Altered inheritance of mitochondria protein 21 - Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

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P40563 (AIM21_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 96. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Altered inheritance of mitochondria protein 21

Gene names

Name:	AIM21
Ordered Locus Names:	YIR003W
ORF Names:	YIB3W

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›

Protein attributes

Sequence length	679 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in mitochondrial migration along actin filaments. Ref.15
Subunit structure	Interacts with ribosomes. Interacts with ABP1. Ref.4 Ref.7
Subcellular location	Cytoplasm › cytoskeleton › actin patch. Note: Cortical actin patches. Localizes at the shmoo tip. Ref.5 Ref.14
Disruption phenotype	Increases the sensitivity to farnesol. Ref.10
Miscellaneous	Present with 450 molecules/cell in log phase SD medium.
Sequence similarities	Belongs to the AIM21 family.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	mitochondrion migration along actin filament Inferred from mutant phenotype Ref.15. Source: SGD
Cellular_component	actin cortical patch Inferred from electronic annotation. Source: UniProtKB-SubCell actin cytoskeleton Inferred from direct assay Ref.5. Source: SGD mating projection tip Inferred from direct assay Ref.14. Source: SGD
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
ABP1	P15891	4	EBI-25376,EBI-2036

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 679

679

Altered inheritance of mitochondria protein 21

PRO_0000203003

Regions

Region

383 – 396

Interaction with SH3 domain of ABP1

Amino acid modifications

Modified residue

Phosphothreonine Ref.11 Ref.12 Ref.13

Modified residue

Phosphoserine Ref.13

Modified residue

Phosphoserine Ref.13

Modified residue

Phosphoserine Ref.11 Ref.13

Modified residue

Phosphothreonine Ref.8 Ref.11 Ref.12 Ref.13

Modified residue

Phosphothreonine Ref.13

Modified residue

Phosphoserine Ref.13

Modified residue

Phosphoserine Ref.13

Modified residue

Phosphothreonine Ref.12 Ref.13

Modified residue

Phosphothreonine Ref.11 Ref.13

Modified residue

104

Phosphoserine Ref.13

Modified residue

119

Phosphoserine Ref.12 Ref.13

Modified residue

121

Phosphothreonine Ref.13

Modified residue

167

Phosphoserine Ref.13

Modified residue

180

Phosphothreonine Ref.13

Modified residue

183

Phosphoserine Ref.11 Ref.12 Ref.13

Modified residue

185

Phosphoserine Ref.13

Modified residue

231

Phosphoserine Ref.13

Modified residue

257

Phosphoserine Ref.12 Ref.13

Modified residue

277

Phosphothreonine Ref.11 Ref.12 Ref.13

Modified residue

281

Phosphoserine Ref.13

Modified residue

282

Phosphothreonine Ref.13

Modified residue

284

Phosphoserine Ref.13

Modified residue

324

Phosphoserine Ref.13

Modified residue

476

Phosphoserine Ref.13

Modified residue

477

Phosphoserine Ref.13

Modified residue

517

Phosphoserine Ref.13

Modified residue

552

Phosphothreonine Ref.13

Modified residue

567

Phosphoserine Ref.13

Modified residue

576

Phosphoserine Ref.13

Modified residue

620

Phosphoserine Ref.13

Modified residue

623

Phosphoserine Ref.13

Modified residue

625

Phosphoserine Ref.11 Ref.12 Ref.13

Modified residue

659

Phosphoserine Ref.13

Modified residue

667

Phosphoserine Ref.13

Modified residue

671

Phosphoserine Ref.13

Modified residue

675

Phosphoserine Ref.13

Modified residue

678

Phosphoserine Ref.11

Sequences

Sequence

Length

Mass (Da)

Tools

P40563 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: 9DF79500375339E7
Show »

FASTA

679

74,763

        10         20         30         40         50         60 
MPSEVTPKVP ERPSRRKTSE LFPLSGSESG DIKANSEPPT PAGTPNVPTR RPILKAKTMT 

        70         80         90        100        110        120 
SFESGMDQES LPKVPLQRPV RRSTTEELNN VMNNTSKELE EIESLISKHN IHNVSRKKSP 

       130        140        150        160        170        180 
TSVEEGKVAA IHQNGQRSAS DNKTSTNPSP LEKNEHEGAE GNESAISPSN LVNKSNNEVT 

       190        200        210        220        230        240 
EHSDSEDLTE KQKVHAALDN EAGDRSHFEE KLIPGDMKVQ VDVSKDVEEG SLNALPPSGI 

       250        260        270        280        290        300 
TESDDKAEKF TKHPESSLEE LQKHQEQQEE KIFQNPTDEE STTSLNEKQE GKDNMEVNSQ 

       310        320        330        340        350        360 
PQGPSDTETV IAATSSNVPS QIASEEENDV PVIPRSRPKK DFEAHVQKEE LPNTQEKRVS 

       370        380        390        400        410        420 
EECDSTLIST EEESKIPKIP SERPKRRAPP PVPKKPSSRI AAFQEMLQKQ QQQDLHNNGN 

       430        440        450        460        470        480 
SSATTASADI AKKHTDSSIT SDTTKADFTS KLNGLFALPG MVNPGQLPPS LEKKLSSPDT 

       490        500        510        520        530        540 
ESKLGPQDQS QAKTGPLGGT RRGRGPRGRK LPSKVASVEK IEEDDNTNKI EIFNNWNVSS 

       550        560        570        580        590        600 
SFSKEKVLID TTPGEQAERA LDEKSKSIPE EQREQSPNKM EAALCPFELD EKEKLPANAE 

       610        620        630        640        650        660 
SDPLSQLPQT NAVGNRKAIS EESLSPSEAI ANRDQNDTTE IQEQQMEDQM EVDMERELSG 

       670 
GYEDVDSALH SEEASFHSL

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Nucleotide sequence and analysis of the centromeric region of yeast chromosome IX." Voss H., Tamames J., Teodoru C., Valencia A., Sensen C., Wiemann S., Schwager C., Zimmermann J., Sander C., Ansorge W. Yeast 11:61-78(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[2]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome IX." Churcher C.M., Bowman S., Badcock K., Bankier A.T., Brown D., Chillingworth T., Connor R., Devlin K., Gentles S., Hamlin N., Harris D.E., Horsnell T., Hunt S., Jagels K., Jones M., Lye G., Moule S., Odell C. Barrell B.G. Nature 387:84-87(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[3]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[4]	"Unusual binding properties of the SH3 domain of the yeast actin-binding protein Abp1: structural and functional analysis." Fazi B., Cope M.J.T.V., Douangamath A., Ferracuti S., Schirwitz K., Zucconi A., Drubin D.G., Wilmanns M., Cesareni G., Castagnoli L. J. Biol. Chem. 277:5290-5298(2002) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH ABP1.
[5]	"Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[6]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[7]	"Protein interaction networks by proteome peptide scanning." Landgraf C., Panni S., Montecchi-Palazzi L., Castagnoli L., Schneider-Mergener J., Volkmer-Engert R., Cesareni G. PLoS Biol. 2:94-103(2004) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH ABP1.
[8]	"Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway." Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J., Mann M., Jensen O.N. Mol. Cell. Proteomics 4:310-327(2005) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-58, MASS SPECTROMETRY. Strain: YAL6B.
[9]	"Systematic identification and functional screens of uncharacterized proteins associated with eukaryotic ribosomal complexes." Fleischer T.C., Weaver C.M., McAfee K.J., Jennings J.L., Link A.J. Genes Dev. 20:1294-1307(2006) [PubMed] [Europe PMC] [Abstract] Cited for: COPURIFICATION WITH RIBOSOMAL COMPLEXES, MASS SPECTROMETRY.
[10]	"A chemogenomic screen in Saccharomyces cerevisiae uncovers a primary role for the mitochondria in farnesol toxicity and its regulation by the Pkc1 pathway." Fairn G.D., Macdonald K., McMaster C.R. J. Biol. Chem. 282:4868-4874(2007) [PubMed] [Europe PMC] [Abstract] Cited for: DISRUPTION PHENOTYPE.
[11]	"Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae." Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P. J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-18; SER-36; THR-58; THR-85; SER-183; THR-277; SER-625 AND SER-678, MASS SPECTROMETRY. Strain: ADR376.
[12]	"Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases." Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H. Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-18; THR-58; THR-84; SER-119; SER-183; SER-257; THR-277 AND SER-625, MASS SPECTROMETRY.
[13]	"A multidimensional chromatography technology for in-depth phosphoproteome analysis." Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H. Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-18; SER-19; SER-25; SER-36; THR-58; THR-60; SER-61; SER-83; THR-84; THR-85; SER-104; SER-119; THR-121; SER-167; THR-180; SER-183; SER-185; SER-231; SER-257; THR-277; SER-281; THR-282; SER-284; SER-324; SER-476; SER-477; SER-517; THR-552; SER-567; SER-576; SER-620; SER-623; SER-625; SER-659; SER-667; SER-671 AND SER-675, MASS SPECTROMETRY.
[14]	"Systematic definition of protein constituents along the major polarization axis reveals an adaptive reuse of the polarization machinery in pheromone-treated budding yeast." Narayanaswamy R., Moradi E.K., Niu W., Hart G.T., Davis M., McGary K.L., Ellington A.D., Marcotte E.M. J. Proteome Res. 8:6-19(2009) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION.
[15]	"Computationally driven, quantitative experiments discover genes required for mitochondrial biogenesis." Hess D.C., Myers C.L., Huttenhower C., Hibbs M.A., Hayes A.P., Paw J., Clore J.J., Mendoza R.M., Luis B.S., Nislow C., Giaever G., Costanzo M., Troyanskaya O.G., Caudy A.A. PLoS Genet. 5:E1000407-E1000407(2009) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X79743 Genomic DNA. No translation available. Z38062 Genomic DNA. Translation: CAA86205.1. BK006942 Genomic DNA. Translation: DAA08549.1.
PIR	S48437.
RefSeq	NP_012268.3. NM_001179525.3.
3D structure databases
ProteinModelPortal	P40563.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-5096N.
IntAct	P40563. 11 interactions.
MINT	MINT-554749.
STRING	4932.YIR003W.
Proteomic databases
PaxDb	P40563.
PeptideAtlas	P40563.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YIR003W; YIR003W; YIR003W.
GeneID	854819.
KEGG	sce:YIR003W. sce:YIR010W.
Organism-specific databases
CYGD	YIR003w.
SGD	S000001442. AIM21.
Phylogenomic databases
eggNOG	NOG12793.
GeneTree	ENSGT00680000100978.
KO	K11560.
OMA	KANSEPP.
OrthoDB	EOG4QZBWS.
Gene expression databases
Genevestigator	P40563.
GermOnline	YIR003W. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR021582. DUF3210. [Graphical view]
Pfam	PF11489. DUF3210. 2 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	977663.

Entry information

Entry name

AIM21_YEAST

Accession

Primary (citable) accession number: P40563
Secondary accession number(s): D6VVT3

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	April 3, 2013
This is version 96 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome IX

Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

SIMILARITY comments

Index of protein domains and families

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents