Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P40556

- YIA6_YEAST

UniProt

P40556 - YIA6_YEAST

Protein

Mitochondrial nicotinamide adenine dinucleotide transporter 1

Gene

YIA6

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Mitochondrial inner membrane carrier protein involved in the import of NAD+ into mitochondria by unidirectional transport or by exchange with intramitochondrially generated dAMP and dGMP.3 Publications

    Kineticsi

    1. KM=0.38 mM for NAD+1 Publication

    Vmax=617 nmol/min/mg enzyme1 Publication

    GO - Molecular functioni

    1. NAD transporter activity Source: SGD
    2. pyruvate secondary active transmembrane transporter activity Source: SGD
    3. transporter activity Source: SGD

    GO - Biological processi

    1. mitochondrial pyruvate transport Source: SGD
    2. NAD transmembrane transport Source: SGD
    3. pyruvate transmembrane transport Source: GOC
    4. transport Source: SGD

    Keywords - Biological processi

    Transport

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31285-MONOMER.

    Protein family/group databases

    TCDBi2.A.29.10.5. the mitochondrial carrier (mc) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitochondrial nicotinamide adenine dinucleotide transporter 1
    Alternative name(s):
    Mitochondrial NAD(+) transporter 1
    Gene namesi
    Name:YIA6
    Synonyms:NDT1
    Ordered Locus Names:YIL006W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome IX

    Organism-specific databases

    CYGDiYIL006w.
    SGDiS000001268. YIA6.

    Subcellular locationi

    Mitochondrion inner membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: SGD
    3. mitochondrion Source: SGD

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 373373Mitochondrial nicotinamide adenine dinucleotide transporter 1PRO_0000090698Add
    BLAST

    Expressioni

    Gene expression databases

    GenevestigatoriP40556.

    Interactioni

    Protein-protein interaction databases

    BioGridi34986. 11 interactions.
    DIPiDIP-4960N.
    MINTiMINT-570805.
    STRINGi4932.YIL006W.

    Structurei

    3D structure databases

    ProteinModelPortaliP40556.
    SMRiP40556. Positions 82-359.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 8080Mitochondrial matrixSequence AnalysisAdd
    BLAST
    Topological domaini102 – 14140Mitochondrial intermembraneSequence AnalysisAdd
    BLAST
    Topological domaini163 – 17614Mitochondrial matrixSequence AnalysisAdd
    BLAST
    Topological domaini200 – 23536Mitochondrial intermembraneSequence AnalysisAdd
    BLAST
    Topological domaini257 – 28024Mitochondrial matrixSequence AnalysisAdd
    BLAST
    Topological domaini298 – 33538Mitochondrial intermembraneSequence AnalysisAdd
    BLAST
    Topological domaini359 – 37315Mitochondrial matrixSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei81 – 10121Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei142 – 16221Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei177 – 19923Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei236 – 25621Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei281 – 29717Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei336 – 35823Helical; Name=6Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati75 – 16692Solcar 1Add
    BLAST
    Repeati174 – 26390Solcar 2Add
    BLAST
    Repeati276 – 36489Solcar 3Add
    BLAST

    Sequence similaritiesi

    Contains 3 Solcar repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG314559.
    GeneTreeiENSGT00600000084419.
    HOGENOMiHOG000188210.
    KOiK15115.
    OMAiWAIYFTM.
    OrthoDBiEOG73Z352.

    Family and domain databases

    Gene3Di1.50.40.10. 1 hit.
    InterProiIPR002067. Mit_carrier.
    IPR018108. Mitochondrial_sb/sol_carrier.
    IPR023395. Mt_carrier_dom.
    [Graphical view]
    PfamiPF00153. Mito_carr. 3 hits.
    [Graphical view]
    PRINTSiPR00926. MITOCARRIER.
    SUPFAMiSSF103506. SSF103506. 1 hit.
    PROSITEiPS50920. SOLCAR. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P40556-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTQTDNPVPN CGLLPEQQYC SADHEEPLLL HEEQLIFPDH SSQLSSADII    50
    EPIKMNSSTE SIIGTTLRKK WVPLSSTQIT ALSGAFAGFL SGVAVCPLDV 100
    AKTRLQAQGL QTRFENPYYR GIMGTLSTIV RDEGPRGLYK GLVPIVLGYF 150
    PTWMIYFSVY EFSKKFFHGI FPQFDFVAQS CAAITAGAAS TTLTNPIWVV 200
    KTRLMLQSNL GEHPTHYKGT FDAFRKLFYQ EGFKALYAGL VPSLLGLFHV 250
    AIHFPIYEDL KVRFHCYSRE NNTNSINLQR LIMASSVSKM IASAVTYPHE 300
    ILRTRMQLKS DIPDSIQRRL FPLIKATYAQ EGLKGFYSGF TTNLVRTIPA 350
    SAITLVSFEY FRNRLENIST MVI 373
    Length:373
    Mass (Da):41,954
    Last modified:February 1, 1995 - v1
    Checksum:i976C767C1D40E8DF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z38113 Genomic DNA. Translation: CAA86245.1.
    BK006942 Genomic DNA. Translation: DAA08540.1.
    PIRiS48451.
    RefSeqiNP_012260.1. NM_001179356.1.

    Genome annotation databases

    EnsemblFungiiYIL006W; YIL006W; YIL006W.
    GeneIDi854811.
    KEGGisce:YIL006W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z38113 Genomic DNA. Translation: CAA86245.1 .
    BK006942 Genomic DNA. Translation: DAA08540.1 .
    PIRi S48451.
    RefSeqi NP_012260.1. NM_001179356.1.

    3D structure databases

    ProteinModelPortali P40556.
    SMRi P40556. Positions 82-359.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 34986. 11 interactions.
    DIPi DIP-4960N.
    MINTi MINT-570805.
    STRINGi 4932.YIL006W.

    Protein family/group databases

    TCDBi 2.A.29.10.5. the mitochondrial carrier (mc) family.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YIL006W ; YIL006W ; YIL006W .
    GeneIDi 854811.
    KEGGi sce:YIL006W.

    Organism-specific databases

    CYGDi YIL006w.
    SGDi S000001268. YIA6.

    Phylogenomic databases

    eggNOGi NOG314559.
    GeneTreei ENSGT00600000084419.
    HOGENOMi HOG000188210.
    KOi K15115.
    OMAi WAIYFTM.
    OrthoDBi EOG73Z352.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-31285-MONOMER.

    Miscellaneous databases

    NextBioi 977639.

    Gene expression databases

    Genevestigatori P40556.

    Family and domain databases

    Gene3Di 1.50.40.10. 1 hit.
    InterProi IPR002067. Mit_carrier.
    IPR018108. Mitochondrial_sb/sol_carrier.
    IPR023395. Mt_carrier_dom.
    [Graphical view ]
    Pfami PF00153. Mito_carr. 3 hits.
    [Graphical view ]
    PRINTSi PR00926. MITOCARRIER.
    SUPFAMi SSF103506. SSF103506. 1 hit.
    PROSITEi PS50920. SOLCAR. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. "Phylogenetic classification of the mitochondrial carrier family of Saccharomyces cerevisiae."
      el Moualij B., Duyckaerts C., Lamotte-Brasseur J., Sluse F.E.
      Yeast 13:573-581(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    4. "Identification of the mitochondrial pyruvate carrier in Saccharomyces cerevisiae."
      Hildyard J.C., Halestrap A.P.
      Biochem. J. 374:607-611(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    5. "Identification of the mitochondrial NAD+ transporter in Saccharomyces cerevisiae."
      Todisco S., Agrimi G., Castegna A., Palmieri F.
      J. Biol. Chem. 281:1524-1531(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, BIOPHYSICOCHEMICAL PROPERTIES.
    6. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
      Kim H., Melen K., Oesterberg M., von Heijne G.
      Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
      Strain: ATCC 208353 / W303-1A.

    Entry informationi

    Entry nameiYIA6_YEAST
    AccessioniPrimary (citable) accession number: P40556
    Secondary accession number(s): D6VVS4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 121 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Caution

    Was first identified as the mitochondrial pyruvate transporter (PubMed:12887330). However, later experiments showed that was a NAD+ transporter (PubMed:16291748).2 Publications

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome IX
      Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

    External Data

    Dasty 3