable) accession number: P40567 Secondary accession number(s): D6VVT9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
	Last sequence update:	February 1, 1995
	Last modified:	June 20, 2018
	This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Fungal Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
Yeast chromosome IX
Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

UniProtKB

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Supporting data

UniProtKB - P40567 (MSL1_YEAST)

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U2 small nuclear ribonucleoprotein B''

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ