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P40563

- AIM21_YEAST

UniProt

P40563 - AIM21_YEAST

Protein

Altered inheritance of mitochondria protein 21

Gene

AIM21

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Involved in mitochondrial migration along actin filaments.1 Publication

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. mitochondrion migration along actin filament Source: SGD

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31424-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Altered inheritance of mitochondria protein 21
    Gene namesi
    Name:AIM21
    Ordered Locus Names:YIR003W
    ORF Names:YIB3W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome IX

    Organism-specific databases

    CYGDiYIR003w.
    SGDiS000001442. AIM21.

    Subcellular locationi

    Cytoplasmcytoskeletonactin patch 2 Publications
    Note: Cortical actin patches. Localizes at the shmoo tip.

    GO - Cellular componenti

    1. actin cortical patch Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton

    Pathology & Biotechi

    Disruption phenotypei

    Increases the sensitivity to farnesol.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 679679Altered inheritance of mitochondria protein 21PRO_0000203003Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei18 – 181Phosphothreonine2 Publications
    Modified residuei36 – 361Phosphoserine3 Publications
    Modified residuei58 – 581Phosphothreonine2 Publications
    Modified residuei70 – 701Phosphoserine1 Publication
    Modified residuei85 – 851Phosphothreonine2 Publications
    Modified residuei104 – 1041Phosphoserine1 Publication
    Modified residuei183 – 1831Phosphoserine2 Publications
    Modified residuei206 – 2061Phosphoserine1 Publication
    Modified residuei231 – 2311Phosphoserine1 Publication
    Modified residuei277 – 2771Phosphothreonine3 Publications
    Modified residuei284 – 2841Phosphoserine1 Publication
    Modified residuei324 – 3241Phosphoserine1 Publication
    Modified residuei552 – 5521Phosphothreonine1 Publication
    Modified residuei576 – 5761Phosphoserine2 Publications
    Modified residuei620 – 6201Phosphoserine2 Publications
    Modified residuei623 – 6231Phosphoserine1 Publication
    Modified residuei625 – 6251Phosphoserine1 Publication
    Modified residuei627 – 6271Phosphoserine1 Publication
    Modified residuei667 – 6671Phosphoserine1 Publication
    Modified residuei671 – 6711Phosphoserine2 Publications
    Modified residuei675 – 6751Phosphoserine1 Publication
    Modified residuei678 – 6781Phosphoserine2 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP40563.
    PaxDbiP40563.
    PeptideAtlasiP40563.

    Expressioni

    Gene expression databases

    GenevestigatoriP40563.

    Interactioni

    Subunit structurei

    Interacts with ribosomes. Interacts with ABP1.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ABP1P1589110EBI-25376,EBI-2036
    BBC1P470688EBI-25376,EBI-3437
    BZZ1P388227EBI-25376,EBI-3889
    HSE1P387534EBI-25376,EBI-1382
    LSB1P532815EBI-25376,EBI-23329
    LSB3P436032EBI-25376,EBI-22980
    MYO3P360063EBI-25376,EBI-11670
    MYO5Q044392EBI-25376,EBI-11687
    NBP2Q121634EBI-25376,EBI-34713
    SLA1P327904EBI-25376,EBI-17313

    Protein-protein interaction databases

    BioGridi34994. 35 interactions.
    DIPiDIP-5096N.
    IntActiP40563. 19 interactions.
    MINTiMINT-554749.
    STRINGi4932.YIR003W.

    Structurei

    3D structure databases

    ProteinModelPortaliP40563.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni383 – 39614Interaction with SH3 domain of ABP1Add
    BLAST

    Sequence similaritiesi

    Belongs to the AIM21 family.Curated

    Phylogenomic databases

    eggNOGiNOG12793.
    OMAiINADSAN.
    OrthoDBiEOG79GTG2.

    Family and domain databases

    InterProiIPR021582. DUF3210.
    [Graphical view]
    PfamiPF11489. DUF3210. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P40563-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPSEVTPKVP ERPSRRKTSE LFPLSGSESG DIKANSEPPT PAGTPNVPTR    50
    RPILKAKTMT SFESGMDQES LPKVPLQRPV RRSTTEELNN VMNNTSKELE 100
    EIESLISKHN IHNVSRKKSP TSVEEGKVAA IHQNGQRSAS DNKTSTNPSP 150
    LEKNEHEGAE GNESAISPSN LVNKSNNEVT EHSDSEDLTE KQKVHAALDN 200
    EAGDRSHFEE KLIPGDMKVQ VDVSKDVEEG SLNALPPSGI TESDDKAEKF 250
    TKHPESSLEE LQKHQEQQEE KIFQNPTDEE STTSLNEKQE GKDNMEVNSQ 300
    PQGPSDTETV IAATSSNVPS QIASEEENDV PVIPRSRPKK DFEAHVQKEE 350
    LPNTQEKRVS EECDSTLIST EEESKIPKIP SERPKRRAPP PVPKKPSSRI 400
    AAFQEMLQKQ QQQDLHNNGN SSATTASADI AKKHTDSSIT SDTTKADFTS 450
    KLNGLFALPG MVNPGQLPPS LEKKLSSPDT ESKLGPQDQS QAKTGPLGGT 500
    RRGRGPRGRK LPSKVASVEK IEEDDNTNKI EIFNNWNVSS SFSKEKVLID 550
    TTPGEQAERA LDEKSKSIPE EQREQSPNKM EAALCPFELD EKEKLPANAE 600
    SDPLSQLPQT NAVGNRKAIS EESLSPSEAI ANRDQNDTTE IQEQQMEDQM 650
    EVDMERELSG GYEDVDSALH SEEASFHSL 679
    Length:679
    Mass (Da):74,763
    Last modified:February 1, 1995 - v1
    Checksum:i9DF79500375339E7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X79743 Genomic DNA. No translation available.
    Z38062 Genomic DNA. Translation: CAA86205.1.
    BK006942 Genomic DNA. Translation: DAA08549.1.
    PIRiS48437.
    RefSeqiNP_012268.3. NM_001179525.3.

    Genome annotation databases

    EnsemblFungiiYIR003W; YIR003W; YIR003W.
    GeneIDi854819.
    KEGGisce:YIR003W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X79743 Genomic DNA. No translation available.
    Z38062 Genomic DNA. Translation: CAA86205.1 .
    BK006942 Genomic DNA. Translation: DAA08549.1 .
    PIRi S48437.
    RefSeqi NP_012268.3. NM_001179525.3.

    3D structure databases

    ProteinModelPortali P40563.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 34994. 35 interactions.
    DIPi DIP-5096N.
    IntActi P40563. 19 interactions.
    MINTi MINT-554749.
    STRINGi 4932.YIR003W.

    Proteomic databases

    MaxQBi P40563.
    PaxDbi P40563.
    PeptideAtlasi P40563.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YIR003W ; YIR003W ; YIR003W .
    GeneIDi 854819.
    KEGGi sce:YIR003W.

    Organism-specific databases

    CYGDi YIR003w.
    SGDi S000001442. AIM21.

    Phylogenomic databases

    eggNOGi NOG12793.
    OMAi INADSAN.
    OrthoDBi EOG79GTG2.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-31424-MONOMER.

    Miscellaneous databases

    NextBioi 977663.

    Gene expression databases

    Genevestigatori P40563.

    Family and domain databases

    InterProi IPR021582. DUF3210.
    [Graphical view ]
    Pfami PF11489. DUF3210. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence and analysis of the centromeric region of yeast chromosome IX."
      Voss H., Tamames J., Teodoru C., Valencia A., Sensen C., Wiemann S., Schwager C., Zimmermann J., Sander C., Ansorge W.
      Yeast 11:61-78(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. "Unusual binding properties of the SH3 domain of the yeast actin-binding protein Abp1: structural and functional analysis."
      Fazi B., Cope M.J.T.V., Douangamath A., Ferracuti S., Schirwitz K., Zucconi A., Drubin D.G., Wilmanns M., Cesareni G., Castagnoli L.
      J. Biol. Chem. 277:5290-5298(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ABP1.
    5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    7. Cited for: INTERACTION WITH ABP1.
    8. "Systematic identification and functional screens of uncharacterized proteins associated with eukaryotic ribosomal complexes."
      Fleischer T.C., Weaver C.M., McAfee K.J., Jennings J.L., Link A.J.
      Genes Dev. 20:1294-1307(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: COPURIFICATION WITH RIBOSOMAL COMPLEXES, IDENTIFICATION BY MASS SPECTROMETRY.
    9. "A chemogenomic screen in Saccharomyces cerevisiae uncovers a primary role for the mitochondria in farnesol toxicity and its regulation by the Pkc1 pathway."
      Fairn G.D., Macdonald K., McMaster C.R.
      J. Biol. Chem. 282:4868-4874(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISRUPTION PHENOTYPE.
    10. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
      Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
      J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-18; SER-36; THR-58; THR-85; SER-183; THR-277; SER-625 AND SER-678, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Strain: ADR376.
    11. "Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry."
      Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L., Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.
      Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-36; SER-231; THR-277; SER-324; SER-576; SER-620 AND SER-671, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. "Systematic definition of protein constituents along the major polarization axis reveals an adaptive reuse of the polarization machinery in pheromone-treated budding yeast."
      Narayanaswamy R., Moradi E.K., Niu W., Hart G.T., Davis M., McGary K.L., Ellington A.D., Marcotte E.M.
      J. Proteome Res. 8:6-19(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    14. "Computationally driven, quantitative experiments discover genes required for mitochondrial biogenesis."
      Hess D.C., Myers C.L., Huttenhower C., Hibbs M.A., Hayes A.P., Paw J., Clore J.J., Mendoza R.M., Luis B.S., Nislow C., Giaever G., Costanzo M., Troyanskaya O.G., Caudy A.A.
      PLoS Genet. 5:E1000407-E1000407(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    15. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-18; SER-36; THR-58; SER-70; THR-85; SER-104; SER-183; SER-206; THR-277; SER-284; THR-552; SER-576; SER-620; SER-623; SER-627; SER-667; SER-671; SER-675 AND SER-678, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiAIM21_YEAST
    AccessioniPrimary (citable) accession number: P40563
    Secondary accession number(s): D6VVT3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 109 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 450 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome IX
      Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

    External Data

    Dasty 3