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P40567

- MSL1_YEAST

UniProt

P40567 - MSL1_YEAST

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Protein

U2 small nuclear ribonucleoprotein B''

Gene

MSL1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Involved in pre-mRNA splicing. This protein is associated with snRNP U2. It binds stem loop IV of U2 snRNA.1 Publication

GO - Molecular functioni

  1. nucleotide binding Source: InterPro
  2. U2 snRNA binding Source: SGD

GO - Biological processi

  1. mRNA splicing, via spliceosome Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Biological processi

mRNA processing, mRNA splicing

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-31430-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
U2 small nuclear ribonucleoprotein B''
Short name:
U2 snRNP B''
Gene namesi
Name:MSL1
Ordered Locus Names:YIR009W
ORF Names:YIB9W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome IX

Organism-specific databases

CYGDiYIR009w.
SGDiS000001448. MSL1.

Subcellular locationi

GO - Cellular componenti

  1. U2 snRNP Source: SGD
  2. U2-type prespliceosome Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 111111U2 small nuclear ribonucleoprotein B''PRO_0000081895Add
BLAST

Proteomic databases

MaxQBiP40567.
PaxDbiP40567.

Expressioni

Gene expression databases

GenevestigatoriP40567.

Interactioni

Subunit structurei

Belongs to the CWC complex (or CEF1-associated complex), a spliceosome sub-complex reminiscent of a late-stage spliceosome composed of the U2, U5 and U6 snRNAs and at least BUD13, BUD31, BRR2, CDC40, CEF1, CLF1, CUS1, CWC2, CWC15, CWC21, CWC22, CWC23, CWC24, CWC25, CWC27, ECM2, HSH155, IST3, ISY1, LEA1, MSL1, NTC20, PRP8, PRP9, PRP11, PRP19, PRP21, PRP22, PRP45, PRP46, SLU7, SMB1, SMD1, SMD2, SMD3, SMX2, SMX3, SNT309, SNU114, SPP2, SYF1, SYF2, RSE1 and YJU2. Interacts with RDS3. Interacts with LEA1.2 Publications

Protein-protein interaction databases

BioGridi35001. 71 interactions.
DIPiDIP-816N.
IntActiP40567. 10 interactions.
MINTiMINT-572508.
STRINGi4932.YIR009W.

Structurei

3D structure databases

ProteinModelPortaliP40567.
SMRiP40567. Positions 29-108.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 10679RRMPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG317159.
GeneTreeiENSGT00390000007046.
HOGENOMiHOG000000973.
OMAiRTIDQAS.
OrthoDBiEOG7DC2H6.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR024888. U1_snRNP_A/U2_snRNP_B''.
[Graphical view]
PANTHERiPTHR10501. PTHR10501. 1 hit.
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P40567-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVEPARKKQR IDRDTHHTVA EPVTEAKNTL YVSQLNEKIN MQRLRVNLFL
60 70 80 90 100
LFATFGEVLK VSMNFKKQRG QAFITMRTID QASLAQISLN GERFFGKPLK
110
VEFSKSETKT L
Length:111
Mass (Da):12,830
Last modified:February 1, 1995 - v1
Checksum:i8FB0974FC30994AE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X79743 Genomic DNA. No translation available.
Z37996 Genomic DNA. Translation: CAA86079.1.
AY558237 Genomic DNA. Translation: AAS56563.1.
BK006942 Genomic DNA. Translation: DAA08555.1.
PIRiS48353.
RefSeqiNP_012274.1. NM_001179531.1.

Genome annotation databases

EnsemblFungiiYIR009W; YIR009W; YIR009W.
GeneIDi854826.
KEGGisce:YIR009W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X79743 Genomic DNA. No translation available.
Z37996 Genomic DNA. Translation: CAA86079.1 .
AY558237 Genomic DNA. Translation: AAS56563.1 .
BK006942 Genomic DNA. Translation: DAA08555.1 .
PIRi S48353.
RefSeqi NP_012274.1. NM_001179531.1.

3D structure databases

ProteinModelPortali P40567.
SMRi P40567. Positions 29-108.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 35001. 71 interactions.
DIPi DIP-816N.
IntActi P40567. 10 interactions.
MINTi MINT-572508.
STRINGi 4932.YIR009W.

Proteomic databases

MaxQBi P40567.
PaxDbi P40567.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YIR009W ; YIR009W ; YIR009W .
GeneIDi 854826.
KEGGi sce:YIR009W.

Organism-specific databases

CYGDi YIR009w.
SGDi S000001448. MSL1.

Phylogenomic databases

eggNOGi NOG317159.
GeneTreei ENSGT00390000007046.
HOGENOMi HOG000000973.
OMAi RTIDQAS.
OrthoDBi EOG7DC2H6.

Enzyme and pathway databases

BioCyci YEAST:G3O-31430-MONOMER.

Miscellaneous databases

NextBioi 977683.

Gene expression databases

Genevestigatori P40567.

Family and domain databases

Gene3Di 3.30.70.330. 1 hit.
InterProi IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR024888. U1_snRNP_A/U2_snRNP_B''.
[Graphical view ]
PANTHERi PTHR10501. PTHR10501. 1 hit.
SMARTi SM00360. RRM. 1 hit.
[Graphical view ]
PROSITEi PS50102. RRM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence and analysis of the centromeric region of yeast chromosome IX."
    Voss H., Tamames J., Teodoru C., Valencia A., Sensen C., Wiemann S., Schwager C., Zimmermann J., Sander C., Ansorge W.
    Yeast 11:61-78(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  5. "Identification and characterization of a yeast gene encoding the U2 small nuclear ribonucleoprotein particle B' protein."
    Tang J., Abovich N., Rosbash M.
    Mol. Cell. Biol. 16:2787-2795(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. "The yeast U2A'/U2B complex is required for pre-spliceosome formation."
    Caspary F., Seraphin B.
    EMBO J. 17:6348-6358(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH LEA1.
  7. "Proteomics analysis reveals stable multiprotein complexes in both fission and budding yeasts containing Myb-related Cdc5p/Cef1p, novel pre-mRNA splicing factors, and snRNAs."
    Ohi M.D., Link A.J., Ren L., Jennings J.L., McDonald W.H., Gould K.L.
    Mol. Cell. Biol. 22:2011-2024(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE CWC COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
  8. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiMSL1_YEAST
AccessioniPrimary (citable) accession number: P40567
Secondary accession number(s): D6VVT9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: October 1, 2014
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 504 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IX
    Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

External Data

Dasty 3