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Protein

Altered inheritance of mitochondria protein 21

Gene

AIM21

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in mitochondrial migration along actin filaments.1 Publication

GO - Biological processi

  • mitochondrion migration along actin filament Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-31424-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Altered inheritance of mitochondria protein 21
Gene namesi
Name:AIM21
Ordered Locus Names:YIR003W
ORF Names:YIB3W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IX

Organism-specific databases

EuPathDBiFungiDB:YIR003W.
SGDiS000001442. AIM21.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Disruption phenotypei

Increases the sensitivity to farnesol.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002030031 – 679Altered inheritance of mitochondria protein 21Add BLAST679

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei18PhosphothreonineCombined sources1
Modified residuei36PhosphoserineCombined sources1
Modified residuei58PhosphothreonineCombined sources1
Modified residuei70PhosphoserineCombined sources1
Modified residuei85PhosphothreonineCombined sources1
Modified residuei104PhosphoserineCombined sources1
Modified residuei183PhosphoserineCombined sources1
Modified residuei206PhosphoserineCombined sources1
Modified residuei231PhosphoserineCombined sources1
Modified residuei277PhosphothreonineCombined sources1
Modified residuei284PhosphoserineCombined sources1
Modified residuei324PhosphoserineCombined sources1
Modified residuei552PhosphothreonineCombined sources1
Modified residuei576PhosphoserineCombined sources1
Modified residuei620PhosphoserineCombined sources1
Modified residuei623PhosphoserineCombined sources1
Modified residuei625PhosphoserineCombined sources1
Modified residuei627PhosphoserineCombined sources1
Modified residuei667PhosphoserineCombined sources1
Modified residuei671PhosphoserineCombined sources1
Modified residuei675PhosphoserineCombined sources1
Modified residuei678PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP40563.
PRIDEiP40563.

PTM databases

iPTMnetiP40563.

Interactioni

Subunit structurei

Interacts with ribosomes. Interacts with ABP1.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ABP1P1589110EBI-25376,EBI-2036
BBC1P470688EBI-25376,EBI-3437
BZZ1P388227EBI-25376,EBI-3889
HSE1P387534EBI-25376,EBI-1382
LSB1P532815EBI-25376,EBI-23329
LSB3P436032EBI-25376,EBI-22980
MYO3P360063EBI-25376,EBI-11670
MYO5Q044392EBI-25376,EBI-11687
NBP2Q121634EBI-25376,EBI-34713
SLA1P327904EBI-25376,EBI-17313

Protein-protein interaction databases

BioGridi34994. 34 interactors.
DIPiDIP-5096N.
IntActiP40563. 19 interactors.
MINTiMINT-554749.

Structurei

3D structure databases

ProteinModelPortaliP40563.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni383 – 396Interaction with SH3 domain of ABP1Add BLAST14

Sequence similaritiesi

Belongs to the AIM21 family.Curated

Phylogenomic databases

InParanoidiP40563.
OMAiENHEAAN.
OrthoDBiEOG092C1KE8.

Family and domain databases

InterProiIPR021582. Aim21.
[Graphical view]
PfamiPF11489. Aim21. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P40563-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSEVTPKVP ERPSRRKTSE LFPLSGSESG DIKANSEPPT PAGTPNVPTR
60 70 80 90 100
RPILKAKTMT SFESGMDQES LPKVPLQRPV RRSTTEELNN VMNNTSKELE
110 120 130 140 150
EIESLISKHN IHNVSRKKSP TSVEEGKVAA IHQNGQRSAS DNKTSTNPSP
160 170 180 190 200
LEKNEHEGAE GNESAISPSN LVNKSNNEVT EHSDSEDLTE KQKVHAALDN
210 220 230 240 250
EAGDRSHFEE KLIPGDMKVQ VDVSKDVEEG SLNALPPSGI TESDDKAEKF
260 270 280 290 300
TKHPESSLEE LQKHQEQQEE KIFQNPTDEE STTSLNEKQE GKDNMEVNSQ
310 320 330 340 350
PQGPSDTETV IAATSSNVPS QIASEEENDV PVIPRSRPKK DFEAHVQKEE
360 370 380 390 400
LPNTQEKRVS EECDSTLIST EEESKIPKIP SERPKRRAPP PVPKKPSSRI
410 420 430 440 450
AAFQEMLQKQ QQQDLHNNGN SSATTASADI AKKHTDSSIT SDTTKADFTS
460 470 480 490 500
KLNGLFALPG MVNPGQLPPS LEKKLSSPDT ESKLGPQDQS QAKTGPLGGT
510 520 530 540 550
RRGRGPRGRK LPSKVASVEK IEEDDNTNKI EIFNNWNVSS SFSKEKVLID
560 570 580 590 600
TTPGEQAERA LDEKSKSIPE EQREQSPNKM EAALCPFELD EKEKLPANAE
610 620 630 640 650
SDPLSQLPQT NAVGNRKAIS EESLSPSEAI ANRDQNDTTE IQEQQMEDQM
660 670
EVDMERELSG GYEDVDSALH SEEASFHSL
Length:679
Mass (Da):74,763
Last modified:February 1, 1995 - v1
Checksum:i9DF79500375339E7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X79743 Genomic DNA. No translation available.
Z38062 Genomic DNA. Translation: CAA86205.1.
BK006942 Genomic DNA. Translation: DAA08549.1.
PIRiS48437.
RefSeqiNP_012268.3. NM_001179525.3.

Genome annotation databases

EnsemblFungiiYIR003W; YIR003W; YIR003W.
GeneIDi854819.
KEGGisce:YIR003W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X79743 Genomic DNA. No translation available.
Z38062 Genomic DNA. Translation: CAA86205.1.
BK006942 Genomic DNA. Translation: DAA08549.1.
PIRiS48437.
RefSeqiNP_012268.3. NM_001179525.3.

3D structure databases

ProteinModelPortaliP40563.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34994. 34 interactors.
DIPiDIP-5096N.
IntActiP40563. 19 interactors.
MINTiMINT-554749.

PTM databases

iPTMnetiP40563.

Proteomic databases

MaxQBiP40563.
PRIDEiP40563.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYIR003W; YIR003W; YIR003W.
GeneIDi854819.
KEGGisce:YIR003W.

Organism-specific databases

EuPathDBiFungiDB:YIR003W.
SGDiS000001442. AIM21.

Phylogenomic databases

InParanoidiP40563.
OMAiENHEAAN.
OrthoDBiEOG092C1KE8.

Enzyme and pathway databases

BioCyciYEAST:G3O-31424-MONOMER.

Miscellaneous databases

PROiP40563.

Family and domain databases

InterProiIPR021582. Aim21.
[Graphical view]
PfamiPF11489. Aim21. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAIM21_YEAST
AccessioniPrimary (citable) accession number: P40563
Secondary accession number(s): D6VVT3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 2, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 450 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IX
    Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.