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P40563

- AIM21_YEAST

UniProt

P40563 - AIM21_YEAST

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Protein

Altered inheritance of mitochondria protein 21

Gene

AIM21

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Involved in mitochondrial migration along actin filaments.1 Publication

GO - Biological processi

  1. mitochondrion migration along actin filament Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-31424-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Altered inheritance of mitochondria protein 21
Gene namesi
Name:AIM21
Ordered Locus Names:YIR003W
ORF Names:YIB3W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome IX

Organism-specific databases

CYGDiYIR003w.
SGDiS000001442. AIM21.

Subcellular locationi

Cytoplasmcytoskeletonactin patch 2 Publications
Note: Cortical actin patches. Localizes at the shmoo tip.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. cytoskeleton Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Disruption phenotypei

Increases the sensitivity to farnesol.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 679679Altered inheritance of mitochondria protein 21PRO_0000203003Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei18 – 181Phosphothreonine2 Publications
Modified residuei36 – 361Phosphoserine3 Publications
Modified residuei58 – 581Phosphothreonine2 Publications
Modified residuei70 – 701Phosphoserine1 Publication
Modified residuei85 – 851Phosphothreonine2 Publications
Modified residuei104 – 1041Phosphoserine1 Publication
Modified residuei183 – 1831Phosphoserine2 Publications
Modified residuei206 – 2061Phosphoserine1 Publication
Modified residuei231 – 2311Phosphoserine1 Publication
Modified residuei277 – 2771Phosphothreonine3 Publications
Modified residuei284 – 2841Phosphoserine1 Publication
Modified residuei324 – 3241Phosphoserine1 Publication
Modified residuei552 – 5521Phosphothreonine1 Publication
Modified residuei576 – 5761Phosphoserine2 Publications
Modified residuei620 – 6201Phosphoserine2 Publications
Modified residuei623 – 6231Phosphoserine1 Publication
Modified residuei625 – 6251Phosphoserine1 Publication
Modified residuei627 – 6271Phosphoserine1 Publication
Modified residuei667 – 6671Phosphoserine1 Publication
Modified residuei671 – 6711Phosphoserine2 Publications
Modified residuei675 – 6751Phosphoserine1 Publication
Modified residuei678 – 6781Phosphoserine2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP40563.
PaxDbiP40563.
PeptideAtlasiP40563.

Expressioni

Gene expression databases

GenevestigatoriP40563.

Interactioni

Subunit structurei

Interacts with ribosomes. Interacts with ABP1.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ABP1P1589110EBI-25376,EBI-2036
BBC1P470688EBI-25376,EBI-3437
BZZ1P388227EBI-25376,EBI-3889
HSE1P387534EBI-25376,EBI-1382
LSB1P532815EBI-25376,EBI-23329
LSB3P436032EBI-25376,EBI-22980
MYO3P360063EBI-25376,EBI-11670
MYO5Q044392EBI-25376,EBI-11687
NBP2Q121634EBI-25376,EBI-34713
SLA1P327904EBI-25376,EBI-17313

Protein-protein interaction databases

BioGridi34994. 35 interactions.
DIPiDIP-5096N.
IntActiP40563. 19 interactions.
MINTiMINT-554749.
STRINGi4932.YIR003W.

Structurei

3D structure databases

ProteinModelPortaliP40563.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni383 – 39614Interaction with SH3 domain of ABP1Add
BLAST

Sequence similaritiesi

Belongs to the AIM21 family.Curated

Phylogenomic databases

eggNOGiNOG12793.
InParanoidiP40563.
OMAiINADSAN.
OrthoDBiEOG79GTG2.

Family and domain databases

InterProiIPR021582. DUF3210.
[Graphical view]
PfamiPF11489. DUF3210. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P40563-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPSEVTPKVP ERPSRRKTSE LFPLSGSESG DIKANSEPPT PAGTPNVPTR
60 70 80 90 100
RPILKAKTMT SFESGMDQES LPKVPLQRPV RRSTTEELNN VMNNTSKELE
110 120 130 140 150
EIESLISKHN IHNVSRKKSP TSVEEGKVAA IHQNGQRSAS DNKTSTNPSP
160 170 180 190 200
LEKNEHEGAE GNESAISPSN LVNKSNNEVT EHSDSEDLTE KQKVHAALDN
210 220 230 240 250
EAGDRSHFEE KLIPGDMKVQ VDVSKDVEEG SLNALPPSGI TESDDKAEKF
260 270 280 290 300
TKHPESSLEE LQKHQEQQEE KIFQNPTDEE STTSLNEKQE GKDNMEVNSQ
310 320 330 340 350
PQGPSDTETV IAATSSNVPS QIASEEENDV PVIPRSRPKK DFEAHVQKEE
360 370 380 390 400
LPNTQEKRVS EECDSTLIST EEESKIPKIP SERPKRRAPP PVPKKPSSRI
410 420 430 440 450
AAFQEMLQKQ QQQDLHNNGN SSATTASADI AKKHTDSSIT SDTTKADFTS
460 470 480 490 500
KLNGLFALPG MVNPGQLPPS LEKKLSSPDT ESKLGPQDQS QAKTGPLGGT
510 520 530 540 550
RRGRGPRGRK LPSKVASVEK IEEDDNTNKI EIFNNWNVSS SFSKEKVLID
560 570 580 590 600
TTPGEQAERA LDEKSKSIPE EQREQSPNKM EAALCPFELD EKEKLPANAE
610 620 630 640 650
SDPLSQLPQT NAVGNRKAIS EESLSPSEAI ANRDQNDTTE IQEQQMEDQM
660 670
EVDMERELSG GYEDVDSALH SEEASFHSL
Length:679
Mass (Da):74,763
Last modified:February 1, 1995 - v1
Checksum:i9DF79500375339E7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X79743 Genomic DNA. No translation available.
Z38062 Genomic DNA. Translation: CAA86205.1.
BK006942 Genomic DNA. Translation: DAA08549.1.
PIRiS48437.
RefSeqiNP_012268.3. NM_001179525.3.

Genome annotation databases

EnsemblFungiiYIR003W; YIR003W; YIR003W.
GeneIDi854819.
KEGGisce:YIR003W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X79743 Genomic DNA. No translation available.
Z38062 Genomic DNA. Translation: CAA86205.1 .
BK006942 Genomic DNA. Translation: DAA08549.1 .
PIRi S48437.
RefSeqi NP_012268.3. NM_001179525.3.

3D structure databases

ProteinModelPortali P40563.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 34994. 35 interactions.
DIPi DIP-5096N.
IntActi P40563. 19 interactions.
MINTi MINT-554749.
STRINGi 4932.YIR003W.

Proteomic databases

MaxQBi P40563.
PaxDbi P40563.
PeptideAtlasi P40563.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YIR003W ; YIR003W ; YIR003W .
GeneIDi 854819.
KEGGi sce:YIR003W.

Organism-specific databases

CYGDi YIR003w.
SGDi S000001442. AIM21.

Phylogenomic databases

eggNOGi NOG12793.
InParanoidi P40563.
OMAi INADSAN.
OrthoDBi EOG79GTG2.

Enzyme and pathway databases

BioCyci YEAST:G3O-31424-MONOMER.

Miscellaneous databases

NextBioi 977663.

Gene expression databases

Genevestigatori P40563.

Family and domain databases

InterProi IPR021582. DUF3210.
[Graphical view ]
Pfami PF11489. DUF3210. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence and analysis of the centromeric region of yeast chromosome IX."
    Voss H., Tamames J., Teodoru C., Valencia A., Sensen C., Wiemann S., Schwager C., Zimmermann J., Sander C., Ansorge W.
    Yeast 11:61-78(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "Unusual binding properties of the SH3 domain of the yeast actin-binding protein Abp1: structural and functional analysis."
    Fazi B., Cope M.J.T.V., Douangamath A., Ferracuti S., Schirwitz K., Zucconi A., Drubin D.G., Wilmanns M., Cesareni G., Castagnoli L.
    J. Biol. Chem. 277:5290-5298(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ABP1.
  5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  7. Cited for: INTERACTION WITH ABP1.
  8. "Systematic identification and functional screens of uncharacterized proteins associated with eukaryotic ribosomal complexes."
    Fleischer T.C., Weaver C.M., McAfee K.J., Jennings J.L., Link A.J.
    Genes Dev. 20:1294-1307(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: COPURIFICATION WITH RIBOSOMAL COMPLEXES, IDENTIFICATION BY MASS SPECTROMETRY.
  9. "A chemogenomic screen in Saccharomyces cerevisiae uncovers a primary role for the mitochondria in farnesol toxicity and its regulation by the Pkc1 pathway."
    Fairn G.D., Macdonald K., McMaster C.R.
    J. Biol. Chem. 282:4868-4874(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE.
  10. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
    Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
    J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-18; SER-36; THR-58; THR-85; SER-183; THR-277; SER-625 AND SER-678, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ADR376.
  11. "Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry."
    Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L., Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.
    Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-36; SER-231; THR-277; SER-324; SER-576; SER-620 AND SER-671, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "Systematic definition of protein constituents along the major polarization axis reveals an adaptive reuse of the polarization machinery in pheromone-treated budding yeast."
    Narayanaswamy R., Moradi E.K., Niu W., Hart G.T., Davis M., McGary K.L., Ellington A.D., Marcotte E.M.
    J. Proteome Res. 8:6-19(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  14. "Computationally driven, quantitative experiments discover genes required for mitochondrial biogenesis."
    Hess D.C., Myers C.L., Huttenhower C., Hibbs M.A., Hayes A.P., Paw J., Clore J.J., Mendoza R.M., Luis B.S., Nislow C., Giaever G., Costanzo M., Troyanskaya O.G., Caudy A.A.
    PLoS Genet. 5:E1000407-E1000407(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  15. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-18; SER-36; THR-58; SER-70; THR-85; SER-104; SER-183; SER-206; THR-277; SER-284; THR-552; SER-576; SER-620; SER-623; SER-627; SER-667; SER-671; SER-675 AND SER-678, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiAIM21_YEAST
AccessioniPrimary (citable) accession number: P40563
Secondary accession number(s): D6VVT3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: October 29, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 450 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IX
    Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

External Data

Dasty 3